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  1. Article ; Online: Acute kidney injury.

    Ostermann, Marlies / Basu, Rajit K / Mehta, Ravindra L

    Intensive care medicine

    2023  Volume 49, Issue 2, Page(s) 219–222

    MeSH term(s) Humans ; Acute Kidney Injury ; Risk Factors
    Language English
    Publishing date 2023-01-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06946-0
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  2. Article ; Online: The authors reply.

    Selewski, David T / Gillespie, Scott E / Gist, Katja M / Basu, Rajit K

    Critical care medicine

    2023  Volume 51, Issue 8, Page(s) e170–e172

    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005927
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  3. Article ; Online: Combining biomarkers for acute kidney injury, moving forward with integration.

    Basu, Rajit K

    Journal of critical care

    2019  Volume 54, Page(s) 282

    MeSH term(s) Acute Kidney Injury ; Biomarkers ; Child ; Creatinine ; Critical Illness ; Humans ; Lipocalin-2 ; Phenotype
    Chemical Substances Biomarkers ; Lipocalin-2 ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2019-08-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2019.08.004
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  4. Article: Dynamic Biomarker Assessment: A Diagnostic Paradigm to Match the AKI Syndrome.

    Basu, Rajit K

    Frontiers in pediatrics

    2020  Volume 7, Page(s) 535

    Abstract: Acute kidney injury (AKI) affects one in four neonates, children, and adults admitted to the intensive care unit (ICU). AKI-associated outcomes, including mortality, are significantly worsened. Several decades of research demonstrate evidence for a need ... ...

    Abstract Acute kidney injury (AKI) affects one in four neonates, children, and adults admitted to the intensive care unit (ICU). AKI-associated outcomes, including mortality, are significantly worsened. Several decades of research demonstrate evidence for a need to rethink the pathophysiology and drivers of injury as well as to reconsider the existing diagnostic framework. Novel urinary and serum biomarkers of injury have, however, not been readily integrated into practice-partially because of the limited scope to current testing. The predominant focus to date has been the adjudication of a single biomarker measured at a single point of time for the prediction of either AKI progression or disease-related mortality. This approach is pragmatically problematic. The imprecise, umbrella classification of AKI diagnosis coupled with the absence of a consistently effective set of therapies creates a difficult rubric for biomarkers to demonstrate value in the scope of practice. AKI is, however, not a binary process but more an ICU syndrome-with complex biology underpinning injury, interacting and disrupting other organ function, multidimensional in manifestation, and varying in severity over time. As such, a more appropriate diagnostic paradigm is needed. In this minireview, the status quo for AKI diagnosis and associated limitations will be discussed, and a novel, dynamic, and multidimensional paradigm will be presented. Appreciation of AKI as an ICU syndrome and creation of an appropriately matching and sophisticated diagnostic platform of injury assessment are possible and represent the next step in AKI management.
    Language English
    Publishing date 2020-01-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2019.00535
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  5. Article: Traumatic Stress After Critical Illness, Could a Hippocratic Approach Limit the Reverberations of an ICU Stay?

    Basu, Rajit K

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2019  Volume 20, Issue 8, Page(s) 787–788

    MeSH term(s) Child ; Critical Care ; Critical Illness ; Humans ; Intensive Care Units ; Parents
    Language English
    Publishing date 2019-08-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000001992
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  6. Article ; Online: Targeting Acute Kidney Injury: Can an Innovative Approach to Existing and Novel Biomarkers Shift the Paradigm?

    Basu, Rajit K

    Nephron

    2019  Volume 143, Issue 3, Page(s) 207–210

    Abstract: Acute kidney injury (AKI) continues to be an epidemic problem among hospitalized patients. Diagnostic stasis has, in part, contributed to the poor outcomes associated with AKI. Incorporation of newer diagnostic methodology, longitudinal assessment of ... ...

    Abstract Acute kidney injury (AKI) continues to be an epidemic problem among hospitalized patients. Diagnostic stasis has, in part, contributed to the poor outcomes associated with AKI. Incorporation of newer diagnostic methodology, longitudinal assessment of markers of AKI alone and in combination may improve appreciation of patient risk and the speed of recognition, augment the precision of diagnosis, and target management.
    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/therapy ; Biomarkers ; Hospitalization ; Humans ; Risk Assessment
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-05-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000500421
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  7. Article ; Online: Prevention of Acute Kidney Injury after Cardiac Surgery: When Fixing Broken Hearts, Is Breaking Kidneys Avoidable?

    Basu, Rajit K / Gist, Katja M

    Clinical journal of the American Society of Nephrology : CJASN

    2021  Volume 16, Issue 10, Page(s) 1459–1461

    MeSH term(s) Acute Kidney Injury/etiology ; Acute Kidney Injury/prevention & control ; Cardiac Surgical Procedures/adverse effects ; Humans ; Kidney
    Language English
    Publishing date 2021-10-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.11000821
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  8. Article ; Online: Kidney support therapy in the pediatric patient: Unique considerations for a unique population.

    Askenazi, David / Basu, Rajit K

    Seminars in dialysis

    2021  Volume 34, Issue 6, Page(s) 530–536

    Abstract: The use of kidney support therapy (KST) for use in managing patients with acute kidney injury (AKI) has expanded greatly in the last several decades. The growing use of KST modalities in children, and now in neonates, has been associated with ... ...

    Abstract The use of kidney support therapy (KST) for use in managing patients with acute kidney injury (AKI) has expanded greatly in the last several decades. The growing use of KST modalities in children, and now in neonates, has been associated with opportunities for education, clinical research, clinical practice improvements, and outcomes research. A multitude of controversies exist in the field of pediatric KST-many of which are shared by adult critical care nephrology practice. Simultaneously, pediatric KST has led the way to a burgeoning exploration of the importance of fluid overload as it relates to KST initiation and management and also with quality improvement. In this review, we will explore and describe the paradigms contained with pediatric KST used to support children with AKI. In addition to the governing principles related to the mechanics of KST, we will describe the novel aspects of newer support machines and ethical considerations of KST provision. Anticoagulation, dose, and modality will be discussed as well as priming procedures for special considerations. The utilization of KST across pediatric populations represents the next frontier of critical care nephrology.
    MeSH term(s) Acute Kidney Injury/epidemiology ; Child ; Humans ; Infant, Newborn ; Kidney ; Nephrology ; Renal Dialysis/adverse effects ; Water-Electrolyte Imbalance/etiology
    Language English
    Publishing date 2021-04-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1028193-9
    ISSN 1525-139X ; 0894-0959
    ISSN (online) 1525-139X
    ISSN 0894-0959
    DOI 10.1111/sdi.12978
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  9. Article ; Online: Acute Kidney Injury: Gaps and Opportunities for Knowledge and Growth.

    Claure-Del Granado, Rolando / Neyra, Javier A / Basu, Rajit K

    Seminars in nephrology

    2023  Volume 43, Issue 4, Page(s) 151439

    Abstract: Acute kidney injury (AKI) occurs frequently in hospitalized patients, regardless of age or prior medical history. Increasing awareness of the epidemiologic problem of AKI has directly led to increased study of global recognition, diagnostic tools, both ... ...

    Abstract Acute kidney injury (AKI) occurs frequently in hospitalized patients, regardless of age or prior medical history. Increasing awareness of the epidemiologic problem of AKI has directly led to increased study of global recognition, diagnostic tools, both reactive and proactive management, and analysis of long-term sequelae. Many gaps remain, however, and in this article we highlight opportunities to add significantly to the increasing bodies of evidence surrounding AKI. Practical considerations related to initiation, prescription, anticoagulation, and monitoring are discussed. In addition, the importance of AKI follow-up evaluation, particularly for those surviving the receipt of renal replacement therapy, is highlighted as a push for global equity in the realm of critical care nephrology is broached. Addressing these gaps presents an opportunity to impact patient care directly and improve patient outcomes.
    MeSH term(s) Humans ; Renal Replacement Therapy ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/therapy ; Acute Kidney Injury/complications ; Nephrology
    Language English
    Publishing date 2023-11-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2023.151439
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  10. Article ; Online: Acute Kidney Injury in Hospitalized Pediatric Patients.

    Basu, Rajit K

    Pediatric annals

    2018  Volume 47, Issue 7, Page(s) e286–e291

    Abstract: Acute kidney injury (AKI) is pervasive, affecting a significant proportion of critically ill and noncritically ill children. Recent data demonstrate a clear independent association of escalating AKI severity with not only mortality, but also with longer- ... ...

    Abstract Acute kidney injury (AKI) is pervasive, affecting a significant proportion of critically ill and noncritically ill children. Recent data demonstrate a clear independent association of escalating AKI severity with not only mortality, but also with longer-term disability and chronic kidney disease in children. The paradigm has shifted-patients are no longer dying with AKI, but rather from AKI. In this review, AKI is described in the paradigms of "past," "present," and "future" to stimulate a reassessment of our understanding of this organ dysfunction syndrome. Current treatment strategies as well as novel methodologies are discussed. A global effort is required to make progress in the fight against AKI and improve patient outcomes. [Pediatr Ann. 2018;47(7):e286-e291.].
    MeSH term(s) Acute Kidney Injury/therapy ; Child ; Child, Hospitalized ; Disease Management ; Humans ; Practice Guidelines as Topic
    Language English
    Publishing date 2018-08-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 195430-1
    ISSN 1938-2359 ; 0090-4481
    ISSN (online) 1938-2359
    ISSN 0090-4481
    DOI 10.3928/19382359-20180619-02
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