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  1. Article ; Online: Final height of adults with childhood-onset steroid-responsive idiopathic nephrotic syndrome.

    Donatti, Teresinha Lermen / Koch, Vera Hermina

    Pediatric nephrology (Berlin, Germany)

    2009  Volume 24, Issue 12, Page(s) 2401–2408

    Abstract: The aim of this study was to evaluate the final stature of adults with childhood-onset steroid-responsive idiopathic nephrotic syndrome (INS) and the influence of disease-related issues on the achievement of their target heights. We analyzed 60 (41 male) ...

    Abstract The aim of this study was to evaluate the final stature of adults with childhood-onset steroid-responsive idiopathic nephrotic syndrome (INS) and the influence of disease-related issues on the achievement of their target heights. We analyzed 60 (41 male) patients and/or their records, with a minimum age of 19 years or at a Tanner's pubertal stage 4 for boys or status postmenarche for girls, and normal glomerular filtration rate. Mean age at first and last consultation was 5.3+/-2.4 years and 20.5+/-3.1 years, respectively. Mean follow-up period was 15.10 years. Mean cumulative dose of prednisone was 1254+/-831.40 mg/kg. Mean initial and final height Z scores (HtZ) were, respectively, -0.60+/-1.0 and -0.64+/-0.92 (p=0.72). The final HtZ showed a significant correlation only with the initial HtZ and the target HtZ (THZ). Six patients achieved a final HtZ below -2, which in male patients correlated strongly to the initial HtZ and THZ. A strong correlation was demonstrated between final HtZ, initial HtZ, and THZ. INS-related issues did not prevent the final stature to reach the predicted target height.
    MeSH term(s) Body Height/drug effects ; Child ; Child Development/drug effects ; Child, Preschool ; Chlorambucil/therapeutic use ; Cyclophosphamide/therapeutic use ; Cyclosporine/therapeutic use ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Glucocorticoids/therapeutic use ; Growth Disorders/drug therapy ; Humans ; Immunosuppressive Agents/therapeutic use ; Longitudinal Studies ; Male ; Nephrotic Syndrome/drug therapy ; Nephrotic Syndrome/pathology ; Prednisone/therapeutic use ; Retrospective Studies ; Sex Factors ; Time Factors ; Young Adult
    Chemical Substances Glucocorticoids ; Immunosuppressive Agents ; Chlorambucil (18D0SL7309) ; Cyclosporine (83HN0GTJ6D) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2009-10-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-009-1301-z
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  2. Article ; Online: Serological markers of viral, syphilitic and toxoplasmic infection in children and teenagers with nephrotic syndrome: case series from Mato Grosso State, Brazil.

    Soares, Silvania França da Silva / Donatti, Teresinha Lermen / Souto, Francisco José Dutra

    Revista do Instituto de Medicina Tropical de Sao Paulo

    2014  Volume 56, Issue 6, Page(s) 499–504

    Abstract: Some infections can be the cause of secondary nephrotic syndrome. The aim of this study was to describe the experience of a Renal Disease Reference Clinic from Central Brazil, in which serological markers of some infectious agents are systematically ... ...

    Abstract Some infections can be the cause of secondary nephrotic syndrome. The aim of this study was to describe the experience of a Renal Disease Reference Clinic from Central Brazil, in which serological markers of some infectious agents are systematically screened in children with nephrotic syndrome. Data were obtained from the assessment of medical files of all children under fifteen years of age, who matched nephrotic syndrome criteria. Subjects were tested for IgG and IgM antibodies against T. gondii and cytomegalovirus; antibodies against Herpes simplex, hepatitis C virus and HIV; and surface antigen (HBsAg) of hepatitis B virus. The VDRL test was also performed. 169 cases were studied. The median age on the first visit was 44 months and 103 (60.9%) patients were male. Anti-CMV IgG and IgM were found in 70.4% and 4.1%, respectively. IgG and IgM against Toxoplasma gondii were present in 32.5% and 5.3%, respectively. Two patients were positive for HBsAg, but none showed markers for HIV, hepatitis C, or Treponema pallidum. IgG and IgM against herpes simplex virus were performed on 54 patients, of which 48.1% and 22.2% were positive. IgM antibodies in some children with clinical signs of recent infection suggest that these diseases may play a role in the genesis of nephrotic syndrome.
    MeSH term(s) Biomarkers/blood ; Child, Preschool ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/diagnosis ; Enzyme-Linked Immunosorbent Assay ; Female ; HIV Infections/complications ; HIV Infections/diagnosis ; Hepatitis B/complications ; Hepatitis B/diagnosis ; Hepatitis C/complications ; Hepatitis C/diagnosis ; Herpes Simplex/complications ; Herpes Simplex/diagnosis ; Humans ; Male ; Nephrotic Syndrome/parasitology ; Nephrotic Syndrome/virology ; Syphilis/complications ; Syphilis/diagnosis ; Toxoplasmosis/complications ; Toxoplasmosis/diagnosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2014-10-29
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 128928-7
    ISSN 1678-9946 ; 0036-4665
    ISSN (online) 1678-9946
    ISSN 0036-4665
    DOI 10.1590/s0036-46652014000600008
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    Zs.A 292: Show issues Location:
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  3. Article ; Online: SEROLOGICAL MARKERS OF VIRAL, SYPHILITIC AND TOXOPLASMIC INFECTION IN CHILDREN AND TEENAGERS WITH NEPHROTIC SYNDROME

    Silvania França da Silva Soares / Teresinha Lermen Donatti / Francisco José Dutra Souto

    Revista do Instituto de Medicina Tropical de São Paulo, Vol 56, Iss 6, Pp 499-

    CASE SERIES FROM MATO GROSSO STATE, BRAZIL

    2014  Volume 504

    Abstract: Some infections can be the cause of secondary nephrotic syndrome. The aim of this study was to describe the experience of a Renal Disease Reference Clinic from Central Brazil, in which serological markers of some infectious agents are systematically ... ...

    Abstract Some infections can be the cause of secondary nephrotic syndrome. The aim of this study was to describe the experience of a Renal Disease Reference Clinic from Central Brazil, in which serological markers of some infectious agents are systematically screened in children with nephrotic syndrome. Data were obtained from the assessment of medical files of all children under fifteen years of age, who matched nephrotic syndrome criteria. Subjects were tested for IgG and IgM antibodies against T. gondii and cytomegalovirus; antibodies against Herpes simplex, hepatitis C virus and HIV; and surface antigen (HBsAg) of hepatitis B virus. The VDRL test was also performed. 169 cases were studied. The median age on the first visit was 44 months and 103 (60.9%) patients were male. Anti-CMV IgG and IgM were found in 70.4% and 4.1%, respectively. IgG and IgM against Toxoplasma gondii were present in 32.5% and 5.3%, respectively. Two patients were positive for HBsAg, but none showed markers for HIV, hepatitis C, or Treponema pallidum. IgG and IgM against herpes simplex virus were performed on 54 patients, of which 48.1% and 22.2% were positive. IgM antibodies in some children with clinical signs of recent infection suggest that these diseases may play a role in the genesis of nephrotic syndrome.
    Keywords Nephrotic syndrome ; Kidney diseases/epidemiology ; Infant ; Mato Grosso State ; Infectious diseases ; Arctic medicine. Tropical medicine ; RC955-962
    Subject code 610
    Language English
    Publishing date 2014-12-01T00:00:00Z
    Publisher Universidade de São Paulo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: SEROLOGICAL MARKERS OF VIRAL, SYPHILITIC AND TOXOPLASMIC INFECTION IN CHILDREN AND TEENAGERS WITH NEPHROTIC SYNDROME

    Silvania França da Silva Soares / Teresinha Lermen Donatti / Francisco José Dutra Souto

    Revista do Instituto de Medicina Tropical de São Paulo, Vol 56, Iss 6, Pp 499-

    CASE SERIES FROM MATO GROSSO STATE, BRAZIL

    2014  Volume 504

    Abstract: Some infections can be the cause of secondary nephrotic syndrome. The aim of this study was to describe the experience of a Renal Disease Reference Clinic from Central Brazil, in which serological markers of some infectious agents are systematically ... ...

    Abstract Some infections can be the cause of secondary nephrotic syndrome. The aim of this study was to describe the experience of a Renal Disease Reference Clinic from Central Brazil, in which serological markers of some infectious agents are systematically screened in children with nephrotic syndrome. Data were obtained from the assessment of medical files of all children under fifteen years of age, who matched nephrotic syndrome criteria. Subjects were tested for IgG and IgM antibodies against T. gondii and cytomegalovirus; antibodies against Herpes simplex, hepatitis C virus and HIV; and surface antigen (HBsAg) of hepatitis B virus. The VDRL test was also performed. 169 cases were studied. The median age on the first visit was 44 months and 103 (60.9%) patients were male. Anti-CMV IgG and IgM were found in 70.4% and 4.1%, respectively. IgG and IgM against Toxoplasma gondii were present in 32.5% and 5.3%, respectively. Two patients were positive for HBsAg, but none showed markers for HIV, hepatitis C, or Treponema pallidum. IgG and IgM against herpes simplex virus were performed on 54 patients, of which 48.1% and 22.2% were positive. IgM antibodies in some children with clinical signs of recent infection suggest that these diseases may play a role in the genesis of nephrotic syndrome.
    Keywords Nephrotic syndrome ; Kidney diseases/epidemiology ; Infant ; Mato Grosso State ; Infectious diseases ; Arctic medicine. Tropical medicine ; RC955-962
    Subject code 610
    Language English
    Publishing date 2014-12-01T00:00:00Z
    Publisher Universidade de São Paulo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Equivalência conceitual, de itens e semântica da versão brasileira do instrumento Dysfunctional Voiding Scoring System (DVSS) para avaliação de disfunção do trato urinário inferior em crianças.

    Rizzini, Marta / Donatti, Teresinha Lermen / Bergamaschi, Denise Pimentel / Brunken, Gisela Soares

    Cadernos de saude publica

    2009  Volume 25, Issue 8, Page(s) 1743–1755

    Abstract: This article investigates the conceptual, item, and semantic equivalence between the Dysfunctional Voiding Scoring System (DVSS) originally developed in English and a Portuguese-language version for use in Brazil. The instrument is used to evaluate lower ...

    Title translation Conceptual, item, and semantic equivalence of the Brazilian version of the Dysfunctional Voiding Scoring System (DVSS) instrument for evaluating lower urinary tract dysfunction in children.
    Abstract This article investigates the conceptual, item, and semantic equivalence between the Dysfunctional Voiding Scoring System (DVSS) originally developed in English and a Portuguese-language version for use in Brazil. The instrument is used to evaluate lower urinary tract dysfunction in children. The first stage evaluated the conceptual and item equivalence, followed by two independent translations of the original instrument into Portuguese. In the second stage, 63 individuals were interviewed and items were modified according to difficulties in interpretation. In the third stage, the Portuguese instrument was back-translated into English, and the semantic equivalence was evaluated, based on referential and general (connotative) meaning. In the fourth stage, the pre-test version of the instrument was applied to 20 individuals from the target population. The Portuguese version of the instrument is presented with conceptual, item, and semantic equivalence. Nevertheless, unlike the original instrument, DVSS information collection was more adequate for the Brazilian population when performed through interviews as compared to self-applied questionnaires.
    MeSH term(s) Brazil ; Child ; Cross-Cultural Comparison ; Cultural Characteristics ; Humans ; Language ; Psychometrics ; Semantics ; Sensitivity and Specificity ; Surveys and Questionnaires/standards ; Translations ; Urinary Bladder/physiopathology ; Urinary Incontinence/diagnosis ; Urination Disorders/diagnosis ; Urination Disorders/physiopathology
    Language Portuguese
    Publishing date 2009-07-30
    Publishing country Brazil
    Document type English Abstract ; Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1115730-6
    ISSN 1678-4464 ; 0102-311X
    ISSN (online) 1678-4464
    ISSN 0102-311X
    DOI 10.1590/s0102-311x2009000800010
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    Zs.A 4981: Show issues Location:
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  6. Article ; Online: Effects of glucocorticoids on growth and bone mineralization.

    Donatti, Teresinha Lermen / Koch, Vera Hermina Kalika / Takayama, Liliam / Pereira, Rosa Maria Rodrigues

    Jornal de pediatria

    2011  Volume 87, Issue 1, Page(s) 4–12

    Abstract: Objective: To review the various mechanisms of glucocorticoid action and the ability of these agents to induce osteoporosis and growth deficits.: Sources: A review of the scientific literature was conducted on the basis of a MEDLINE search using the ... ...

    Abstract Objective: To review the various mechanisms of glucocorticoid action and the ability of these agents to induce osteoporosis and growth deficits.
    Sources: A review of the scientific literature was conducted on the basis of a MEDLINE search using the keywords and descriptors "glucocorticoids," "bone mineralization," "growth," and "side effects" and limited to articles published in the last decade. The references cited by these articles were used to identify relevant older publications, with an emphasis on landmark studies essential to an understanding of the topic.
    Summary of the findings: Emphasis was placed on the actions of glucocorticoids on the hormones and cytokines that modulate linear growth. The end effects of glucocorticoids on the skeletal system are the result of systemic effects on bone metabolism and of direct actions on bone cells, which alter bone cell counts and predispose to bone loss. The mechanisms underlying catch-up growth and bone mass recovery after discontinuation of glucocorticoid treatment are discussed, followed by a review of diagnostic methods available for assessment of bone metabolism and mineralization and of measures for prevention and management of glucocorticoid-induced bone changes.
    Conclusion: Patient monitoring on a case-by-case basis plays an essential role in detection and, potentially, reversal of the damage associated with chronic glucocorticoid therapy.
    MeSH term(s) Adolescent ; Adult ; Bone Density/drug effects ; Bone Development/drug effects ; Female ; Fractures, Bone/chemically induced ; Fractures, Bone/metabolism ; Glucocorticoids/adverse effects ; Humans ; Male ; Osteoporosis/chemically induced ; Osteoporosis/metabolism ; Risk Factors
    Chemical Substances Glucocorticoids
    Language Portuguese
    Publishing date 2011-01-13
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 731324-x
    ISSN 1678-4782 ; 0021-7557
    ISSN (online) 1678-4782
    ISSN 0021-7557
    DOI 10.2223/JPED.2052
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    Zs.B 1265: Show issues Location:
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  7. Article ; Online: Equivalência conceitual, de itens e semântica da versão brasileira do instrumento Dysfunctional Voiding Scoring System (DVSS) para avaliação de disfunção do trato urinário inferior em crianças Conceptual, item, and semantic equivalence of the Brazilian version of the Dysfunctional Voiding Scoring System (DVSS) instrument for evaluating lower urinary tract dysfunction in children

    Marta Rizzini / Teresinha Lermen Donatti / Denise Pimentel Bergamaschi / Gisela Soares Brunken

    Cadernos de Saúde Pública, Vol 25, Iss 8, Pp 1743-

    2009  Volume 1755

    Abstract: Investiga-se a equivalência conceitual, de itens e semântica entre o instrumento Dysfunctional Voiding Scoring System (DVSS), utilizado para avaliar a disfunção funcional do trato urinário inferior em crianças, concebido em inglês e uma versão em ... ...

    Abstract Investiga-se a equivalência conceitual, de itens e semântica entre o instrumento Dysfunctional Voiding Scoring System (DVSS), utilizado para avaliar a disfunção funcional do trato urinário inferior em crianças, concebido em inglês e uma versão em português. Na primeira etapa realizou-se a avaliação da equivalência conceitual e de itens, seguida de duas traduções do instrumento original para o português. Na segunda etapa foram realizadas 63 entrevistas, com crianças de 3 a 10 anos e responsáveis, e modificação de itens segundo dificuldades de interpretação. Na terceira etapa foi realizada a retradução do instrumento em português para o inglês e avaliação da equivalência semântica. Na quarta etapa, a versão pré-teste foi aplicada em vinte duplas de crianças de 3 a 10 anos e responsáveis. Apresenta-se o instrumento em português com equivalência conceitual, de itens e semântica. Sugere-se que a aplicação do DVSS seja realizada por meio de entrevista por profissional treinado e não baseada em autopreenchimento como proposto no instrumento original. This article investigates the conceptual, item, and semantic equivalence between the Dysfunctional Voiding Scoring System (DVSS) originally developed in English and a Portuguese-language version for use in Brazil. The instrument is used to evaluate lower urinary tract dysfunction in children. The first stage evaluated the conceptual and item equivalence, followed by two independent translations of the original instrument into Portuguese. In the second stage, 63 individuals were interviewed and items were modified according to difficulties in interpretation. In the third stage, the Portuguese instrument was back-translated into English, and the semantic equivalence was evaluated, based on referential and general (connotative) meaning. In the fourth stage, the pre-test version of the instrument was applied to 20 individuals from the target population. The Portuguese version of the instrument is presented with conceptual, item, and semantic equivalence. Nevertheless, unlike the original instrument, DVSS information collection was more adequate for the Brazilian population when performed through interviews as compared to self-applied questionnaires.
    Keywords Transtornos Urinários ; Questionários ; Saúde da Criança ; Urination Disorders ; Questionnaires ; Child Health ; Medicine ; R ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2009-08-01T00:00:00Z
    Publisher Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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