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  1. Article: Insulin-induced mTOR signaling and gluconeogenesis in renal proximal tubules: A mini-review of current evidence and therapeutic potential.

    Nakamura, Motonobu / Satoh, Nobuhiko / Horita, Shoko / Nangaku, Masaomi

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 1015204

    Abstract: Energy is continuously expended in the body, and gluconeogenesis maintains glucose homeostasis during starvation. Gluconeogenesis occurs in the liver and kidneys. The proximal tubule is the primary location for renal gluconeogenesis, accounting for up to ...

    Abstract Energy is continuously expended in the body, and gluconeogenesis maintains glucose homeostasis during starvation. Gluconeogenesis occurs in the liver and kidneys. The proximal tubule is the primary location for renal gluconeogenesis, accounting for up to 25% and 60% of endogenous glucose production during fasting and after a meal, respectively. The mechanistic target of rapamycin (mTOR), which exists downstream of the insulin pathway, plays an important role in regulating proximal tubular gluconeogenesis. mTOR is an atypical serine/threonine kinase present in two complexes. mTORC1 phosphorylates substrates that enhance anabolic processes such as mRNA translation and lipid synthesis and catabolic processes such as autophagy. mTORC2 regulates cytoskeletal dynamics and controls ion transport and proliferation
    Language English
    Publishing date 2022-10-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.1015204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Oxidized alkyl phospholipids stimulate sodium transport in proximal tubules via a nongenomic PPARγ-dependent pathway.

    Mizuno, Tomohito / Satoh, Nobuhiko / Horita, Shoko / Tsukada, Hiroyuki / Takagi, Mayuko / Sato, Yusuke / Kume, Haruki / Nangaku, Masaomi / Nakamura, Motonobu

    The Journal of biological chemistry

    2022  Volume 298, Issue 3, Page(s) 101681

    Abstract: Oxidized phospholipids have been shown to exhibit pleiotropic effects in numerous biological contexts. For example, 1-O-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine (azPC), an oxidized phospholipid formed from alkyl phosphatidylcholines, is a ... ...

    Abstract Oxidized phospholipids have been shown to exhibit pleiotropic effects in numerous biological contexts. For example, 1-O-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine (azPC), an oxidized phospholipid formed from alkyl phosphatidylcholines, is a peroxisome proliferator-activated receptor gamma (PPARγ) nuclear receptor agonist. Although it has been reported that PPARγ agonists including thiazolidinediones can induce plasma volume expansion by enhancing renal sodium and water retention, the role of azPC in renal transport functions is unknown. In the present study, we investigated the effect of azPC on renal proximal tubule (PT) transport using isolated PTs and kidney cortex tissues and also investigated the effect of azPC on renal sodium handling in vivo. We showed using a microperfusion technique that azPC rapidly stimulated Na
    MeSH term(s) Animals ; CD36 Antigens/antagonists & inhibitors ; CD36 Antigens/metabolism ; Hypoglycemic Agents/pharmacology ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/metabolism ; Oxidation-Reduction ; PPAR gamma/metabolism ; Phospholipids/metabolism ; Rats ; Signal Transduction ; Sodium-Hydrogen Exchangers/metabolism ; Thiazolidinediones/pharmacology
    Chemical Substances CD36 Antigens ; Hypoglycemic Agents ; PPAR gamma ; Phospholipids ; Sodium-Hydrogen Exchangers ; Thiazolidinediones
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2022.101681
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  3. Article ; Online: Evaluation of Right Ventricular Function on Cardiac Magnetic Resonance Imaging and Correlation With Hemodynamics in Patients With Chronic Thromboembolic Pulmonary Hypertension.

    Nishina, Yoshio / Inami, Takumi / Kataoka, Masaharu / Kariyasu, Toshiya / Shimura, Nobuhiko / Ishiguro, Haruhisa / Yokoyama, Kenichi / Yoshino, Hideaki / Satoh, Toru

    Circulation reports

    2020  Volume 2, Issue 3, Page(s) 174–181

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2020-02-22
    Publishing country Japan
    Document type Journal Article
    ISSN 2434-0790
    ISSN (online) 2434-0790
    DOI 10.1253/circrep.CR-20-0004
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  4. Article ; Online: The effect of exposure on cattle thyroid after the Fukushima Daiichi nuclear power plant accident.

    Horikami, Daiki / Sayama, Naoya / Sasaki, Jun / Kusuno, Haruka / Matsuzaki, Hiroyuki / Hayashi, Akane / Nakamura, Tatsuro / Satoh, Hiroshi / Natsuhori, Masahiro / Okada, Keiji / Ito, Nobuhiko / Sato, Itaru / Murata, Takahisa

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 21754

    Abstract: Nuclear plant accidents can be a risk for thyroid cancer due to iodine radioisotopes. Near the Fukushima Daiichi nuclear power plant, cattle were exposed to radiation after the accident occurred in May 2011. Here we estimated the total radiation exposure ...

    Abstract Nuclear plant accidents can be a risk for thyroid cancer due to iodine radioisotopes. Near the Fukushima Daiichi nuclear power plant, cattle were exposed to radiation after the accident occurred in May 2011. Here we estimated the total radiation exposure to cattle thyroid and its effects on thyroid function. Until October 2016, the estimated external exposure dose in Farm A was 1416 mGy, while internal exposure dose of
    MeSH term(s) Cattle ; Animals ; Fukushima Nuclear Accident ; Nuclear Power Plants ; Thyroid Gland/radiation effects ; Iodine Radioisotopes/adverse effects ; Iodine Radioisotopes/analysis ; Radiation Exposure/adverse effects ; Japan/epidemiology ; Radiation Dosage
    Chemical Substances Iodine Radioisotopes
    Language English
    Publishing date 2022-12-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-25269-0
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  5. Article ; Online: A novel testis-specific long noncoding RNA, Tesra, activates the Prss42/Tessp-2 gene during mouse spermatogenesis†.

    Satoh, Yui / Takei, Natsumi / Kawamura, Shohei / Takahashi, Nobuhiko / Kotani, Tomoya / Kimura, Atsushi P

    Biology of reproduction

    2018  Volume 100, Issue 3, Page(s) 833–848

    Abstract: The progression of spermatogenesis is precisely controlled by meiotic stage-specific genes, but the molecular mechanism for activation of such genes is still elusive. Here we found a novel testis-specific long noncoding RNA (lncRNA), Tesra, that was ... ...

    Abstract The progression of spermatogenesis is precisely controlled by meiotic stage-specific genes, but the molecular mechanism for activation of such genes is still elusive. Here we found a novel testis-specific long noncoding RNA (lncRNA), Tesra, that was specifically expressed in the mouse testis at the Prss/Tessp gene cluster on chromosome 9. Tesra was transcribed downstream of Prss44/Tessp-4, starting within the gene, as a 4435-nucleotide transcript and developmentally activated at a stage similar to that for Prss/Tessp genes. By in situ hybridization, Tesra was found to be localized in and around germ cells and Leydig cells, being consistent with biochemical data showing its existence in cytoplasmic, nuclear, and extracellular fractions. Based on the finding of more signals in nuclei of pachytene spermatocytes, we explored the possibility that Tesra plays a role in transcriptional activation of Prss/Tessp genes. By a ChIRP assay, the Tesra transcript was found to bind to the Prss42/Tessp-2 promoter region in testicular germ cells, and transient overexpression of Tesra significantly activated endogenous Prss42/Tessp-2 expression and increased Prss42/Tessp-2 promoter activity in a reporter construct. These findings suggest that Tesra activates the Prss42/Tessp-2 gene by binding to the promoter. Finally, we investigated whether Tesra co-functioned with enhancers adjacent to another lncRNA, lncRNA-HSVIII. In the Tet-on system, Tesra transcription significantly increased activity of one enhancer, but Tesra and the enhancer were not interdependent. Collectively, our results proposed a potential function of an lncRNA, Tesra, in transcriptional activation and suggest a novel relationship between an lncRNA and an enhancer.
    MeSH term(s) Animals ; Cell Line ; Cloning, Molecular ; Gene Expression Regulation, Enzymologic/physiology ; Male ; Mice ; Mice, Inbred C57BL ; RNA, Long Noncoding/metabolism ; Serine Proteases/genetics ; Serine Proteases/metabolism ; Spermatogenesis/physiology ; Testis/cytology ; Testis/metabolism
    Chemical Substances RNA, Long Noncoding ; Serine Proteases (EC 3.4.-) ; Prss42 protein, mouse (EC 3.4.21.-)
    Language English
    Publishing date 2018-10-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1118-6
    ISSN 1529-7268 ; 0006-3363
    ISSN (online) 1529-7268
    ISSN 0006-3363
    DOI 10.1093/biolre/ioy230
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 551: Show issues Location:
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  6. Article: The role of renal proximal tubule transport in the regulation of blood pressure.

    Horita, Shoko / Nakamura, Motonobu / Suzuki, Masashi / Satoh, Nobuhiko / Suzuki, Atsushi / Homma, Yukio / Nangaku, Masaomi

    Kidney research and clinical practice

    2017  Volume 36, Issue 1, Page(s) 12–21

    Abstract: The electrogenic sodium/bicarbonate cotransporter 1 (NBCe1) on the basolateral side of the renal proximal tubule plays a pivotal role in systemic acid-base homeostasis. Mutations in the gene encoding NBCe1 cause severe proximal renal tubular acidosis ... ...

    Abstract The electrogenic sodium/bicarbonate cotransporter 1 (NBCe1) on the basolateral side of the renal proximal tubule plays a pivotal role in systemic acid-base homeostasis. Mutations in the gene encoding NBCe1 cause severe proximal renal tubular acidosis accompanied by other extrarenal symptoms. The proximal tubule reabsorbs most of the sodium filtered in the glomerulus, contributing to the regulation of plasma volume and blood pressure. NBCe1 and other sodium transporters in the proximal tubule are regulated by hormones, such as angiotensin II and insulin. Angiotensin II is probably the most important stimulator of sodium reabsorption. Proximal tubule AT
    Language English
    Publishing date 2017-03-31
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2656420-8
    ISSN 2211-9132
    ISSN 2211-9132
    DOI 10.23876/j.krcp.2017.36.1.12
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  7. Article: Functional coupling of V-ATPase and CLC-5.

    Satoh, Nobuhiko / Suzuki, Masashi / Nakamura, Motonobu / Suzuki, Atsushi / Horita, Shoko / Seki, George / Moriya, Kyoji

    World journal of nephrology

    2016  Volume 6, Issue 1, Page(s) 14–20

    Abstract: Dent's disease is an X-linked renal tubulopathy characterized by low molecular weight proteinuria, hypercalciuria and progressive renal failure. Disease aetiology is associated with mutations in ... ...

    Abstract Dent's disease is an X-linked renal tubulopathy characterized by low molecular weight proteinuria, hypercalciuria and progressive renal failure. Disease aetiology is associated with mutations in the
    Language English
    Publishing date 2016-12-23
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 2220-6124
    ISSN 2220-6124
    DOI 10.5527/wjn.v6.i1.14
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  8. Article ; Online: Impaired Respiratory Function in Chronic Thromboembolic Pulmonary Hypertension: A Comparative Study with Healthy Control Subjects.

    Fukushi, Kei / Kataoka, Masaharu / Shimura, Nobuhiko / Inami, Takumi / Fukuda, Keiichi / Yoshino, Hideaki / Satoh, Toru

    Annals of the American Thoracic Society

    2016  Volume 13, Issue 7, Page(s) 1183–1184

    MeSH term(s) Case-Control Studies ; Chronic Disease ; Humans ; Hypertension, Pulmonary ; Pulmonary Embolism ; Respiratory Insufficiency
    Language English
    Publishing date 2016-07-04
    Publishing country United States
    Document type Letter
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201601-048LE
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    Zs.A 5828: Show issues Location:
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  9. Article: Bacteremia in hemodialysis patients.

    Suzuki, Masashi / Satoh, Nobuhiko / Nakamura, Motonobu / Horita, Shoko / Seki, George / Moriya, Kyoji

    World journal of nephrology

    2016  Volume 5, Issue 6, Page(s) 489–496

    Abstract: Infection is a common complication and is the second leading cause of death in hemodialysis patients. The risk of bacteremia in hemodialysis patients is 26-fold higher than in the general population, and 1/2-3/4 of the causative organisms of bacteremia ... ...

    Abstract Infection is a common complication and is the second leading cause of death in hemodialysis patients. The risk of bacteremia in hemodialysis patients is 26-fold higher than in the general population, and 1/2-3/4 of the causative organisms of bacteremia in hemodialysis patients are Gram-positive bacteria. The ratio of resistant bacteria in hemodialysis patients compared to the general population is unclear. Several reports have indicated that hemodialysis patients have a higher risk of methicillin-resistant
    Language English
    Publishing date 2016-11-08
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 2220-6124
    ISSN 2220-6124
    DOI 10.5527/wjn.v5.i6.489
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  10. Article: Thiazolidinediones and Edema: Recent Advances in the Pathogenesis of Thiazolidinediones-Induced Renal Sodium Retention.

    Horita, Shoko / Nakamura, Motonobu / Satoh, Nobuhiko / Suzuki, Masashi / Seki, George

    PPAR research

    2015  Volume 2015, Page(s) 646423

    Abstract: Thiazolidinediones (TZDs) are one of the major classes of antidiabetic drugs that are used widely. TZDs improve insulin resistance by activating peroxisome proliferator-activated receptor gamma (PPARγ) and ameliorate diabetic and other nephropathies, at ... ...

    Abstract Thiazolidinediones (TZDs) are one of the major classes of antidiabetic drugs that are used widely. TZDs improve insulin resistance by activating peroxisome proliferator-activated receptor gamma (PPARγ) and ameliorate diabetic and other nephropathies, at least, in experimental animals. However, TZDs have side effects, such as edema, congestive heart failure, and bone fracture, and may increase bladder cancer risk. Edema and heart failure, which both probably originate from renal sodium retention, are of great importance because these side effects make it difficult to continue the use of TZDs. However, the pathogenesis of edema remains a matter of controversy. Initially, upregulation of the epithelial sodium channel (ENaC) in the collecting ducts by TZDs was thought to be the primary cause of edema. However, the results of other studies do not support this view. Recent data suggest the involvement of transporters in the proximal tubule, such as sodium-bicarbonate cotransporter and sodium-proton exchanger. Other studies have suggested that sodium-potassium-chloride cotransporter 2 in the thick ascending limb of Henle and aquaporins are also possible targets for TZDs. This paper will discuss the recent advances in the pathogenesis of TZD-induced sodium reabsorption in the renal tubules and edema.
    Language English
    Publishing date 2015-05-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2237981-2
    ISSN 1687-4765 ; 1687-4757
    ISSN (online) 1687-4765
    ISSN 1687-4757
    DOI 10.1155/2015/646423
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