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  1. Article ; Online: Advances in the Pathogenesis of Diabetic Kidney Disease.

    Kourtidou, Christodoula / Tziomalos, Konstantinos

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: Diabetic kidney disease (DKD) is both a frequent complication of diabetes mellitus (DM) [ ... ]. ...

    Abstract Diabetic kidney disease (DKD) is both a frequent complication of diabetes mellitus (DM) [...].
    MeSH term(s) Diabetic Nephropathies/etiology ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/pathology ; Humans ; Animals
    Language English
    Publishing date 2024-04-22
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Epidemiology and Risk Factors for Stroke in Chronic Kidney Disease: A Narrative Review.

    Kourtidou, Christodoula / Tziomalos, Konstantinos

    Biomedicines

    2023  Volume 11, Issue 9

    Abstract: Patients with chronic kidney disease (CKD) have a higher risk ofboth ischemic and hemorrhagic stroke. This association appears to be partly independent from the higher prevalence of established risk factors for stroke in patients with CKD, including ... ...

    Abstract Patients with chronic kidney disease (CKD) have a higher risk ofboth ischemic and hemorrhagic stroke. This association appears to be partly independent from the higher prevalence of established risk factors for stroke in patients with CKD, including hypertension and atrial fibrillation. In the present review we aim to discuss the impact of CKD on the risk of stroke and stroke-related consequences, and explore the pathophysiology underpinning the increased risk of stroke in patients with CKD. We cover the clinical association between renal dysfunction and cerebrovascular disease including stroke, silent brain infarct, cerebral small vessel disease, microbleeds, and white matter hyperintensity, and discuss the underlying mechanisms.
    Language English
    Publishing date 2023-08-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11092398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pharmacological Management of Obesity in Patients with Polycystic Ovary Syndrome.

    Kourtidou, Christodoula / Tziomalos, Konstantinos

    Biomedicines

    2023  Volume 11, Issue 2

    Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. A substantial proportion of patients with PCOS are either overweight or obese, and excess body weight aggravates the hormonal, reproductive and metabolic ... ...

    Abstract Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. A substantial proportion of patients with PCOS are either overweight or obese, and excess body weight aggravates the hormonal, reproductive and metabolic manifestations of PCOS. In recent years, several studies evaluated the role of various pharmacological agents in the management of obesity in this population. Most reports assessed glucagon-like peptide-1 receptor agonists and showed a substantial reduction in body weight. More limited data suggest that sodium-glucose cotransporter-2 inhibitors and phosphodiesterase-4 inhibitors might also be effective in the management of obesity in these patients. In the present review, we discuss the current evidence on the safety and efficacy of these agents in overweight and obese patients with PCOS.
    Language English
    Publishing date 2023-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11020496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Role of Histone Modifications in the Pathogenesis of Diabetic Kidney Disease.

    Kourtidou, Christodoula / Tziomalos, Konstantinos

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease. The pathogenesis of DKD is multifactorial, with several molecular pathways implicated. Recent data suggest that histone modification plays an important role in the development ... ...

    Abstract Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease. The pathogenesis of DKD is multifactorial, with several molecular pathways implicated. Recent data suggest that histone modification plays an important role in the development and progression of DKD. Histone modification appears to induce oxidative stress, inflammation and fibrosis in the diabetic kidney. In the present review, we summarize the current knowledge on the association between histone modification and DKD.
    MeSH term(s) Humans ; Diabetic Nephropathies/metabolism ; Histone Code ; Kidney/metabolism ; Renal Insufficiency, Chronic/metabolism ; Protein Processing, Post-Translational ; Diabetes Mellitus/metabolism
    Language English
    Publishing date 2023-03-22
    Publishing country Switzerland
    Document type Review ; Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24066007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Microsomal Prostaglandin E Synthase-1 and -2: Emerging Targets in Non-Alcoholic Fatty Liver Disease.

    Kotsos, Dimitrios / Tziomalos, Konstantinos

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Nonalcoholic fatty liver disease (NAFLD) affects a substantial proportion of the general population and is even more prevalent in obese and diabetic patients. NAFLD, and particularly the more advanced manifestation of the disease, nonalcoholic ... ...

    Abstract Nonalcoholic fatty liver disease (NAFLD) affects a substantial proportion of the general population and is even more prevalent in obese and diabetic patients. NAFLD, and particularly the more advanced manifestation of the disease, nonalcoholic steatohepatitis (NASH), increases the risk for both liver-related and cardiovascular morbidity. The pathogenesis of NAFLD is complex and multifactorial, with many molecular pathways implicated. Emerging data suggest that microsomal prostaglandin E synthase-1 and -2 might participate in the development and progression of NAFLD. It also appears that targeting these enzymes might represent a novel therapeutic approach for NAFLD. In the present review, we discuss the association between microsomal prostaglandin E synthase-1 and -2 and NAFLD.
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/metabolism ; Prostaglandin-E Synthases/metabolism ; Liver/metabolism ; Liver Cirrhosis/metabolism ; Liver Neoplasms/metabolism
    Chemical Substances Prostaglandin-E Synthases (EC 5.3.99.3)
    Language English
    Publishing date 2023-02-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24033049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dilemmas and Treatment Options for Medical Conditions in the Woman's Life Span.

    Tziomalos, Konstantinos / Dinas, Konstantinos

    Current pharmaceutical design

    2021  Volume 27, Issue 36, Page(s) 3753

    MeSH term(s) Female ; Humans ; Longevity ; Women's Health
    Language English
    Publishing date 2021-10-28
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/138161282736210922093936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Nonalcoholic Fatty Liver Disease: Current Concepts.

    Tziomalos, Konstantinos

    Current pharmaceutical design

    2019  Volume 24, Issue 38, Page(s) 4564–4565

    MeSH term(s) Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hypoglycemic Agents/therapeutic use ; Liver/drug effects ; Liver/metabolism ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/metabolism
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Hypoglycemic Agents
    Language English
    Publishing date 2019-04-11
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/138161282438190227124334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Secondary Hypertension: Novel Insights.

    Tziomalos, Konstantinos

    Current hypertension reviews

    2019  Volume 16, Issue 1, Page(s) 11

    Abstract: It is estimated that 5-10% of hypertensive patients have secondary hypertension. The main causes of secondary hypertension are parenchymal renal disease, primary aldosteronism and renovascular hypertension. The identification of these patients is ... ...

    Abstract It is estimated that 5-10% of hypertensive patients have secondary hypertension. The main causes of secondary hypertension are parenchymal renal disease, primary aldosteronism and renovascular hypertension. The identification of these patients is important because it enables the etiological management of the underlying disease and in some cases leads to blood pressure control without antihypertensive medications. On the other hand, diagnostic evaluation for secondary hypertension often includes complex and expensive tests and should be performed only in patients with a strong clinical suspicion for its presence. If preliminary screening tests suggest the presence of secondary hypertension, these patients should be referred to specialized centers for further diagnostic evaluation and comprehensive management.
    MeSH term(s) Blood Pressure ; Humans ; Hypertension/diagnosis ; Hypertension/etiology ; Hypertension/physiopathology ; Hypertension/therapy ; Prognosis ; Risk Factors
    Language English
    Publishing date 2019-04-30
    Publishing country United Arab Emirates
    Document type Editorial ; Introductory Journal Article
    ISSN 1875-6506
    ISSN (online) 1875-6506
    DOI 10.2174/1573402115666190416161116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Role of Histone Modifications in the Pathogenesis of Diabetic Kidney Disease

    Christodoula Kourtidou / Konstantinos Tziomalos

    International Journal of Molecular Sciences, Vol 24, Iss 6007, p

    2023  Volume 6007

    Abstract: Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease. The pathogenesis of DKD is multifactorial, with several molecular pathways implicated. Recent data suggest that histone modification plays an important role in the development ... ...

    Abstract Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease. The pathogenesis of DKD is multifactorial, with several molecular pathways implicated. Recent data suggest that histone modification plays an important role in the development and progression of DKD. Histone modification appears to induce oxidative stress, inflammation and fibrosis in the diabetic kidney. In the present review, we summarize the current knowledge on the association between histone modification and DKD.
    Keywords diabetes mellitus ; chronic kidney disease ; diabetic kidney disease ; histone modification ; oxidative stress ; inflammation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Epidemiology and Risk Factors for Stroke in Chronic Kidney Disease

    Christodoula Kourtidou / Konstantinos Tziomalos

    Biomedicines, Vol 11, Iss 2398, p

    A Narrative Review

    2023  Volume 2398

    Abstract: Patients with chronic kidney disease (CKD) have a higher risk ofboth ischemic and hemorrhagic stroke. This association appears to be partly independent from the higher prevalence of established risk factors for stroke in patients with CKD, including ... ...

    Abstract Patients with chronic kidney disease (CKD) have a higher risk ofboth ischemic and hemorrhagic stroke. This association appears to be partly independent from the higher prevalence of established risk factors for stroke in patients with CKD, including hypertension and atrial fibrillation. In the present review we aim to discuss the impact of CKD on the risk of stroke and stroke-related consequences, and explore the pathophysiology underpinning the increased risk of stroke in patients with CKD. We cover the clinical association between renal dysfunction and cerebrovascular disease including stroke, silent brain infarct, cerebral small vessel disease, microbleeds, and white matter hyperintensity, and discuss the underlying mechanisms.
    Keywords chronic kidney disease ; stroke ; hypertension ; dyslipidemia ; thrombosis ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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