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  1. Article ; Online: Yuan‑zhi‑san inhibits tau protein aggregation in an Aβ

    Li, Bin / Xie, Pei-Jun / Hao, Yan-Wei / Guo, Yu / Yu, Jun-Rong / Gong, Dao-Yin / Guo, Jing / Zeng, Jin-Hao / Zhang, Yi

    Molecular medicine reports

    2021  Volume 23, Issue 4

    Abstract: Yuan‑zhi‑san (YZS) is a classic type of Traditional Chinese Medicine, which has been reported ...

    Abstract Yuan‑zhi‑san (YZS) is a classic type of Traditional Chinese Medicine, which has been reported to aid in the treatment of Alzheimer's disease (AD). The present study aimed to investigate the effects of YZS on tau protein aggregation, a hallmark of AD pathology, and its possible mechanisms. The results demonstrated that YZS improved learning and memory abilities, and decreased the severity of AD pathology in β‑amyloid (Aβ
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Animals ; Brain/drug effects ; Brain/metabolism ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Humans ; Peptide Fragments/genetics ; Phosphorylation/drug effects ; Proteasome Endopeptidase Complex/drug effects ; Proteasome Endopeptidase Complex/genetics ; Protein Aggregates/drug effects ; Rats ; Ubiquitin/genetics ; tau Proteins/genetics
    Chemical Substances Amyloid beta-Peptides ; Drugs, Chinese Herbal ; Peptide Fragments ; Protein Aggregates ; Ubiquitin ; amyloid beta-protein (1-40) ; tau Proteins ; yuan zhi ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2021-02-19
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2469505-1
    ISSN 1791-3004 ; 1791-2997
    ISSN (online) 1791-3004
    ISSN 1791-2997
    DOI 10.3892/mmr.2021.11918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Protective Effects of Shen-Yuan-Dan Capsule against Ischemia/Reperfusion Injury in Cardiomyocytes by Alleviating Endoplasmic Reticulum Stress.

    Tong, Tong / Yang, Zhihai / Chen, Jiaxing / Gong, Tao / Liu, Hongxu

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 7775876

    Abstract: ... via the ER stress pathway. We previously found that Shen-Yuan-Dan capsule (SYDC), a widely used ...

    Abstract Objective: Endoplasmic reticulum (ER) stress leads to the accumulation of misfolded proteins and an active unfolded protein response (UPR). If the ER stress is not resolved, the UPR triggers activation of the apoptotic cell death program. It has been shown that ischemia/reperfusion (I/R) injury can induce apoptosis via the ER stress pathway. We previously found that Shen-Yuan-Dan capsule (SYDC), a widely used traditional Chinese medicine, reduces I/R injury. Here, we investigated whether SYDC protects against cardiomyocyte apoptosis by reducing ER stress during I/R injury and. if so, explored its mechanism of action.
    Methods: We use forty male Wistar rats to prepare the SYDC pharmacological serum. An I/R injury model was established using cultures of neonatal rat ventricular myocytes where cells were exposed to 2 h of reduced oxygenation followed by 4 h of normal oxygenation. After treatment of cultured cells with serum containing SYDC for 4 h, reverse transcription polymerase chain reaction and western blotting were performed to assess the expression levels of target molecules.
    Results: Ischemia/reperfusion (I/R) clearly decreased cell viability. Treatment of cells with SYDC in serum (5% and 10%) increased cell viability compared with control serum-treated I/R cardiomyocytes. The mRNA levels of glucose-regulated protein 78 (Grp78), C/EBP homologous protein (CHOP), and caspase-12 were significantly upregulated in the I/R group. The mRNA levels of Grp78, CHOP, and caspase-12 were significantly decreased in the 5% and 10% SYDC groups compared to the I/R group. The protein expression levels of Grp78, CHOP, and caspase-12 were significantly upregulated in the I/R group. Treatment of I/R cardiomyocytes with 5% or 10% SYDC reduced the expression levels of CHOP and caspase-12, while the control serum did not show this effect.
    Conclusions: These findings demonstrate that SYDC alleviates ER stress and prevents ER stress-induced apoptosis via the CHOP-dependent pathway.
    Language English
    Publishing date 2022-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/7775876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
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  3. Article: Integration of small RNAs, degradome, and transcriptome sequencing provides insights into the differences between Shizhu ginseng and Yuan ginseng

    Peng, Mengyuan / Chen, Yanlin / Wang, Wenjuan / He, Zhihua / Dai, Wangqiang / Lin, Zhiyun / Yang, Zemin / Gong, Mengjuan / Yin, Yongqin / Han, Bin / Zeng, Yu / Wang, Yingfang

    Journal of plant biochemistry and biotechnology. 2021 Sept., v. 30, no. 3

    2021  

    Abstract: ... traditional Chinese medicine since ancient times. Yuan ginseng and Shizhu ginseng,which belong to P. ginseng, are widely used ... of Shizhu ginseng is better than Yuan ginseng. However, current research cannot completely explain ... challenging to investigate differential miRNAs between Shizhu ginseng and Yuan ginseng. In this study ...

    Abstract Panax ginseng is one of the most popular herbs which have been used as an important traditional Chinese medicine since ancient times. Yuan ginseng and Shizhu ginseng,which belong to P. ginseng, are widely used as substitutes for wild ginseng in clinical practice. Clinical practice has proved that the clinical efficacy of Shizhu ginseng is better than Yuan ginseng. However, current research cannot completely explain this phenomenon. Considering that small RNA may be one of the pharmacodynamic substances of P. ginseng, it is challenging to investigate differential miRNAs between Shizhu ginseng and Yuan ginseng. In this study, the transcriptome, small RNAome and degradome of P. ginseng were studied by high-throughput sequencing. A total of 63,875 unigenes and 43,950,137 small RNA clean reads were obtained from the roots of P. ginseng. Among 3206 differentially expressed genes, 1190 genes were up-regulated in Yuan ginseng when compared with Shizhu ginseng. 24 known differential miRNAs and 7 novel differential miRNAs were obtained. The 304 targets of 24 differentially expressed miRNA (17 known and 7 novel) families are mainly related to energy metabolism, biotic stress and disease immunity in ginseng itself. Through the association analysis of mRNA and miRNA, our work gives a better understanding of the difference between Yuan ginseng and Shizhu ginseng. Considering the cross-kingdom regulation of plant miRNAs, our results may provide a foundation for understanding the miRNA-dependent clinical efficacy in P. ginseng.
    Keywords Oriental traditional medicine ; Panax ginseng ; biotechnology ; biotic stress ; energy metabolism ; gene expression regulation ; immunity ; microRNA ; pharmacodynamics ; plant biochemistry ; transcriptome ; unigenes
    Language English
    Dates of publication 2021-09
    Size p. 429-439.
    Publishing place Springer India
    Document type Article
    ZDB-ID 2206337-7
    ISSN 0974-1275 ; 0971-7811
    ISSN (online) 0974-1275
    ISSN 0971-7811
    DOI 10.1007/s13562-020-00613-5
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Shen-Yuan-Dan Capsule Attenuates Verapamil-Induced Zebrafish Heart Failure and Exerts Antiapoptotic and Anti-Inflammatory Effects via Reactive Oxygen Species-Induced NF-κB Pathway.

    Li, Sinai / Liu, Hongxu / Li, Yue / Qin, Xiaomei / Li, Mengjie / Shang, Juju / Xing, Wenlong / Gong, Yanbing / Liu, Weihong / Zhou, Mingxue

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 626515

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.626515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Zhongguo gong li yi yuan yi sheng xin chou zhi du gai ge yan jiu

    Gong, Sen

    A study of doctors' remuneration system in China's public hospitals

    2016  

    Title variant Study of doctors' remuneration system in China's public hospitals
    Author's details Gong Sen, Ge Yanfeng, Wang Liejun zhu bian
    MeSH term(s) Physicians/economics ; Income ; Health Care Reform
    Keywords China
    Language Chinese
    Size 4, 3, 208 pages :, illustrations
    Edition Di 1 ban.
    Document type Book
    ISBN 9787509778203 ; 7509778204
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Book: Shou shi bao yuan

    Gong, Tingxian

    1993  

    Title translation General clinical medicine.
    Author's details Gong Tingxian zhuan ; Sun Qiaxi ... [deng] dian jiao
    MeSH term(s) Medicine, Chinese Traditional ; Drugs, Chinese Herbal
    Keywords China
    Language Chinese
    Size 3, 2, 2, 13, 686 p.
    Edition Di 1 ban.
    Publisher Zhongguo Zhong yi yao chu ban she
    Publishing place Beijing Shi
    Document type Book
    ISBN 9787800891472 ; 780089147X
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Book: Yi lin zhuang yuan ji shi quan shu

    Gong, Tingxian

    (Beijing da xue tu shu guan guan cang shan ben yi shu ; 2)

    1987  

    Title translation Complete works for succoring the sick.
    Title variant Ji shi quan shu ; Xin kan yi lin zhuang yuan ji shi quan shu
    Author's details Gong Tingxian zhuan
    Series title Beijing da xue tu shu guan guan cang shan ben yi shu ; 2
    MeSH term(s) Medicine, Chinese Traditional ; Drug Prescriptions ; Drugs, Chinese Herbal
    Language Chinese ; Japanese
    Dates of publication 1987-1636
    Size 966 p.
    Edition Di 1 ban.
    Publisher Zhong yi gu ji chu ban she
    Publishing place Peking
    Document type Book
    Note Reprint of the 1636 Japanese edition.
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Book: Shou shi bao yuan

    Gong, Tingxian

    1959  

    Title translation General clinical medicine.
    Author's details Gong Tingxian bian
    MeSH term(s) Medicine, Chinese Traditional
    Keywords China
    Language Chinese
    Size 6, 738 p.
    Publisher Shanghai ke xue ji shu chu ban she
    Publishing place Shanghai
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article ; Online: Accurate Measurements of NH

    Yuan, Zhenxuan / Bai, Yunxing / Gong, Ke / Huang, Weixin

    The journal of physical chemistry letters

    2024  Volume 15, Issue 4, Page(s) 863–868

    Abstract: Differential adsorption heats of ... ...

    Abstract Differential adsorption heats of NH
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c03336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Does patent pledge reduce pollution and carbon emissions? Evidence from China.

    Gong, Yuhan / Cao, Hongjian / Yuan, Li

    Environmental research

    2024  Volume 247, Page(s) 118274

    Abstract: The existing literature has extensively examined the impact of green innovations, such as patents, on pollution and carbon emissions. However, there has been comparatively less emphasis on the debt financing of green innovation by using patents as ... ...

    Abstract The existing literature has extensively examined the impact of green innovations, such as patents, on pollution and carbon emissions. However, there has been comparatively less emphasis on the debt financing of green innovation by using patents as collateral. This oversight may have implications for the realization of pollution and carbon emissions reduction goals. Using a natural experiment based on the patent pledge pilot policy in China, this study investigates the impact of patent pledge on pollution and carbon emissions. We find that a significant reduction in the emissions of sulfur dioxide and carbon dioxide attributable to the patent pledge pilot policy, particularly in cities with lower initial green patent rates, and these results still hold after an array of robustness checks. We show that the encouragement of green innovation and the stimulation of environmental entrepreneurship are the mechanisms underlying these emission reduction effects. Furthermore, our analysis indicates that the impact of patent pledges on emission reduction is more pronounced in cities characterized by higher levels of government-reported environmental concern, public engagement in environmentally related searches, pollution information transparency indices, and green development evaluation indices.
    MeSH term(s) China ; Carbon Dioxide ; Cities ; Environmental Pollution ; Government
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2024-01-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.118274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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