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Article ; Online: Predicting Gene Expression From Computed Tomography Angiography.

Wu, Congqing / Ley, Klaus

Arteriosclerosis, thrombosis, and vascular biology

2021 Volume 41, Issue 5, Page(s) 1751–1752

MeSH term(s)	Atherosclerosis ; Biology ; Brain Ischemia ; Cerebral Angiography ; Computed Tomography Angiography ; Humans ; Transcriptome
Language	English
Publishing date	2021-04-08
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/ATVBAHA.121.316195
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Article ; Online: Aortic Aneurysm and Dissection: Heterogeneity and Molecular Mechanisms.

Lu, Hong S / Sawada, Hisashi / Wu, Congqing

Biomolecules

2022 Volume 12, Issue 10

Abstract: Aortic aneurysms and dissections (AAD) are devastating aortic diseases with high risks for aortic rupture, leading to uncontrolled bleeding and death [ ... ]. ...

Abstract	Aortic aneurysms and dissections (AAD) are devastating aortic diseases with high risks for aortic rupture, leading to uncontrolled bleeding and death [...].
MeSH term(s)	Humans ; Aortic Aneurysm, Thoracic/genetics ; Aneurysm, Dissecting ; Aortic Aneurysm
Language	English
Publishing date	2022-10-21
Publishing country	Switzerland
Document type	Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom12101536
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Article: Functional Status of Pancreatic

Guo, Hang / Ma, Chunlei / Wu, Xiaoming / Pan, Congqing

International journal of endocrinology

2021 Volume 2021, Page(s) 9976067

Abstract: Objective: To investigate the functional status of pancreatic : Methods: A total of 328 patients with T2DM were divided into three groups according to different TG levels: the TGL group: TG < 1.7 mmol/L; TGM group: 1.7 mmol/L ≤ TG < 2.3 mmol/L; and ... ...

Abstract	Objective: To investigate the functional status of pancreatic Methods: A total of 328 patients with T2DM were divided into three groups according to different TG levels: the TGL group: TG < 1.7 mmol/L; TGM group: 1.7 mmol/L ≤ TG < 2.3 mmol/L; and TGH group: TG ≥ 2.3 mmol/L. An oral glucose tolerance test (OGTT), insulin release test, and glucagon release test were performed in each patient. The changes of glucagon, glucagon/insulin ratio, early insulin secretion index (Δ Results: With the increase of TG, the fasting and postprandial glucagon levels, the glucagon/insulin ratio, and the area under the glucagon curve (AUC Conclusion: Hypertriglyceridemia aggravated the dysfunction of pancreatic
Language	English
Publishing date	2021-08-17
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2502951-4
ISSN	1687-8345 ; 1687-8337
ISSN (online)	1687-8345
ISSN	1687-8337
DOI	10.1155/2021/9976067
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Article: Association of Thyroid Hormone Levels with Microvascular Complications in Euthyroid Type 2 Diabetes Mellitus Patients.

Hu, Yonghui / Hu, Zhibo / Tang, Wangna / Liu, Wenjie / Wu, Xiaoming / Pan, Congqing

Diabetes, metabolic syndrome and obesity : targets and therapy

2022 Volume 15, Page(s) 2467–2477

Abstract: Purpose: To examine the prevalence of different microvascular complications and investigate the association between thyroid hormones (THs) and these complications in euthyroid patients with type 2 diabetes mellitus (T2DM).: Methods: A total of 248 ... ...

Abstract	Purpose: To examine the prevalence of different microvascular complications and investigate the association between thyroid hormones (THs) and these complications in euthyroid patients with type 2 diabetes mellitus (T2DM). Methods: A total of 248 T2DM patients were analyzed retrospectively for the study. All patients received a detailed and standard assessment to identify diabetic peripheral neuropathy (DPN), diabetic nephropathy (DN), and diabetic retinopathy (DR). Multivariate logistic regression was carried out to analyze the association between THs and diabetic microvascular complications. Results: The study found the prevalence of any microangiopathy to be 72.18% (n = 179). At the same time, the prevalence of DPN was 54.84% (n=136), while that of DN was 31.85% (n=79). Likewise, the prevalence of DR was 35.48% (n=88). The odds ratios (ORs) for free triiodothyronine (FT3) developing any microangiopathy, DPN, DN and DR were 0.200, 0.361, 0.310, and 0.588 (P<0.05), respectively. Also, the ORs for free thyroxine (FT4) developing any microangiopathy, DPN, DN and DR were 0.643, 0.800, 0.702 and 0.726 (P<0.05), respectively. Lastly, the ORs for thyroid-stimulating hormone (TSH) developing DPN was 1.57 (95% CI: 1.148-2.137, P=0.005). Conclusion: The study concludes that serum FT3 and FT4 levels are negatively associated with any microangiopathy, DPN, DN and DR in euthyroid patients with T2DM, independent of traditional risk factors. However, the TSH levels are positively associated with DPN. Future larger sample-size studies are needed to confirm the relationship between thyroid hormone levels and microvascular complications in euthyroid patients with T2DM.
Language	English
Publishing date	2022-08-12
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S354872
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Article ; Online: Inflammasome activation and pyroptosis mediate coagulopathy and inflammation in Salmonella systemic infection

Pandeya, Ankit / Zhang, Yan / Cui, Jian / Yang, Ling / Li, Jeffery / Zhang, Guoying / Wu, Congqing / Li, Zhenyu / Wei, Yinan

Microbiological Research. 2023 Oct., v. 275 p.127460-

2023

Abstract: Inflammasome activation is a critical defense mechanism against bacterial infection. Previous studies suggest that inflammasome activation protects against Salmonella oral infection. Here we find inflammasome activation plays a critical role in the ... ...

Abstract	Inflammasome activation is a critical defense mechanism against bacterial infection. Previous studies suggest that inflammasome activation protects against Salmonella oral infection. Here we find inflammasome activation plays a critical role in the pathogenesis of Salmonella systemic infection. We show that in a systemic infection model by i.p. injection of Salmonella, deficiency of caspase-1 or gasdermin-D prolonged survival time, reduced plasma concentrations of the proinflammatory cytokines IL-1β, IL-6 and TNFα. These deficiencies also protected against coagulopathy during Salmonella infection as evidenced by diminished prolongation of prothrombin time and increase in plasma thrombin-antithrombin complex concentrations in the caspase-1 or gasdermin-D deficient mice. Activation of the NAIP/NLRC4 inflammasome by flagellin and/or the components of the SPI1 type 3 secretion system played a critical role in Salmonella-induced coagulopathy. In the absence of flagellin and SPI1, the Salmonella mutant strain still triggered coagulopathy through the caspase-11/NLRP3 pathway. Our results reveal a previously undisclosed role of the inflammasomes and pyroptosis in the pathogenesis of Salmonella systemic infection.
Keywords	Salmonella ; caspase-1 ; flagellin ; inflammasomes ; inflammation ; interleukin-6 ; models ; mutants ; pathogenesis ; prothrombin ; pyroptosis ; research ; salmonellosis ; type III secretion system ; Inflammasome ; Macrophage ; Coagulation ; DIC
Language	English
Dates of publication	2023-10
Publishing place	Elsevier GmbH
Document type	Article ; Online
ZDB-ID	1189614-0
ISSN	1618-0623 ; 0944-5013
ISSN (online)	1618-0623
ISSN	0944-5013
DOI	10.1016/j.micres.2023.127460
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Inflammasome activation and pyroptosis mediate coagulopathy and inflammation in Salmonella systemic infection.

Pandeya, Ankit / Zhang, Yan / Cui, Jian / Yang, Ling / Li, Jeffery / Zhang, Guoying / Wu, Congqing / Li, Zhenyu / Wei, Yinan

Microbiological research

2023 Volume 275, Page(s) 127460

Abstract	Inflammasome activation is a critical defense mechanism against bacterial infection. Previous studies suggest that inflammasome activation protects against Salmonella oral infection. Here we find inflammasome activation plays a critical role in the pathogenesis of Salmonella systemic infection. We show that in a systemic infection model by i.p. injection of Salmonella, deficiency of caspase-1 or gasdermin-D prolonged survival time, reduced plasma concentrations of the proinflammatory cytokines IL-1β, IL-6 and TNFα. These deficiencies also protected against coagulopathy during Salmonella infection as evidenced by diminished prolongation of prothrombin time and increase in plasma thrombin-antithrombin complex concentrations in the caspase-1 or gasdermin-D deficient mice. Activation of the NAIP/NLRC4 inflammasome by flagellin and/or the components of the SPI1 type 3 secretion system played a critical role in Salmonella-induced coagulopathy. In the absence of flagellin and SPI1, the Salmonella mutant strain still triggered coagulopathy through the caspase-11/NLRP3 pathway. Our results reveal a previously undisclosed role of the inflammasomes and pyroptosis in the pathogenesis of Salmonella systemic infection.
MeSH term(s)	Mice ; Animals ; Inflammasomes/metabolism ; Pyroptosis ; Flagellin ; Calcium-Binding Proteins/metabolism ; Apoptosis Regulatory Proteins/metabolism ; Gasdermins ; Caspases/metabolism ; Salmonella typhimurium/metabolism ; Caspase 1/metabolism ; Salmonella Infections ; Inflammation
Chemical Substances	Inflammasomes ; Flagellin (12777-81-0) ; Calcium-Binding Proteins ; Apoptosis Regulatory Proteins ; Gasdermins ; Caspases (EC 3.4.22.-) ; Caspase 1 (EC 3.4.22.36)
Language	English
Publishing date	2023-07-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1189614-0
ISSN	1618-0623 ; 0944-5013
ISSN (online)	1618-0623
ISSN	0944-5013
DOI	10.1016/j.micres.2023.127460
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Article ; Online: Updates on Approaches for Studying Atherosclerosis.

Wu, Congqing / Daugherty, Alan / Lu, Hong S

Arteriosclerosis, thrombosis, and vascular biology

2019 Volume 39, Issue 4, Page(s) e108–e117

MeSH term(s)	Animals ; Animals, Genetically Modified ; Atherosclerosis/etiology ; Atherosclerosis/genetics ; Atherosclerosis/therapy ; Disease Models, Animal ; Genetic Techniques ; Humans ; In Vitro Techniques ; Inflammation ; Lipid Metabolism/genetics ; Models, Animal ; Research Design
Language	English
Publishing date	2019-03-27
Publishing country	United States
Document type	Introductory Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/ATVBAHA.119.312001
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Article: Antisense oligonucleotides targeting hepatic angiotensinogen reduce atherosclerosis and liver steatosis in hypercholesterolemic mice.

Ye, Dien / Wu, Congqing / Cai, Lei / Howatt, Deborah A / Liang, Ching-Ling / Katsumata, Yuriko / Mullick, Adam E / Temel, Ryan E / Danser, A H Jan / Daugherty, Alan / Lu, Hong S

Global translational medicine

2023 Volume 2, Issue 1

Abstract: Hepatocyte-derived angiotensinogen (AGT) is the precursor of angiotensin II (AngII). We determined the effects of hepatocyte-specific ( ...

Abstract	Hepatocyte-derived angiotensinogen (AGT) is the precursor of angiotensin II (AngII). We determined the effects of hepatocyte-specific (
Language	English
Publishing date	2023-02-24
Publishing country	Singapore
Document type	Journal Article
DOI	10.36922/gtm.288
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Article ; Online: Local Excision Versus Radical Resection for Grade 2 Rectal Neuroendocrine Tumors: A Multicenter Propensity Score-Matched Analysis.

Zeng, Xinyu / Zhang, Rui / Jiang, Weizhong / Li, Chengguo / Yu, Minhao / Liu, Weizhen / Di, Maojun / Wu, Hongxue / Sun, Yueming / Xiong, Zhiguo / Jiang, Congqing / Yu, Bin / Zhou, Shengning / Li, Yong / Liao, Xiaofeng / Xia, Lijian / Zhang, Wei / Lin, Guole / Tao, Kaixiong

Diseases of the colon and rectum

2024

Abstract: Background: Studies on the grade 2 rectal neuroendocrine tumors are limited and the optimal treatment for these tumors is not well established.: Objective: To compare the oncologic results of local excision versus radical resection for the treatment ... ...

Abstract	Background: Studies on the grade 2 rectal neuroendocrine tumors are limited and the optimal treatment for these tumors is not well established. Objective: To compare the oncologic results of local excision versus radical resection for the treatment of grade 2 rectal neuroendocrine tumors. Design: Retrospective multicenter propensity score-matched study to minimize heterogeneity between groups and focus on the difference between surgery strategies. Settings: Seventeen Chinese large-scale medical centers participated in this study. Patients: A total of 144 patients with pathologically confirmed grade 2 rectal neuroendocrine tumors were retrospectively analyzed. Main outcome measures: Cancer-specific survival and relapse-free survival were assessed to compare surgery strategies. Results: A total of 144 patients with grade 2 rectal neuroendocrine tumors were enrolled in this study. Twenty-seven patients underwent endoscopic resection, 55 underwent transanal excision, 50 underwent radical resection, and 12 underwent palliative surgery or biopsy for distant metastasis. Of the 50 patients who underwent radical resection, 30 (60.0%) had clinically positive lymph nodes based on the histopathology results. The optimal cutoff value for tumor size to predict cancer-specific survival was 1.5 cm. In patients with grade 2 rectal neuroendocrine tumors ≤ 1.5 cm, there were no significant differences in cancer-specific survival and relapse-free survival between local excision and radical resection groups (P >0.05). In patients with grade 2 rectal neuroendocrine tumors > 1.5 cm, relapse-free survival was significantly lower in the local excision group than in the radical resection group (P = 0.04). Limitations: The nature of retrospective review and relatively short follow-up period are limitations of this study. Conclusions: Grade 2 rectal neuroendocrine tumors have a nonnegligible rate of lymph node metastasis. Local excision is a feasible choice for tumors ≤ 1.5 cm without metastasis, while radical resection is more beneficial in those > 1.5 cm. See Video Abstract.
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	212581-x
ISSN	1530-0358 ; 0012-3706
ISSN (online)	1530-0358
ISSN	0012-3706
DOI	10.1097/DCR.0000000000003097
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Article: Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation.

Cui, Jian / Li, Hua / Zhang, Guoying / Zhang, Yan / Yang, Ling / Sim, Martha M S / Wood, Jeremy P / Wei, Yinan / Li, Zhenyu / Wu, Congqing

bioRxiv : the preprint server for biology

2023

Abstract: Systemic blood coagulation accompanies inflammation during severe infection like sepsis and COVID. We've previously established a link between pyroptosis, a vital defense mechanism against infection, and coagulopathy. During pyroptosis, the formation of ... ...

Abstract	Systemic blood coagulation accompanies inflammation during severe infection like sepsis and COVID. We've previously established a link between pyroptosis, a vital defense mechanism against infection, and coagulopathy. During pyroptosis, the formation of gasdermin-D (GSDMD) pores on the plasma membrane leads to the release of tissue factor (TF)-positive microvesicles (MVs) that are procoagulant. Mice lacking GSDMD release fewer TF MVs. However, the specific mechanisms leading from activation of GSDMD to MV release remain unclear. Plasma membrane rupture (PMR) in pyroptosis was recently reported to be actively mediated by the transmembrane protein Ninjurin-1 (NINJ1). Here we show that NINJ1 promotes procoagulant MV release during pyroptosis. Haploinsuffciency or glycine inhibition of NINJ1 limited the release of procoagulant MVs and inflammatory cytokines and protected against blood coagulation and lethality triggered by bacterial flagellin. Our findings suggest a crucial role for NINJ1-dependent PMR in inflammasome-induced blood coagulation and inflammation.
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.08.30.555561
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