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Article: Prevention and control of COVID-19 transmission in the indoor environment.

Xu, Chunwen / Yu, Chuck Wah Francis

Indoor + built environment : the journal of the International Society of the Built Environment

2023 Volume 31, Issue 5, Page(s) 1159–1160

Language	English
Publishing date	2023-05-10
Publishing country	England
Document type	Editorial
ZDB-ID	1317694-8
ISSN	1420-326X
ISSN	1420-326X
DOI	10.1177/1420326X221098883
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Complex with Linear B-B-B Skeleton Trapped in Dinitrogen Matrix: Matrix Infrared Spectra and Quantum Chemical Calculations.

Cheng, Juanjuan / Cai, Liyan / Cong, Fei / Qiu, Ruizhi / Pan, Chunwen / Xu, Bing / Wang, Xuefeng

Inorganic chemistry

2023 Volume 62, Issue 16, Page(s) 6314–6322

Abstract: The neutral (NN)-B-B-B-( ... ...

Abstract	The neutral (NN)-B-B-B-(N
Language	English
Publishing date	2023-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c00027
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Integrating MWCNTs-doped MXene with multi-spiral-channel architecture enables field effect transistor biosensor capable of ultrasensitive determination of methotrexate

Chunwen Lu / Ping Xu / Dahui Wang / Dong Fu

Arabian Journal of Chemistry, Vol 16, Iss 8, Pp 104943- (2023)

2023

Abstract: Previous breakthroughs in biosensor diagnostics stem from engineering and nanocomposites. Accurately detecting low-abundance compounds such as methotrexate in complex biospecimens (e.g. serum) is an important clinical challenge. To address this issue, a ... ...

Abstract	Previous breakthroughs in biosensor diagnostics stem from engineering and nanocomposites. Accurately detecting low-abundance compounds such as methotrexate in complex biospecimens (e.g. serum) is an important clinical challenge. To address this issue, a MWCNTs-doped MXene-based multi-spiral-channel field-effect transistor (MMSFETs) biosensor was constructed for ultrasensitive quantification of methotrexate. Our integrated biosensor exhibited following merits: a) The synergetic performance of MXene and MWCNTs for enhanced transconductance (0.63 mS) and detection capability (methotrexate, linear range of 0.001–100 μM and LOD down to 0.352 nM); b) Favorable selectivity, stability (one month), reproducibility (RSD = 0.99%, n = 7) for biosensing of methotrexate; c) Acceptable clinical performances on comparisons of MMFETs against commercial Abbott automatic immunoluminescence instrument (ARCHITECT I1000): favorable linearity and correlation coefficient (YMMSFETs = 1.4305 × Xtargeted concentration + 4.3791 with R2 = 0.949), significant p value (7.68E-12 < 0.001) and diagnosis capability of AUC (0.9907). Those advantages are anticipated to pave an avenue to design of the FETs-based biosensor towards the point-of-care diagnostics applications.
Keywords	MWCNTs-doped MXene ; Multi-spiral ; Field effect transistor ; Biosensor ; Methotrexate ; Chemistry ; QD1-999
Subject code	600
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intervention of personalized ventilation on interpersonal airborne disease transmission

Ren Yijing / Pan Shihai / Li Na / Xu Chunwen

E3S Web of Conferences, Vol 356, p

2022 Volume 05020

Abstract: Personalized ventilation (PV) has been integrated to reduce the risk of interpersonal infection exposure in the office environment. Some studies showed that PV systems may increase occupants’ risk of airborne infection. Therefore, the aim of this study ... ...

Abstract	Personalized ventilation (PV) has been integrated to reduce the risk of interpersonal infection exposure in the office environment. Some studies showed that PV systems may increase occupants’ risk of airborne infection. Therefore, the aim of this study is to investigate the intervention of PV on interpersonal airborne disease transmission in office environment. A three-dimensional computational fluid dynamics model (CFD) was developed and experimentally validated in a clean chamber. Then the validated CFD model was used to calculate the diffusion of exhaled droplets under different particle size. Results showed at the size of 0.7μm particles, compared to pure mixing ventilation, the personal ventilation of 6L/s reduced the inhalation fraction （IF）from 0.121% to 0.092%，and the reduction ratio of IF is 23.96%. As of 5μm, the IF also decreased from 0.165% to 0.102%, and the reduction ratio of IF is 38.18%. The percentage of 50μm particles deposited on the ground rises from 6.29% to 43.22% of exhaled particles. Therefore, the personalized ventilation can reduce the risk of inhalation in exposed person, and for large size particles, the number of particles falling on the floor increased greatly, which lead to the risk of resuspension increases. The results may be helpful for maximizing the effect of PV in interpersonal airborne disease control.
Keywords	Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Combination of ultrathin micro-patterned MXene and PEDOT: Poly(styrenesulfonate) enables organic electrochemical transistor for amperometric determination of survivin protein in children osteosarcoma.

Xu, Ping / Lu, Chunwen / Wang, Dahui / Fu, Dong

Mikrochimica acta

2021 Volume 188, Issue 9, Page(s) 301

Abstract: An ultrathin micro-patterned MXene/PEDOT:PSS-based organic electrochemical transistor biosensor was constructed, which can significantly amplify the amperometric signal and transistor's performance. A novel interdigitated OECTs biosensor has been ... ...

Abstract	An ultrathin micro-patterned MXene/PEDOT:PSS-based organic electrochemical transistor biosensor was constructed, which can significantly amplify the amperometric signal and transistor's performance. A novel interdigitated OECTs biosensor has been developed for reliable determination of survivin for the following considerations: (1) The synergistic effect of intercalated MXene and ionic PEDOT:PSS enhanced the mobility and volumetric capacitance of OECTs biosensor. (2) Compared with the best previous literatures, our assay demonstrated enhanced detection limit of survivin down to 10 pg mL
MeSH term(s)	Child ; Electrochemistry/methods ; Humans ; Osteosarcoma/therapy ; Polystyrenes/pharmacology ; Polystyrenes/therapeutic use ; Survivin/metabolism
Chemical Substances	Polystyrenes ; Survivin ; polystyrene sulfonic acid (70KO0R01RY)
Language	English
Publishing date	2021-08-18
Publishing country	Austria
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	89-9
ISSN	1436-5073 ; 0026-3672
ISSN (online)	1436-5073
ISSN	0026-3672
DOI	10.1007/s00604-021-04947-2
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Article ; Online: Experimental of natural ventilation in a semi-transparent photovoltaic double skin façade in summer

Ni Yuhan / Shi Xiaopeng / Lei Xingyu / Wang Luhang / Xu Chunwen

E3S Web of Conferences, Vol 356, p

2022 Volume 03049

Abstract: Semi-transparent photovoltaic double skin façade (STPV-DSF) is a novel structure which integrates photoelectric, photothermal, ventilation and energy-saving features, which proves to be extremely attractive and promising. In this study, a full-scale ... ...

Abstract	Semi-transparent photovoltaic double skin façade (STPV-DSF) is a novel structure which integrates photoelectric, photothermal, ventilation and energy-saving features, which proves to be extremely attractive and promising. In this study, a full-scale experimental system was built, airflow and heat transfer in a rectangular cavity with different transmittance (τ) and different ventilation modes in summer that studies a STPV-DSF and includes natural ventilation were examined experimentally. The Rayleigh number and Nusselt number of STPV-DSF is significantly higher than that of traditional DSF. This also means stronger intense flow. And the maximum temperature difference at night between mode 1 and mode 2 can reach 7.3°C. When the external air circulation mode is switched to the external and internal mode, the indoor temperature drops by 2.88°C in ten minutes. Therefore, making fully use of natural ventilation can effectively reduce the cooling load of air conditioning in summer. The solar radiation intensity is proved to have the greatest influence on the cavity temperature, followed by the transmittance, and the the ventilation mode least influence. Applying naturally ventilated STPV-DSF would be a new efficient way for the curtain wall buildings to meet the task of sustainable building design.
Keywords	Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Geriatric nutritional risk index as a prognostic factor in elderly patients with non-muscle-invasive bladder cancer: a propensity score-matched study.

Wu, Jingxin / Cheng, Xiaofeng / Yang, Heng / Xiao, Song / Xu, Linhao / Zhang, Cheng / Huang, Wei / Jiang, Chunwen / Wang, Gongxian

International urology and nephrology

2024 Volume 56, Issue 5, Page(s) 1627–1637

Abstract: Purpose: The Geriatric Nutrition Risk Index (GNRI) is a simple and validated tool used to assess the nutritional status of elderly patients and predict the risk of short-term postoperative complications, as well as the long-term prognosis, after cancer ... ...

Abstract	Purpose: The Geriatric Nutrition Risk Index (GNRI) is a simple and validated tool used to assess the nutritional status of elderly patients and predict the risk of short-term postoperative complications, as well as the long-term prognosis, after cancer surgery. In this study, we aimed to evaluate the predictive value of GNRI for the long-term postoperative prognosis in elderly patients with primary non-muscle-invasive bladder cancer (NMIBC) who underwent transurethral resection of bladder tumor (TURBT). Methods: We retrospectively analyzed data from 292 elderly patients with primary NMIBC. Using X-tile software, we divided the cohort into two groups based on GNRI and determined the cut-off value for postoperative recurrence-free survival (RFS). Propensity score matching (PSM) with a ratio of 1:3, Kaplan-Meier analysis, log-rank test, and COX proportional hazards regression were used to assess the correlation between GNRI and prognosis and identify factors predicting recurrence and progression. Results: In the entire cohort, the 3 year recurrence group had significantly lower GNRI compared to the 3 year non-recurrence group (P = 0.0109). The determined GNRI cut-off value was 93.82. After PSM, the low GNRI group had significantly lower RFS (P < 0.0001) and progression-free survival (PFS) (P = 0.0040) than the high GNRI group. Multivariate COX regression showed that GNRI independently predicted RFS (HR 2.108; 95% CI 1.266-3.512; P = 0.004) and PFS (HR 2.155; 95% CI 1.135-4.091; P = 0.019) in elderly patients with primary NMIBC. Conclusion: Preoperative GNRI is a prognostic marker for disease recurrence and progression in elderly patients with primary NMIBC undergoing TURBT.
MeSH term(s)	Humans ; Aged ; Prognosis ; Non-Muscle Invasive Bladder Neoplasms ; Retrospective Studies ; Propensity Score ; Neoplasm Recurrence, Local ; Urinary Bladder Neoplasms/pathology ; Nutritional Status ; Nutrition Assessment ; Geriatric Assessment ; Risk Factors
Language	English
Publishing date	2024-01-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-023-03905-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 733: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: A novel ferroptosis-related microRNA signature with prognostic value in osteosarcoma.

Shao, Jie / Zhang, Yi / Chang, Zhu / Du, Shiyao / Li, Wei / Bai, Yushu / Lu, Chunwen / Xu, Tianming

Acta biochimica et biophysica Sinica

2023 Volume 55, Issue 11, Page(s) 1758–1769

Abstract: The induction of ferroptosis is suggested to be a potential therapeutic strategy for cancers. MicroRNAs (miRNAs) are reported to play an important role in cell death processes. This study aims to construct and validate a risk model based on ferroptosis- ... ...

Abstract	The induction of ferroptosis is suggested to be a potential therapeutic strategy for cancers. MicroRNAs (miRNAs) are reported to play an important role in cell death processes. This study aims to construct and validate a risk model based on ferroptosis-related miRNAs (FR_miRNAs) to predict prognosis and identify novel therapeutic targets for osteosarcoma. Data from the Therapeutically Applicable Research to Generate Effective Treatments database are used as the training cohort. A prognostic signature based on two FR_miRNAs (miR-635 and miR-593) is developed using univariate Cox regression, least absolute shrinkage and selection operator regression, and multivariate Cox regression analyses. The area under the curve values of the prognostic signature to predict the 1-year, 2-year, 3-year, and 5-year overall survival rates in patients with osteosarcoma are 0.782, 0.781, 0.722, and 0.777, respectively, indicating a good predictive ability. Based on the risk score, patients are divided into low-risk and high-risk groups. Patients with high-risk scores are associated with poor survival. The risk level is determined to be an independent prognostic factor. A nomogram is established for predicting prognosis. The expression levels of
MeSH term(s)	Humans ; MicroRNAs/genetics ; Prognosis ; Ferroptosis/genetics ; Osteosarcoma/genetics ; Bone Neoplasms/genetics
Chemical Substances	MicroRNAs ; MIRN593 microRNA, human
Language	English
Publishing date	2023-10-09
Publishing country	China
Document type	Journal Article
ZDB-ID	2175256-4
ISSN	1745-7270 ; 0582-9879 ; 1672-9145
ISSN (online)	1745-7270
ISSN	0582-9879 ; 1672-9145
DOI	10.3724/abbs.2023236
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Article: Study of microwave reduction of graphene oxide suspension: structure and functional groups

Xiang, Xu / Zhu, Ying / Yin, Mingyu / Xia, Shuang / Guo, Chunwen

Journal of materials science. 2022 Feb., v. 57, no. 5

2022

Abstract: Reduced graphene oxide (rGO) has been studied as a possible substitute for graphene in many applications because it is cheaper and easier to prepare than graphene. RGO with low reduction degree has good hydrophilicity and can be stably dispersed in water. ...

Abstract	Reduced graphene oxide (rGO) has been studied as a possible substitute for graphene in many applications because it is cheaper and easier to prepare than graphene. RGO with low reduction degree has good hydrophilicity and can be stably dispersed in water. These properties are conducive to the preparation of hydrophilic composites. Here, the method of microwave reduction of GO suspension to prepare rGO with low reduction degree was studied. By controlling the reduction time, the rGO samples with different reduction degrees are prepared. After studying the characterization data of rGO with different reduction degrees, we propose the hypothesis of the reduction pathway of GO suspension, that is, the oxygen-containing groups on the surface of GO sheet are reduced first. FTIR, TGA and XPS data verify this hypothesis and are consistent with the simulation results. Therefore, the low reduction degree rGO has a large-area conjugated structure similar to graphene and also has good hydrophilicity due to the residual oxygen-containing groups on the periphery of the rGO sheet. This structure provides convenience for its composite with hydrophilic materials. In sum, the microwave reduction of GO suspension provides a simple method for researchers to prepare rGO with low reduction degree.
Keywords	graphene ; graphene oxide ; hydrophilicity
Language	English
Dates of publication	2022-02
Size	p. 3280-3294.
Publishing place	Springer US
Document type	Article
ZDB-ID	2015305-3
ISSN	1573-4803 ; 0022-2461
ISSN (online)	1573-4803
ISSN	0022-2461
DOI	10.1007/s10853-021-06748-7
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: One-stop assembly of adherent 3D retinal organoids from hiPSCs based on 3D-printed derived PDMS microwell platform.

Sun, Xihao / Cui, Zekai / Liang, Yuqin / Duan, Chunwen / Chan, Hon Fai / Mao, Shengru / Gu, Jianing / Ding, Chengcheng / Yang, Xu / Wang, Qing / Tang, Shibo / Chen, Jiansu

Biofabrication

2023 Volume 15, Issue 3

Abstract: The three-dimensional (3D) retinal organoids (ROs) derived from human induced pluripotent stem cells (hiPSCs), mimicking the growth and development of the human retina, is a promising model for investigating inherited retinal ... ...

Abstract	The three-dimensional (3D) retinal organoids (ROs) derived from human induced pluripotent stem cells (hiPSCs), mimicking the growth and development of the human retina, is a promising model for investigating inherited retinal diseases
MeSH term(s)	Humans ; Induced Pluripotent Stem Cells ; Reactive Oxygen Species ; Retina ; Cell Differentiation ; Organoids ; Opsins ; Dimethylpolysiloxanes ; Printing, Three-Dimensional
Chemical Substances	Reactive Oxygen Species ; Opsins ; Dimethylpolysiloxanes
Language	English
Publishing date	2023-04-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2500944-8
ISSN	1758-5090 ; 1758-5082
ISSN (online)	1758-5090
ISSN	1758-5082
DOI	10.1088/1758-5090/acc761
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