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  1. Article: Editorial: Ozone in medicine: Biochemical background, physiological modulation and clinical applications.

    Clavo, Bernardino / Borrelli, Emma

    Frontiers in physiology

    2023  Volume 14, Page(s) 1112860

    Language English
    Publishing date 2023-02-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1112860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ozone potential to fight against SAR-COV-2 pandemic: facts and research needs.

    Blanco, Angeles / Ojembarrena, Francisco de Borja / Clavo, Bernardino / Negro, Carlos

    Environmental science and pollution research international

    2021  Volume 28, Issue 13, Page(s) 16517–16531

    Abstract: The greatest challenge the world is facing today is to win the battle against COVID-19 pandemic as soon as possible. Until a vaccine is available, personal protection, social distancing, and disinfection are the main tools against SARS-CoV-2. Although it ...

    Abstract The greatest challenge the world is facing today is to win the battle against COVID-19 pandemic as soon as possible. Until a vaccine is available, personal protection, social distancing, and disinfection are the main tools against SARS-CoV-2. Although it is quite infectious, the SARS-CoV-2 virus itself is an enveloped virus that is relatively fragile because its protective fatty layer is sensitive to heat, ultraviolet radiation, and certain chemicals. However, heat and liquid treatments can damage some materials, and ultraviolet light is not efficient in shaded areas, so other disinfection alternatives are required to allow safe re-utilization of materials and spaces. As of this writing, evidences are still accumulating for the use of ozone gas as a disinfectant for sanitary materials and ambient disinfection in indoor areas. This paper reviews the most relevant results of virus disinfection by the application of gaseous ozone. The review covers disinfection treatments of both air and surfaces carried out in different volumes, which varies from small boxes and controlled chambers to larger rooms, as a base to develop future ozone protocols against COVID-19. Published papers have been critically analyzed to evaluate trends in the required ozone dosages, as a function of relative humidity (RH), contact time, and viral strains. The data have been classified depending on the disinfection objective and the volume and type of the experimental set-up. Based on these data, conservative dosages and times to inactivate the SARS-CoV-2 are estimated. In small chambers, 10-20 mg ozone/m
    MeSH term(s) COVID-19 ; Disinfection ; Humans ; Ozone ; Pandemics ; SARS-CoV-2 ; Ultraviolet Rays
    Chemical Substances Ozone (66H7ZZK23N)
    Language English
    Publishing date 2021-01-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-020-12036-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: New trends in cardiac surgery: Toward a less-invasive surgical procedure.

    Abad, Cipriano / Urso, Stefano / Clavo, Bernardino

    The Journal of thoracic and cardiovascular surgery

    2019  Volume 157, Issue 5, Page(s) e268–e269

    MeSH term(s) Atrial Fibrillation ; Cardiac Surgical Procedures ; Heart-Assist Devices ; Humans ; Pericardiectomy
    Language English
    Publishing date 2019-03-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2018.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Commentary: Transcatheter tricuspid valve devices-A word of caution.

    Abad, Cipriano / Urso, Stefano / Clavo, Bernardino

    The Journal of thoracic and cardiovascular surgery

    2019  Volume 159, Issue 2, Page(s) e113–e114

    MeSH term(s) Feasibility Studies ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/surgery ; Tricuspid Valve Insufficiency/diagnostic imaging ; Tricuspid Valve Insufficiency/surgery
    Language English
    Publishing date 2019-07-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2019.06.091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Commentary: Combined surgery of mitral valve and atrial fibrillation. A demonstrated better alternative.

    Abad, Cipriano / Urso, Stefano / Clavo, Bernardino

    The Journal of thoracic and cardiovascular surgery

    2018  Volume 157, Issue 4, Page(s) 1531–1532

    MeSH term(s) Atrial Fibrillation ; Cardiac Surgical Procedures ; Humans ; Mitral Valve ; Mitral Valve Insufficiency
    Language English
    Publishing date 2018-10-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2018.09.094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Postoperative atrial fibrillation is not an innocuous arrhythmia in patients with left ventricular assist devices.

    Abad, Cipriano / Urso, Stefano / Clavo, Bernardino

    The Journal of thoracic and cardiovascular surgery

    2018  Volume 156, Issue 4, Page(s) 1550–1551

    MeSH term(s) Atrial Fibrillation ; Heart Failure ; Heart-Assist Devices ; Humans ; Postoperative Period
    Language English
    Publishing date 2018-04-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2018.04.087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Do erythropoietin receptors on cancer cells explain unexpected clinical findings?

    Clavo, Bernardino

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2007  Volume 25, Issue 11, Page(s) 1447–8; author reply 1448

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Carcinoma/drug therapy ; Carcinoma/metabolism ; Disease Progression ; Erythropoietin/adverse effects ; Erythropoietin/therapeutic use ; Female ; Gene Expression Profiling ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/metabolism ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Prognosis ; Randomized Controlled Trials as Topic ; Receptors, Erythropoietin/metabolism ; Recombinant Proteins ; Retrospective Studies ; Survival Analysis ; Treatment Outcome
    Chemical Substances Receptors, Erythropoietin ; Recombinant Proteins ; epoetin beta ; Erythropoietin (11096-26-7)
    Language English
    Publishing date 2007-04-10
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2006.09.9713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An Artificial Intelligence Prediction Model of Insulin Sensitivity, Insulin Resistance, and Diabetes Using Genes Obtained through Differential Expression.

    González-Martín, Jesús María / Torres-Mata, Laura B / Cazorla-Rivero, Sara / Fernández-Santana, Cristina / Gómez-Bentolila, Estrella / Clavo, Bernardino / Rodríguez-Esparragón, Francisco

    Genes

    2023  Volume 14, Issue 12

    Abstract: Insulin is a powerful pleiotropic hormone that affects processes such as cell growth, energy expenditure, and carbohydrate, lipid, and protein metabolism. The molecular mechanisms by which insulin regulates muscle metabolism and the underlying defects ... ...

    Abstract Insulin is a powerful pleiotropic hormone that affects processes such as cell growth, energy expenditure, and carbohydrate, lipid, and protein metabolism. The molecular mechanisms by which insulin regulates muscle metabolism and the underlying defects that cause insulin resistance have not been fully elucidated. This study aimed to perform a microarray data analysis to find differentially expressed genes. The analysis has been based on the data of a study deposited in Gene Expression Omnibus (GEO) with the identifier "GSE22309". The selected data contain samples from three types of patients after taking insulin treatment: patients with diabetes (DB), patients with insulin sensitivity (IS), and patients with insulin resistance (IR). Through an analysis of omics data, 20 genes were found to be differentially expressed (DEG) between the three possible comparisons obtained (DB vs. IS, DB vs. IR, and IS vs. IR); these data sets have been used to develop predictive models through machine learning (ML) techniques to classify patients with respect to the three categories mentioned previously. All the ML techniques present an accuracy superior to 80%, reaching almost 90% when unifying IR and DB categories.
    MeSH term(s) Humans ; Insulin Resistance/genetics ; Artificial Intelligence ; Diabetes Mellitus/genetics ; Insulin/genetics ; Microarray Analysis
    Chemical Substances Insulin
    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14122119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Long-term improvement by ozone treatment in chronic pain secondary to chemotherapy-induced peripheral neuropathy: A preliminary report.

    Clavo, Bernardino / Rodríguez-Abreu, Delvys / Galván, Saray / Federico, Mario / Martínez-Sánchez, Gregorio / Ramallo-Fariña, Yolanda / Antonelli, Carla / Benítez, Gretel / Rey-Baltar, Dolores / Jorge, Ignacio J / Rodríguez-Esparragón, Francisco / Serrano-Aguilar, Pedro

    Frontiers in physiology

    2022  Volume 13, Page(s) 935269

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.935269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Persistence of SARS-CoV-2 infection on personal protective equipment (PPE).

    Córdoba-Lanús, Elizabeth / García-Pérez, Omar / Cazorla-Rivero, Sara / Rodríguez-Esparragón, Francisco / Piñero, José-Enrique / Clavo, Bernardino / Lorenzo-Morales, Jacob

    BMC infectious diseases

    2021  Volume 21, Issue 1, Page(s) 1169

    Abstract: Background: SARS-CoV-2 stability and infection persistence has been studied on different surfaces, but scarce data exist related to personal protective equipment (PPE), moreover using realist viral loads for infection. Due to the importance for adequate ...

    Abstract Background: SARS-CoV-2 stability and infection persistence has been studied on different surfaces, but scarce data exist related to personal protective equipment (PPE), moreover using realist viral loads for infection. Due to the importance for adequate PPE management to avoid risk of virus infection, RNA stability was evaluated on PPE.
    Methods: Persistence of SARS-CoV-2 infection and detection of genomic RNA in PPE (gowns and face masks) were determined by in-vitro assays and RT-qPCR, respectively. Samples were infected with a clinical sample positive for SARS-CoV-2 (Clin-Inf), and with a heat-inactivated SARS-CoV-2 strain sample (Str-Inf) as a control.
    Results: PPE samples infected with Clin-Inf were positive for the 3 viral genes on gowns up to 5 days post-infection, whereas these overall genes were detected up to 30 days in the case of face masks. However, gowns and FFP2 masks samples contaminated with Clin-Inf showed a cytopathic effect over VERO cells up to 5-7 days post-infection.
    Conclusions: SARS-CoV-2 RNA was detected on different PPE materials for 5 to 30 days, but PPE contaminated with the virus was infectious up to 5-7 days. These findings demonstrate the need to improve PPE management and to formulate strategies to introduce viricidal compounds in PPE fabrics.
    MeSH term(s) Animals ; COVID-19 ; Chlorocebus aethiops ; Health Personnel ; Humans ; Infection Control ; Personal Protective Equipment ; RNA, Viral/genetics ; SARS-CoV-2 ; Vero Cells
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-11-19
    Publishing country England
    Document type Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-021-06861-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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