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Article: Primary Squamous Cell Carcinoma of the Sigmoid Revealed by Acute Intestinal Occlusion in Moroccan Young Male Patient: A Case Report and Literature Review.

Haouane, Mohamed Amine / Badr, Jouabri / Kaakoua, Mohamed / Azami, Mohamed Amine

2023 Volume 15, Issue 1, Page(s) e34283

Abstract: Primary colorectal squamous cell carcinoma (SCC) is an extremely rare subtype of colon cancer, with an incidence of less than 1% of colorectal malignancies. We report a case of a 40-year-old male patient admitted to the emergency department with symptoms ...

Abstract	Primary colorectal squamous cell carcinoma (SCC) is an extremely rare subtype of colon cancer, with an incidence of less than 1% of colorectal malignancies. We report a case of a 40-year-old male patient admitted to the emergency department with symptoms of acute intestinal obstruction. Histopathological evaluation of colonoscopic biopsies revealed squamous cell carcinoma. A sigmoidectomy was performed. In order to enrich the medical literature, we add our case to the collection of colorectal squamous cell carcinoma cases by analyzing and summarizing the clinical, pathological, and therapeutic features of this rare entity.
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.34283
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; Thesis: Morphomolekulare Analyse des Immun-Mikromilieus im Kopf-Hals-Karzinom

Badr, Mohamed [Verfasser]

2021

Author's details	Mohamed Badr
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Medizinische Fakultät Charité - Universitätsmedizin Berlin
Publishing place	Berlin
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: An eco-friendly one-pot spectrofluorimetric approach for the facile determination of overactive bladder drug, tolterodine: Application to dosage forms and biological fluids.

Derayea, Sayed M / Badr El-Din, Khalid M / Ahmed, Ahmed S / Abdelshakour, Mohamed A / Oraby, Mohamed

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2024 Volume 311, Page(s) 123986

Abstract: Tolterodine tartrate (TTD) was the first antimuscarinic medication developed exclusively for the treatment of overactive bladder syndrome and was approved by the FDA in 1998. As a result of the drug's extensive utilization within the local community ... ...

Abstract	Tolterodine tartrate (TTD) was the first antimuscarinic medication developed exclusively for the treatment of overactive bladder syndrome and was approved by the FDA in 1998. As a result of the drug's extensive utilization within the local community following its authorization, there is a pressing need to develop and validate a spectrofluorometric method that is economically efficient, easily reproducible, environmentally sustainable, and possesses high sensitivity. The developed approach relies on enhancing the fluorescence intensity of TTD to reach a level 720 % higher than its initial value, achieved through the application of an aqueous sodium dodecyl sulfate (SDS) solution. A strong correlation was observed with a correlation coefficient of 0.9998 between the concentration of TTD and the fluorescence intensity within the range of 25.0-500.0 ng mL
MeSH term(s)	Humans ; Tolterodine Tartrate ; Urinary Bladder, Overactive/drug therapy ; Spectrometry, Fluorescence/methods ; Muscarinic Antagonists/therapeutic use ; Sodium Dodecyl Sulfate
Chemical Substances	Tolterodine Tartrate (5T619TQR3R) ; Muscarinic Antagonists ; Sodium Dodecyl Sulfate (368GB5141J)
Language	English
Publishing date	2024-02-04
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2024.123986
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Article: Detection and quantification of adenovirus, polyomavirus, and papillomavirus in urban sewage.

Shaheen, Mohamed N F / Ahmed, Nehal / Rady Badr, Kareem / Elmahdy, Elmahdy Mohamed

Journal of water and health

2024 Volume 22, Issue 2, Page(s) 401–413

Abstract: The objective of this study was to assess the occurrence and seasonal frequency of human adenovirus (HAdV), human polyomavirus (HPyV), and human papillomavirus (HPV) in urban sewage. The detection of these viruses was carried out by polymerase chain ... ...

Abstract	The objective of this study was to assess the occurrence and seasonal frequency of human adenovirus (HAdV), human polyomavirus (HPyV), and human papillomavirus (HPV) in urban sewage. The detection of these viruses was carried out by polymerase chain reaction (PCR), and then the viral concentrations in the positive samples were quantified by quantitative PCR (qPCR). Additionally, HAdV and HPyV genotyping was also performed by PCR. A total of 38/60 (63.3%) positive samples were found. HAdV was the most prevalent virus (26/60; 43.3%), followed by HPyV (21/60; 35%) and HPV (21/60; 35%). The viral concentrations ranged from 3.56 × 10
MeSH term(s)	Humans ; Adenoviridae ; Sewage ; Polyomavirus/genetics ; Papillomavirus Infections ; Adenoviruses, Human
Chemical Substances	Sewage
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2123845-5
ISSN	1996-7829 ; 1477-8920
ISSN (online)	1996-7829
ISSN	1477-8920
DOI	10.2166/wh.2024.322
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Article: Hamartoma of the soft palate: Case report and review of literature.

Zineb, El Krimi / Badr, Saoutarrih / Loubna, Douimi / Walid, Bijou / Mohamed, Mahtar

International journal of surgery case reports

2024 Volume 115, Page(s) 109281

Abstract: Introduction: Hamartoma is a tumor-like malformation that represents a focal proliferation of normal cells. Hamartoma of the soft palate is a rare entity, which can lead to serious, life-threatening clinical manifestations, given its anatomical location. ...

Abstract	Introduction: Hamartoma is a tumor-like malformation that represents a focal proliferation of normal cells. Hamartoma of the soft palate is a rare entity, which can lead to serious, life-threatening clinical manifestations, given its anatomical location. However, if properly treated surgically, their prognosis is excellent. Case presentation: The literature reports very few similar cases. So, we report a case of hamartoma of the soft palate, which presented as a sessile velar outgrowth arising on the midline of a 12-day-old newborn. The final diagnosis was based on histopathology. The patient was treated surgically and had excellent evolution. Clinical Discussion. Clinical examination shows hamartomas of the palate to be polyploid lesions, with a firm surface. A CT scan and magnetic resonance imaging (MRI) are indicated to establish the extent of the tumor. The diagnosis of certainty is determined by a histopathological examination. The only treatment is surgery, generally via the transoral approach. Prognosis is excellent. Conclusion: Hamartomas of the palate are diagnosed histologically, with imaging being of great help in assessing extension, and their therapeutic management is exclusively surgical. The prognosis after successful surgery is practically always good, with no recurrence.
Language	English
Publishing date	2024-01-20
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2024.109281
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Effect of Glycyrrhizin on the Viability and Proliferation of Dental Pulp Stem Cells Compared to Intracanal Medicaments.

Alrashidi, Mohammad A / Badawi, Manal F / Elbeltagy, Mohamed G / Badr, Amany E

The journal of contemporary dental practice

2024 Volume 25, Issue 3, Page(s) 267–275

Abstract: Aim: To study the effect of glycyrrhizin (GA) on the viability and proliferation of dental pulp stem cells (DPSCs) compared with intracanal medicaments.: Materials and methods: Third molars of an adult donor were used to obtain the DPSCs. Flow ... ...

Abstract	Aim: To study the effect of glycyrrhizin (GA) on the viability and proliferation of dental pulp stem cells (DPSCs) compared with intracanal medicaments. Materials and methods: Third molars of an adult donor were used to obtain the DPSCs. Flow cytometry was utilized to conduct phenotypic analysis for DPSCs. The methyl-thiazol tetrazolium (MTT) test was used to detect the cell viability. Cell proliferation assay was conducted at distinct time intervals: 3, 5, and 7 days. Results: The flow cytometry analysis verified the positive expression of mesenchymal cell surface antigen molecules (CD73, CD90, and CD105) and the absence of hematological markers (CD14, CD34, and CD45) in the DPSCs. The cells that treated with concentrations more than 0.5 mg/mL of Ca(OH Conclusion: Based upon the potential of GA on DPSCs proliferation compared with Ca(OH) Clinical significance: This study emphasizes the significance of assessing alternative root canal medicaments and their impact on the proliferation and viability of DPSCs. The results regarding GA, specifically its impact on the viability and growth of DPSCs, provide essential understanding for its potential application as an intracanal medicine. This study adds to the continuous endeavors in identifying safer and more efficient intracanal therapies, which are essential for improving patient outcomes in endodontic operations. How to cite this article: Alrashidi MA, Badawi MF, Elbeltagy MG,
MeSH term(s)	Humans ; Dental Pulp/cytology ; Dental Pulp/drug effects ; Glycyrrhizic Acid/pharmacology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Root Canal Irrigants/pharmacology ; Stem Cells/drug effects ; Flow Cytometry ; Calcium Hydroxide/pharmacology ; Cells, Cultured ; Adult
Chemical Substances	Glycyrrhizic Acid (6FO62043WK) ; Root Canal Irrigants ; Calcium Hydroxide (PF5DZW74VN)
Language	English
Publishing date	2024-03-19
Publishing country	India
Document type	Journal Article ; Comparative Study
ISSN	1526-3711
ISSN (online)	1526-3711
DOI	10.5005/jp-journals-10024-3652
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Examining the Effects of Asiaticoside on Dental Pulp Stem Cell Viability and Proliferation: A Promising Approach to Root Canal Treatment.

Alazemi, Mohammad J / Badawi, Manal F / Elbeltagy, Mohamed G / Badr, Amany E

The journal of contemporary dental practice

2024 Volume 25, Issue 2, Page(s) 118–127

Abstract: Aim: This study aims to evaluate the impact of asiaticoside (AC) on the viability and proliferation of dental pulp stem cells (DPSCs), considering the known negative effects of routinely used intracanal medicaments. This evaluation will be compared with ...

Abstract	Aim: This study aims to evaluate the impact of asiaticoside (AC) on the viability and proliferation of dental pulp stem cells (DPSCs), considering the known negative effects of routinely used intracanal medicaments. This evaluation will be compared with the outcomes from using traditional intracanal medicaments, specifically triple antibiotic paste (TAP) and calcium hydroxide [Ca(OH) Materials and methods: The DPSCs were obtained from the third molars of an adult donor. The application of flow cytometry was employed to do a phenotypic analysis on DPSCs using CD90, CD73, CD105, CD34, CD14, and CD45 antibodies. The methylthiazol tetrazolium (MTT) assay was employed to assess cellular viability. The cells were treated with different concentrations of TAP and Ca(OH) Results: The characterization of DPSCs was conducted by flow cytometry analysis, which verified the presence of mesenchymal cell surface antigen molecules (CD105, CD73, and CD90) and demonstrated the absence of hematopoietic markers (CD34, CD45, and CD14). Cells treated with concentrations over 0.5 mg/mL of TAP and Ca(OH) Conclusion: The cellular viability of the AC-treated cells was superior to that of the TAP and Ca(OH) Clinical significance: This study underscores the importance of evaluating alternative root canal medicaments and their effects on DPSCs' growth and vitality. The findings on AC, particularly its influence on the survival and proliferation of DPSCs, offer valuable insights for its probable use as an intracanal medication. This research contributes to the ongoing efforts to identify safer and more effective intracanal treatments, which are crucial for enhancing patient outcomes in endodontic procedures. How to cite this article: Alazemi MJ, Badawi MF, Elbeltagy MG,
MeSH term(s)	Humans ; Dental Pulp ; Dental Pulp Cavity ; Cell Survival ; Anti-Bacterial Agents/pharmacology ; Calcium Hydroxide/pharmacology ; Cell Proliferation ; Triterpenes
Chemical Substances	asiaticoside (PKO39VY215) ; Anti-Bacterial Agents ; Calcium Hydroxide (PF5DZW74VN) ; Triterpenes
Language	English
Publishing date	2024-02-01
Publishing country	India
Document type	Journal Article
ISSN	1526-3711
ISSN (online)	1526-3711
DOI	10.5005/jp-journals-10024-3636
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The value of local dexmedetomidine as an adjuvant to ultrasound-guided wide awake local anesthesia no tourniquet (WALANT) in flexor tendon repair surgeries: a randomized controlled trial.

Alseoudy, Mahmoud Mohammed / Abdelkarime, Elsayed Mohamed / Nour, Khaled / Badr, May Elsherbiny

BMC anesthesiology

2024 Volume 24, Issue 1, Page(s) 120

Abstract: Background: The Wide-Awake Local Anesthesia No Tourniquet (WALANT) technique allows intraoperative motor assessment of tendon repair integrity of the hand compared with general anesthesia or brachial plexus block. No studies have tested the effect of ... ...

Abstract	Background: The Wide-Awake Local Anesthesia No Tourniquet (WALANT) technique allows intraoperative motor assessment of tendon repair integrity of the hand compared with general anesthesia or brachial plexus block. No studies have tested the effect of adding dexmedetomidine to lidocaine on the analgesic properties of the WALANT technique, which is the aim of our study. Methods: A total of 128 patients aged more than 18 years were scheduled for surgical flexor tendon injury repair using WALANT technique. Patients were divided into two equal groups. Ultrasound-guided subcutaneous injection of lidocaine 1% with dexmedetomidine (1 µg/kg), Group D, or without dexmedetomidine, Group C, was performed at four points: proximal to the wrist joint, the distal forearm, palm region, and proximal phalanges. The primary outcome was total morphine consumption throughout the first postoperative day. Secondary outcomes included number of patients requiring rescue analgesia, time to first analgesic request, and pain score. Results: Total morphine consumption was significantly (P < 0.001) lower in group D (2.66 ± 0.998) than in group C (3.66 ± 1.144) mg. Number of patients requiring rescue analgesia was significantly (P < 0.001) lower in group D (54.7% (35)) than group C (100.0% (64)). The time for first request for analgesia was significantly (P < 0.001) longer in group D (11.31 ± 6.944) than in group C (5.91 ± 4.839) h. Pain score was significantly higher in group C than D at three (P < 0.001), and six (P = 0.001) hours (P = 0.001) postoperatively. Conclusion: Dexmedetomidine significantly improves the analgesic quality of WALANT when added to lidocaine with less opioid consumption. Trial registration: (ID: PACTR202203906027106; Date: 31/07/2023).
MeSH term(s)	Humans ; Analgesics ; Anesthesia, Local/methods ; Anesthetics, Local ; Dexmedetomidine ; Lidocaine ; Morphine ; Pain, Postoperative/drug therapy ; Tendons ; Ultrasonography, Interventional ; Adolescent ; Young Adult
Chemical Substances	Analgesics ; Anesthetics, Local ; Dexmedetomidine (67VB76HONO) ; Lidocaine (98PI200987) ; Morphine (76I7G6D29C)
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2091252-3
ISSN	1471-2253 ; 1471-2253
ISSN (online)	1471-2253
ISSN	1471-2253
DOI	10.1186/s12871-024-02504-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Effect of Rosmarinus Officinalis as a Potential Root Canal Medication on the Viability of Dental Pulp Stem Cells.

Othman, Nesma Mohamed / Elhawary, Yousry Mahmoud / Elbeltagy, Mohamed G / Badr, Amany Elsaid

The journal of contemporary dental practice

2023 Volume 24, Issue 9, Page(s) 623–631

Abstract: Aim: The objective of the current study was to assess and compare the impact of triple antibiotic paste (TAP) and calcium hydroxide (Ca(OH): Materials and methods: Dental pulp stem cells were isolated and characterized using flow cytometry. The cells ...

Abstract	Aim: The objective of the current study was to assess and compare the impact of triple antibiotic paste (TAP) and calcium hydroxide (Ca(OH) Materials and methods: Dental pulp stem cells were isolated and characterized using flow cytometry. The cells were treated with (0.25, 0.5, 1, 2.5, and 5 mg/mL) concentrations for TAP and Ca(OH) Results: Following the cell viability test, 0.25 and 0.5 mg/mL of TAP and Ca(OH) Conclusion: Rosmarinic acid showed a significant increase in cell viability when used at 6.25 and 12.5 µM concentrations compared to TAP and CA(OH) Clinical significance: The assessment of cytotoxicity associated with bioactive compounds like RA, which processes antimicrobial and anti-inflammatory properties, holds importance. This evaluation could pave the way for novel intracanal medicaments that enhance the regenerative potential of DPSCs.
MeSH term(s)	Rosmarinus ; Dental Pulp ; Dental Pulp Cavity ; Anti-Bacterial Agents/pharmacology ; Calcium Hydroxide ; Zinc Oxide/pharmacology ; Stem Cells
Chemical Substances	Anti-Bacterial Agents ; Calcium Hydroxide (PF5DZW74VN) ; Zinc Oxide (SOI2LOH54Z)
Language	English
Publishing date	2023-09-01
Publishing country	India
Document type	Journal Article
ISSN	1526-3711
ISSN (online)	1526-3711
DOI	10.5005/jp-journals-10024-3570
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Assessment of bone morphogenetic protein-7 loaded chitosan/β-Glycerophosphate hydrogel on periodontium tissues regeneration of class III furcation defects.

Badr, Ahmed M / Shalaby, Hany K / Awad, Mohamed A / Hashem, Mohamed A

The Saudi dental journal

2023 Volume 35, Issue 6, Page(s) 760–767

Abstract: Background: Periodontitis is a long-term, multifactorial inflammatory condition that is triggered by bacterial germs and interacts with the host's immune system. The unique attachment of fibrous tissue between the cementum and bone presents a challenge ... ...

Abstract	Background: Periodontitis is a long-term, multifactorial inflammatory condition that is triggered by bacterial germs and interacts with the host's immune system. The unique attachment of fibrous tissue between the cementum and bone presents a challenge for periodontal regeneration. Aim: To achieve the lowest optimum dose of BMP-7 that helps in periodontal regeneration, involving newly formed cementum, PDL and bone. Materials and methods: Five healthy mongrel dogs were used for the study. A critical class III furcation defect was created using rotating burs. The bone defects (ten defects for each group) were allocated to one of the subsequent groups: (Group 1) control with the surgical defect only. (Group 2) Surgical defect implanted with hydrogel only (CS/β-GP). (Group 3) Surgical defect implanted with CS/BMP-7 (50 ng/ml). (Group 4) Surgical defect implanted with CS/BMP-7 (100 ng/ml). Results: Histomorphometric and H&E analysis revealed a statistically significant difference in bone, PDL, and cementum regeneration defects filled with CS/BMP-7 (100 ng/ml) compared with other groups. Conclusion: The standard effective dose for BMP-7 use in periodontal regeneration is 100 ng/ml.
Language	English
Publishing date	2023-06-03
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	1058421-3
ISSN	1658-3558 ; 1013-9052
ISSN (online)	1658-3558
ISSN	1013-9052
DOI	10.1016/j.sdentj.2023.05.027
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