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  1. Article ; Online: Evaluation of phytoremediation potential and resistance of Gladiolus grandiflora L. against cadmium stress.

    Bukhari, Syed Ali Qasim / Nawaz, Aamir / Dawood, Muhammad

    Environmental geochemistry and health

    2023  Volume 45, Issue 7, Page(s) 5231–5244

    Abstract: Although irrigation water is a fundamental need for plant growth, it is also a source of pollutants if contaminated with harmful materials like cadmium (Cd). Irrigation water possessing abundant Cd causes damage to soil, plants, animals and ultimately ... ...

    Abstract Although irrigation water is a fundamental need for plant growth, it is also a source of pollutants if contaminated with harmful materials like cadmium (Cd). Irrigation water possessing abundant Cd causes damage to soil, plants, animals and ultimately human beings through the food chain. A pot experiment was conducted to evaluate the gladiolus (Gladiolus grandiflora L.) potential of Cd accumulation and the capability of the plant to be an economically beneficial choice in presence of high Cd irrigation water supply. Artificially prepared four levels of Cd irrigation water were applied to the plants viz., 30, 60, 90 and 120 mg L
    MeSH term(s) Humans ; Cadmium/toxicity ; Cadmium/analysis ; Biodegradation, Environmental ; Soil Pollutants/toxicity ; Soil Pollutants/analysis ; Water ; Soil ; Plant Roots/chemistry
    Chemical Substances Cadmium (00BH33GNGH) ; Soil Pollutants ; Water (059QF0KO0R) ; Soil
    Language English
    Publishing date 2023-04-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 52039-1
    ISSN 1573-2983 ; 0142-7245 ; 0269-4042
    ISSN (online) 1573-2983
    ISSN 0142-7245 ; 0269-4042
    DOI 10.1007/s10653-023-01579-8
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  2. Article ; Online: Rosuvastatin Attenuates Rheumatoid Arthritis-Associated Manifestations via Modulation of the Pro- and Anti-inflammatory Cytokine Network: A Combination of

    Qasim, Sumera / Alamgeer / Kalsoom, Saima / Shahzad, Muhammad / Bukhari, Ishfaq Ali / Vohra, Fahim / Afzal, Sibtain

    ACS omega

    2021  Volume 6, Issue 3, Page(s) 2074–2084

    Abstract: The current investigation employed rosuvastatin for evaluation as an antiarthritic agent ... ...

    Abstract The current investigation employed rosuvastatin for evaluation as an antiarthritic agent by
    Language English
    Publishing date 2021-01-14
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.0c05054
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  3. Article ; Online: Functional connectivity of fMRI using differential covariance predicts structural connectivity and behavioral reaction times.

    Chen, Yusi / Bukhari, Qasim / Lin, Tiger W / Sejnowski, Terrence J

    Network neuroscience (Cambridge, Mass.)

    2022  Volume 6, Issue 2, Page(s) 614–633

    Abstract: Recordings from resting-state functional magnetic resonance imaging (rs-fMRI) reflect the influence of pathways between brain areas. A wide range of methods have been proposed to measure this functional connectivity (FC), but the lack of "ground truth" ... ...

    Abstract Recordings from resting-state functional magnetic resonance imaging (rs-fMRI) reflect the influence of pathways between brain areas. A wide range of methods have been proposed to measure this functional connectivity (FC), but the lack of "ground truth" has made it difficult to systematically validate them. Most measures of FC produce connectivity estimates that are symmetrical between brain areas. Differential covariance (dCov) is an algorithm for analyzing FC with directed graph edges. When we applied dCov to rs-fMRI recordings from the human connectome project (HCP) and anesthetized mice, dCov-FC accurately identified strong cortical connections from diffusion magnetic resonance imaging (dMRI) in individual humans and viral tract tracing in mice. In addition, those HCP subjects whose dCov-FCs were more integrated, as assessed by a graph-theoretic measure, tended to have shorter reaction times in several behavioral tests. Thus, dCov-FC was able to identify anatomically verified connectivity that yielded measures of brain integration significantly correlated with behavior.
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Journal Article
    ISSN 2472-1751
    ISSN (online) 2472-1751
    DOI 10.1162/netn_a_00239
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  4. Thesis ; Online: Network Analysis and Multivariate Pattern Recognition Methods to Study Drug Effects on Functional Connectivity in Mice Based on Resting State fMRI

    Bukhari, Qasim

    2017  

    Abstract: Resting state fMRI aims at establishing the functional relationship between two spatially distinct brain regions based on temporal correlation of the respective signals. The method has been applied to study functional connectivity (FC) across species and ...

    Abstract Resting state fMRI aims at establishing the functional relationship between two spatially distinct brain regions based on temporal correlation of the respective signals. The method has been applied to study functional connectivity (FC) across species and was found of special value for studies in mice fMRI studies due to its experimental simplicity, which allowed eliminating confounds typically observed in stimulus-evoked fMRI studies. Yet, analysis of fMRI data in animals face a number of problems. First, fMRI studies in mice typically require the use of anaesthetics, which are known to alter responses to stimuli or functional networks at rest. Proper interpretation of fMRI data collected in animals under anaesthesia animals requires investigation of the effects of these drugs on brain processing per se. Second, since fMRI analysis tools have been typically developed for processing of human fMRI data, translation to animals including mice may be challenging due to anatomical and physiological differences across species. It therefore appears appropriate to evaluate several state of the art analysis tools for human fMRI for their potential use in mice fMRI. In the first study, we have used Dual Regression analysis Network Modelling to test its feasibility in mouse resting-state fMRI analysis to investigate effects of two commonly used anaesthetics, isoflurane and medetomidine, on rs-fMRI derived functional networks, and in particular to study to what extent anaesthesia affected the interaction within and between brain networks. The analysis revealed both similarities and specific differences in network patterns of the two groups. Under isoflurane anaesthesia, intra- and interhemispheric cortical interactions have been predominantly observed, with only minor interactions involving subcortical structures. In particular, cortico—thalamic connectivity appeared significantly attenuated in line with previous observations. In contrast, medetomidine anesthetized mice displayed significant subcortical functional ...
    Keywords fMRI ; machine learning ; network analysis ; functional connectivity analysis ; Dynamic functional connectivity ; dynamic effective connectivity ; info:eu-repo/classification/ddc/610 ; Medical sciences ; medicine
    Subject code 006
    Language English
    Publisher ETH Zurich
    Publishing country ch
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Niche partitioning by sympatric civets in the Himalayan foothills of Pakistan.

    Akrim, Faraz / Mahmood, Tariq / Belant, Jerrold L / Nadeem, Muhammad Sajid / Qasim, Siddiqa / Dhendup, Tashi / Fatima, Hira / Bukhari, Syed Afaq / Aslam, Asad / Younis, Humera / Rafique, Aamish / Subhani, Zahid Ahmed / Hashmi, Shafqaat Ahmed / Munawar, Nadeem

    PeerJ

    2023  Volume 11, Page(s) e14741

    Abstract: Niche overlap between sympatric species can indicate the extent of interspecific competition. Sympatric competing species can exhibit spatial, temporal, and dietary adjustments to reduce competition. We investigated spatial, temporal, and dietary niche ... ...

    Abstract Niche overlap between sympatric species can indicate the extent of interspecific competition. Sympatric competing species can exhibit spatial, temporal, and dietary adjustments to reduce competition. We investigated spatial, temporal, and dietary niche overlap of sympatric Asian palm civet (
    MeSH term(s) Animals ; Mice ; Viverridae ; Sympatry ; Pakistan ; Gerbillinae
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.14741
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  6. Article ; Online: Appraisal of the Antiarthritic Potential of Prazosin via Inhibition of Proinflammatory Cytokine TNF-α: A Key Player in Rheumatoid Arthritis.

    Qasim, Sumera / Alamgeer / Saleem, Muhammad / Alotaibi, Nasser Hadal / Bukhari, Syed Nasir Abbas / Alharbi, Khalid Saad / Irfan, Hafiz Muhammad / Anwar, Rukhsana

    ACS omega

    2021  Volume 6, Issue 3, Page(s) 2379–2388

    Abstract: Prazosin, a selective ... ...

    Abstract Prazosin, a selective α
    Language English
    Publishing date 2021-01-15
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.0c05698
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  7. Article ; Online: Rosuvastatin Attenuates Rheumatoid Arthritis-Associated Manifestations via Modulation of the Pro- and Anti-inflammatory Cytokine Network

    Sumera Qasim / Alamgeer / Saima Kalsoom / Muhammad Shahzad / Ishfaq Ali Bukhari / Fahim Vohra / Sibtain Afzal

    ACS Omega, Vol 6, Iss 3, Pp 2074-

    A Combination of In Vitro and In Vivo Studies

    2021  Volume 2084

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Effects of Weather on Coronavirus Pandemic.

    Bukhari, Qasim / Massaro, Joseph M / D'Agostino, Ralph B / Khan, Sheraz

    International journal of environmental research and public health

    2020  Volume 17, Issue 15

    Abstract: The novel coronavirus (SARS-CoV-2) has spread globally and has been declared a pandemic by the World Health Organization. While influenza virus shows seasonality, it is unknown if COVID-19 has any weather-related affect. In this work, we analyze the ... ...

    Abstract The novel coronavirus (SARS-CoV-2) has spread globally and has been declared a pandemic by the World Health Organization. While influenza virus shows seasonality, it is unknown if COVID-19 has any weather-related affect. In this work, we analyze the patterns in local weather of all the regions affected by COVID-19 globally. Our results indicate that approximately 85% of the COVID-19 reported cases until 1 May 2020, making approximately 3 million reported cases (out of approximately 29 million tests performed) have occurred in regions with temperature between 3 and 17 °C and absolute humidity between 1 and 9 g/m
    MeSH term(s) Betacoronavirus ; COVID-19 ; Cities ; Coronavirus Infections/transmission ; Humans ; Pandemics ; Pneumonia, Viral/transmission ; Public Health ; SARS-CoV-2 ; Seasons ; Temperature ; Weather
    Keywords covid19
    Language English
    Publishing date 2020-07-27
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph17155399
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  9. Article ; Online: Interaction Between Cerebellum and Cerebral Cortex, Evidence from Dynamic Causal Modeling.

    Bukhari, Qasim / Ruf, Sebastian F / Guell, Xavier / Whitfield-Gabrieli, Susan / Anteraper, Sheeba

    Cerebellum (London, England)

    2021  Volume 21, Issue 2, Page(s) 225–233

    Abstract: The interaction of the cerebellum with cerebral cortical dynamics is still poorly understood. In this paper, dynamical causal modeling is used to examine the interaction between cerebellum and cerebral cortex as indexed by MRI resting-state functional ... ...

    Abstract The interaction of the cerebellum with cerebral cortical dynamics is still poorly understood. In this paper, dynamical causal modeling is used to examine the interaction between cerebellum and cerebral cortex as indexed by MRI resting-state functional connectivity in three large-scale networks on healthy young adults (N = 200; Human Connectome Project dataset). These networks correspond roughly to default mode, task positive, and motor as determined by prior cerebellar functional gradient analyses. We find uniform interactions within all considered networks from cerebellum to cerebral cortex, providing support for the notion of a universal cerebellar transform. Our results provide a foundation for future analyses to quantify and further investigate whether this is a property that is unique to the interactions from cerebellum to cerebral cortex.
    MeSH term(s) Cerebellum/diagnostic imaging ; Cerebral Cortex/diagnostic imaging ; Connectome/methods ; Humans ; Magnetic Resonance Imaging ; Nerve Net/diagnostic imaging ; Young Adult
    Language English
    Publishing date 2021-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2112586-7
    ISSN 1473-4230 ; 1473-4222
    ISSN (online) 1473-4230
    ISSN 1473-4222
    DOI 10.1007/s12311-021-01284-1
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  10. Article ; Online: Correction to: Appraisal of disease-modifying potential of amlodipine as an anti-arthritic agent: new indication for an old drug.

    Qasim, Sumera / Alamgeer / Kalsoom, Saima / Shahzad, Muhammad / Irfan, Hafiz Muhammad / Zafar, Muhammad Shoaib / Bukhari, Ishfaq Ali / Vohra, Fahim / Afzal, Sibtain

    Inflammopharmacology

    2020  Volume 28, Issue 4, Page(s) 1137

    Abstract: Unfortunately, the 4th author name was incorrectly published in the original publication. ...

    Abstract Unfortunately, the 4th author name was incorrectly published in the original publication.
    Language English
    Publishing date 2020-04-30
    Publishing country Switzerland
    Document type Journal Article ; Published Erratum
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-020-00706-6
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