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Article ; Online: Genetic Variants in Transcription Factor Binding Sites in Humans: Triggered by Natural Selection and Triggers of Diseases.

Tseng, Chia-Chun / Wong, Man-Chun / Liao, Wei-Ting / Chen, Chung-Jen / Lee, Su-Chen / Yen, Jeng-Hsien / Chang, Shun-Jen

International journal of molecular sciences

2021 Volume 22, Issue 8

Abstract: Variants of transcription factor binding sites (TFBSs) constitute an important part of the human genome. Current evidence demonstrates close links between nucleotides within TFBSs and gene expression. There are multiple pathways through which genomic ... ...

Abstract	Variants of transcription factor binding sites (TFBSs) constitute an important part of the human genome. Current evidence demonstrates close links between nucleotides within TFBSs and gene expression. There are multiple pathways through which genomic sequences located in TFBSs regulate gene expression, and recent genome-wide association studies have shown the biological significance of TFBS variation in human phenotypes. However, numerous challenges remain in the study of TFBS polymorphisms. This article aims to cover the current state of understanding as regards the genomic features of TFBSs and TFBS variants; the mechanisms through which TFBS variants regulate gene expression; the approaches to studying the effects of nucleotide changes that create or disrupt TFBSs; the challenges faced in studies of TFBS sequence variations; the effects of natural selection on collections of TFBSs; in addition to the insights gained from the study of TFBS alleles related to gout, its associated comorbidities (increased body mass index, chronic kidney disease, diabetes, dyslipidemia, coronary artery disease, ischemic heart disease, hypertension, hyperuricemia, osteoporosis, and prostate cancer), and the treatment responses of patients.
MeSH term(s)	Binding Sites ; Genome-Wide Association Study ; Humans ; Protein Binding ; Selection, Genetic/genetics ; Selection, Genetic/physiology ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	Transcription Factors
Language	English
Publishing date	2021-04-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22084187
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Article ; Online: Cell lineage-specific methylome and genome alterations in gout.

Tseng, Chia-Chun / Liao, Wei-Ting / Wong, Man-Chun / Chen, Chung-Jen / Lee, Su-Chen / Yen, Jeng-Hsien / Chang, Shun-Jen

Aging

2021 Volume 13, Issue 3, Page(s) 3843–3865

Abstract: In this study, we examined data from 69 gout patients and 1,455 non-gout controls using a MethylationEPIC BeadChip assay and Illumina HiSeq platform to identify lineage-specific epigenetic alterations and associated genetic factors that contributed to ... ...

Abstract	In this study, we examined data from 69 gout patients and 1,455 non-gout controls using a MethylationEPIC BeadChip assay and Illumina HiSeq platform to identify lineage-specific epigenetic alterations and associated genetic factors that contributed to gouty inflammation. Cell lineage-specific differentially methylated sites were identified using CellDMC after adjusting for sex, age, alcohol drinking, smoking status, and smoking history (total pack-years). Different cell lineages displayed distinct differential methylation. Ingenuity Pathway Analysis and NetworkAnalyst indicated that many differential methylated sites were associated with interleukin-1β expression in monocytes. On the UCSC Genome Browser and WashU Epigenome Browser, metabolic trait, cis-methylation quantitative trait loci, genetic, and functional annotation analyses identified nine methylation loci located in interleukin-1β-regulating genes (
MeSH term(s)	Adult ; B-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Case-Control Studies ; Cell Lineage ; Eosinophils/metabolism ; Epigenome ; Epigenomics ; Female ; Gene Expression Regulation ; Genomics ; Gout/genetics ; Humans ; Inflammation/genetics ; Interleukin-1beta/genetics ; Killer Cells, Natural/metabolism ; Leukocytes/metabolism ; Male ; Middle Aged ; Monocytes/metabolism ; Neutrophils/metabolism
Chemical Substances	IL1B protein, human ; Interleukin-1beta
Language	English
Publishing date	2021-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.202353
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Article ; Online: Impact of carbohydrate quantity and quality on maternal and pregnancy outcomes in gestational diabetes mellitus: A systematic review and meta-analysis.

Wong, Martin Ming Him / Yuen-Man Chan, Mandy / Ng, Tsoi Pan / Louie, Jimmy Chun Yu

Diabetes & metabolic syndrome

2024 Volume 18, Issue 1, Page(s) 102941

Abstract: Objective: To evaluate the impact of carbohydrate quantity and quality on maternal and pregnancy outcomes in gestational diabetes mellitus.: Methods: Using a pre-defined search strategy, two researchers systematically searched MEDLINE, CINAHL Plus, ... ...

Abstract	Objective: To evaluate the impact of carbohydrate quantity and quality on maternal and pregnancy outcomes in gestational diabetes mellitus. Methods: Using a pre-defined search strategy, two researchers systematically searched MEDLINE, CINAHL Plus, and PubMed for randomized controlled trials comparing low-carbohydrate, low-glycaemic index, or low-glycaemic load diets with usual care in gestational diabetes mellitus. Mean differences and risk ratios were extracted. Results: Thirteen studies with 877 participants were included. Low-carbohydrate diet did not significantly differ from usual care for fasting blood glucose (3 studies; mean difference: 1.60 mmol/L; 95 % confidence interval: -1.95, 5.15), insulin requirement (2 studies; risk ratio: 1.01; 95 % confidence interval: 0.31, 3.05), birthweight (4 studies; mean difference: -0.23 kg; 95 % confidence interval: -1.90, 1.45), caesarean delivery (5 studies; risk ratio: 1.11; 95 % confidence interval: 0.66, 1.85), macrosomia (3 studies; risk ratio: 0.35; 95 % confidence interval: 0.00, 2130.64), large-for-gestational-age (2 studies; risk ratio: 0.46; 95 % confidence interval: 0.03, 7.20), and small-for-gestational-age infants (2 studies; risk ratio: 0.94; 95 % confidence interval: 0.00, 231.18). Low-glycaemic index diet did not significantly differ from usual care for the above outcomes either. However, low-glycaemic load diet reduced macrosomia risk (2 studies; risk ratio: 0.51; 95 % confidence interval: 0.43, 0.59). Conclusions: Low-carbohydrate and low-glycaemic index diets do not differ from usual care for most maternal and foetal outcomes in gestational diabetes mellitus. But low-glycaemic load diet may reduce macrosomia risk.
MeSH term(s)	Pregnancy ; Female ; Humans ; Diabetes, Gestational ; Pregnancy Outcome/epidemiology ; Fetal Macrosomia/etiology ; Fetal Macrosomia/prevention & control ; Diet, Carbohydrate-Restricted ; Weight Gain ; Carbohydrates
Chemical Substances	Carbohydrates
Language	English
Publishing date	2024-01-04
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2273766-2
ISSN	1878-0334 ; 1871-4021
ISSN (online)	1878-0334
ISSN	1871-4021
DOI	10.1016/j.dsx.2024.102941
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Article ; Online: Multi-spatiotemporal AOD trends and association with land use changes over the Guangdong-Hong Kong-Macao Greater Bay Area during 2001-2021.

Yu, Xinyu / Wong, Man Sing / Liu, Chun-Ho

Environmental science and pollution research international

2023 Volume 30, Issue 15, Page(s) 44782–44794

Abstract: Analyzing long-term variations of aerosol optical depth (AOD) is beneficial for determining high-pollutant-risk areas and formulating mitigation policies. In this study, multi-spatiotemporal trends and periodicity of AOD, as well as the persistence over ... ...

Abstract	Analyzing long-term variations of aerosol optical depth (AOD) is beneficial for determining high-pollutant-risk areas and formulating mitigation policies. In this study, multi-spatiotemporal trends and periodicity of AOD, as well as the persistence over the Guangdong-Hong Kong-Macao Greater Bay Area from 2001 to 2021, were investigated by the extreme-point symmetric mode decomposition (ESMD), Theil-Sen Median trend analysis and Hurst exponent. The results elucidate that AOD exhibits fluctuant variations during the 21-year period with the year 2012 as the turning point. There is a slight upward tendency (0.009 year
MeSH term(s)	Hong Kong ; Macau ; Environmental Monitoring/methods ; Environmental Pollutants ; Aerosols/analysis
Chemical Substances	Environmental Pollutants ; Aerosols
Language	English
Publishing date	2023-01-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-25451-5
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Article ; Online: Case series of HIV SARS-CoV-2 co-infection in Chinese adults.

Ng, Rita Wai-Yin / Wong, Chun-Kwok / Lui, Grace Chung-Yan / Tso, Eugene Yuk-Keung / Chen, Zigui / Tsang, Owen Tak-Yin / Boon, Siaw Shi / Lai, Christopher Koon-Chi / Fung, Kitty Sau-Chun / Yeung, Apple Chung-Man / Ho, Wendy Ching-Sze / Hui, David Shu-Cheong / Chan, Paul Kay-Sheung / Chan, Jacky Man-Chun

Journal of clinical virology plus

2022 Volume 2, Issue 1, Page(s) 100062

Abstract: Objectives: Little is known whether differences exist in virus shedding, immune and inflammatory response related to SARS-CoV-2 in people living with human immunodeficiency virus (PLWH). We assessed viral RNA and cytokine profiles of HIV and SARS-CoV-2 ... ...

Abstract	Objectives: Little is known whether differences exist in virus shedding, immune and inflammatory response related to SARS-CoV-2 in people living with human immunodeficiency virus (PLWH). We assessed viral RNA and cytokine profiles of HIV and SARS-CoV-2 coinfection in Hong Kong. Methods: PLWH hospitalized with SARS-CoV-2 infection in Hong Kong were included, compared with age-matched and disease severity-matched SARS-CoV-2 infected controls (ratio of 1:5) from February 1st 2020 to July 31st 2020. SARS-CoV-2 infection was confirmed by public health laboratory and virus concentration was quantified by an in-house real-time reverse transcription-quantitative polymerase chain reaction. A panel of cytokines and chemokines were performed. Results: HIV patients had a similar respiratory shedding profile compared to controls. Duration of faecal shedding of patient A, B, C and D were at least 9, 10, 33, and 11 days, respectively. HIV patients had lower plasma levels of IL-10 and NT-pro-BNP. All 4 PLWH cases showed seroconversion to SARS-CoV-2 with anti-SARS-CoV-2 S antibodies detected in serum collected between day 18 and 30 after symptom onset. Conclusions: PLWH behaves similarly with HIV-negative controls in respiratory viral load, but with decrease in IL-10 and NT-proBNP. PLWH may have a lower risk of immunostimulatory effect due to lower IL-10.
Language	English
Publishing date	2022-01-10
Publishing country	England
Document type	Journal Article
ISSN	2667-0380
ISSN (online)	2667-0380
DOI	10.1016/j.jcvp.2022.100062
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Article ; Online: (-)-Epiafzelechin Protects against Ovariectomy-induced Bone Loss in Adult Mice and Modulate Osteoblastic and Osteoclastic Functions In Vitro.

Wong, Ka-Chun / Cao, Sisi / Dong, Xiaoli / Law, Man-Chun / Chan, Tak-Hang / Wong, Man-Sau

Nutrients

2017 Volume 9, Issue 5

Abstract: The present study was designed to characterize the bone protective effects of (-)- ...

Abstract	The present study was designed to characterize the bone protective effects of (-)-
Language	English
Publishing date	2017-05-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu9050530
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Article ; Online: Cardiovascular outcomes following hospitalisation for exacerbation of bronchiectasis: a territory-wide study.

Kwok, Wang Chun / Tsui, Chung Ki / Leung, Sze Him Isaac / Wong, Chun Ka Emmanuel / Tam, Terence Chi Chun / Ho, James Chung-Man

BMJ open respiratory research

2024 Volume 11, Issue 1

Abstract: Background: Although bronchiectasis is reported to be associated with cardiovascular disease, evidence for an association with cardiovascular events (CVEs) is lacking.: Methods: A territory-wide retrospective cohort study was conducted in Hong Kong ... ...

Abstract	Background: Although bronchiectasis is reported to be associated with cardiovascular disease, evidence for an association with cardiovascular events (CVEs) is lacking. Methods: A territory-wide retrospective cohort study was conducted in Hong Kong involving all patients who had bronchiectasis diagnosed in public hospitals and clinics between 1 January 1993 and 31 December 2017 were included. Patients were allocated to be exacerbator or non-exacerbator group based on hospitalzied bronchiecsis history and CVEs over the next 5 years determined. Propensity score matching was used to balance baseline characteristics. Results: 10 714 bronchiectasis patients (mean age 69.6±14.4 years, 38.9% men), including 1230 in exacerbator group and 9484 in non-exacerbator group, were analysed. At 5 years, 113 (9.2%) subjects in the exacerbator group and 87 (7.1%) in the non-exacerbator group developed composite CVEs. After adjustment for age, sex, smoking and risk factors for cardiovascular disease, bronchiectasis exacerbation was associated with increased risks for acute myocardial infarction (AMI), congestive heart failure (CHF) and CVE compared with those in the non-exacerbator group with adjusted HR of 1.602 (95% CI 1.006-2.552, p value=0.047), 1.371 (95% CI 1.016-1.851, p value=0.039) and 1.238 (95% CI 1.001-1.532, p=0.049) in the whole cohort. Findings were similar for the propensity score-matched cohort for AMI and CVE. Conclusion: Patients who were hospitalised for exacerbation of bronchiectasis were at significantly increased risk of AMI, CHF and CVE over a 5-year follow-up period.
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Retrospective Studies ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Risk Factors ; Bronchiectasis/epidemiology ; Heart Failure/epidemiology ; Heart Failure/etiology ; Hospitalization
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2736454-9
ISSN	2052-4439 ; 2052-4439
ISSN (online)	2052-4439
ISSN	2052-4439
DOI	10.1136/bmjresp-2023-001804
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Article ; Online: Oleaginous Heterotrophic Dinoflagellates-Crypthecodiniaceae.

Kwok, Alvin Chun Man / Law, Stanley Ping Chuen / Wong, Joseph Tin Yum

Marine drugs

2023 Volume 21, Issue 3

Abstract: ... The ... ...

Abstract	The heterotrophic
MeSH term(s)	Dinoflagellida/genetics ; Phylogeny ; Docosahexaenoic Acids ; Biotechnology ; Heterotrophic Processes
Chemical Substances	Docosahexaenoic Acids (25167-62-8)
Language	English
Publishing date	2023-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md21030162
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Article ; Online: Genetic Variants in Transcription Factor Binding Sites in Humans

Chia-Chun Tseng / Man-Chun Wong / Wei-Ting Liao / Chung-Jen Chen / Su-Chen Lee / Jeng-Hsien Yen / Shun-Jen Chang

International Journal of Molecular Sciences, Vol 22, Iss 4187, p

Triggered by Natural Selection and Triggers of Diseases

2021 Volume 4187

Abstract	Variants of transcription factor binding sites (TFBSs) constitute an important part of the human genome. Current evidence demonstrates close links between nucleotides within TFBSs and gene expression. There are multiple pathways through which genomic sequences located in TFBSs regulate gene expression, and recent genome-wide association studies have shown the biological significance of TFBS variation in human phenotypes. However, numerous challenges remain in the study of TFBS polymorphisms. This article aims to cover the current state of understanding as regards the genomic features of TFBSs and TFBS variants; the mechanisms through which TFBS variants regulate gene expression; the approaches to studying the effects of nucleotide changes that create or disrupt TFBSs; the challenges faced in studies of TFBS sequence variations; the effects of natural selection on collections of TFBSs; in addition to the insights gained from the study of TFBS alleles related to gout, its associated comorbidities (increased body mass index, chronic kidney disease, diabetes, dyslipidemia, coronary artery disease, ischemic heart disease, hypertension, hyperuricemia, osteoporosis, and prostate cancer), and the treatment responses of patients.
Keywords	gout ; transcription factor binding sites ; natural selection ; histone modification ; methylation ; chromatin conformation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	570
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Complement C3 From Astrocytes Plays Significant Roles in Sustained Activation of Microglia and Cognitive Dysfunctions Triggered by Systemic Inflammation After Laparotomy in Adult Male Mice.

Chen, Ying / Chu, John Man-Tak / Wong, Gordon Tin-Chun / Chang, Raymond Chuen-Chung

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

2024 Volume 19, Issue 1, Page(s) 8

Abstract: Aberrant activation of complement cascades plays an important role in the progress of neurological disorders. Complement C3, the central complement component, has been implicated in synaptic loss and cognitive impairment. Recent study has shown that ... ...

Abstract	Aberrant activation of complement cascades plays an important role in the progress of neurological disorders. Complement C3, the central complement component, has been implicated in synaptic loss and cognitive impairment. Recent study has shown that wound injury-induced systemic inflammation can trigger the increase of C3 in the brain. Our previous studies have demonstrated that laparotomy-triggered systemic inflammation could induce neuroinflammation and cognitive dysfunctions. Furthermore, sustained activation of microglia was observed even 14 days after laparotomy, while most of cytokines had returned to basal levels rapidly at the earlier time point. Although we have demonstrated that anti-inflammatory intervention successfully attenuated cognitive dysfunction by preventing increase of cytokines and activation of microglia, how sustained activation of microglia and cognitive dysfunction occur is still a mystery. In this study, we investigated the role of C3 in mediating activation of microglia and cognitive dysfunction by using laparotomy in adult male mouse only as the experimental model of systemic inflammation and AAV9-C3shRNA. Our data observed that laparotomy induced neurotoxic reactive astrocytes with an increase of C3 in the hippocampus. Furthermore, inhibition of C3 by AAV9-C3shRNA prevented synaptic engulfment by microglia and attenuated cognitive dysfunctions after laparotomy. Inhibition of C3 did not modulate activation of astrocytes and expression of various cytokines. Current findings demonstrated that C3 plays significant roles in sustained activation of microglia and cognitive dysfunctions, which suggests that C3 is the valuable molecule target to attenuate in neurological conditions characterised by neuroinflammation and cognitive dysfunction.
MeSH term(s)	Animals ; Male ; Mice ; Astrocytes/metabolism ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/metabolism ; Complement C3/genetics ; Complement C3/metabolism ; Cytokines/metabolism ; Disease Models, Animal ; Inflammation/metabolism ; Laparotomy/adverse effects ; Mice, Inbred C57BL ; Microglia/metabolism ; Neuroinflammatory Diseases
Chemical Substances	Complement C3 ; Cytokines ; C3 protein, mouse
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2227405-4
ISSN	1557-1904 ; 1557-1890
ISSN (online)	1557-1904
ISSN	1557-1890
DOI	10.1007/s11481-024-10107-z
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