LIVIVO - Search results -

Search results

Result 1 - 10 of total 637

Search options

Article: Management of Comorbidities in Treated HIV Infection: A Long Way to Go: HIV, comorbidities and aging

Martínez-Sanz, Javier / Serrano-Villar, Sergio / Vivancos, María Jesús / Rubio, Rafael / Moreno, Santiago

International journal of antimicrobial agents. 2022 Jan., v. 59, no. 1

2022

Abstract: Modern ART has now achieved the goal of maintaining HIV RNA suppression with minimum drug-related toxicities. Indeed, in high-income settings, the main health issues in adult people living with HIV (PLWH) today are diseases not directly associated with ... ...

Institution	HIV-associated comorbidities Study Group
Abstract	Modern ART has now achieved the goal of maintaining HIV RNA suppression with minimum drug-related toxicities. Indeed, in high-income settings, the main health issues in adult people living with HIV (PLWH) today are diseases not directly associated with HIV. These conditions have become the central topic of discussion in HIV clinical forums. While they are common in the general population and typically associated with the aging process, their burden, diagnosis, clinical course and subsequent therapy alongside treated HIV infection exhibit specific features. Currently, we are confronted with the formidable challenge of normalizing the health of PLWH and creating a more comprehensive HIV management program. Here, we compile the opinions of a joint effort of 30 HIV specialists who reviewed the literature and debated the latest major challenges in the field of HIV-associated comorbidities and delineated future strategies to fully normalize health in HIV. Six key questions are answered and developed, such as the relevance of comorbidities in the management of HIV-infected patients, their drivers, management, prevention strategies, and possible evolution in the future.
Keywords	HIV infections ; RNA ; adults ; comorbidity ; disease course ; evolution ; people ; therapeutics
Language	English
Dates of publication	2022-01
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2021.106493
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 500: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: From Innovation to Implementation: The Evolution of HIV Pre-Exposure Prophylaxis and Future Implications.

Rosas Cancio-Suárez, Marta / Díaz-Álvarez, Jorge / Ron, Raquel / Martínez-Sanz, Javier / Serrano-Villar, Sergio / Moreno, Santiago / Sánchez-Conde, Matilde

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 7

Abstract: Pre-exposure prophylaxis (PrEP) is a highly effective HIV-prevention strategy that involves the continuous administration of antiretroviral drugs to HIV-negative individuals with a substantial risk of contracting an HIV infection. The use of PrEP has ... ...

Abstract	Pre-exposure prophylaxis (PrEP) is a highly effective HIV-prevention strategy that involves the continuous administration of antiretroviral drugs to HIV-negative individuals with a substantial risk of contracting an HIV infection. The use of PrEP has shown a reduction in the risk of HIV acquisition through sexual intercourse by up to 99%. Despite its effectiveness, PrEP uptake remains low among populations at high risk of HIV infection. This highlights the need for further research in strategies to enhance awareness and uptake of PrEP amongst these specific populations. This article presents a comprehensive overview of the existing literature on the effectiveness of PrEP in reducing HIV transmission rates. Additionally, we examine the obstacles related to PrEP implementation and uptake and put forward potential strategies to raise awareness and improve its use among populations at an increased risk of contracting HIV.
Language	English
Publishing date	2023-07-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12070924
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Executive summary of the consensus document on the shared care of patients with HIV infection between primary and hospital care.

Martínez-Sanz, Javier / Losa-García, Juan E / Orozco, Nuria / Alastrué, Ignacio / Mascort, Juanjo / Pérez-Elías, María Jesús

Enfermedades infecciosas y microbiologia clinica (English ed.)

2023 Volume 42, Issue 2, Page(s) 102–107

Abstract: The current reality of the diagnosis and treatment of HIV infection justifies a multidisciplinary and coordinated approach between Primary Care and Hospital Care, contemplating bidirectionality and communication between the two care settings. The ... ...

Abstract	The current reality of the diagnosis and treatment of HIV infection justifies a multidisciplinary and coordinated approach between Primary Care and Hospital Care, contemplating bidirectionality and communication between the two care settings. The consensus document, coordinated by the AIDS Study Group of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC-GeSIDA) and the Spanish Society of Family and Community Medicine (semFYC), was born out of this need. Here, the recommendations of the four sections that comprise it are summarized: the first deals with aspects of prevention and diagnosis of HIV infection; the second contemplates the clinical care of people living with HIV; the third deals with social factors, including legal and confidentiality issues, quality of life, and the role of NGOs; finally, the fourth block addresses bidirectional and shared training/teaching and research.
MeSH term(s)	Humans ; HIV Infections/therapy ; HIV Infections/drug therapy ; Consensus ; Quality of Life ; Hospitals
Language	English
Publishing date	2023-10-31
Publishing country	Spain
Document type	Practice Guideline
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2023.05.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Pulmonary valve spindle-cell lipoma: A case report.

Sauchelli-Faas, Guadalupe / Barragán-Acea, Antonio / Álvarez-Argüelles, Hugo / Montoto-López, Javier / Jiménez-Rivera, Juan José / Martínez-Sanz, Rafael

SAGE open medical case reports

2023 Volume 11, Page(s) 2050313X231216544

Abstract: Primary cardiac tumours are rare and most of them are benign. Myxomas, fibroelastomas and lipomas are common in adults. Primary valvular cardiac tumours are even more rare and affect all four valves in a similar proportion. Valvular lipomas are very rare. ...

Abstract	Primary cardiac tumours are rare and most of them are benign. Myxomas, fibroelastomas and lipomas are common in adults. Primary valvular cardiac tumours are even more rare and affect all four valves in a similar proportion. Valvular lipomas are very rare. In the pulmonary valve there is only one described. Lipomas can be spindle-cell varieties. But of these, there is only one described in a valve, and it is placed in the aortic valve. Pulmonary valve lipomas can produce obstruction to the right ventricular outflow tract as well as pulmonary valve regurgitation, or pulmonary embolism. Symptoms may be dyspnoea, angina, arrhythmias, or syncope. We aim to illustrate with this case report how we came into this very rare pathology, so we present a 54-year-old woman with a giant spindle-cell lipoma located in the anterior pulmonary leaflet and severe dyspnoea. Total resection of the tumour was performed and restoration of valve function was obtained by means of bicuspidization of the remaining pulmonary leaflets. She had a good recovery after surgery and no complication during the postoperative evolution, being discharged from hospital after 7 days from surgery, with echocardiographic control showing good biventricular function, absence of tumour or obstruction, and minimal pulmonary valve regurgitation.
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Case Reports
ZDB-ID	2736953-5
ISSN	2050-313X
ISSN	2050-313X
DOI	10.1177/2050313X231216544
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: CD4/CD8 Ratio During Human Immunodeficiency Virus Treatment: Time for Routine Monitoring?

Ron, Raquel / Moreno, Elena / Martínez-Sanz, Javier / Brañas, Fátima / Sainz, Talía / Moreno, Santiago / Serrano-Villar, Sergio

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2023 Volume 76, Issue 9, Page(s) 1688–1696

Abstract: In the last decade, studies in persons with HIV (PWH) on antiretroviral therapy (ART) have shed light on the significance of persistently high CD8 counts and low CD4/CD8 ratios. A low CD4/CD8 ratio reflects increased immune activation and is associated ... ...

Abstract	In the last decade, studies in persons with HIV (PWH) on antiretroviral therapy (ART) have shed light on the significance of persistently high CD8 counts and low CD4/CD8 ratios. A low CD4/CD8 ratio reflects increased immune activation and is associated with an increased risk of severe non-AIDS events. As a result, many clinicians now believe that the CD4/CD8 ratio can help in HIV monitoring, and many researchers now report it as an efficacy marker in interventional studies. However, the topic is more complex. Recent studies have not yielded unanimous conclusions on the ability of the CD4/CD8 ratio to predict adverse outcomes, and only some clinical guidelines recommend monitoring it. Knowledge gaps remain on the best cutoff points, associated clinical events, effects of treatments, and how the CD4/CD8 ratio could improve decision making in the clinic. Here, we critically review the literature, identify knowledge gaps, and discuss the role of the CD4/CD8 ratio as a marker for HIV monitoring.
MeSH term(s)	Humans ; HIV ; Anti-HIV Agents/therapeutic use ; CD4-CD8 Ratio ; HIV Infections ; CD8-Positive T-Lymphocytes ; CD4 Lymphocyte Count ; Viral Load
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciad136
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 480: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Prevalence, characteristics, and associated risk factors of drug consumption and chemsex use among individuals attending an STI clinic (EpITs STUDY).

Rosas Cancio-Suárez, Marta / Ron, Raquel / Díaz-Álvarez, Jorge / Martínez-Sanz, Javier / Serrano-Villar, Sergio / Moreno, Santiago / Sánchez-Conde, Matilde

Frontiers in public health

2023 Volume 11, Page(s) 1285057

Abstract: Sex-related drug consumption and its health-related consequences have gained relevance in the assessment of patients with sexually transmitted infections (STIs), which pose a significant challenge to public health. We aim to assess the prevalence and ... ...

Abstract	Sex-related drug consumption and its health-related consequences have gained relevance in the assessment of patients with sexually transmitted infections (STIs), which pose a significant challenge to public health. We aim to assess the prevalence and characteristics of drug consumption and chemsex practices, describe the associated risk factors among general individuals attending an STI clinic, and evaluate the psychological impact associated with these behaviors. We conducted an online anonymous survey offered to patients with a diagnosis of STI in a tertiary hospital in Spain. Data included sociodemographic characteristics, sexual preferences and behavior, and assessment of drug use, chemsex, and psychological and mental health symptoms. Data from 145 subjects was collected, with a higher proportion of cis-gender men (71%), and a median age of 32 years. 64 participants (44%) reported drug use in the last year, with an observed 33.8% prevalence of chemsex consumption. Drug use and chemsex were more frequent among cis-gender men, Men who have Sex with Men (MSM), people living with HIV (PLHIV), and those reporting previous group sex. Poppers and cannabis were the most frequently reported drugs, with a prevalence close to 20% for cocaine, mephedrone, extasis, and GHB. Consequences related to drug use included unpleasant physical sensations, sexual dysfunction, and impaired sexual experience after reduction or drug discontinuation. The prevalence of drug use and chemsex practices are high among patients evaluated for STIs, especially between men, MSM, and subjects practicing group sex. The study highlights the urgent need for targeted interventions on prevention and reduction of their impact on health and social well-being.
MeSH term(s)	Male ; Humans ; Adult ; Homosexuality, Male ; Prevalence ; Sexual and Gender Minorities ; Sexually Transmitted Diseases/epidemiology ; Substance-Related Disorders/epidemiology ; Risk Factors
Language	English
Publishing date	2023-10-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1285057
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Are the Dietary-Nutritional Recommendations Met? Analysis of Intake in Endurance Competitions.

Jiménez-Alfageme, Rubén / Álvarez, Javier / Garbisu-Hualde, Arkaitz / Romero-García, David / Giménez-Monzó, Daniel / Sospedra, Isabel / Ausó, Eva / Martínez-Sanz, José Miguel

Nutrients

2024 Volume 16, Issue 2

Abstract: Background: In recent decades the number of endurance events has increased, as well as the number of athletes participating in them. Adequate nutritional and water planning is essential to maintain optimal sports performance and to reduce the incidence ... ...

Abstract	Background: In recent decades the number of endurance events has increased, as well as the number of athletes participating in them. Adequate nutritional and water planning is essential to maintain optimal sports performance and to reduce the incidence of gastrointestinal problems. The main objective of this study is to determine the dietary intake and compliance with nutritional recommendations of athletes in two endurance competitions, as well as to assess the incidence of gastrointestinal complaints. Methods: An observational and cross-sectional study was carried out on the consumption of liquids, food, and supplements in 42 triathletes and mountain runners (MRs) participating in a Vi-Half-Gasteiz triathlon and the Ultra Sierra de Cazorla trail run. At the completion of the trials, participants completed a validated questionnaire (NIQEC). Results: The mean caloric intake during the test of the participants in this study was 192.17 kcal/h, while the mean carbohydrate intake was 43.67 g/h, the mean sodium intake was 267.43 mg/h, and the mean caffeine intake was 15.53 mg/h, with no significant differences between the two sports. The amount of liquids consumed by the participants was 421.21 mL/h, with no significant differences between the triathletes and MRs. As for gastrointestinal problems, it was observed that the participants presented gastrointestinal discomfort in 61.9% of the cases. Conclusions: The intakes of energy, carbohydrates, water, sodium, and caffeine were lower than the current recommendations. There were no differences in the energy, carbohydrate, water, sodium, and caffeine intakes between the triathletes and mountain runners. Gastrointestinal problems showed a high prevalence in these athletes.
MeSH term(s)	Humans ; Caffeine ; Cross-Sectional Studies ; Dietary Supplements ; Carbohydrates ; Sodium ; Water
Chemical Substances	Caffeine (3G6A5W338E) ; Carbohydrates ; Sodium (9NEZ333N27) ; Water (059QF0KO0R)
Language	English
Publishing date	2024-01-05
Publishing country	Switzerland
Document type	Observational Study ; Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16020189
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: HIV, Cancer, and the Microbiota: Common Pathways Influencing Different Diseases.

Herrera, Sabina / Martínez-Sanz, Javier / Serrano-Villar, Sergio

Frontiers in immunology

2019 Volume 10, Page(s) 1466

Abstract: HIV infection exerts profound and perhaps irreversible damage to the gut mucosal-associated lymphoid tissues, resulting in long-lasting changes in the signals required for the coordination of commensal colonization and in perturbations at the ... ...

Abstract	HIV infection exerts profound and perhaps irreversible damage to the gut mucosal-associated lymphoid tissues, resulting in long-lasting changes in the signals required for the coordination of commensal colonization and in perturbations at the compositional and functional level of the gut microbiota. These abnormalities in gut microbial communities appear to affect clinical outcomes, including T-cell recovery, vaccine responses, HIV transmission, cardiovascular disease, and cancer pathogenesis. For example, the microbial signature associated with HIV infection has been shown to induce tryptophan catabolism, affect the butyrate synthesis pathway, impair anti-tumoral immunity and affect oxidative stress, which have also been linked to the pathogenesis of cancer. Furthermore, some of the taxa that are depleted in subjects with HIV have proved to modulate the anti-tumor efficacy of various chemotherapies and immunotherapeutic agents. The aim of this work is to provide a broad overview of recent advances in our knowledge of how HIV might affect the microbiota, with a focus on the pathways shared with cancer pathogenesis.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Dysbiosis/immunology ; Gastrointestinal Microbiome/immunology ; HIV Infections/immunology ; HIV Infections/transmission ; HIV Infections/virology ; Humans ; Immunity, Mucosal/immunology ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/immunology ; Intestinal Mucosa/microbiology ; Microbiota/immunology ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/metabolism ; Signal Transduction/drug effects ; Signal Transduction/immunology
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2019-06-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2019.01466
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Corrigendum: CD4/CD8 ratio and CD8+ T-cell count as prognostic markers for non-AIDS mortality in people living with HIV. A systematic review and meta-analysis.

Ron, Raquel / Martínez-Sanz, Javier / Herrera, Sabina / Ramos-Ruperto, Luis / Díez-Vidal, Alejandro / Sainz, Talía / Álvarez-Díaz, Noelia / Correa-Pérez, Andrea / Muriel, Alfonso / López-Alcalde, Jesús / Pérez-Molina, José A / Moreno, Santiago / Serrano-Villar, Sergio

Frontiers in immunology

2024 Volume 15, Page(s) 1383117

Abstract: This corrects the article DOI: 10.3389/fimmu.2024.1343124.]. ...

Abstract	[This corrects the article DOI: 10.3389/fimmu.2024.1343124.].
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1383117
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Management of Comorbidities in Treated HIV Infection: A Long Way to Go: HIV, comorbidities and aging.

Martínez-Sanz, Javier / Serrano-Villar, Sergio / Vivancos, María Jesús / Rubio, Rafael / Moreno, Santiago

International journal of antimicrobial agents

2021 Volume 59, Issue 1, Page(s) 106493

Abstract	Modern ART has now achieved the goal of maintaining HIV RNA suppression with minimum drug-related toxicities. Indeed, in high-income settings, the main health issues in adult people living with HIV (PLWH) today are diseases not directly associated with HIV. These conditions have become the central topic of discussion in HIV clinical forums. While they are common in the general population and typically associated with the aging process, their burden, diagnosis, clinical course and subsequent therapy alongside treated HIV infection exhibit specific features. Currently, we are confronted with the formidable challenge of normalizing the health of PLWH and creating a more comprehensive HIV management program. Here, we compile the opinions of a joint effort of 30 HIV specialists who reviewed the literature and debated the latest major challenges in the field of HIV-associated comorbidities and delineated future strategies to fully normalize health in HIV. Six key questions are answered and developed, such as the relevance of comorbidities in the management of HIV-infected patients, their drivers, management, prevention strategies, and possible evolution in the future.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Aging/drug effects ; Anti-Retroviral Agents/adverse effects ; Anti-Retroviral Agents/therapeutic use ; Comorbidity ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Male ; Middle Aged ; Risk Factors
Chemical Substances	Anti-Retroviral Agents
Language	English
Publishing date	2021-12-03
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2021.106493
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 500: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito