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  1. Article ; Online: The quiescent centre of the root apical meristem: conceptual developments from Clowes to modern times.

    Dubrovsky, Joseph G / Ivanov, Victor B

    Journal of experimental botany

    2021  Volume 72, Issue 19, Page(s) 6687–6707

    Abstract: In this review we discuss the concepts of the quiescent centre (QC) of the root apical meristem (RAM) and their change over time, from their formulation by F.A.L. Clowes to the present. This review is dedicated to the 100th anniversary of the birth of ... ...

    Abstract In this review we discuss the concepts of the quiescent centre (QC) of the root apical meristem (RAM) and their change over time, from their formulation by F.A.L. Clowes to the present. This review is dedicated to the 100th anniversary of the birth of Clowes, and we present his short biography and a full bibliography of Clowes' work. Over time, the concept of the QC proved to be useful for the understanding of RAM organization and behaviour. We focus specifically on conceptual developments, from the organization of the QC to understanding its functions in RAM maintenance and activity, ranging from a model species, Arabidopsis thaliana, to crops. Concepts of initial cells, stem cells, and heterogeneity of the QC cells in the context of functional and structural stem cells are considered. We review the role of the QC in the context of cell flux in the RAM and the nature of quiescence of the QC cells. We discuss the origin of the QC and fluctuation of its size in ontogenesis and why the QC cells are more resistant to stress. Contemporary concepts of the organizer and stem cell niche are also considered. We also propose how the stem cell niche in the RAM can be defined in roots of a non-model species.
    MeSH term(s) Arabidopsis ; Arabidopsis Proteins/genetics ; Cell Division ; Meristem ; Plant Roots ; Stem Cell Niche
    Chemical Substances Arabidopsis Proteins
    Language English
    Publishing date 2021-06-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2976-2
    ISSN 1460-2431 ; 0022-0957
    ISSN (online) 1460-2431
    ISSN 0022-0957
    DOI 10.1093/jxb/erab305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 55/29: Show issues

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  2. Article ; Online: Cardiac RNase Z edited via CRISPR-Cas9 drives heart hypertrophy in Drosophila.

    Migunova, Ekaterina / Rajamani, Saathvika / Bonanni, Stefania / Wang, Fei / Zhou, Chao / Dubrovsky, Edward B

    PloS one

    2023  Volume 18, Issue 5, Page(s) e0286214

    Abstract: Cardiomyopathy (CM) is a group of diseases distinguished by morphological and functional abnormalities in the myocardium. It is etiologically heterogeneous and may develop via cell autonomous and/or non-autonomous mechanisms. One of the most severe forms ...

    Abstract Cardiomyopathy (CM) is a group of diseases distinguished by morphological and functional abnormalities in the myocardium. It is etiologically heterogeneous and may develop via cell autonomous and/or non-autonomous mechanisms. One of the most severe forms of CM has been linked to the deficiency of the ubiquitously expressed RNase Z endoribonuclease. RNase Z cleaves off the 3'-trailer of both nuclear and mitochondrial primary tRNA (pre-tRNA) transcripts. Cells mutant for RNase Z accumulate unprocessed pre-tRNA molecules. Patients carrying RNase Z variants with reduced enzymatic activity display a plethora of symptoms including muscular hypotonia, microcephaly and severe heart hypertrophy; still, they die primarily due to acute heart decompensation. Determining whether the underlying mechanism of heart malfunction is cell autonomous or not will provide an opportunity to develop novel strategies of more efficient treatments for these patients. In this study, we used CRISPR-TRiM technology to create Drosophila models that carry cardiomyopathy-linked alleles of RNase Z only in the cardiomyocytes. We found that this modification is sufficient for flies to develop heart hypertrophy and systolic dysfunction. These observations support the idea that the RNase Z linked CM is driven by cell autonomous mechanisms.
    MeSH term(s) Animals ; Drosophila/genetics ; Drosophila/metabolism ; RNA Precursors/genetics ; CRISPR-Cas Systems ; Endoribonucleases/genetics ; Endoribonucleases/metabolism ; RNA, Transfer/genetics ; Cardiomegaly/genetics
    Chemical Substances RNase Z (EC 3.1.-) ; RNA Precursors ; Endoribonucleases (EC 3.1.-) ; RNA, Transfer (9014-25-9)
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0286214
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  3. Article ; Online: The association of subjective and objective sleep measures with chronic tinnitus.

    Weingarten, Jeremy A / Islam, Albina / Dubrovsky, Boris / Gharanei, Mayel / Coelho, Daniel H

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2023  Volume 20, Issue 3, Page(s) 399–405

    Abstract: ... Weingarten JA, Islam A, Dubrovsky B, Gharanei M, Coelho DH. The association of subjective and objective sleep ...

    Abstract Study objectives: Poor sleep is a prevalent complaint in the population with chronic tinnitus, but the relationship between the two is not well-characterized. The objective of this study was to understand how subjective and objective measures of sleep compare in patients with or without chronic tinnitus.
    Methods: This prospective cohort study included consecutive adult patients who presented to a sleep laboratory between January 19, 2017, and January 10, 2020. All patients underwent an in-laboratory nocturnal polysomnogram and filled out questionnaires including the Pittsburgh Sleep Quality Index (PSQI), Tinnitus Screener, and Tinnitus Handicap Inventory, among others.
    Results: The study included 1,968 participants, out of which 284 (14.4%) reported chronic tinnitus. Patients with chronic tinnitus were younger (51.6 years vs 54.1 years;
    Conclusions: Chronic tinnitus is associated with significant changes in qualitative sleep (higher PSQI) but no major differences in quantitative sleep measures were observed.
    Citation: Weingarten JA, Islam A, Dubrovsky B, Gharanei M, Coelho DH. The association of subjective and objective sleep measures with chronic tinnitus.
    MeSH term(s) Adult ; Humans ; Female ; Middle Aged ; Prospective Studies ; Sleepiness ; Tinnitus/complications ; Sleep ; Polysomnography
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.10882
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6590: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Correction: ELAC2/RNaseZ-linked cardiac hypertrophy in Drosophila melanogaster.

    Migunova, Ekaterina / Theophilopoulos, Joanna / Mercadante, Marisa / Men, Jing / Zhou, Chao / Dubrovsky, Edward B

    Disease models & mechanisms

    2022  Volume 15, Issue 3

    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.049509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cardiac RNase Z edited via CRISPR-Cas9 drives heart hypertrophy in Drosophila.

    Ekaterina Migunova / Saathvika Rajamani / Stefania Bonanni / Fei Wang / Chao Zhou / Edward B Dubrovsky

    PLoS ONE, Vol 18, Iss 5, p e

    2023  Volume 0286214

    Abstract: Cardiomyopathy (CM) is a group of diseases distinguished by morphological and functional abnormalities in the myocardium. It is etiologically heterogeneous and may develop via cell autonomous and/or non-autonomous mechanisms. One of the most severe forms ...

    Abstract Cardiomyopathy (CM) is a group of diseases distinguished by morphological and functional abnormalities in the myocardium. It is etiologically heterogeneous and may develop via cell autonomous and/or non-autonomous mechanisms. One of the most severe forms of CM has been linked to the deficiency of the ubiquitously expressed RNase Z endoribonuclease. RNase Z cleaves off the 3'-trailer of both nuclear and mitochondrial primary tRNA (pre-tRNA) transcripts. Cells mutant for RNase Z accumulate unprocessed pre-tRNA molecules. Patients carrying RNase Z variants with reduced enzymatic activity display a plethora of symptoms including muscular hypotonia, microcephaly and severe heart hypertrophy; still, they die primarily due to acute heart decompensation. Determining whether the underlying mechanism of heart malfunction is cell autonomous or not will provide an opportunity to develop novel strategies of more efficient treatments for these patients. In this study, we used CRISPR-TRiM technology to create Drosophila models that carry cardiomyopathy-linked alleles of RNase Z only in the cardiomyocytes. We found that this modification is sufficient for flies to develop heart hypertrophy and systolic dysfunction. These observations support the idea that the RNase Z linked CM is driven by cell autonomous mechanisms.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Cardiac RNase Z edited via CRISPR-Cas9 drives heart hypertrophy in Drosophila

    Ekaterina Migunova / Saathvika Rajamani / Stefania Bonanni / Fei Wang / Chao Zhou / Edward B. Dubrovsky

    PLoS ONE, Vol 18, Iss

    2023  Volume 5

    Abstract: Cardiomyopathy (CM) is a group of diseases distinguished by morphological and functional abnormalities in the myocardium. It is etiologically heterogeneous and may develop via cell autonomous and/or non-autonomous mechanisms. One of the most severe forms ...

    Abstract Cardiomyopathy (CM) is a group of diseases distinguished by morphological and functional abnormalities in the myocardium. It is etiologically heterogeneous and may develop via cell autonomous and/or non-autonomous mechanisms. One of the most severe forms of CM has been linked to the deficiency of the ubiquitously expressed RNase Z endoribonuclease. RNase Z cleaves off the 3’-trailer of both nuclear and mitochondrial primary tRNA (pre-tRNA) transcripts. Cells mutant for RNase Z accumulate unprocessed pre-tRNA molecules. Patients carrying RNase Z variants with reduced enzymatic activity display a plethora of symptoms including muscular hypotonia, microcephaly and severe heart hypertrophy; still, they die primarily due to acute heart decompensation. Determining whether the underlying mechanism of heart malfunction is cell autonomous or not will provide an opportunity to develop novel strategies of more efficient treatments for these patients. In this study, we used CRISPR-TRiM technology to create Drosophila models that carry cardiomyopathy-linked alleles of RNase Z only in the cardiomyocytes. We found that this modification is sufficient for flies to develop heart hypertrophy and systolic dysfunction. These observations support the idea that the RNase Z linked CM is driven by cell autonomous mechanisms.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Management of a large delayed esophageal perforation in a fresh liver transplant patient with endoscopic placement of a nasopleural drainage tube-a case report.

    Seth, Rashmi / Dubrovsky, Genia / Busuttil, Ronald W / Cameron, Robert B

    Journal of surgical case reports

    2020  Volume 2020, Issue 9, Page(s) rjaa385

    Abstract: Esophageal perforation in liver transplant recipients is a rare phenomenon. We herein report a case of an esophageal perforation due to Sengstaken-Blakemore tube in a liver-transplant recipient diagnosed 6 weeks post-transplant. A 2.5-cm mid-esophageal ... ...

    Abstract Esophageal perforation in liver transplant recipients is a rare phenomenon. We herein report a case of an esophageal perforation due to Sengstaken-Blakemore tube in a liver-transplant recipient diagnosed 6 weeks post-transplant. A 2.5-cm mid-esophageal perforation communicating with large complex fluid collection in the pleural space was found. During endoscopy, 16Fr Salem Sump nasopleural tube (NP) was placed traversing through esophageal perforation into inferior aspect of the collection. Over the following 4 weeks, NP decompressed the cavity, allowed its closure and the tube was slowly retracted. By the end of 4 weeks, NP was removed with follow-up esophagogram showing no extravasation of contrast and a healed perforation. Hence, the esophageal perforation was successfully treated via this unique nonoperative approach without the need for major surgery. In instances of chronic leak with a stable patient, this nonoperative strategy should be considered even in immunocompromised patients.
    Language English
    Publishing date 2020-09-30
    Publishing country England
    Document type Case Reports
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjaa385
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  8. Article ; Online: ELAC2/RNaseZ-linked cardiac hypertrophy in Drosophila melanogaster.

    Migunova, Ekaterina / Theophilopoulos, Joanna / Mercadante, Marisa / Men, Jing / Zhou, Chao / Dubrovsky, Edward B

    Disease models & mechanisms

    2021  Volume 14, Issue 8

    Abstract: A severe form of infantile cardiomyopathy (CM) has been linked to mutations in ELAC2, a highly conserved human gene. It encodes Zinc phosphodiesterase ELAC protein 2 (ELAC2), which plays an essential role in the production of mature tRNAs. To establish a ...

    Abstract A severe form of infantile cardiomyopathy (CM) has been linked to mutations in ELAC2, a highly conserved human gene. It encodes Zinc phosphodiesterase ELAC protein 2 (ELAC2), which plays an essential role in the production of mature tRNAs. To establish a causal connection between ELAC2 variants and CM, here we used the Drosophila melanogaster model organism, which carries the ELAC2 homolog RNaseZ. Even though RNaseZ and ELAC2 have diverged in some of their biological functions, our study demonstrates the use of the fly model to study the mechanism of ELAC2-related pathology. We established transgenic lines harboring RNaseZ with CM-linked mutations in the background of endogenous RNaseZ knockout. Importantly, we found that the phenotype of these flies is consistent with the pathological features in human patients. Specifically, expression of CM-linked variants in flies caused heart hypertrophy and led to reduction in cardiac contractility associated with a rare form of CM. This study provides first experimental evidence for the pathogenicity of CM-causing mutations in the ELAC2 protein, and the foundation to improve our understanding and diagnosis of this rare infantile disease. This article has an associated First Person interview with the first author of the paper.
    MeSH term(s) Animals ; Cardiomegaly/genetics ; Drosophila Proteins/genetics ; Drosophila melanogaster/metabolism ; Mutation/genetics ; Neoplasm Proteins ; Phenotype ; RNA, Transfer/genetics
    Chemical Substances Drosophila Proteins ; Neoplasm Proteins ; RNA, Transfer (9014-25-9)
    Language English
    Publishing date 2021-08-31
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.048931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Correction

    Ekaterina Migunova / Joanna Theophilopoulos / Marisa Mercadante / Jing Men / Chao Zhou / Edward B. Dubrovsky

    Disease Models & Mechanisms, Vol 15, Iss

    ELAC2/RNaseZ-linked cardiac hypertrophy in Drosophila melanogaster

    2022  Volume 3

    Keywords Medicine ; R ; Pathology ; RB1-214
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: A paracrine component of salient symptoms of depression in Cushing's of diencephalic origin, and in perimenstrual syndromes: a hypothesis.

    Dubrovsky, B

    Medical hypotheses

    2006  Volume 66, Issue 5, Page(s) 936–938

    Abstract: Interrelationships between adrenocortical secretions and depression syndromes have been known since early in the 20th century. Now, the fact that pregnane and pregnene steroids are also known to be synthesized in the brain (they are termed neurosteroids ( ...

    Abstract Interrelationships between adrenocortical secretions and depression syndromes have been known since early in the 20th century. Now, the fact that pregnane and pregnene steroids are also known to be synthesized in the brain (they are termed neurosteroids (NS)), raises the possibility that these natural compounds could have paracrine effects. Adrenocorticotropic hormone (ACTH) can modulate biosynthesis of NSs. 17beta estradiol has been shown to decrease THP concentration in the brain. It is hypothesized that imbalance between stimulatory and depressant NSs induced by ACTH elevation in hypothalamo pituitary dependent Cushing's, and by estrogen concentration changes during the menstrual cycle, may be associated with the pathophysiology of salient symptoms of depression in Cushing's and in perimenstrual syndromes.
    MeSH term(s) Adrenocorticotropic Hormone/metabolism ; Cushing Syndrome/physiopathology ; Depression/physiopathology ; Diencephalon/physiopathology ; Estrogens/metabolism ; Female ; Humans ; Hypothalamic Diseases/physiopathology ; Menstruation Disturbances/physiopathology ; Models, Biological ; Paracrine Communication
    Chemical Substances Estrogens ; Adrenocorticotropic Hormone (9002-60-2)
    Language English
    Publishing date 2006
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2005.11.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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