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  1. Book: Dopamine

    Ben-Jonathan, Nira

    endocrine and oncogenic functions

    2020  

    Author's details Nira Ben-Jonathan
    Language English
    Size x, 423 Seiten, Illustrationen
    Edition First edition
    Publisher CRC Press
    Publishing place Boca Raton
    Publishing country United States
    Document type Book
    HBZ-ID HT020000699
    ISBN 978-1-138-39223-6 ; 9780429402272 ; 1-138-39223-5 ; 0429402279
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 707 available for loan (reading room) Lesesaal EG

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  2. Article: Dopamine Receptors in Breast Cancer: Prevalence, Signaling, and Therapeutic Applications.

    Ben-Jonathan, Nira / Borcherding, Dana C / Hugo, Eric R

    Critical reviews in oncogenesis

    2023  Volume 27, Issue 2, Page(s) 51–71

    Abstract: Breast cancer (BC) is the most common malignancy among women, with over one million cases occurring annually worldwide. Although therapies against estrogen receptors and HER2 have improved response rate and survival, patients with advanced disease, who ... ...

    Abstract Breast cancer (BC) is the most common malignancy among women, with over one million cases occurring annually worldwide. Although therapies against estrogen receptors and HER2 have improved response rate and survival, patients with advanced disease, who are resistant to anti-hormonal therapy and/or to chemotherapy, have limited treatment options for reducing morbidity and mortality. These limitations provide major incentives for developing new, effective, and personalized therapeutic interventions. This review presents evidence on the involvement of dopamine (DA) and its type 1 receptors (D1R) in BC. DA is produced in multiple peripheral organs and is present in the systemic circulation in significant amounts. D1R is overexpressed in ~ 30% of BC cases and is associated with advanced disease and shortened patient survival. Activation of D1R, which signals via the cGMP/PKG pathway, results in apoptosis, inhibition of cell invasion, and increased chemosensitivity in multiple BC cell lines. Fenoldopam, a peripheral D1R agonist that does not penetrate the brain, dramatically suppressed tumor growth in mouse models with D1R-expressing BC xenografts. It is proposed that D1R should serve as a novel diagnostic/prognostic factor through the use of currently available D1R detection methods. Fenoldopam, which is FDA-approved to treat renal hypertension, could be repurposed as an effective therapeutic agent for patients with D1R-expressing tumors. Several drugs that interfere with the cGMP/PKG pathway and are approved for treating other diseases should also be considered as potential treatments for BC.
    MeSH term(s) Mice ; Animals ; Humans ; Female ; Fenoldopam/pharmacology ; Fenoldopam/therapeutic use ; Prevalence ; Receptors, Dopamine ; Signal Transduction ; Dopamine/therapeutic use ; Breast Neoplasms/diagnosis ; Breast Neoplasms/drug therapy ; Breast Neoplasms/epidemiology
    Chemical Substances Fenoldopam (INU8H2KAWG) ; Receptors, Dopamine ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1036388-9
    ISSN 0893-9675
    ISSN 0893-9675
    DOI 10.1615/CritRevOncog.2022043641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Catecholamines as hormone regulators

    Ben-Jonathan, Nira

    (Serono Symposia publications from Raven Press ; 18)

    1985  

    Author's details eds. Nira Ben-Jonathan
    Series title Serono Symposia publications from Raven Press ; 18
    Collection
    Keywords Catecholamines / congresses ; Endocrine Glands / drug effects / congresses ; Catecholamine ; Endokrinologie
    Subject Catechinamine ; Katecholamine
    Size XIV, 382 S. : Ill., graph. Darst.
    Publisher Raven Pr
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT002321594
    ISBN 0-89004-607-7 ; 978-0-89004-607-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1986 A 1005 order for loan Magazin

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  4. Article: Prolactin (PRL) in adipose tissue: regulation and functions.

    Ben-Jonathan, Nira / Hugo, Eric

    Advances in experimental medicine and biology

    2015  Volume 846, Page(s) 1–35

    Abstract: New information concerning the effects of prolactin (PRL) on metabolic processes warrants reevaluation of its overall metabolic actions. PRL affects metabolic homeostasis by regulating key enzymes and transporters associated with glucose and lipid ... ...

    Abstract New information concerning the effects of prolactin (PRL) on metabolic processes warrants reevaluation of its overall metabolic actions. PRL affects metabolic homeostasis by regulating key enzymes and transporters associated with glucose and lipid metabolism in several target organs. In the lactating mammary gland, PRL increases the production of milk proteins, lactose, and lipids. In adipose tissue, PRL generally suppresses lipid storage and adipokine release and affect adipogenesis. A specific case is made for PRL in the human breast and adipose tissues, where it acts as a circulating hormone and an autocrine/paracrine factor. Although its overall effects on body composition are both modest and species-specific, PRL may be involved in the manifestation of insulin resistance.
    MeSH term(s) Adipogenesis/physiology ; Adipose Tissue/metabolism ; Animals ; Gene Expression Regulation ; Growth Hormone/physiology ; Humans ; Lipid Metabolism ; Placental Lactogen/physiology ; Prolactin/genetics ; Prolactin/physiology ; Receptors, Prolactin/chemistry ; Receptors, Prolactin/physiology
    Chemical Substances Receptors, Prolactin ; Prolactin (9002-62-4) ; Growth Hormone (9002-72-6) ; Placental Lactogen (9035-54-5)
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-319-12114-7_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Activation of the cGMP/protein kinase G system in breast cancer by the dopamine receptor-1.

    Ben-Jonathan, Nira / Borcherding, Dana C / Fox, Sejal / Hugo, Eric R

    Cancer drug resistance (Alhambra, Calif.)

    2019  Volume 2, Issue 4, Page(s) 933–947

    Abstract: Despite recent advances in the detection and treatment of breast cancer, many shortcomings remain, providing incentives to search for new therapeutic targets. This review provides information on the expression and actions of dopamine receptor-1 (D1R) in ... ...

    Abstract Despite recent advances in the detection and treatment of breast cancer, many shortcomings remain, providing incentives to search for new therapeutic targets. This review provides information on the expression and actions of dopamine receptor-1 (D1R) in breast cancer. D1R is overexpressed in a significant number of primary breast tumors, characterized by having an aggressive phenotype and predicting a shorter survival time for patients. Activation of D1R in breast cancer cells by selective agonists caused suppression of cell viability, stimulation of apoptosis, inhibition of cell invasion, and an increase in chemosensitivity. Instead of being linked to the cAMP/PKA system as expected, D1R in breast cancer is linked to the activation of the cGMP/protein kinase G (PKG) pathway. Fenoldopam, a peripheral D1R agonist that does not penetrate the brain, dramatically suppressed the growth of breast cancer xenografts in immune-deficient mice. A new imaging system for detecting D1R-expressing tumors and metastases was also developed. The review offers a novel concept that D1R can serve as a biomarker for prognosis in advanced breast cancer and its agonists can be used as effective and personalized therapeutics in a subpopulation of patients with D1R-expressing breast tumors. Several drugs, some of which are FDA-approved, that bypass the D1R and directly activate the cGMP/PKG apoptotic system, are also identified.
    Language English
    Publishing date 2019-12-19
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2578-532X
    ISSN (online) 2578-532X
    DOI 10.20517/cdr.2019.83
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  6. Article ; Online: Bisphenols Come in Different Flavors: Is "S" Better Than "A"?

    Ben-Jonathan, Nira / Hugo, Eric R

    Endocrinology

    2016  Volume 157, Issue 4, Page(s) 1321–1323

    MeSH term(s) Adipocytes/drug effects ; Adipogenesis/drug effects ; Cell Differentiation/drug effects ; Female ; Humans ; Phenols/pharmacology ; Sulfones/pharmacology
    Chemical Substances Phenols ; Sulfones
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/en.2016-1120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Suppression of Breast Cancer by Small Molecules That Block the Prolactin Receptor.

    Borcherding, Dana C / Hugo, Eric R / Fox, Sejal R / Jacobson, Eric M / Hunt, Brian G / Merino, Edward J / Ben-Jonathan, Nira

    Cancers

    2021  Volume 13, Issue 11

    Abstract: Prolactin (PRL) is a protein hormone which in humans is secreted by pituitary lactotrophs as well as by many normal and malignant non-pituitary sites. Many lines of evidence demonstrate that both circulating and locally produced PRL increase breast ... ...

    Abstract Prolactin (PRL) is a protein hormone which in humans is secreted by pituitary lactotrophs as well as by many normal and malignant non-pituitary sites. Many lines of evidence demonstrate that both circulating and locally produced PRL increase breast cancer (BC) growth and metastases and confer chemoresistance. Our objective was to identify and then characterize small molecules that block the tumorigenic actions of PRL in BC. We employed three cell-based assays in high throughput screening (HTS) of 51,000 small molecules and identified two small molecule inhibitors (SMIs), named SMI-1 and SMI-6. Both compounds bound to the extracellular domain (ECD) of the PRL receptor (PRLR) at 1-3 micromolar affinity and abrogated PRL-induced breast cancer cell (BCC) invasion and malignant lymphocyte proliferation. SMI-6 effectively reduced the viability of multiple BCC types, had much lower activity against various non-malignant cells, displayed high selectivity, and showed no apparent in vitro or in vivo toxicity. In athymic nude mice, SMI-6 rapidly and dramatically suppressed the growth of PRL-expressing BC xenografts. This report represents a pre-clinical phase of developing novel anti-cancer agents with the potential to become effective therapeutics in breast cancer patients.
    Language English
    Publishing date 2021-05-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13112662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Minireview: Extrapituitary prolactin: an update on the distribution, regulation, and functions.

    Marano, Robert J / Ben-Jonathan, Nira

    Molecular endocrinology (Baltimore, Md.)

    2014  Volume 28, Issue 5, Page(s) 622–633

    Abstract: Prolactin (PRL) is an important hormone with many diverse functions. Although it is predominantly produced by lactrotrophs of the pituitary there are a number of other organs, cells, and tissues in which PRL is expressed and secreted. The impact of this ... ...

    Abstract Prolactin (PRL) is an important hormone with many diverse functions. Although it is predominantly produced by lactrotrophs of the pituitary there are a number of other organs, cells, and tissues in which PRL is expressed and secreted. The impact of this extrapituitary PRL (ePRL) on localized metabolism and cellular functions is gaining widespread attention. In 1996, a comprehensive review on ePRL was published. However, since this time, there have been a number of advancements in ePRL research. This includes a greater understanding of the components of the control elements located within the superdistal promoter of the ePRL gene. Furthermore, several new sites of ePRL have been discovered, each under unique control by a range of transcription factors and elements. The functional role of ePRL at each of the expression sites also varies widely leading to gender and site bias. This review aims to provide an update to the research conducted on ePRL since the 1996 review. The focus is on new data concerning the sites of ePRL expression, its regulation, and its function within the organs in which it is expressed.
    MeSH term(s) Animals ; Brain/metabolism ; Decidua/metabolism ; Female ; Humans ; Immune System/metabolism ; Male ; Mammary Glands, Human/metabolism ; Organ Specificity ; Ovary/metabolism ; Prolactin/metabolism ; Prolactin/physiology ; Testis/metabolism
    Chemical Substances Prolactin (9002-62-4)
    Language English
    Publishing date 2014-04-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639167-9
    ISSN 1944-9917 ; 0888-8809
    ISSN (online) 1944-9917
    ISSN 0888-8809
    DOI 10.1210/me.2013-1349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Dopamine and transforming growth factor-beta1: an odd couple in growth inhibition of the lactotrophs.

    Ben-Jonathan, Nira

    Endocrinology

    2005  Volume 146, Issue 10, Page(s) 4177–4178

    MeSH term(s) Animals ; Cell Division/drug effects ; Cell Division/physiology ; Dopamine/physiology ; Growth Inhibitors/pharmacology ; Hypothalamic Hormones/physiology ; Rats ; Transforming Growth Factor beta/physiology ; Transforming Growth Factor beta1
    Chemical Substances Growth Inhibitors ; Hypothalamic Hormones ; Tgfb1 protein, rat ; Transforming Growth Factor beta ; Transforming Growth Factor beta1 ; lactotropin ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2005-10
    Publishing country United States
    Document type Comment ; News
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/en.2005-0893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Soluble guanylate cyclase stimulators increase sensitivity to cisplatin in head and neck squamous cell carcinoma cells.

    Tuttle, Traci R / Takiar, Vinita / Kumar, Bhavna / Kumar, Pawan / Ben-Jonathan, Nira

    Cancer letters

    2016  Volume 389, Page(s) 33–40

    Abstract: Head and neck squamous cell carcinoma (HNSCC) is an aggressive and often fatal disease. Cisplatin is the most common chemotherapeutic drug in the treatment of HNSCC, but intrinsic and acquired resistance are frequent, and severe side effects occur at ... ...

    Abstract Head and neck squamous cell carcinoma (HNSCC) is an aggressive and often fatal disease. Cisplatin is the most common chemotherapeutic drug in the treatment of HNSCC, but intrinsic and acquired resistance are frequent, and severe side effects occur at high doses. The second messenger cyclic GMP (cGMP) is produced by soluble guanylate cyclase (sGC). We previously reported that activation of the cGMP signaling cascade caused apoptosis in HNSCC cells, while others found that this pathway enhances cisplatin efficacy in some cell types. Here we found that sGC stimulators reduced HNSCC cell viability synergistically with cisplatin, and enhanced apoptosis by cisplatin. Moreover, the sGC stimulators effectively reduced viability in cells with acquired cisplatin resistance, and were synergistic with cisplatin. The sGC stimulator BAY 41-2272 reduced expression of the survival proteins EGFR and β-catenin, and increased pro-apoptotic Bax, suggesting a potential mechanism for the anti-tumorigenic effects of these drugs. The sGC stimulator Riociguat is FDA-approved to treat pulmonary hypertension, and others are being studied for therapeutic use in several diseases. These drugs could provide valuable addition or alternative to cisplatin in the treatment of HNSCC.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Cisplatin/pharmacology ; Drug Resistance, Neoplasm ; ErbB Receptors/analysis ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/pathology ; Humans ; Indazoles/pharmacology ; Proto-Oncogene Proteins c-bcl-2/analysis ; Pyrazoles/pharmacology ; Pyridines/pharmacology ; Soluble Guanylyl Cyclase/physiology ; Squamous Cell Carcinoma of Head and Neck ; bcl-2-Associated X Protein/analysis ; beta Catenin/analysis
    Chemical Substances 3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine ; Antineoplastic Agents ; BAX protein, human ; Indazoles ; Proto-Oncogene Proteins c-bcl-2 ; Pyrazoles ; Pyridines ; bcl-2-Associated X Protein ; beta Catenin ; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (154453-18-6) ; ErbB Receptors (EC 2.7.10.1) ; Soluble Guanylyl Cyclase (EC 4.6.1.2) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2016-12-23
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2016.12.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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