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Article ; Online: METAL ION RELEASE ACCORDING TO LEG LENGTH DISCREPANCY IN CERAMIC-ON-METAL HIP ARTHROPLASTY

YOUNG-HO ROH / TAEHAN KANG / CHAEMOON LIM / KWANG WOO NAM

Acta Ortopédica Brasileira, Vol 31, Iss spe

2023 Volume 2

Abstract: ABSTRACT Objective The ceramic-on-metal (CoM) bearing has the theoretical advantages over ceramic-on-ceramic (CoC) and metal-on-metal bearings. This study aimed to analyze factors affecting the metal ion release of CoM bearings and compare clinical ... ...

Abstract	ABSTRACT Objective The ceramic-on-metal (CoM) bearing has the theoretical advantages over ceramic-on-ceramic (CoC) and metal-on-metal bearings. This study aimed to analyze factors affecting the metal ion release of CoM bearings and compare clinical performance with CoC bearings. Methods The 147 patients were divided into 96 patients in group 1 (CoM group) and 51 patients in group 2 (CoC group). Additionally, within group1, 48 patients and 30 patients were sub-categorized into group 1-A with leg length discrepancy (LLD) less than 1cm and group 1-B greater than 1 cm. The level of serum metal ions, functional scores and plain radiographs were obtained for the analysis. Results The level of cobalt (Co) 2-years after surgery and chromium (Cr) 1-year after surgery showed significantly higher in the group1 than the group2. LLD indicated statistically significant positive correlation between serum metal ion levels among CoM bearing THAs. In comparison of the average metal ions level changes, group 1-B showed higher level of metal ion than group 1-A. Conclusion In patients underwent THA with CoM bearings, large LLD have a higher risk of complications associated to metal ions. Therefore, it is critical to reduce the LLD to 1 cm or less in using CoM bearing. Level of Evidence III; Case Control Study.
Keywords	Leg length inequality ; Ions ; Surgical procedures ; operative ; Follow-Up Studies ; Arthroplasty ; replacement ; hip ; Medicine ; R ; Orthopedic surgery ; RD701-811
Subject code	670
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Sociedade Brasileira de Ortopedia e Traumatologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: METAL ION RELEASE ACCORDING TO LEG LENGTH DISCREPANCY IN CERAMIC-ON-METAL HIP ARTHROPLASTY.

Roh, Young-Ho / Kang, Taehan / Lim, Chaemoon / Nam, Kwang Woo

Acta ortopedica brasileira

2023 Volume 31, Issue spe2, Page(s) e265272

Abstract: Objective: The ceramic-on-metal (CoM) bearing has the theoretical advantages over ceramic-on-ceramic (CoC) and metal-on-metal bearings. This study aimed to analyze factors affecting the metal ion release of CoM bearings and compare clinical performance ... ...

Abstract	Objective: The ceramic-on-metal (CoM) bearing has the theoretical advantages over ceramic-on-ceramic (CoC) and metal-on-metal bearings. This study aimed to analyze factors affecting the metal ion release of CoM bearings and compare clinical performance with CoC bearings. Methods: The 147 patients were divided into 96 patients in group 1 (CoM group) and 51 patients in group 2 (CoC group). Additionally, within group1, 48 patients and 30 patients were sub-categorized into group 1-A with leg length discrepancy (LLD) less than 1cm and group 1-B greater than 1 cm. The level of serum metal ions, functional scores and plain radiographs were obtained for the analysis. Results: The level of cobalt (Co) 2-years after surgery and chromium (Cr) 1-year after surgery showed significantly higher in the group1 than the group2. LLD indicated statistically significant positive correlation between serum metal ion levels among CoM bearing THAs. In comparison of the average metal ions level changes, group 1-B showed higher level of metal ion than group 1-A. Conclusion: In patients underwent THA with CoM bearings, large LLD have a higher risk of complications associated to metal ions. Therefore, it is critical to reduce the LLD to 1 cm or less in using CoM bearing. Level of Evidence III; Case Control Study.
Language	English
Publishing date	2023-06-09
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2105206-2
ISSN	1809-4406 ; 1413-7852
ISSN (online)	1809-4406
ISSN	1413-7852
DOI	10.1590/1413-785220233102e265272
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tobacco price increases in Korea and their impact on socioeconomic inequalities in smoking and subsequent socioeconomic inequalities in mortality: a modelling study.

Lim, Hwa-Kyung / Khang, Young-Ho

Tobacco control

2020

Abstract: Objective: Through a modelling study, we assessed the impact of tobacco price increases on smoking and smoking inequalities by income, and then quantified the subsequent effects on mortality and inequalities in mortality in Korea.: Methods: Eleven- ... ...

Abstract	Objective: Through a modelling study, we assessed the impact of tobacco price increases on smoking and smoking inequalities by income, and then quantified the subsequent effects on mortality and inequalities in mortality in Korea. Methods: Eleven-year pooled data from the Korea National Health and Nutrition Examination Survey (KNHANES) (n=65 197) were used to estimate the income group-specific price elasticity. The price elasticity was then used to calculate changes in current smoking prevalence and per capita cigarette consumption resulting from a spectrum of hypothetical tobacco price increases. The mortality risk function from the 10-year mortality follow-up data of the National Health Insurance Service-National Sample Cohort (n=293 858, numbers of deaths=14 953) and the current distributions of smoking-related variables from the KNHANES 2015-2017 were employed to estimate the effect of tobacco price increases on inequality in mortality. Results: Low-income Korean smokers were more responsive to changes in tobacco price. Increasing the tobacco price by 100% would achieve the overall reduction of 2.0% for 10-year mortality. For mortality inequalities by income, the relative index of inequality (slope index of inequality) would be reduced by 3.8% (4.8%) for 10-year mortality. Conclusions: This modelling study showed that tobacco price increases in Korea can reduce current smoking prevalence and per capita cigarette consumption in the whole population, and especially among the poor, which in turn would reduce the gap in mortality between income groups.
Language	English
Publishing date	2020-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1146554-2
ISSN	1468-3318 ; 0964-4563
ISSN (online)	1468-3318
ISSN	0964-4563
DOI	10.1136/tobaccocontrol-2019-055348
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Article ; Online: The Unequal Burden of Self-Reported Musculoskeletal Pains Among South Korean and European Employees Based on Age, Gender, and Employment Status

Jinwook Bahk / Young-Ho Khang / Sinye Lim

Safety and Health at Work, Vol 12, Iss 1, Pp 57-

2021 Volume 65

Abstract: Background: The objective of this study was to elucidate the relationships musculoskeletal pains with combined vulnerability in terms of age, gender, and employment status Methods: The fifth European Working Conditions Survey (EWCS) in 2010 (43,816 ... ...

Abstract	Background: The objective of this study was to elucidate the relationships musculoskeletal pains with combined vulnerability in terms of age, gender, and employment status Methods: The fifth European Working Conditions Survey (EWCS) in 2010 (43,816 participants aged 15 years and over) analyzed for European employees and the third Korean Working Conditions Survey (KWCS) in 2011 (50,032 participants aged 15 years and older) analyzed for Korean employees. In this study, three well known vulnerable factors to musculoskeletal pains (older age, female gender, and precarious employment status) were combined and defined as combined vulnerability. Associations of musculoskeletal pains with combined vulnerability were assessed with prevalence ratios (PRs) and 95% confidence intervals (CIs) estimated by Poisson regression models with robust estimates of variance. Results: The prevalences of musculoskeletal pains were lower but the absolute and relative differences between combined vulnerabilities were higher among Korean employees compared with the European employees. Furthermore, the increased risk of having musculoskeletal pains according to combined vulnerability was modestly explained by socioeconomic factors and exposure to ergonomic risk factors, especially in Republic of Korea. Conclusions: The results of this study showed that the labor market may be more unfavorable for female and elderly workers in Republic of Korea. Any prevention strategies to ward off musculoskeletal pains, therefore, should be found and implemented to mitigate or buffer against the most vulnerable work population, older, female, and precarious employment status, in Republic of Korea.
Keywords	Europe ; Musculoskeletal pains ; Republic of Korea ; Vulnerable population ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Quantifying the impact of reducing socioeconomic inequalities in modifiable risk factors on mortality and mortality inequalities in South Korea.

Lim, Hwa-Kyung / Khang, Young-Ho

International journal of public health

2019 Volume 64, Issue 4, Page(s) 585–594

Abstract: Objectives: We quantified the impact of reducing socioeconomic inequalities in risk factors on mortality and mortality inequalities in South Korea.: Methods: The mortality risk function from the 12-year mortality follow-up data of the National Health ...

Abstract	Objectives: We quantified the impact of reducing socioeconomic inequalities in risk factors on mortality and mortality inequalities in South Korea. Methods: The mortality risk function from the 12-year mortality follow-up data of the National Health Insurance Service-National Health Screening Cohort, the prevalence of major risk factors from the Korea National Health and Nutrition Examination Survey 2013-2015, and the Health Plan 2020 (HP2020) goals for major risk factors were used to estimate the magnitude of reduction in mortality inequalities by changing the magnitude of income-based inequalities in risk factors in various scenarios under gender-specific models among participants aged 40-79 years. Results: The greatest reduction in absolute and relative inequalities in mortality would occur if the low-income group achieved the HP2020 goals earlier than the high-income group. A 10-20% reduction in all-cause mortality inequalities was expected if absolute gaps between income groups in risk factors were halved. Conclusions: With the practical goal halving the socioeconomic gaps in modifiable risk factors, reducing inequalities in all-cause mortality by 10-20% would be possible. Further reduction in mortality inequalities would need more aggressive policies on social determinants of health.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cause of Death/trends ; Cohort Studies ; Female ; Forecasting ; Health Status Disparities ; Humans ; Male ; Middle Aged ; Population Surveillance ; Republic of Korea ; Risk Factors ; Socioeconomic Factors
Language	English
Publishing date	2019-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2274130-6
ISSN	1661-8564 ; 1661-8556
ISSN (online)	1661-8564
ISSN	1661-8556
DOI	10.1007/s00038-019-01231-2
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Zs.A 843: Show issues

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Article ; Online: Vasodilatory Effect of

Haam, Chae Eun / Byeon, Seonhee / Choi, Soo Jung / Lim, Soyeon / Choi, Soo-Kyoung / Lee, Young-Ho

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 9

Abstract: Background: Alpinia officinarum: Methods: To examine whether : Results: A. officinarum: Conclusion: A. ... ...

Abstract	Background: Alpinia officinarum Methods: To examine whether Results: A. officinarum Conclusion: A. officinarum
MeSH term(s)	Alpinia ; Animals ; Endothelium, Vascular ; Eucalyptol/pharmacology ; Mesenteric Arteries ; Plant Extracts/pharmacology ; Rats ; Vasodilation
Chemical Substances	Plant Extracts ; Eucalyptol (RV6J6604TK)
Language	English
Publishing date	2022-04-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27092711
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Article: The Unequal Burden of Self-Reported Musculoskeletal Pains Among South Korean and European Employees Based on Age, Gender, and Employment Status.

Bahk, Jinwook / Khang, Young-Ho / Lim, Sinye

Safety and health at work

2020 Volume 12, Issue 1, Page(s) 57–65

Abstract: Background: The objective of this study was to elucidate the relationships musculoskeletal pains with combined vulnerability in terms of age, gender, and employment status.: Methods: The fifth European Working Conditions Survey (EWCS) in 2010 (43,816 ...

Abstract	Background: The objective of this study was to elucidate the relationships musculoskeletal pains with combined vulnerability in terms of age, gender, and employment status. Methods: The fifth European Working Conditions Survey (EWCS) in 2010 (43,816 participants aged 15 years and over) analyzed for European employees and the third Korean Working Conditions Survey (KWCS) in 2011 (50,032 participants aged 15 years and older) analyzed for Korean employees. In this study, three well known vulnerable factors to musculoskeletal pains (older age, female gender, and precarious employment status) were combined and defined as combined vulnerability. Associations of musculoskeletal pains with combined vulnerability were assessed with prevalence ratios (PRs) and 95% confidence intervals (CIs) estimated by Poisson regression models with robust estimates of variance. Results: The prevalences of musculoskeletal pains were lower but the absolute and relative differences between combined vulnerabilities were higher among Korean employees compared with the European employees. Furthermore, the increased risk of having musculoskeletal pains according to combined vulnerability was modestly explained by socioeconomic factors and exposure to ergonomic risk factors, especially in Republic of Korea. Conclusions: The results of this study showed that the labor market may be more unfavorable for female and elderly workers in Republic of Korea. Any prevention strategies to ward off musculoskeletal pains, therefore, should be found and implemented to mitigate or buffer against the most vulnerable work population, older, female, and precarious employment status, in Republic of Korea.
Language	English
Publishing date	2020-10-24
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2592798-X
ISSN	2093-7997 ; 2093-7911
ISSN (online)	2093-7997
ISSN	2093-7911
DOI	10.1016/j.shaw.2020.10.007
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Zs.A 6906: Show issues

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Article: Designing multi-target-directed flavonoids: a strategic approach to Alzheimer's disease.

Park, Seongmin / Kim, Mingeun / Lin, Yuxi / Hong, Mannkyu / Nam, Geewoo / Mieczkowski, Adam / Kardos, József / Lee, Young-Ho / Lim, Mi Hee

Chemical science

2023 Volume 14, Issue 35, Page(s) 9293–9305

Abstract: The underlying causes of Alzheimer's disease (AD) remain a mystery, with multiple pathological components, including oxidative stress, acetylcholinesterase, amyloid-β, and metal ions, all playing a role. Here we report a strategic approach to designing ... ...

Abstract	The underlying causes of Alzheimer's disease (AD) remain a mystery, with multiple pathological components, including oxidative stress, acetylcholinesterase, amyloid-β, and metal ions, all playing a role. Here we report a strategic approach to designing flavonoids that can effectively tackle multiple pathological elements involved in AD. Our systematic investigations revealed key structural features for flavonoids to simultaneously target and regulate pathogenic targets. Our findings led to the development of a highly promising flavonoid that exhibits a range of functions, based on a complete structure-activity relationship analysis. Furthermore, our mechanistic studies confirmed that this flavonoid's versatile reactivities are driven by its redox potential and direct interactions with pathogenic factors. This work highlights the potential of multi-target-directed flavonoids as a novel solution in the fight against AD.
Language	English
Publishing date	2023-08-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d3sc00752a
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Associations of resistance training levels with low muscle mass: a nationwide cross-sectional study in Korea.

Park, Jae Ho / Lim, Nam-Kyoo / Park, Hyun-Young

European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity

2024 Volume 21, Issue 1, Page(s) 5

Abstract: Background: Low muscle mass is associated with adverse health outcomes such as functional decline and all-cause mortality. This study investigated the relationship between the risk of low muscle mass and the training period and/or frequency of ... ...

Abstract	Background: Low muscle mass is associated with adverse health outcomes such as functional decline and all-cause mortality. This study investigated the relationship between the risk of low muscle mass and the training period and/or frequency of resistance training (RT). Methods: We included 126,339 participants (81,263 women) from nationwide cohorts in Korea. Low muscle mass was defined based on the fat-free mass index. To investigate the presence of an inverse dose-response relationship between RT levels and the risk of low muscle mass, the training period (months) and frequency (per week) of RT were used. Multiple logistic regression models were used to assess the risk of low muscle mass according to the RT levels. Results: Prevalence rates for low muscle mass in our study population were 21.27% and 6.92% in men and women, respectively. When compared with not performing RT, performing RT for 3-4 days/week and ≥5 days/week decreased the risk of low muscle mass by 22% and 27%, respectively, and performing RT for 12-23 months and ≥24 months decreased the risk by 19% and 41%, respectively. When simultaneously considering both training period and frequency, performing RT for either 3-4 days/week or ≥5 days/week was significantly related to risk reduction, provided that the training period was at least 1 year. Importantly, performing RT for more than 2 years resulted in an additional risk reduction. However, there was no additional effect of performing RT for ≥5 days/week compared to 3-4 days/week, regardless of whether the RT duration was 1-2 years or more than 2 years. Conclusions: Since performing RT for 5 days/week or more did not yield any additional effects on the risk of low muscle mass, performing RT for 3-4 days/week was sufficient to prevent low muscle mass. The effectiveness of this preventive measure can be further enhanced by engaging in long-term RT, specifically for more than 2 years.
Language	English
Publishing date	2024-03-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2236925-9
ISSN	1861-6909 ; 1813-7253
ISSN (online)	1861-6909
ISSN	1813-7253
DOI	10.1186/s11556-024-00339-6
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Article: Dual Effects of Presynaptic Membrane Mimetics on

Lin, Yuxi / Ito, Dai / Yoo, Je Min / Lim, Mi Hee / Yu, Wookyung / Kawata, Yasushi / Lee, Young-Ho

Frontiers in cell and developmental biology

2022 Volume 10, Page(s) 707417

Abstract: Aggregation of intrinsically ... ...

Abstract	Aggregation of intrinsically disordered
Language	English
Publishing date	2022-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2022.707417
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