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  1. Article ; Online: History of the Use and Impact of Compensatory Strategies in Management of Swallowing Disorders.

    Lazarus, Cathy L

    Dysphagia

    2017  Volume 32, Issue 1, Page(s) 3–10

    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632764-3
    ISSN 1432-0460 ; 0179-051X
    ISSN (online) 1432-0460
    ISSN 0179-051X
    DOI 10.1007/s00455-016-9779-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction to: Volumetric Changes to the Pharynx in Healthy Aging: Consequence for Pharyngeal Swallow Mechanics and Function.

    Molfenter, Sonja M / Lenell, Charles / Lazarus, Cathy L

    Dysphagia

    2020  Volume 35, Issue 6, Page(s) 1008–1009

    Abstract: This erratum notifies the readers of the Dysphagia journal of an error in the original published version of this manuscript. In that manuscript, a previously available open source spreadsheet tool was used to calculate the position of the posterior ... ...

    Abstract This erratum notifies the readers of the Dysphagia journal of an error in the original published version of this manuscript. In that manuscript, a previously available open source spreadsheet tool was used to calculate the position of the posterior laryngeal air column on lateral view videofluoroscopic images as a proxy for the bottom of the pharynx. We have subsequently been made aware of an error in the mathematical formula built into the spreadsheet, which resulted in a reversal of the results for the X and Y planes of measurement. This erratum provides corrections to the results and interpretations of the original manuscript.
    Language English
    Publishing date 2020-09-16
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 632764-3
    ISSN 1432-0460 ; 0179-051X
    ISSN (online) 1432-0460
    ISSN 0179-051X
    DOI 10.1007/s00455-020-10189-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Functional MRI during tongue strength tasks before and after partial glossectomy: Insights into the cortical activation of tongue motor function.

    Peck, Kyung K / Cho, Nicholas S / Pasquini, Luca / Jenabi, Mehrnaz / Branski, Ryan C / Lazarus, Cathy L / Kraus, Dennis H / Holodny, Andrei I

    The neuroradiology journal

    2023  , Page(s) 19714009231173105

    Abstract: Aim: Because the tongue is a midline structure, studies on the neural correlates of lateralized tongue function are challenging and remain limited. Patients with tongue cancer who undergo unilateral partial glossectomy may be a unique cohort to study ... ...

    Abstract Aim: Because the tongue is a midline structure, studies on the neural correlates of lateralized tongue function are challenging and remain limited. Patients with tongue cancer who undergo unilateral partial glossectomy may be a unique cohort to study tongue-associated cortical activation, particularly regarding brain hemispheric lateralization. This longitudinal functional magnetic resonance imaging (fMRI) study investigated cortical activation changes for three tongue tasks before and after left-sided partial glossectomy in patients with squamous cell carcinoma of the tongue.
    Methods: Seven patients with squamous cell carcinoma involving the left tongue who underwent fMRI before and 6 months after unilateral partial glossectomy were studied. Post-surgical changes in laterality index (LI) values for tongue-associated precentral and postcentral gyri fMRI activation were calculated for the dry swallow, tongue press, and saliva sucking tasks. Group analysis fMRI activation maps were generated for each of the three tasks.
    Results: There were significant differences in changes in LI values post-surgery between the tongue press (
    Conclusion: Post-surgical fMRI changes following left-sided partial glossectomy may suggest task-specific sensitivities to cortical activation changes following unilateral tongue deficits that may reflect the impacts of surgery and adaptive responses to tongue impairment.
    Language English
    Publishing date 2023-04-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2257770-1
    ISSN 2385-1996 ; 1971-4009 ; 1120-9976
    ISSN (online) 2385-1996
    ISSN 1971-4009 ; 1120-9976
    DOI 10.1177/19714009231173105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Motor Learning, Neuroplasticity, and Strength and Skill Training: Moving From Compensation to Retraining in Behavioral Management of Dysphagia.

    Zimmerman, Emily / Carnaby, Giselle / Lazarus, Cathy L / Malandraki, Georgia A

    American journal of speech-language pathology

    2020  Volume 29, Issue 2S, Page(s) 1065–1077

    Abstract: Purpose Learning a motor skill and regaining a motor skill after it is lost are key tenets to the field of speech-language pathology. Motor learning and relearning have many theoretical underpinnings that serve as a foundation for our clinical practice. ... ...

    Abstract Purpose Learning a motor skill and regaining a motor skill after it is lost are key tenets to the field of speech-language pathology. Motor learning and relearning have many theoretical underpinnings that serve as a foundation for our clinical practice. This review article applies selective motor learning theories and principles to feeding and swallowing across the life span. Conclusion In reviewing these theoretical fundamentals, clinical exemplars surrounding the roles of strength, skill, experience, compensation, and retraining, and their influence on motor learning and plasticity in regard to swallowing/feeding skills throughout the life span are discussed.
    MeSH term(s) Deglutition Disorders/diagnosis ; Deglutition Disorders/therapy ; Humans ; Learning ; Motor Skills ; Neuronal Plasticity
    Language English
    Publishing date 2020-07-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1154406-5
    ISSN 1558-9110 ; 1058-0360
    ISSN (online) 1558-9110
    ISSN 1058-0360
    DOI 10.1044/2019_AJSLP-19-00088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Volumetric Changes to the Pharynx in Healthy Aging: Consequence for Pharyngeal Swallow Mechanics and Function.

    Molfenter, Sonja M / Lenell, Charles / Lazarus, Cathy L

    Dysphagia

    2018  Volume 34, Issue 1, Page(s) 129–137

    Abstract: Pharyngeal lumen volume is prone to increase as a consequence of pharyngeal muscle atrophy in aging. Yet, the impact of this on swallowing mechanics and function is poorly understood. We examined the relationship between pharyngeal volume and pharyngeal ... ...

    Abstract Pharyngeal lumen volume is prone to increase as a consequence of pharyngeal muscle atrophy in aging. Yet, the impact of this on swallowing mechanics and function is poorly understood. We examined the relationship between pharyngeal volume and pharyngeal swallowing mechanics and function in a sample of healthy community-dwelling seniors. Data were collected from 44 healthy seniors (21 male, mean age = 76.9, SD = 7.1). Each participant swallowed 9 boluses of barium (3 × 5 ml thin, 3 × 20 ml thin, 3 × 5 ml nectar). Pharyngeal shortening, pharyngeal constriction, pyriform sinus and vallecular residue were quantified from lateral view videofluorosopic swallowing studies. Pharyngeal lumen volume was captured during an oral breathing task with acoustic pharyngometry. In addition, within-participant measures of strength and anthropometrics were collected. Four linear mixed effects regression models were run to study the relationship between pharyngeal volume and pharyngeal constriction, pharyngeal shortening, pyriform sinus residue, and vallecular residue while controlling for bolus condition, age, sex, and posterior tongue strength. Increasing pharyngeal lumen volume was significantly related to worse constriction and vallecular residue. In general, larger and thicker boluses resulted in worse pharyngeal constriction and residue. Pharyngeal shortening was only significantly related to posterior tongue strength. Our work establishes the utility of acoustic pharyngometry to monitor pharyngeal lumen volume. Increasing pharyngeal lumen volume appears to impact both pharyngeal swallowing mechanics and function in a sample of healthy, functional seniors.
    MeSH term(s) Aged ; Barium Radioisotopes/chemistry ; Deglutition/physiology ; Female ; Healthy Aging/physiology ; Healthy Volunteers ; Humans ; Male ; Muscular Atrophy/pathology ; Muscular Atrophy/physiopathology ; Organ Size ; Pharyngeal Muscles/pathology ; Pharyngeal Muscles/physiopathology ; Pharynx/pathology ; Regression Analysis ; Viscosity
    Chemical Substances Barium Radioisotopes
    Language English
    Publishing date 2018-07-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632764-3
    ISSN 1432-0460 ; 0179-051X
    ISSN (online) 1432-0460
    ISSN 0179-051X
    DOI 10.1007/s00455-018-9924-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Effects of chemoradiotherapy on voice and swallowing.

    Lazarus, Cathy L

    Current opinion in otolaryngology & head and neck surgery

    2009  Volume 17, Issue 3, Page(s) 172–178

    Abstract: Purpose of review: Chemotherapy has been found to result in comparable survival rates to surgery for head and neck cancer. However, toxicity can often be worse after chemoradiotherapy, with impairment in voice, swallowing, nutrition, and quality of life. ...

    Abstract Purpose of review: Chemotherapy has been found to result in comparable survival rates to surgery for head and neck cancer. However, toxicity can often be worse after chemoradiotherapy, with impairment in voice, swallowing, nutrition, and quality of life. Investigators are attempting to modify radiotherapy treatment regimens to spare organs that have an impact on swallowing. This review will highlight voice and swallowing impairment seen after chemoradiotherapy, as well as treatment for voice and swallowing disorders in this population. Results of newer radiotherapy regimens will also be highlighted.
    Recent findings: Specific oropharyngeal swallowing motility disorders after chemoradiotherapy have been identified. Damage to specific structures has been correlated with specific pharyngeal phase swallow impairment. Swallowing function and quality of life have been examined over time, with improvement seen in both. Preventive/prophylactic swallow exercise programs have been encouraging. Chemoradiotherapy effects on voice have been identified in terms of acoustic, aerodynamic, and patient and clinician-rated perception of function. Improvement in voice has also been observed over time after chemoradiotherapy. Voice therapy has been found to have a positive impact on voice and perceptual measures in this population.
    Summary: Current studies show some improvement in swallow function after swallow and voice therapy in patients treated with chemoradiotherapy. Further, there is a suggestion of improved swallow function with sparing of organs with specific radiotherapy protocols. Future research needs to focus on specific voice and swallow treatment regimens in the head and neck cancer patient treated with chemoradiotherapy, specifically, timing, frequency, duration, and specific treatment types.
    MeSH term(s) Combined Modality Therapy ; Deglutition Disorders/etiology ; Deglutition Disorders/therapy ; Humans ; Otorhinolaryngologic Neoplasms/drug therapy ; Otorhinolaryngologic Neoplasms/radiotherapy ; Quality of Life ; Radiation Injuries/etiology ; Radiation Injuries/therapy ; Radiotherapy, Intensity-Modulated ; Risk Factors ; Sound Spectrography ; Voice Disorders/etiology
    Language English
    Publishing date 2009-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1232518-1
    ISSN 1531-6998 ; 1068-9508
    ISSN (online) 1531-6998
    ISSN 1068-9508
    DOI 10.1097/MOO.0b013e32832af12f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Swallow Event Sequencing: Comparing Healthy Older and Younger Adults.

    Herzberg, Erica G / Lazarus, Cathy L / Steele, Catriona M / Molfenter, Sonja M

    Dysphagia

    2018  Volume 33, Issue 6, Page(s) 759–767

    Abstract: Previous research has established that a great deal of variation exists in the temporal sequence of swallowing events for healthy adults. Yet, the impact of aging on swallow event sequence is not well understood. Kendall et al. (Dysphagia 18(2):85-91, ... ...

    Abstract Previous research has established that a great deal of variation exists in the temporal sequence of swallowing events for healthy adults. Yet, the impact of aging on swallow event sequence is not well understood. Kendall et al. (Dysphagia 18(2):85-91, 2003) suggested there are 4 obligatory paired-event sequences in swallowing. We directly compared adherence to these sequences, as well as event latencies, and quantified the percentage of unique sequences in two samples of healthy adults: young (< 45) and old (> 65). The 8 swallowing events that contribute to the sequences were reliably identified from videofluoroscopy in a sample of 23 healthy seniors (10 male, mean age 74.7) and 20 healthy young adults (10 male, mean age 31.5) with no evidence of penetration-aspiration or post-swallow residue. Chi-square analyses compared the proportions of obligatory pairs and unique sequences by age group. Compared to the older subjects, younger subjects had significantly lower adherence to two obligatory sequences: Upper Esophageal Sphincter (UES) opening occurs before (or simultaneous with) the bolus arriving at the UES and UES maximum distention occurs before maximum pharyngeal constriction. The associated latencies were significantly different between age groups as well. Further, significantly fewer unique swallow sequences were observed in the older group (61%) compared with the young (82%) (χ
    MeSH term(s) Adult ; Age Factors ; Aged ; Chi-Square Distribution ; Cineradiography/methods ; Deglutition/physiology ; Esophageal Sphincter, Upper/diagnostic imaging ; Esophageal Sphincter, Upper/physiology ; Female ; Gastrointestinal Transit/physiology ; Healthy Volunteers ; Humans ; Male ; Pharynx/diagnostic imaging ; Pharynx/physiology
    Language English
    Publishing date 2018-04-23
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632764-3
    ISSN 1432-0460 ; 0179-051X
    ISSN (online) 1432-0460
    ISSN 0179-051X
    DOI 10.1007/s00455-018-9898-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Soft palate reconstruction using a combination of a turn-in flap and a radial forearm flap.

    Moubayed, Sami P / Osorio, Marcela / Buchbinder, Daniel / Lazarus, Cathy / Urken, Mark L

    The Laryngoscope

    2017  Volume 127, Issue 8, Page(s) 1772–1774

    Language English
    Publishing date 2017-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.26462
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  9. Article ; Online: Special groups: head and neck cancer.

    Arrese, Loni C / Lazarus, Cathy L

    Otolaryngologic clinics of North America

    2013  Volume 46, Issue 6, Page(s) 1123–1136

    Abstract: Head and neck cancer is a unique cause of dysphagia. Altered swallow function can be secondary to the mechanical effects of a tumor invading normal anatomy needed for deglutition, or as a direct sequela of cancer treatment (surgery and/or radiation ± ... ...

    Abstract Head and neck cancer is a unique cause of dysphagia. Altered swallow function can be secondary to the mechanical effects of a tumor invading normal anatomy needed for deglutition, or as a direct sequela of cancer treatment (surgery and/or radiation ± chemotherapy). This article outlines the incidence of head and neck cancer, effects of anatomic changes associated with common surgical intervention, and the consequences of treatment-induced dysphagia. Assessment and rehabilitation techniques applicable for this population are discussed.
    MeSH term(s) Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/etiology ; Carcinoma, Squamous Cell/physiopathology ; Carcinoma, Squamous Cell/therapy ; Combined Modality Therapy/methods ; Deglutition Disorders/etiology ; Deglutition Disorders/physiopathology ; Deglutition Disorders/rehabilitation ; Drug Therapy/methods ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/epidemiology ; Head and Neck Neoplasms/etiology ; Head and Neck Neoplasms/physiopathology ; Head and Neck Neoplasms/therapy ; Humans ; Incidence ; Mouth Diseases/complications ; Neoplasm Staging ; Outcome Assessment (Health Care) ; Palatine Tonsil/pathology ; Papillomavirus Infections/complications ; Radiotherapy/methods ; Tongue/pathology ; United States
    Language English
    Publishing date 2013-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 417489-6
    ISSN 1557-8259 ; 0030-6665
    ISSN (online) 1557-8259
    ISSN 0030-6665
    DOI 10.1016/j.otc.2013.08.009
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  10. Article ; Online: Total lower lip and chin reconstruction with radial forearm free flap: A novel approach.

    Dewey, Eliza H / Roche, Ansley M / Lazarus, Cathy L / Urken, Mark L

    American journal of otolaryngology

    2017  Volume 38, Issue 5, Page(s) 618–625

    Abstract: Background: The management of large chin and lower lip defects is challenging due to this facial subunit's tremendous functional and aesthetic importance. Specific methods for total lower lip and mentum reconstruction are not well chronicled. Aesthetic ... ...

    Abstract Background: The management of large chin and lower lip defects is challenging due to this facial subunit's tremendous functional and aesthetic importance. Specific methods for total lower lip and mentum reconstruction are not well chronicled. Aesthetic and functional goals of this reconstruction include restoration of oral competence by maintaining lower lip height, vermilion reestablishment, color-matched skin introduction to the chin, sensation restoration, and ideally restoration of dynamic activity to the lower lip.
    Methods: Literature review performed.
    Results: Presentation of novel, two-stage technique for lower lip and chin reconstruction with a submental flap and a radial forearm free flap, suspension of the lower lip and chin with a tensor fascia lata graft, and vermilion reconstruction with a buccal mucosal flap.
    Conclusions: This procedure meets all goals of total lower lip reconstruction with the exception of the introduction of dynamic tissue and represents a novel solution to a challenging reconstructive problem.
    Language English
    Publishing date 2017-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2017.07.004
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