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Article ; Online: Seismic performance of steel-reinforced concrete-filled rectangular steel tubes after exposure to non-uniform fire

Yi Han / Yan-Hong Bao

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 18

Abstract: Abstract In actual engineering, non-uniform fire boundary circumstances including single-sided fire, neighboring or related two-sided fire, and three-sided fire, are created due to the varying placements of the columns. In this paper, the seismic ... ...

Abstract	Abstract In actual engineering, non-uniform fire boundary circumstances including single-sided fire, neighboring or related two-sided fire, and three-sided fire, are created due to the varying placements of the columns. In this paper, the seismic performance of SRCFST members subjected to non-uniform fire was investigated by the method of finite element simulation. First of all, the P-Δ curve, ductility coefficient, stiffness, and energy dissipation of the members following non-uniform fire were investigated. As the number of fire surfaces decreases, the maximum overfire temperature at the center of the section decreases, damage decreases, stiffness degradation decreases, and energy dissipation capacity increases. Next, the load distribution of each component in the SRCFST member was calculated using a three-sided fire as an example, the results show that steel tubes play the most dominant role in the seismic performance after fire, followed by steel sections and concrete the least. Last, a parametric study of the key variables influencing the ductility coefficient was carried out.
Keywords	Medicine ; R ; Science ; Q
Subject code	690
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Seismic performance of steel-reinforced concrete-filled rectangular steel tubes after exposure to non-uniform fire.

Han, Yi / Bao, Yan-Hong

Scientific reports

2023 Volume 13, Issue 1, Page(s) 1322

Abstract: In actual engineering, non-uniform fire boundary circumstances including single-sided fire, neighboring or related two-sided fire, and three-sided fire, are created due to the varying placements of the columns. In this paper, the seismic performance of ... ...

Abstract	In actual engineering, non-uniform fire boundary circumstances including single-sided fire, neighboring or related two-sided fire, and three-sided fire, are created due to the varying placements of the columns. In this paper, the seismic performance of SRCFST members subjected to non-uniform fire was investigated by the method of finite element simulation. First of all, the P-Δ curve, ductility coefficient, stiffness, and energy dissipation of the members following non-uniform fire were investigated. As the number of fire surfaces decreases, the maximum overfire temperature at the center of the section decreases, damage decreases, stiffness degradation decreases, and energy dissipation capacity increases. Next, the load distribution of each component in the SRCFST member was calculated using a three-sided fire as an example, the results show that steel tubes play the most dominant role in the seismic performance after fire, followed by steel sections and concrete the least. Last, a parametric study of the key variables influencing the ductility coefficient was carried out.
Language	English
Publishing date	2023-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-28517-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Nintedanib induces apoptosis in human pterygium cells through the FGFR2-ERK signalling pathway.

Gong, Yan / Liao, Yan-Hong / Yi, Quan-Yong / Li, Meng / Chen, Li-Shuang / Wang, Yan-Yan

International journal of ophthalmology

2023 Volume 16, Issue 4, Page(s) 505–513

Abstract: Aim: To investigate whether nintedanib can inhibit pterygium cells through the fibroblast growth factor receptor 2 (FGFR2)/extracellular-signal-regulated kinase (ERK) pathway.: Methods: Human primary pterygium cells were cultured : Results: The ... ...

Abstract	Aim: To investigate whether nintedanib can inhibit pterygium cells through the fibroblast growth factor receptor 2 (FGFR2)/extracellular-signal-regulated kinase (ERK) pathway. Methods: Human primary pterygium cells were cultured Results: The results showed that nintedanib inhibited the growth of pterygium cells and caused nuclear pyknosis. The results of Annexin-VFITC/PI double staining showed that nintedanib was able to induce early and late apoptosis of pterygium cells, significantly increasing the expression of apoptosis-associated proteins Bax and cleaved-Caspase3 ( Conclusion: Nintedanib induces apoptosis of pterygium cells by inhibiting FGFR2/ERK pathway.
Language	English
Publishing date	2023-04-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2663246-9
ISSN	2227-4898 ; 2222-3959
ISSN (online)	2227-4898
ISSN	2222-3959
DOI	10.18240/ijo.2023.04.03
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Article ; Online: Electrochemical Synthesis of Selenosulfonates from Diselenides and Sulfonyl Hydrazides.

Lv, Jin-Feng / Deng, Yang / Liang, Xin-Yi / Tan, Yu-Fang / He, Yan-Hong / Guan, Zhi

The Journal of organic chemistry

2024 Volume 89, Issue 6, Page(s) 3931–3940

Abstract: The electrochemical oxidative radical-radical cross-coupling of sulfonyl hydrazides with diselenides for the synthesis of selenosulfonates was successfully accomplished. The method is applicable to a wide range of aromatic/aliphatic sulfonyl hydrazides ... ...

Abstract	The electrochemical oxidative radical-radical cross-coupling of sulfonyl hydrazides with diselenides for the synthesis of selenosulfonates was successfully accomplished. The method is applicable to a wide range of aromatic/aliphatic sulfonyl hydrazides and diselenides, providing products in good to excellent yields. Notably, this protocol stands out for its green and sustainable nature, as it does not rely on transition metals and oxidizing agents, and the starting materials are cost-effective and readily available.
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.3c02755
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Zs.A 4473: Show issues

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Article ; Online: PEBP4 deficiency aggravates LPS-induced acute lung injury and alveolar fluid clearance impairment via modulating PI3K/AKT signaling pathway.

Shi, Qiao-Qing / Huang, Yong-Hong / Li, Yu-Fei / Zhen, Shuang-Yan / Li, Yan-Hong / Huang, Jia-Yi / Wang, Jia-Yang / Zhou, Xiao-Yan

Cellular and molecular life sciences : CMLS

2024 Volume 81, Issue 1, Page(s) 133

Abstract: Acute lung injury (ALI) is a common clinical syndrome, which often results in pulmonary edema and respiratory distress. It has been recently reported that phosphatidylethanolamine binding protein 4 (PEBP4), a basic cytoplasmic protein, has anti- ... ...

Abstract	Acute lung injury (ALI) is a common clinical syndrome, which often results in pulmonary edema and respiratory distress. It has been recently reported that phosphatidylethanolamine binding protein 4 (PEBP4), a basic cytoplasmic protein, has anti-inflammatory and hepatoprotective effects, but its relationship with ALI remains undefined so far. In this study, we generated PEBP4 knockout (KO) mice to investigate the potential function of PEBP4, as well as to evaluate the capacity of alveolar fluid clearance (AFC) and the activity of phosphatidylinositide 3-kinases (PI3K)/serine-theronine protein kinase B (PKB, also known as AKT) signaling pathway in lipopolysaccharide (LPS)-induced ALI mice models. We found that PEBP4 deficiency exacerbated lung pathological damage and edema, and increased the wet/dry weight ratio and total protein concentration of bronchoalveolar lavage fluid (BALF) in LPS-treated mice. Meanwhile, PEBP4 KO promoted an LPS-induced rise in the pulmonary myeloperoxidase (MPO) activity, serum interleuin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α levels, and pulmonary cyclooxygenase-2 (COX-2) expression. Mechanically, PEBP4 deletion further reduced the protein expression of Na
MeSH term(s)	Animals ; Mice ; Acute Lung Injury/chemically induced ; Lipopolysaccharides/pharmacology ; Lung/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Sodium-Potassium-Exchanging ATPase/metabolism ; Sodium-Potassium-Exchanging ATPase/pharmacology ; Sodium-Potassium-Exchanging ATPase/therapeutic use ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Lipopolysaccharides ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13) ; Tumor Necrosis Factor-alpha ; PEBP4 protein, mouse
Language	English
Publishing date	2024-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-024-05168-5
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Zs.A 195: Show issues

Location:
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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Advances in Dyslipidaemia Treatments: Focusing on ApoC3 and ANGPTL3 Inhibitors.

Tomlinson, Brian / Wu, Qian-Yan / Zhong, Yi-Ming / Li, Yan-Hong

Journal of lipid and atherosclerosis

2023 Volume 13, Issue 1, Page(s) 2–20

Abstract: Apolipoprotein C3 (apoC3) and angiopoietin-like protein 3 (ANGPTL3) inhibit lipolysis by lipoprotein lipase and may influence the secretion and uptake of various lipoproteins. Genetic studies show that depletion of these proteins is associated with ... ...

Abstract	Apolipoprotein C3 (apoC3) and angiopoietin-like protein 3 (ANGPTL3) inhibit lipolysis by lipoprotein lipase and may influence the secretion and uptake of various lipoproteins. Genetic studies show that depletion of these proteins is associated with improved lipid profiles and reduced cardiovascular events so it was anticipated that drugs which mimic the effects of loss-of-function mutations would be useful lipid treatments. ANGPTL3 inhibitors were initially developed as a treatment for severe hypertriglyceridaemia including familial chylomicronaemia syndrome (FCS), which is usually not adequately controlled with currently available drugs. However, it was found ANGPTL3 inhibitors were also effective in reducing low-density lipoprotein cholesterol (LDL-C) and they were studied in patients with homozygous familial hypercholesterolaemia (FH). Evinacumab targets ANGPTL3 and reduced LDL-C by about 50% in patients with homozygous FH and it has been approved for that indication. The antisense oligonucleotide (ASO) vupanorsen targeting ANGPTL3 was less effective in reducing LDL-C in patients with moderate hypertriglyceridaemia and its development has been discontinued but the small interfering RNA (siRNA) ARO-ANG3 is being investigated in Phase 2 studies. ApoC3 can be inhibited by the ASO volanesorsen, which reduced triglycerides by >70% in patients with FCS and it was approved for FCS in Europe but not in the United States because of concerns about thrombocytopaenia. Olezarsen is an N-acetylgalactosamine-conjugated ASO targeting apoC3 which appears as effective as volanesorsen without the risk of thrombocytopaenia and is undergoing Phase 3 trials. ARO-APOC3 is an siRNA targeting apoC3 that is currently being investigated in Phase 3 studies.
Language	English
Publishing date	2023-10-27
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	3016001-7
ISSN	2288-2561 ; 2287-2892
ISSN (online)	2288-2561
ISSN	2287-2892
DOI	10.12997/jla.2024.13.1.2
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Article: Application of cross-migration theory in limb rehabilitation of stroke patients with hemiplegia.

Lu, Yan-Hong / Fu, Yi / Shu, Jin / Yan, Li-Yan / Shen, Hai-Jian

World journal of clinical cases

2023 Volume 11, Issue 19, Page(s) 4531–4543

Abstract: Background: Stroke is a common cause of neurological dysfunction, often resulting in hemiplegia. Thus, rehabilitation of limb function in stroke patients is an important step towards accelerating recovery and improving quality of life.: Aim: To ... ...

Abstract	Background: Stroke is a common cause of neurological dysfunction, often resulting in hemiplegia. Thus, rehabilitation of limb function in stroke patients is an important step towards accelerating recovery and improving quality of life. Aim: To investigate whether unilateral strength training in hemiplegic stroke patients could lead to cross-migration, an increase in bilateral muscle strength, and an improvement in lower limb motor function. Methods: We randomly divided 120 patients with hemiplegic stroke into two groups: Eexperimental and control groups, with 60 patients in each group. Both groups received routine rehabilitation treatment, while the experimental group additionally received ankle dorsiflexion resistance training on the healthy side for 6 wk. We measured the maximum voluntary contract (MVC), changes in surface electromyography (EMG), and the lower limb motor function using the simplified Fugl Meyer Motor Function Assessment Scale (FMA) before and within 1 wk after training. Results: The FMA score in the experimental group improved significantly compared to both their pre-training score and the control group's post-training score ( Conclusion: Our findings suggest that ankle dorsiflexion resistance training on the healthy side in hemiplegic stroke patients can increase strength in the opposite tibialis anterior muscle and antagonist's muscle, indicating a cross-migration phenomenon of strength training. Furthermore, this type of training can also improve lower limb motor function, providing a new exercise method for improving early ankle dorsiflexion dysfunction.
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Journal Article
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i19.4531
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A new 3,4-dihydroisocoumarin and an antiinflammatory coumarin from the roots of

Sun, Yan / Liu, Yan / Jiang, Peng / Wang, Si-Yi / Pan, Juan / Guan, Wei / Wang, Yu-Xuan / Kuang, Hai-Xue / Wang, Yan-Hong / Yang, Bing-You

Natural product research

2024 , Page(s) 1–10

Abstract: Phytochemical investigation of the roots ... ...

Abstract	Phytochemical investigation of the roots of
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2024.2334317
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Article ; Online: Effect of Optimizing the Induction Regimen in Preventing Cough Reactions in Patients Undergoing General Anesthesia: A Prospective Randomized Controlled Study.

Wang, Lei / Lu, Xing / Cheng, Yi / Zhang, You-Chuan / Zhao, De-Xiang / Zhu, Yan-Hong

Clinical therapeutics

2024 Volume 46, Issue 3, Page(s) 252–257

Abstract: Purpose: During the induction of general anesthesia, opioids and endotracheal intubation may cause coughing. This study aimed to investigate the safety and effectiveness of an optimized drug induction scheme for general anesthesia to prevent coughing in ...

Abstract	Purpose: During the induction of general anesthesia, opioids and endotracheal intubation may cause coughing. This study aimed to investigate the safety and effectiveness of an optimized drug induction scheme for general anesthesia to prevent coughing in patients. Methods: A total of 220 patients aged 18 to 65 years who underwent surgery under general anesthesia with endotracheal intubation were randomly assigned to two groups, each with 110 patients. One group was administered a divided sufentanil bolus (group A) and the other with a single sufentanil bolus (group B). Anesthesia induction was performed according to the drug induction scheme of 1st, 2nd, and 3rd minutes. The primary outcome was a coughing episode associated with the administration of opioids during anesthesia induction. We also recorded the pain associated with drug injection, hemodynamics, and blood oxygen saturation during the induction of anesthesia. Findings: All patients were included in the final statistical analysis. Compared with group B, the incidence of opioid induced cough (OIC) was significantly higher in group A (9.1% vs. 0, P = 0.001). There was no cough reaction of tracheal intubation in either group. There was no severe pain due to propofol and rocuronium injection in either group (P > 0.05). The mean arterial pressure (MAP), heart rate (HR), and peripheral oxygen saturation (SpO Implications: According to the optimized 1st, 2nd, and 3rd minutes anesthesia induction regimen, with a single final intravenous bolus of sufentanil after the diluted rocuronium bromide administration, no sufentanil and tracheal intubation induced coughing reactions were observed. Trial registration: The study protocol was registered in the Chinese Clinical Trial Registry (ChiCTR2200062749, http://www.chictr.org.cn/showproj.aspx?proj=175018) on August 17, 2022.
MeSH term(s)	Humans ; Analgesics, Opioid/adverse effects ; Anesthesia, General/adverse effects ; Anesthesia, General/methods ; Cough/chemically induced ; Cough/prevention & control ; Pain/drug therapy ; Prospective Studies ; Sufentanil/adverse effects ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged
Chemical Substances	Analgesics, Opioid ; Sufentanil (AFE2YW0IIZ)
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	603113-4
ISSN	1879-114X ; 0149-2918
ISSN (online)	1879-114X
ISSN	0149-2918
DOI	10.1016/j.clinthera.2024.01.007
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Zs.A 1435: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 404: Show issues

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Article: Role of conventional MD staging in modern era of hydrops MR imaging.

Yan, Hong-Yu / Young, Yi-Ho

Laryngoscope investigative otolaryngology

2024 Volume 9, Issue 1, Page(s) e1213

Abstract: Objective/hypothesis: This study correlated stage of Meniere's disease (MD) with MR imaging of endolymphatic hydrops (EH) to assess the role of MD staging in modern era.: Study design: Retrospective study.: Methods: Fifty-four MD patients (60 ears) ...

Abstract	Objective/hypothesis: This study correlated stage of Meniere's disease (MD) with MR imaging of endolymphatic hydrops (EH) to assess the role of MD staging in modern era. Study design: Retrospective study. Methods: Fifty-four MD patients (60 ears) underwent an inner ear test battery and were further confirmed by MR imaging. Sixty MD ears were divided into stages I-IV, and hydrops MR images at each stage were compared. Results: Hydrops MRI demonstrated that EH at the cochlea with respective Grades 0/I/II were 3/7/1 ears for stage I, 0/5/3 ears for stage II, 1/6/26 ears for stage III and 0/2/6 ears for stage IV. Significant relationship was not identified between MD stage and grades of cochlear hydrops. Similarly, no significant relationship was shown between MD stage and grades of vestibular (saccular/utricular) hydrops. The optimal cutoff value of four-tone average for predicting severe type (Grade II-III) cochlear/vestibular EH was 48 dB, which was within the stage III. Hence, prevalence of severe type (Grade II) cochlear EH in stages III (79%) and IV (75%) was significantly higher than stages I (9%) and II (38%). Similarly, severe type saccular/utricular EH in stages III (64%) and IV (75%) also showed significantly higher than stages I (18%) and II (25%). Conclusion: Although conventional MD staging fails to correlate with the grades of EH on hydrops MRI, late-stage MD may indicate heightened EH severity in the cochlea and vestibule. Level of evidence: 4.
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Journal Article
ISSN	2378-8038
ISSN	2378-8038
DOI	10.1002/lio2.1213
Database	MEDical Literature Analysis and Retrieval System OnLINE

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