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Article: Reply to: The letter to the editor "More details are needed about the use of multicenter propensity score matching analysis" by Feng

Xu, Xin-Fei / Wang, Ming-Da / Shen, Feng / Yang, Tian

2023 Volume 12, Issue 2, Page(s) 296–297

Language	English
Publishing date	2023-03-16
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	2812398-0
ISSN	2304-389X ; 2304-3881
ISSN (online)	2304-389X
ISSN	2304-3881
DOI	10.21037/hbsn-23-27
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Yu-Ping-Feng-San alleviates inflammation in atopic dermatitis mice by TLR4/MyD88/NF-κB pathway.

Nie, Jing / Jiang, Xiaoyuan / Wang, Guomi / Xu, Yanan / Pan, Rui / Yu, Wantao / Li, Yuanwen / Wang, Jingxiao

Journal of ethnopharmacology

2024 Volume 329, Page(s) 118092

Abstract: Ethnopharmacological relevance: Yu-Ping-Feng-San (YPF) is a traditional Chinese medicine formula ...

Abstract	Ethnopharmacological relevance: Yu-Ping-Feng-San (YPF) is a traditional Chinese medicine formula that has therapeutic effects on allergic diseases such as allergic rhinitis and asthma. However, its potential efficacy and mechanism in the treatment of atopic dermatitis (AD) has not been extensively illustrated. Aim of the study: The purpose of this study was to investigate the efficacy and possible mechanisms of YPF in AD pathogenesis. Methods: Network pharmacology and GEO data mining were adopted to firstly identify the potential mechanisms of YPF on AD. Then DNCB induced-AD murine model was established to test the efficacy of YPF and verify its effects on inflammatory cytokines and NF-κB pathway. In addition, molecular docking was performed to detect the binding affinity of YPF's active components with NF-κB pathway related molecules. Results: Network pharmacology and human data mining suggested that YPF may act on the NF-κB pathway in AD pathogenesis. With DNCB mice model, we found that YPF significantly improved AD symptoms, reduced SCORAD scores, and alleviated skin tissue inflammation in mice. At the same time, the expression of inflammatory cytokines, TNF-α, sPLA2-IIA and IL-6, was down-regulated. Moreover, YPF suppressed TLR4/MyD88/NF-κB pathway in situ in a dose-dependent manner. Molecular docking further confirmed that seven compounds in YPF had exceptional binding properties with TNF-α, IL-6 and TLR4. Conclusion: YPF may help the recovery of AD by inhibiting the TLR4/MyD88/NF-κB pathway, which provides novel insights for the treatment of AD by YPF.
Language	English
Publishing date	2024-04-09
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118092
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: GC-MS Profile of Hua-Feng-Dan and RNA-Seq Analysis of Induced Adaptive Responses in the Liver.

Liu, Jia-Jia / Liang, Yan / Zhang, Ya / Wu, Rui-Xia / Song, Ying-Lian / Zhang, Feng / Shi, Jing-Shan / Liu, Jie / Xu, Shang-Fu / Wang, Zhang

Frontiers in pharmacology

2022 Volume 13, Page(s) 730318

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.730318
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Article ; Online: Sustainable biochar effects on the remediation of contaminated soil: A 2-crop season site practice near a lead-zinc smelter in Feng County, China.

Wang, Ping / Shen, Feng / Xu, Yaqiong / Wang, Xuejia / Huang, Hui / Li, Ronghua / Liu, Tao / Guo, Di / Du, Juan / Guo, Zhanyu / Zhang, Zengqiang

Environmental pollution (Barking, Essex : 1987)

2022 Volume 302, Page(s) 119095

Abstract: ... smelter in Feng County, China, under the rotation condition of different crops. This kind of cultivation ...

Abstract	It is of great significance to explore the remediation pattern in actual heavy metal (HM) contaminated sites. The field trial was carried out to research the remediation effect of biochar near a lead-zinc smelter in Feng County, China, under the rotation condition of different crops. This kind of cultivation mode is very representative in northern of China. And the pattern of production and restoration is suitable for scarce land resources and large food demand in China. The changes of soil physiochemical properties with the biochar addition, crop growth and the accumulated HMs by crops were focused on. The results showed the biochar application was excellent in improving soil nutrient elements and crop growth. The contents of TK were more obvious than those of TN and TP, with an increase of 2.6%-28.2% compared with the controls (without the addition of biochar). The yield of first season crops, i.e., soybean and corn, increased by 30%-42% and 34%-61%, respectively, and the second season crops, i.e., rape and wheat, with the increment of 25%-41% and 9%-29%, respectively. The availability forms of Cd and Pb decreased by 1.07-10.0% and 2.92-8.35%, respectively. While the improvement on the status of the HMs accumulated by crops was disappointing. The contents of HMs accumulated by crops increased to varying degrees (e.g., Pb and Zn in root, Cu and Pb in grain, and Cd in stems and leaves). Moreover, the concentrations of HMs in seeds of crops were higher than the limited levels given by the Chinese directive. Considering the results of the study and food safety, it is suggested to change the nature of the land around the smelter into woodland or construction land to prohibit the cultivation of food crops in this area.
MeSH term(s)	Cadmium/analysis ; Charcoal/chemistry ; China ; Metals, Heavy/analysis ; Seasons ; Soil/chemistry ; Soil Pollutants/analysis ; Zinc/analysis
Chemical Substances	Metals, Heavy ; Soil ; Soil Pollutants ; biochar ; Cadmium (00BH33GNGH) ; Charcoal (16291-96-6) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2022-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.119095
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Article ; Online: Evaluation of microbial communities of Chinese Feng-flavor Daqu with effects of environmental factors using traceability analysis.

Zhang, Yongli / Xu, Chen / Xing, Gang / Yan, Zongke / Chen, Yaodong

Scientific reports

2023 Volume 13, Issue 1, Page(s) 7657

Abstract: Analysis of the changes of microorganisms during Chinese Feng-flavor Daqu fermentation, and ... technology and SourceTracker software were used to analyze the microbial diversity of Feng-flavor Daqu ... before and after fermentation. 85 fungal and 105 bacterial were detected in the newly pressed Feng-flavor ...

Abstract	Analysis of the changes of microorganisms during Chinese Feng-flavor Daqu fermentation, and the specific contribution of different environmental factors to Daqu microorganisms. High throughput sequencing technology and SourceTracker software were used to analyze the microbial diversity of Feng-flavor Daqu before and after fermentation. 85 fungal and 105 bacterial were detected in the newly pressed Feng-flavor Daqu, while 33 fungal and 50 bacterial in the mature Daqu, and 202 fungal and 555 bacterial in the environmental samples. After fermentation, the microbial community structure of Daqu changed and decreased significantly. 94.7% of fungi come from raw materials and 1.8% from outdoor ground, 60.95% of bacteria come from indoor ground, 20.44% from raw materials, and 8.98% from tools. By comparing the changes of microorganisms in Daqu before and after fermentation, the microorganisms in mature Daqu may mainly come from not only the enhanced strains but also the environment.The source of main microorganisms in Feng-flavor Daqu and the influence of environmental factors on the quality of Daqu were clarified, which provided a basis for improving the quality of Feng-flavor Daqu.
MeSH term(s)	Alcoholic Beverages/microbiology ; Bacteria/genetics ; Fermentation ; Microbiota
Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-34506-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cinnabar-containing Chinese medicine Hua-Feng-Dan differs from mercury sulfide and mercury chloride in affecting gut microbiota in mice

Yong-Mei Liu / Bo Liu / Jie Liu / Shang-Fu Xu / Feng Zhang / Ming-Liang Cheng / Jing-Shan Shi

Pharmacological Research - Modern Chinese Medicine, Vol 8, Iss , Pp 100279- (2023)

2023

Abstract: Introduction: Cinnabar (96% HgS) is included in Chinese medicines, including Hua-Feng-Dan. We have ... shown the protective effects of Hua-Feng-Dan against LPS plus rotenone-induced neurotoxicity in rats and ... However, the effects of HgS-containing Hua-Feng-Dan in comparison to HgS and HgCl2 are unknown. Methods: Mice were ...

Abstract	Introduction: Cinnabar (96% HgS) is included in Chinese medicines, including Hua-Feng-Dan. We have shown the protective effects of Hua-Feng-Dan against LPS plus rotenone-induced neurotoxicity in rats and against LPS plus MPTP-induced neuroinflammation in mice by modulation of gut microbiota. However, the effects of HgS-containing Hua-Feng-Dan in comparison to HgS and HgCl2 are unknown. Methods: Mice were given orally with Hua-Feng-Dan at clinical doses (0.6 and 1.5 g/kg), approximate Hg as HgS or HgCl2 for 7 days. Intestinal histology and Hg accumulation were examined. Bacterial DNA from the colon contents was extracted and subjected to DNA sequencing and qPCR verification with 16S rRNA probes. Results: Hua-Feng-Dan and HgS did not affect animal body weight gain, intestinal histology, nor produce overt intestinal Hg accumulation (2-fold). In contrast, HgCl2 reduced body weight gain, produced spotted mild inflammation, and produced 20-fold Hg accumulation in the duodenum. Operational taxonomic unit (OTU) from DNA sequencing showed that at phyla levels, HgS increased Firmicutes and decreased Bacteroidetes, while HgCl2 produced opposite effects; at the family levels, Hua-Feng-Dan increased Streptococcaceae and Dehalobacteriaceae, HgS had similar effects; at the genus levels, Hua-Feng-Dan and HgS increased Streptococcaceae__garvieae and Paraprevotellaceae__Prevotella, while HgCl2 increased Dehalobacteriaceae__Dehalobacterium and Odoribacteraceae__Odoribacter. HgS also increased Verrucomicrobiaceae__Akkermansia and produced many other alterations. Discussion: Cinnabar-containing Hua-Feng-Dan had minimal effects on animal health, gut histology and Hg accumulation but produced modulations of gut microbiota. Effects of Hua-Feng-Dan on gut microbiota were different from HgS and HgCl2.
Keywords	Cinnabar-containing Hua-Feng-Dan ; HgS ; HgCl2 ; Intestine histology ; Hg accumulation ; Gut microbiota ; Other systems of medicine ; RZ201-999 ; Therapeutics. Pharmacology ; RM1-950
Subject code	501
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction: Feng et al. Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway.

Feng, Duo / Xu, DongZhu / Murakoshi, Nobuyuki / Tajiri, Kazuko / Qin, Rujie / Yonebayashi, Saori / Okabe, Yuta / Li, Siqi / Yuan, Zixun / Aonuma, Kazutaka / Ieda, Masaki

International journal of molecular sciences

2021 Volume 22, Issue 19

Abstract: The authors wish to make the following corrections to this paper [ ... ]. ...

Abstract	The authors wish to make the following corrections to this paper [...].
Language	English
Publishing date	2021-10-08
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms221910881
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: In Vitro Immature Embryo Culture of Paeonia ostii ‘Feng Dan’

Xu, Li / Cheng, Fangyun / Zhong, Yuan

HortScience. 2022 May, v. 57, no. 5

2022

Abstract: Paeonia ostii ‘Feng Dan’ is an economically important, multipurpose woody plant in terms ... for in vitro immature embryo culture in P. ostii ‘Feng Dan’, which involves two steps: 1) immature seeds at 30 ...

Abstract	Paeonia ostii ‘Feng Dan’ is an economically important, multipurpose woody plant in terms of its medical, ornamental, and oil values; however, there is a noticeable contradiction between the increasing demands and the lack of excellent germplasm resources because of traditional breeding and propagation approaches. In vitro embryo culture is an attractive option for this issue. This study presents a protocol for in vitro immature embryo culture in P. ostii ‘Feng Dan’, which involves two steps: 1) immature seeds at 30 days after anthesis (DAA) (cellularization stage of endosperm, proembryo stage) or after being cultured in vitro for cotyledon embryo formation (upward micropyle with placenta was the best inoculation method with the highest ratio of seed with cotyledon embryo of 66.67%); and 2) seedling establishment was realized within 7 months via embryo (at 40 DAA or after) germination, shoot induction, rooting, and acclimatization. The multiplication potential was increased with embryo maturity. This protocol provides an available reference for embryo rescue and propagation of tree peony and will be beneficial to shortening the breeding cycle.
Keywords	Paeonia ostii ; Paeonia suffruticosa ; acclimation ; cotyledons ; embryo culture ; endosperm ; flowering ; germination ; germplasm ; inoculation methods ; oils ; ovule culture ; placenta ; plant establishment ; woody plants
Language	English
Dates of publication	2022-05
Size	p. 599-605.
Publishing place	American Society for Horticultural Science
Document type	Article
ISSN	2327-9834
DOI	10.21273/HORTSCI16477-21
Database	NAL-Catalogue (AGRICOLA)

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Article: Sustainable biochar effects on the remediation of contaminated soil: A 2-crop season site practice near a lead-zinc smelter in Feng County, China

Wang, Ping / Shen, Feng / Xu, Yaqiong / Wang, Xuejia / Huang, Hui / Li, Ronghua / Liu, Tao / Guo, Di / Du, Juan / Guo, Zhanyu / Zhang, Zengqiang

Environmental pollution. 2022 June 01, v. 302

2022

Abstract: ... smelter in Feng County, China, under the rotation condition of different crops. This kind of cultivation ...

Abstract	It is of great significance to explore the remediation pattern in actual heavy metal (HM) contaminated sites. The field trial was carried out to research the remediation effect of biochar near a lead-zinc smelter in Feng County, China, under the rotation condition of different crops. This kind of cultivation mode is very representative in northern of China. And the pattern of production and restoration is suitable for scarce land resources and large food demand in China. The changes of soil physiochemical properties with the biochar addition, crop growth and the accumulated HMs by crops were focused on. The results showed the biochar application was excellent in improving soil nutrient elements and crop growth. The contents of TK were more obvious than those of TN and TP, with an increase of 2.6%–28.2% compared with the controls (without the addition of biochar). The yield of first season crops, i.e., soybean and corn, increased by 30%–42% and 34%–61%, respectively, and the second season crops, i.e., rape and wheat, with the increment of 25%–41% and 9%–29%, respectively. The availability forms of Cd and Pb decreased by 1.07–10.0% and 2.92–8.35%, respectively. While the improvement on the status of the HMs accumulated by crops was disappointing. The contents of HMs accumulated by crops increased to varying degrees (e.g., Pb and Zn in root, Cu and Pb in grain, and Cd in stems and leaves). Moreover, the concentrations of HMs in seeds of crops were higher than the limited levels given by the Chinese directive. Considering the results of the study and food safety, it is suggested to change the nature of the land around the smelter into woodland or construction land to prohibit the cultivation of food crops in this area.
Keywords	biochar ; corn ; field experimentation ; food safety ; heavy metals ; polluted soils ; pollution ; remediation ; soil nutrients ; soybeans ; wheat ; woodlands
Language	English
Dates of publication	2022-0601
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.119095
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Mercury sulfide-containing Hua-Feng-Dan and 70W (Rannasangpei) protect against LPS plus MPTP-induced neurotoxicity and disturbance of gut microbiota in mice.

Hu, An-Ling / Song, Sheng / Li, Yi / Xu, Shang-Fu / Zhang, Feng / Li, Cen / Liu, Jie

Journal of ethnopharmacology

2020 Volume 254, Page(s) 112674

Abstract: ... remains elusive. The present study examined the protective effects of α-HgS-containing Hua-Feng-Dan and β ... treatment, mice were fed with clinically-relevant doses of Hua-Feng-Dan (0.6 g/kg) and 70W (0.2 g/kg) for 35 ... intensified microglia activation and loss of dopaminergic neurons. Both Hua-Feng-Dan and 70W increased rotarod ...

Abstract	Ethnopharmacological relevance: Mercury sulfides (HgS) are frequently included in Ayurveda, Tibetan and Chinese medicines to assist the presumed therapeutic effects, but the ethnopharmacology remains elusive. The present study examined the protective effects of α-HgS-containing Hua-Feng-Dan and β-HgS-containing 70 Wei-Zhen-Zhu-Wan (70W, Rannasangpei) against Parkinson's disease mice induced by lipopolysaccharide (LPS) plus 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Method: A single injection of LPS (5 mg/kg ip) was given to adult male C57BL/6 mice, and 150 days later, the low dose of MPTP (15 mg/kg, ip, for 4 days) was given to produce the "two-hit" Parkinson's disease model. Together with MPTP treatment, mice were fed with clinically-relevant doses of Hua-Feng-Dan (0.6 g/kg) and 70W (0.2 g/kg) for 35 days. Rotarod test was performed to examine muscle coordination capability. At the end of the experiment, brain was transcardially perfused with paraformaldehyde, the substantia nigra was sectioned for microglia (Iba1 staining) and dopaminergic neuron (THir staining) determination. Colon bacterial DNA was extracted and subjected to qPCR analysis with 16S rRNA probes. Results: The low-grade, chronic neuroinflammation produced by LPS aggravated MPTP neurotoxicity, as evidenced by decreased motor activity, intensified microglia activation and loss of dopaminergic neurons. Both Hua-Feng-Dan and 70W increased rotarod activity and ameliorated the pathological lesions in the brain. In gut microbiomes examined, LPS plus MPTP increased Verrucomicrobiaceae, Methanobacteriaceae, Pronicromonosporaceae, and Clostridaceae species were attenuated by Hua-Feng-Dan and 70W. Conclusions: α-HgS-containing Hua-Feng-Dan and β-HgS-containing 70W at clinical doses protected against chronic LPS plus MPTP-induced toxicity to the brain and gut, suggesting HgS-containing traditional medicines could target gut microbiota as a mechanism of their therapeutic effects.
MeSH term(s)	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Colon/drug effects ; Colon/microbiology ; Dopaminergic Neurons/pathology ; Lipopolysaccharides ; Male ; Mercury Compounds/pharmacology ; Mice ; Microglia/pathology ; Parkinson Disease, Secondary/chemically induced ; Parkinson Disease, Secondary/prevention & control ; Rotarod Performance Test ; Substantia Nigra/pathology
Chemical Substances	Lipopolysaccharides ; Mercury Compounds ; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (9P21XSP91P) ; cinnabar (ZI0T668SF1)
Language	English
Publishing date	2020-02-24
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.112674
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