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Article ; Online: Functions of the SNAI family in chondrocyte-to-osteocyte development.

Razmara, Ehsan / Bitaraf, Amirreza / Karimi, Behnaz / Babashah, Sadegh

Annals of the New York Academy of Sciences

2021 Volume 1503, Issue 1, Page(s) 5–22

Abstract: Different cellular mechanisms contribute to osteocyte development. And while critical roles for members of the zinc finger protein SNAI family (SNAIs) have been discussed in cancer-related models, there are few reviews summarizing their importance for ... ...

Abstract	Different cellular mechanisms contribute to osteocyte development. And while critical roles for members of the zinc finger protein SNAI family (SNAIs) have been discussed in cancer-related models, there are few reviews summarizing their importance for chondrocyte-to-osteocyte development. To help fill this gap, we review the roles of SNAIs in the development of mature osteocytes from chondrocytes, including the regulation of chondro- and osteogenesis through different signaling pathways and in programmed cell death. We also discuss how epigenetic factors-including DNA methylation, histone methylation and acetylation, and noncoding RNAs-contribute differently to both chondrocyte and osteocyte development. To better grasp the important roles of SNAIs in bone development, we also review genotype-phenotype correlations in different animal models. We end with comments about the possible importance of the SNAI family in cartilage/bone development and the potential applications for therapeutic goals.
MeSH term(s)	Animals ; Bone Development/genetics ; Cell Differentiation/genetics ; Chondrocytes/cytology ; Chondrocytes/metabolism ; Chondrogenesis/genetics ; Epigenesis, Genetic ; Gene Expression Regulation, Developmental ; Humans ; Osteocytes/cytology ; Osteocytes/metabolism ; Osteogenesis/genetics ; Signal Transduction ; Snail Family Transcription Factors/genetics ; Snail Family Transcription Factors/metabolism
Chemical Substances	Snail Family Transcription Factors
Language	English
Publishing date	2021-08-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	211003-9
ISSN	1749-6632 ; 0077-8923
ISSN (online)	1749-6632
ISSN	0077-8923
DOI	10.1111/nyas.14668
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Article ; Online: The Iranian Integrated Care Electronic Health Record.

Bitaraf, Ehsan / Jafarpour, Maryam / Jami, Vajiheh / Sarani Rad, Fatemeh

Studies in health technology and informatics

2021 Volume 281, Page(s) 654–658

Abstract: E-health plays a crucial role in E-government by proposing healthcare services based on information technology. However, the way to administer these services by using E-health solutions is one of the challenging issues. One of these significant ... ...

Abstract	E-health plays a crucial role in E-government by proposing healthcare services based on information technology. However, the way to administer these services by using E-health solutions is one of the challenging issues. One of these significant challenges is how one integrates heterogeneous healthcare information of the different point of care systems. This paper introduces the Iranian integrated care electronic health record using the information gathered from several point-of-care systems in healthcare enterprises in Iran. This service-oriented architecture has a remarkable characteristic - its accessibility to medical knowledge and medical concepts through archetypes and ontology, respectively. The Ministry of Health and Medical Education of the Islamic Republic of Iran has designed and implemented this national architecture.
MeSH term(s)	Delivery of Health Care, Integrated ; Electronic Health Records ; Iran
Language	English
Publishing date	2021-05-27
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI210252
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Article: Pilot analysis of intravenous lipid infusion role in COVID-19 mortality.

Ahmadi, Seyyed Amir Yasin / Moradi, Mohammad / Elmi, Mitra / Bitaraf, Ehsan / Kabir, Ali

Przeglad epidemiologiczny

2022 Volume 76, Issue 2, Page(s) 164–167

Abstract: Introduction: How to reduce the fatality of coronavirus disease (COVID-19) is still challenging. A proper nutritional support has been always a matter of attention in critically ill patients.: Material and methods: We assessed COVID-19 patients who ... ...

Abstract	Introduction: How to reduce the fatality of coronavirus disease (COVID-19) is still challenging. A proper nutritional support has been always a matter of attention in critically ill patients. Material and methods: We assessed COVID-19 patients who had received intralipid infusion due to medical indications and compared them with those who did not receive it regarding fatality rate and prognosis. As a part of a data mining project using data of observational cohort of COVID-19 patients hospitalized in the educational centers of Iran University of Medical Sciences, Tehran, Iran, an inferential case series was performed. A total of 19 patients with SARS-CoV-2 infection were selected from the cohort. Briefly, 13 patients survived and 6 patients died, and 12 patients were admitted in intensive care unit (ICU). All dead cases were ICU admitted. The association of intralipid infusion and survival rate was examined using Fisher exact test. No association was observed between intralipid infusion and survival. Conclusions: No significant protecting effect was observed for patients who received intralipid for medical indications. Since intralipid was administered according to medical indications, surviving of all the non-ICU admitted patients despite having underlying diseases was remarkable. Despite the fact, due to several bias factors that could not be controlled in such a retrospective study, the results might be accidental. We suggest to assess such an effect retrospectively in other centers as well.
MeSH term(s)	COVID-19 ; Humans ; Intensive Care Units ; Iran ; Lipids ; Poland ; Retrospective Studies ; SARS-CoV-2
Chemical Substances	Lipids
Language	English
Publishing date	2022-05-31
Publishing country	Poland
Document type	Journal Article
ZDB-ID	421782-2
ISSN	0033-2100
ISSN	0033-2100
DOI	10.32394/pe.76.16
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Article ; Online: Circular RNAs play roles in regulatory networks of cell signaling pathways in human cancers.

Almouh, Mansour / Razmara, Ehsan / Bitaraf, Amirreza / Ghazimoradi, Mohammad H / Hassan, Zuhair Mohammad / Babashah, Sadegh

Life sciences

2022 Volume 309, Page(s) 120975

Abstract: Aims: Circular RNAs (circRNAs) are endogenous covalently closed non-coding RNAs produced by reverse splicing of linear RNA. These molecules are highly expressed in mammalian cells and show cell/tissue-specific expression patterns. They are also ... ...

Abstract	Aims: Circular RNAs (circRNAs) are endogenous covalently closed non-coding RNAs produced by reverse splicing of linear RNA. These molecules are highly expressed in mammalian cells and show cell/tissue-specific expression patterns. They are also significantly dysregulated in various cancers and function as oncogenes or tumor suppressors. Emerging evidence reveals that circRNAs contribute to cancer progression via modulating different cell signaling pathways. Nevertheless, the functional significance of circRNAs in cell signaling pathways regulation is still largely elusive. Considering this, shedding light on the multi-pathway effects of circRNAs may improve our understanding of targeted cancer therapy. Here, we discuss how circRNAs regulate the major cell signaling pathways in human cancers. Materials and methods: We adopted a systematic search in PubMed using the following MeSH terms: circRNAs, non-coding RNAs, lncRNAs, exosomal circRNAs, cancer, and cell signaling. Key findings: We discussed different roles of circRNAs during tumorigenesis in which circRNAs affect tumor development through activating or inactivating certain cell signaling pathways via molecular interactions using various signaling pathways. We also discussed how crosstalk between circRNAs and lncRNAs modulate tumorigenesis and provides a resource for the identification of cancer therapeutic targets. Significance: We here elucidated how circRNAs can modulate different cell signaling pathways and play roles in cancer. This can broaden our horizons toward introducing promising prognostic, diagnostic, and therapeutic targets.
MeSH term(s)	Animals ; Humans ; RNA, Circular/genetics ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Neoplasms/genetics ; Neoplasms/diagnosis ; Signal Transduction/genetics ; Carcinogenesis ; Mammals/genetics ; Mammals/metabolism
Chemical Substances	RNA, Circular ; RNA, Long Noncoding
Language	English
Publishing date	2022-09-17
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2022.120975
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Article ; Online: A near real-time electronic health record-based COVID-19 surveillance system: An experience from a developing country.

Sheikhtaheri, Abbas / Tabatabaee Jabali, Seyed Mohammad / Bitaraf, Ehsan / TehraniYazdi, Alireza / Kabir, Ali

Health information management : journal of the Health Information Management Association of Australia

2022 , Page(s) 18333583221104213

Abstract: Context: Access to real-time data that provide accurate and timely information about the status and extent of disease spread could assist management of the COVID-19 pandemic and inform decision-making.: Aim: To demonstrate our experience with regard ... ...

Abstract	Context: Access to real-time data that provide accurate and timely information about the status and extent of disease spread could assist management of the COVID-19 pandemic and inform decision-making. Aim: To demonstrate our experience with regard to implementation of technical and architectural infrastructure for a near real-time electronic health record-based surveillance system for COVID-19 in Iran. Method: This COVID-19 surveillance system was developed from hospital information and electronic health record (EHR) systems available in the study hospitals in conjunction with a set of open-source solutions; and designed to integrate data from multiple resources to provide near real-time access to COVID-19 patients' data, as well as a pool of health data for analytical and decision-making purposes. Outcomes: Using this surveillance system, we were able to monitor confirmed and suspected cases of COVID-19 in our population and to automatically notify stakeholders. Based on aggregated data collected, this surveillance system was able to facilitate many activities, such as resource allocation for hospitals, including managing bed allocations, providing and distributing equipment and funding, and setting up isolation centres. Conclusion: Electronic health record systems and an integrated data analytics infrastructure are effective tools to enable policymakers to make better decisions, and for epidemiologists to conduct improved analyses regarding COVID-19. Implications: Improved quality of clinical coding for better case finding, improved quality of health information in data sources, data-sharing agreements, and increased EHR coverage in the population can empower EHR-based COVID-19 surveillance systems.
Language	English
Publishing date	2022-07-15
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2390067-2
ISSN	1833-3575 ; 1833-3583
ISSN (online)	1833-3575
ISSN	1833-3583
DOI	10.1177/18333583221104213
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Article ; Online: DITAS: An Integrated Gateway to E-health Communications.

Bitaraf, Ehsan / Sarani Rad, Fatemeh / Jafarpour, Maryam / Jami, Vajiheh / Keshavarz Safari, Ebrahim / Nasimi, Pourya

Studies in health technology and informatics

2021 Volume 281, Page(s) 452–456

Abstract: Today, the demand for health-oriented systems to facilitate and improve treatment processes is growing. For different information systems with different structures and technologies to be able to communicate with each other, a single gateway is required. ... ...

Abstract	Today, the demand for health-oriented systems to facilitate and improve treatment processes is growing. For different information systems with different structures and technologies to be able to communicate with each other, a single gateway is required. The gateway acts as an interface between information systems and unifies protocols, rules, and standards related to communication processes. Health-related systems need a unique regulator that explains data models, coding, and data exchange structures. Moreover, the gateway has control over information systems and the data transmitted between them. In this paper, we explain an integrated gateway of health information exchange named DITAS which is a bridging point between health-related systems.
MeSH term(s)	Health Communication ; Health Information Exchange ; Information Systems
Language	English
Publishing date	2021-05-27
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI210199
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Article ; Online: An Easy-to-Use Platform for Reporting COVID-19 Patients by Private Offices and Clinics Without IT Support: A Pilot Study.

Sabermahani, Farveh / Manafimourkani, Anahita / Bitaraf, Ehsan / Seifi, Nahid / Chinichian, Mahdi / Ghaemi, Adel / Farhadi, Leila-Sadat / Sheikhtaheri, Abbas

Studies in health technology and informatics

2022 Volume 293, Page(s) 242–249

Abstract: Background: It is feasible to collect data rapidly and online using IT solutions.: Objectives: To present a data collection platform for COVID-19 suspected patients in private offices and clinics without a standard software.: Methods: The proposed ...

Abstract	Background: It is feasible to collect data rapidly and online using IT solutions. Objectives: To present a data collection platform for COVID-19 suspected patients in private offices and clinics without a standard software. Methods: The proposed system for collecting and sharing data of patients with respiratory symptoms was designed to be simple to use, without the need for special technology, and with proper security to authenticate reporters. Results: Two methods were developed to collect data from private physicians and offices. Finally, the data collected by both approaches is integrated and provided to primary healthcare staff to arrange appropriate healthcare measures. Conclusion: Our platform can provide an easy-to-use case reporting system for private physicians.
MeSH term(s)	COVID-19 ; Health Personnel ; Humans ; Pilot Projects
Language	English
Publishing date	2022-05-18
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI220376
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Article: Circular RNAs play roles in regulatory networks of cell signaling pathways in human cancers

Almouh, Mansour / Razmara, Ehsan / Bitaraf, Amirreza / Ghazimoradi, Mohammad H. / Hassan, Zuhair Mohammad / Babashah, Sadegh

Life sciences. 2022 Nov. 15, v. 309

2022

Abstract: Circular RNAs (circRNAs) are endogenous covalently closed non-coding RNAs produced by reverse splicing of linear RNA. These molecules are highly expressed in mammalian cells and show cell/tissue-specific expression patterns. They are also significantly ... ...

Abstract	Circular RNAs (circRNAs) are endogenous covalently closed non-coding RNAs produced by reverse splicing of linear RNA. These molecules are highly expressed in mammalian cells and show cell/tissue-specific expression patterns. They are also significantly dysregulated in various cancers and function as oncogenes or tumor suppressors. Emerging evidence reveals that circRNAs contribute to cancer progression via modulating different cell signaling pathways. Nevertheless, the functional significance of circRNAs in cell signaling pathways regulation is still largely elusive. Considering this, shedding light on the multi-pathway effects of circRNAs may improve our understanding of targeted cancer therapy. Here, we discuss how circRNAs regulate the major cell signaling pathways in human cancers. We adopted a systematic search in PubMed using the following MeSH terms: circRNAs, non-coding RNAs, lncRNAs, exosomal circRNAs, cancer, and cell signaling. We discussed different roles of circRNAs during tumorigenesis in which circRNAs affect tumor development through activating or inactivating certain cell signaling pathways via molecular interactions using various signaling pathways. We also discussed how crosstalk between circRNAs and lncRNAs modulate tumorigenesis and provides a resource for the identification of cancer therapeutic targets. We here elucidated how circRNAs can modulate different cell signaling pathways and play roles in cancer. This can broaden our horizons toward introducing promising prognostic, diagnostic, and therapeutic targets.
Keywords	RNA ; cancer therapy ; carcinogenesis ; chemical bonding ; humans ; neoplasm progression ; neoplasms ; oncogenes
Language	English
Dates of publication	2022-1115
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2022.120975
Database	NAL-Catalogue (AGRICOLA)

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Article: Advantages of a Web-Based Real-Time Bed-Management System for Hospital Admission Monitoring in Iran.

Abedian, Somayeh / Bitaraf, Ehsan / Askari, Marjan

Studies in health technology and informatics

2018 Volume 247, Page(s) 536–540

Abstract: Lack of up-to-date information of hospitals beds, specifically in emergencies, is a significant problem in many large countries; The Ministry of Health and Medical Education of Iran (MOHME) designed and implemented a dynamic system that reports the ... ...

Abstract	Lack of up-to-date information of hospitals beds, specifically in emergencies, is a significant problem in many large countries; The Ministry of Health and Medical Education of Iran (MOHME) designed and implemented a dynamic system that reports the status of beds in 2012. This system created great opportunities for national bed management, including real-time hospital admission monitoring, especially for emergency departments, ICUs and CCUs. Therefore, an additional online system was planned to be implemented for monitoring hospital admissions, including a national alert system. Prior to the design of this system, a study was done using literature study and expert opinion to investigate the advantages and features that this monitoring system was required to have. We used the MoSCoW method to prioritize the requirements of the system. This system was designed to have the following advantages, among other things: the hospitals as well as government should be able to track the patients, manage patient distribution in healthcare centers, and make policy for supplying extra beds. It should also be possible for the hospitals executive board, as well as the government, to monitor the performance of the hospitals regarding patient admissions (i.e., the rate of rejection of patients with severe conditions).
MeSH term(s)	Hospital Bed Capacity ; Hospitalization ; Humans ; Internet ; Iran ; Patient Admission
Language	English
Publishing date	2018
Publishing country	Netherlands
Document type	Journal Article
ISSN	0926-9630
ISSN	0926-9630
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Article ; Online: Functional Analysis of

Esmaeilzadeh-Gharehdaghi, Elika / Razmara, Ehsan / Bitaraf, Amirreza / Jamshidi, Ahmadreza / Mahmoudi, Mahdi / Garshasbi, Masoud

Archives of Iranian medicine

2020 Volume 23, Issue 10, Page(s) 688–696

Abstract: Background: Ankylosing spondylitis (AS; OMIM:106300) is a common complex inflammatory disease; in a previous study, we introduced a novel mutation in the : Methods: The impact of the S2486G on reelin protein secretion was investigated in CHO-K1 and ... ...

Abstract	Background: Ankylosing spondylitis (AS; OMIM:106300) is a common complex inflammatory disease; in a previous study, we introduced a novel mutation in the Methods: The impact of the S2486G on reelin protein secretion was investigated in CHO-K1 and HEK-293T cells by constructing wild-type and mutant plasmids. Besides, the possible effect of the mutation on expression and concentration of Results: Our results showed that S2486G not only causes a significant reduction in reelin secretion in both HEK-293T and CHO-K1 cells, but also it leads to a significant reduction in Conclusion: The S2486G mutation in
MeSH term(s)	1-Alkyl-2-acetylglycerophosphocholine Esterase/genetics ; Animals ; CHO Cells ; Cell Adhesion Molecules, Neuronal/genetics ; Cricetulus ; Extracellular Matrix Proteins/genetics ; HEK293 Cells ; Humans ; Mutation ; Nerve Tissue Proteins/genetics ; Serine Endopeptidases/genetics ; Spondylitis, Ankylosing/genetics ; THP-1 Cells
Chemical Substances	Cell Adhesion Molecules, Neuronal ; Extracellular Matrix Proteins ; Nerve Tissue Proteins ; 1-Alkyl-2-acetylglycerophosphocholine Esterase (EC 3.1.1.47) ; PLA2G7 protein, human (EC 3.1.1.47) ; Serine Endopeptidases (EC 3.4.21.-) ; reelin protein (EC 3.4.21.-)
Language	English
Publishing date	2020-10-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2204979-4
ISSN	1735-3947 ; 1029-2977
ISSN (online)	1735-3947
ISSN	1029-2977
DOI	10.34172/aim.2020.87
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