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  1. Article: Modelling of Tissue Invasion in Epithelial Monolayers.

    Alsubaie, Faris Saad / Khataee, Hamid / Neufeld, Zoltan

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 2

    Abstract: Mathematical and computational models are used to describe biomechanical processes in multicellular systems. Here, we develop a model to analyse how two types of epithelial cell layers interact during tissue invasion depending on their cellular ... ...

    Abstract Mathematical and computational models are used to describe biomechanical processes in multicellular systems. Here, we develop a model to analyse how two types of epithelial cell layers interact during tissue invasion depending on their cellular properties, i.e., simulating cancer cells expanding into a region of normal cells. We model the tissue invasion process using the cellular Potts model and implement our two-dimensional computational simulations in the software package CompuCell3D. The model predicts that differences in mechanical properties of cells can lead to tissue invasion, even if the division rates and death rates of the two cell types are the same. We also show how the invasion speed varies depending on the cell division and death rates and the mechanical properties of the cells.
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13020427
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  2. Article: Modelling the Collective Mechanical Regulation of the Structure and Morphology of Epithelial Cell Layers.

    Khataee, Hamid / Fraser, Madeleine / Neufeld, Zoltan

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 767688

    Abstract: The morphology and function of epithelial sheets play an important role in healthy tissue development and cancer progression. The maintenance of structure of closely packed epithelial layers requires the coordination of various mechanical forces due to ... ...

    Abstract The morphology and function of epithelial sheets play an important role in healthy tissue development and cancer progression. The maintenance of structure of closely packed epithelial layers requires the coordination of various mechanical forces due to intracellular activities and interactions with other cells and tissues. However, a general model for the combination of mechanical properties which determine the cell shape and the overall structure of epithelial layers remains elusive. Here, we propose a computational model, based on the Cellular Potts Model, to analyse the interplay between mechanical properties of cells and dynamical transitions in epithelial cell shapes and structures. We map out phase diagrams as functions of cellular properties and the orientation of cell division. Results show that monolayers of squamous, cuboidal, and columnar cells are formed when the axis of cell proliferation is perpendicular to the substrate or along the major axis of the cells. Monolayer-to-multilayer transition is promoted via cell extrusion, depending on the mechanical properties of cells and the orientation of cell division. The results and model predictions are discussed in the context of experimental observations.
    Language English
    Publishing date 2022-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.767688
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  3. Article ; Online: Targeted adaptive isolation strategy for Covid-19 pandemic

    Zoltan Neufeld / Hamid Khataee

    Abstract: We investigate the effects of social distancing in controlling the impact of the Covid-19 epidemic using a simple SIR epidemic model. We show that an alternative or complementaryapproach based on targeted isolation of the vulnerable subpopulation may ... ...

    Abstract We investigate the effects of social distancing in controlling the impact of the Covid-19 epidemic using a simple SIR epidemic model. We show that an alternative or complementaryapproach based on targeted isolation of the vulnerable subpopulation may provide a moreefficient and robust strategy at a lower economic and social cost within a shorter timeframe.
    Keywords covid19
    Publisher medrxiv
    Document type Article ; Online
    DOI 10.1101/2020.03.23.20041897
    Database COVID19

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  4. Article ; Online: Modelling the Collective Mechanical Regulation of the Structure and Morphology of Epithelial Cell Layers

    Hamid Khataee / Madeleine Fraser / Zoltan Neufeld

    Frontiers in Cell and Developmental Biology, Vol

    2022  Volume 10

    Abstract: The morphology and function of epithelial sheets play an important role in healthy tissue development and cancer progression. The maintenance of structure of closely packed epithelial layers requires the coordination of various mechanical forces due to ... ...

    Abstract The morphology and function of epithelial sheets play an important role in healthy tissue development and cancer progression. The maintenance of structure of closely packed epithelial layers requires the coordination of various mechanical forces due to intracellular activities and interactions with other cells and tissues. However, a general model for the combination of mechanical properties which determine the cell shape and the overall structure of epithelial layers remains elusive. Here, we propose a computational model, based on the Cellular Potts Model, to analyse the interplay between mechanical properties of cells and dynamical transitions in epithelial cell shapes and structures. We map out phase diagrams as functions of cellular properties and the orientation of cell division. Results show that monolayers of squamous, cuboidal, and columnar cells are formed when the axis of cell proliferation is perpendicular to the substrate or along the major axis of the cells. Monolayer-to-multilayer transition is promoted via cell extrusion, depending on the mechanical properties of cells and the orientation of cell division. The results and model predictions are discussed in the context of experimental observations.
    Keywords computational modeling ; tissue modelling ; mechanobiolgy ; cell morphological analysis ; cellular mechanics ; stochastic modelling and simulation ; Biology (General) ; QH301-705.5
    Subject code 612
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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  5. Article ; Online: Force Generated by Two Kinesin Motors Depends on the Load Direction and Intermolecular Coupling.

    Khataee, Hamid / Howard, Jonathon

    Physical review letters

    2019  Volume 122, Issue 18, Page(s) 188101

    Abstract: Kinesins are molecular motors that carry cellular cargoes. While the mechanics of single kinesins are well characterized experimentally, the behavior of multiple kinesins varies considerably among experiments. The basis for this variability is unknown. ... ...

    Abstract Kinesins are molecular motors that carry cellular cargoes. While the mechanics of single kinesins are well characterized experimentally, the behavior of multiple kinesins varies considerably among experiments. The basis for this variability is unknown. Here, we resolve single-motor force measurements into a vertical component, which accelerates kinesin detachment, and a horizontal component, which decelerates the detachment when resisting the motor. This directionality, when the different experimental geometries are considered, can account for much of the variation in multiple motor dynamics.
    Language English
    Publishing date 2019-05-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.122.188101
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  6. Article ; Online: Effects of social distancing on the spreading of COVID-19 inferred from mobile phone data.

    Khataee, Hamid / Scheuring, Istvan / Czirok, Andras / Neufeld, Zoltan

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 1661

    Abstract: A better understanding of how the COVID-19 pandemic responds to social distancing efforts is required for the control of future outbreaks and to calibrate partial lock-downs. We present quantitative relationships between key parameters characterizing the ...

    Abstract A better understanding of how the COVID-19 pandemic responds to social distancing efforts is required for the control of future outbreaks and to calibrate partial lock-downs. We present quantitative relationships between key parameters characterizing the COVID-19 epidemiology and social distancing efforts of nine selected European countries. Epidemiological parameters were extracted from the number of daily deaths data, while mitigation efforts are estimated from mobile phone tracking data. The decrease of the basic reproductive number ([Formula: see text]) as well as the duration of the initial exponential expansion phase of the epidemic strongly correlates with the magnitude of mobility reduction. Utilizing these relationships we decipher the relative impact of the timing and the extent of social distancing on the total death burden of the pandemic.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/pathology ; COVID-19/transmission ; COVID-19/virology ; Cell Phone ; Europe/epidemiology ; Geographic Information Systems ; Humans ; Pandemics ; Physical Distancing ; Quarantine ; SARS-CoV-2/isolation & purification ; Travel/statistics & numerical data
    Language English
    Publishing date 2021-01-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-81308-2
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  7. Article ; Online: Contact inhibition of locomotion generates collective cell migration without chemoattractants in an open domain.

    Khataee, Hamid / Czirok, Andras / Neufeld, Zoltan

    Physical review. E

    2021  Volume 104, Issue 1-1, Page(s) 14405

    Abstract: Neural crest cells are embryonic stem cells that migrate throughout embryos and, at different target locations, give rise to the formation of a variety of tissues and organs. The directional migration of the neural crest cells is experimentally described ...

    Abstract Neural crest cells are embryonic stem cells that migrate throughout embryos and, at different target locations, give rise to the formation of a variety of tissues and organs. The directional migration of the neural crest cells is experimentally described using a process referred to as contact inhibition of locomotion, by which cells redirect their movement upon the cell-cell contacts. However, it is unclear how the migration alignment is affected by the motility properties of the cells. Here, we theoretically model the migration alignment as a function of the motility dynamics and interaction of the cells in an open domain with a channel geometry. The results indicate that by increasing the influx rate of the cells into the domain a transition takes place from random movement to an organized collective migration, where the migration alignment is maximized and the migration time is minimized. This phase transition demonstrates that the cells can migrate efficiently over long distances without any external chemoattractant information about the direction of migration just based on local interactions with each other. The analysis of the dependence of this transition on the characteristic properties of cellular motility shows that the cell density determines the coordination of collective migration whether the migration domain is open or closed. In the open domain, this density is determined by a feedback mechanism between the flux and order parameter, which characterises the alignment of collective migration. The model also demonstrates that the coattraction mechanism proposed earlier is not necessary for collective migration and a constant flux of cells moving into the channel is sufficient to produce directed movement over arbitrary long distances.
    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.104.014405
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  8. Article ; Online: Effects of social distancing on the spreading of COVID-19 inferred from mobile phone data

    Hamid Khataee / Istvan Scheuring / Andras Czirok / Zoltan Neufeld

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 9

    Abstract: Abstract A better understanding of how the COVID-19 pandemic responds to social distancing efforts is required for the control of future outbreaks and to calibrate partial lock-downs. We present quantitative relationships between key parameters ... ...

    Abstract Abstract A better understanding of how the COVID-19 pandemic responds to social distancing efforts is required for the control of future outbreaks and to calibrate partial lock-downs. We present quantitative relationships between key parameters characterizing the COVID-19 epidemiology and social distancing efforts of nine selected European countries. Epidemiological parameters were extracted from the number of daily deaths data, while mitigation efforts are estimated from mobile phone tracking data. The decrease of the basic reproductive number ( $$R_0$$ R 0 ) as well as the duration of the initial exponential expansion phase of the epidemic strongly correlates with the magnitude of mobility reduction. Utilizing these relationships we decipher the relative impact of the timing and the extent of social distancing on the total death burden of the pandemic.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Targeted adaptive isolation strategy for COVID-19 pandemic.

    Neufeld, Zoltan / Khataee, Hamid / Czirok, Andras

    Infectious Disease Modelling

    2020  Volume 5, Page(s) 357–361

    Abstract: We investigate the effects of social distancing in controlling the impact of the COVID-19 epidemic using a simple susceptible-infected-removed epidemic model. We show that an alternative or complementary approach based on targeted isolation of the ... ...

    Abstract We investigate the effects of social distancing in controlling the impact of the COVID-19 epidemic using a simple susceptible-infected-removed epidemic model. We show that an alternative or complementary approach based on targeted isolation of the vulnerable sub-population may provide a more efficient and robust strategy at a lower economic and social cost within a shorter timeframe resulting in a collectively immune population.
    Keywords covid19
    Language English
    Publishing date 2020-06-05
    Publishing country China
    Document type Journal Article
    ZDB-ID 3015225-2
    ISSN 2468-0427 ; 2468-2152
    ISSN (online) 2468-0427
    ISSN 2468-2152
    DOI 10.1016/j.idm.2020.04.003
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  10. Article ; Online: Different metal-doped ZnS quantum dots photocatalysts for enhancing the permeability and antifouling performances of polysulfone membranes with and without UV irradiation.

    Vatanpour, Vahid / Karatas, Okan / Amiri, Saba / Rajabi, Hamid Reza / Koyuncu, Ismail / Khataee, Alireza

    Chemosphere

    2022  Volume 294, Page(s) 133705

    Abstract: In this study, the effect of three different transition metal ion dopants ( ... ...

    Abstract In this study, the effect of three different transition metal ion dopants (Mn
    MeSH term(s) Biofouling/prevention & control ; Permeability ; Polymers ; Quantum Dots ; Sulfides ; Sulfones ; Zinc Compounds
    Chemical Substances Polymers ; Sulfides ; Sulfones ; Zinc Compounds ; polysulfone P 1700 (25135-51-7) ; zinc sulfide (KPS085631O)
    Language English
    Publishing date 2022-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2022.133705
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    In stock of ZB MED Cologne/Königswinter

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