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  1. Article ; Online: Effect of red light on epidermal proliferation and mitochondrial activity.

    Umino, Yuki / Denda, Mitsuhiro

    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

    2023  Volume 29, Issue 9, Page(s) e13447

    Abstract: Background/purpose: We previously demonstrated that irradiation with red light accelerates recovery of the epidermal water-impermeable barrier, whereas blue light delays it, and white and green light have no effect. Here, we aimed to examine in detail ... ...

    Abstract Background/purpose: We previously demonstrated that irradiation with red light accelerates recovery of the epidermal water-impermeable barrier, whereas blue light delays it, and white and green light have no effect. Here, we aimed to examine in detail the effects of red and blue light in a human epidermal-equivalent model and in human skin.
    Methods: We used light-emitting diodes (red light, 630 nm, 6.2 mW/cm
    Results: Irradiation of the epidermal-equivalent model with red light for 2 h (44.64 J/cm
    Conclusion: These results suggest that red light accelerates epidermal proliferation in both an epidermal-equivalent model and human skin, and may promote epidermal homeostasis.
    MeSH term(s) Humans ; Epidermis ; Skin ; Light ; Cell Proliferation ; Homeostasis
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1229160-2
    ISSN 1600-0846 ; 0909-752X ; 1397-1344
    ISSN (online) 1600-0846
    ISSN 0909-752X ; 1397-1344
    DOI 10.1111/srt.13447
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  2. Article ; Online: Will Electronic Skins Be the Next Miraculous Skin Care Devices?

    Menon, Gopinathan K / Wakefield, Joan S / Elias, Peter M / Denda, Mitsuhiro

    The Journal of investigative dermatology

    2023  Volume 143, Issue 11, Page(s) 2102–2104

    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2023.06.196
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  3. Article: Distinct sets of olfactory receptors highly expressed in different human tissues evaluated by meta-transcriptome analysis: Association of OR10A6 in skin with keratinization.

    Nakanishi, Shinobu / Tsutsui, Taiki / Itai, Nao / Denda, Mitsuhiro

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1102585

    Abstract: Olfactory receptors (ORs) are expressed in many tissues and have multiple functions. However, most studies have focused on individual ORs. Here, we aimed to conduct a comprehensive meta-transcriptome analysis of OR gene expression in human tissues by ... ...

    Abstract Olfactory receptors (ORs) are expressed in many tissues and have multiple functions. However, most studies have focused on individual ORs. Here, we aimed to conduct a comprehensive meta-transcriptome analysis of OR gene expression in human tissues by using open-source tools to search a large, publicly available genotype-tissue expression (GTEx) data set. Analysis of RNA-seq data from GTEx revealed that OR expression patterns were tissue-dependent, and we identified distinct sets of ORs that were highly expressed in 12 tissues, involving 97 ORs in total. Among them,
    Language English
    Publishing date 2023-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1102585
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  4. Article ; Online: Effects of the Molecular Structure of Malodor Substances and Their Masking on 1,2-Dioleoyl-

    Yotsumoto, Mai / Fujita, Risa / Matsuo, Muneyuki / Nakanishi, Shinobu / Denda, Mitsuhiro / Nakata, Satoshi

    Langmuir : the ACS journal of surfaces and colloids

    2024  Volume 40, Issue 13, Page(s) 6878–6883

    Abstract: Certain odors have been shown not only to cause health problems and stress but also to affect skin barrier function. Therefore, it is important to understand olfactory masking to develop effective fragrances to mask malodors. However, olfaction and ... ...

    Abstract Certain odors have been shown not only to cause health problems and stress but also to affect skin barrier function. Therefore, it is important to understand olfactory masking to develop effective fragrances to mask malodors. However, olfaction and olfactory masking mechanisms are not yet fully understood. To understand the mechanism of the masking effect that has been studied, the responses of several target substance (TS) molecules-1,2-dioleoyl-
    MeSH term(s) Molecular Structure ; Lipid Bilayers/chemistry ; Phosphatidylcholines/chemistry ; Phospholipids/chemistry ; Glycerylphosphorylcholine
    Chemical Substances 1,2-oleoylphosphatidylcholine (EDS2L3ODLV) ; Lipid Bilayers ; Phosphatidylcholines ; Phospholipids ; Glycerylphosphorylcholine (60M22SGW66)
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c03796
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  5. Article ; Online: Do epidermal keratinocytes have sensory and information processing systems?

    Denda, Mitsuhiro / Nakanishi, Shinobu

    Experimental dermatology

    2021  Volume 31, Issue 4, Page(s) 459–474

    Abstract: It was long considered that the role of epidermal keratinocytes is solely to construct a water-impermeable protective membrane, the stratum corneum, at the uppermost layer of the skin. However, in the last two decades, it has been found that ... ...

    Abstract It was long considered that the role of epidermal keratinocytes is solely to construct a water-impermeable protective membrane, the stratum corneum, at the uppermost layer of the skin. However, in the last two decades, it has been found that keratinocytes contain multiple sensory systems that detect environmental changes, including mechanical stimuli, sound, visible radiation, electric fields, magnetic fields, temperature and chemical stimuli, and also a variety of receptor molecules associated with olfactory or taste sensation. Moreover, neurotransmitters and their receptors that play crucial roles in the brain are functionally expressed in keratinocytes. Recent studies have demonstrated that excitation of keratinocytes can induce sensory perception in the brain. Here, we review the sensory and information processing capabilities of keratinocytes. We discuss the possibility that epidermal keratinocytes might represent the earliest stage in the development of the brain during the evolution of vertebrates.
    MeSH term(s) Animals ; Epidermis/physiology ; Keratinocytes/physiology ; Skin
    Language English
    Publishing date 2021-11-12
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.14494
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    Zs.A 3508: Show issues Location:
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  6. Article: Keratinocytes at the uppermost layer of epidermis might act as sensors of atmospheric pressure change.

    Denda, Mitsuhiro

    Extreme physiology & medicine

    2016  Volume 5, Page(s) 11

    Abstract: It has long been suggested that climate, especially atmospheric pressure change, can cause health problems ranging from migraine to myocardial infarction. Here, I hypothesize that the sensory system of epidermal keratinocytes mediates the influence of ... ...

    Abstract It has long been suggested that climate, especially atmospheric pressure change, can cause health problems ranging from migraine to myocardial infarction. Here, I hypothesize that the sensory system of epidermal keratinocytes mediates the influence of atmospheric pressure change on the human physiological condition. We previously demonstrated that even subtle changes of atmospheric pressure (5-20 hPa) induce elevation of intracellular calcium level in cultured human keratinocytes (excitation of keratinocytes). It is also established that communication occurs between epidermal keratinocytes and peripheral nerve systems. Moreover, various neurotransmitters and hormones that influence multiple systems (nervous, cardiovascular, endocrine, and immune systems) are generated and released from epidermal keratinocytes in response to various external stimuli. Thus, I suggest that pathophysiological phenomena induced by atmospheric pressure changes might be triggered by epidermal keratinocytes.
    Language English
    Publishing date 2016-10-06
    Publishing country England
    Document type Editorial
    ZDB-ID 2681369-5
    ISSN 2046-7648
    ISSN 2046-7648
    DOI 10.1186/s13728-016-0052-2
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  7. Article ; Online: Newly discovered olfactory receptors in epidermal keratinocytes are associated with proliferation, migration, and re-epithelialization of keratinocytes.

    Denda, Mitsuhiro

    The Journal of investigative dermatology

    2014  Volume 134, Issue 11, Page(s) 2677–2679

    Abstract: Skin contains receptors for various environmental factors. In this issue of the Journal, Busse et al. cloned a new olfactory receptor, OR2AT4, in keratinocytes. They show that the activation of OR2AT4 induces phosphorylation of extracellular signal- ... ...

    Abstract Skin contains receptors for various environmental factors. In this issue of the Journal, Busse et al. cloned a new olfactory receptor, OR2AT4, in keratinocytes. They show that the activation of OR2AT4 induces phosphorylation of extracellular signal-regulated kinases and p38 mitogen-activated protein kinases, and that it accelerates wound healing. OR2AT4 may be a promising candidate as a target in clinical drug development.
    MeSH term(s) Gene Expression Regulation ; Humans ; Keratinocytes/cytology ; Keratinocytes/metabolism ; Receptors, Odorant/metabolism ; Santalum/chemistry ; Wound Healing
    Chemical Substances OR2AT4 protein, human ; Receptors, Odorant
    Language English
    Publishing date 2014-10-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1038/jid.2014.229
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  8. Article ; Online: Phospholipid Molecular Layer that Enhances Distinction of Odors Based on Artificial Sniffing.

    Yotsumoto, Mai / Matsuo, Muneyuki / Kitahata, Hiroyuki / Nakanishi, Shinobu / Denda, Mitsuhiro / Nagayama, Masaharu / Nakata, Satoshi

    ACS sensors

    2023  Volume 8, Issue 12, Page(s) 4494–4503

    Abstract: We propose a novel odor-sensing system based on the dynamic response of phospholipid molecular layers for artificial olfaction. Organisms obtain information about their surroundings based on multidimensional information obtained from sniffing, i.e., ... ...

    Abstract We propose a novel odor-sensing system based on the dynamic response of phospholipid molecular layers for artificial olfaction. Organisms obtain information about their surroundings based on multidimensional information obtained from sniffing, i.e., periodic perturbations. Semiconductor- and receptor-based odor sensors have been developed previously. However, these sensors predominantly identify odors based on one-dimensional information, which limits the type of odor molecule they can identify. Therefore, the development of odor sensors that mimic the olfactory systems of living organisms is useful to overcome this limitation. In this study, we developed a novel odor-sensing system based on the dynamics of phospholipids that responds delicately to chemical substances at room temperature using multidimensional information obtained from periodic perturbations. Odor molecules are periodically supplied to the phospholipid molecular layer as an input sample. The waveform of the surface tension of the phospholipid molecular layer changes depending on the odor molecules and serves as an output. Such characteristic responses originating from the dynamics of odor molecules on the phospholipid molecular layer can be reproduced numerically. The phospholipid molecular layer amplified the information originating from the odor molecule, and the mechanism was evaluated by using surface pressure-area isotherms. This paper offers a platform for an interface-chemistry-based artificial sniffing system as an active sensor and a novel olfactory mechanism via physicochemical responses of the receptor-independent membranes of the organism.
    MeSH term(s) Odorants ; Smell/physiology
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3694
    ISSN (online) 2379-3694
    DOI 10.1021/acssensors.3c00382
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  9. Article ; Online: Glutathione Counteracts the Effects of Japanese Cedar (Cryptomeria japonica) Pollen Allergen Cry j1.

    Nakanishi, Shinobu / Kurihara, Kanna / Denda, Mitsuhiro

    Biological & pharmaceutical bulletin

    2021  Volume 43, Issue 10, Page(s) 1591–1594

    Abstract: Japanese cedar (Cryptomeria japonica) pollen allergen Cry j1 increases the intracellular calcium concentration in human keratinocytes, and also impairs the epidermal barrier function. Here, we show that reduced glutathione (GSH) blocks both thrombin ... ...

    Abstract Japanese cedar (Cryptomeria japonica) pollen allergen Cry j1 increases the intracellular calcium concentration in human keratinocytes, and also impairs the epidermal barrier function. Here, we show that reduced glutathione (GSH) blocks both thrombin activation and the Cry j1-induced intracellular calcium elevation in cultured human keratinocytes, and also prevents the Cry j1-induced decrease of barrier function in ex vivo human skin.
    MeSH term(s) Adult ; Allergens/adverse effects ; Antigens, Plant/adverse effects ; Cells, Cultured ; Cryptomeria ; Dose-Response Relationship, Drug ; Female ; Glutathione/pharmacology ; Humans ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Organ Culture Techniques ; Plant Proteins/adverse effects ; Pollen/adverse effects ; Skin Absorption/drug effects ; Skin Absorption/physiology
    Chemical Substances Allergens ; Antigens, Plant ; Cry j I protein, Cryptomeria japonica ; Plant Proteins ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2021-03-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.b20-00264
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  10. Article ; Online: Effects of trans-2-nonenal and olfactory masking odorants on proliferation of human keratinocytes.

    Nakanishi, Shinobu / Makita, Mio / Denda, Mitsuhiro

    Biochemical and biophysical research communications

    2021  Volume 548, Page(s) 1–6

    Abstract: Malodorous compounds induce stress responses, mood changes, an increase of skin conductance, activation of the sympathetic nervous system and other physiological changes, and it has been suggested that sensing malodors could provide warning of danger to ... ...

    Abstract Malodorous compounds induce stress responses, mood changes, an increase of skin conductance, activation of the sympathetic nervous system and other physiological changes, and it has been suggested that sensing malodors could provide warning of danger to health. Furthermore, the human body secretes various malodorous compounds as waste products of metabolism, including trans-2-nonenal ((E)-2-nonenal), the amount of which increases with aging. In the present study, we examined the effects of some endogenous malodorous compounds ((E)-2-nonenal, nonanal, pentanal, hexanal, hexanoic acid, hexylamine and isovaleric acid) on cultured human keratinocytes. (E)-2-Nonenal decreased the viability and promoted apoptosis of cultured keratinocytes. It also reduced the thickness and the number of proliferative cells in a three-dimensional epidermal equivalent model. Co-application of masking odorants (dihydromycenol, benzaldehyde, linalool, phenethyl alcohol, benzyl acetate and anisaldehyde), but not non-masking odorants (1,8-cineol, β-damascone, and o-t-butylcyclohexyl acetate), reduced the effect of (E)-2-nonenal on keratinocyte proliferation, and restored the thickness and number of proliferative cells in a three-dimensional epidermal equivalent model.
    MeSH term(s) Aldehydes/pharmacology ; Cell Proliferation/drug effects ; Epidermis/drug effects ; Humans ; Infant, Newborn ; Keratinocytes/cytology ; Keratinocytes/drug effects ; Male ; Models, Biological ; Odorants ; Smell/drug effects
    Chemical Substances Aldehydes ; 2-nonenal (2463-53-8)
    Language English
    Publishing date 2021-02-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2021.02.050
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