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  1. Article ; Online: Corrigendum to "Towards circular and sustainable restoration of a deeply polluted river basin: The Odiel River catchment (SW Spain)" [Sci. Total Environ. 907 (2024) 168078].

    Millán-Becerro, Ricardo / León, Rafael / Romero-Matos, Jonatan / Moreno-González, Raúl / Pérez-López, Rafael

    The Science of the total environment

    2024  Volume 922, Page(s) 171341

    Language English
    Publishing date 2024-03-05
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Corrigendum to "Towards circular and sustainable restoration of a deeply polluted river basin: The Odiel River catchment (SW Spain)" [Sci. Total Environ. 907 (2024) 168078].

    Millán-Becerro, Ricardo / León, Rafael / Romero-Matos, Jonatan / Moreno-González, Raúl / Pérez-López, Rafael

    The Science of the total environment

    2023  Volume 912, Page(s) 169379

    Language English
    Publishing date 2023-12-18
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.169379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Towards circular and sustainable restoration of a deeply polluted river basin: The Odiel River catchment (SW Spain).

    Millán-Becerro, Ricardo / León, Rafael / Romero-Matos, Jonatan / Moreno-González, Raul / Pérez-López, Rafael

    The Science of the total environment

    2023  Volume 907, Page(s) 168078

    Language English
    Publishing date 2023-10-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.168078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Podoconiosis.

    Mansilla-Polo, Miguel / López-León, Paula Teresa / Botella-Estrada, Rafael

    JAMA dermatology

    2023  Volume 160, Issue 1, Page(s) 101

    MeSH term(s) Humans ; Elephantiasis/diagnosis ; Elephantiasis/etiology ; Risk Factors
    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2023.4143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.32: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Extracellular Vesicles' Genetic Cargo as Noninvasive Biomarkers in Cancer: A Pilot Study Using ExoGAG Technology.

    Herrero, Carolina / Ferreirós, Alba / Pérez-Fentes, Daniel / León-Mateos, Luis / López-López, Rafael / Abal, Miguel / Alonso-Alconada, Lorena

    Biomedicines

    2023  Volume 11, Issue 2

    Abstract: The two most developed biomarkers in liquid biopsy (LB)-circulating tumor cells and circulating tumor DNA-have been joined by the analysis of extracellular vesicles (EVs). EVs are lipid-bilayer enclosed structures released by all cell types containing a ... ...

    Abstract The two most developed biomarkers in liquid biopsy (LB)-circulating tumor cells and circulating tumor DNA-have been joined by the analysis of extracellular vesicles (EVs). EVs are lipid-bilayer enclosed structures released by all cell types containing a variety of molecules, including DNA, mRNA and miRNA. However, fast, efficient and a high degree of purity isolation technologies are necessary for their clinical routine implementation. In this work, the use of ExoGAG, a new easy-to-use EV isolation technology, was validated for the isolation of EVs from plasma and urine samples. After demonstrating its efficiency, an analysis of the genetic material contained in the EVs was carried out. Firstly, the sensitivity of the detection of point mutations in DNA from plasma EVs isolated by ExoGAG was analyzed. Then, a pilot study of mRNA expression using the nCounter NanoString platform in EV-mRNA from a healthy donor, a benign prostate hyperplasia patient and metastatic prostate cancer patient plasma and urine samples was performed, identifying the prostate cancer pathway as one of the main ones. This work provides evidence for the value of using ExoGAG for the isolation of EVs from plasma and urine samples, enabling downstream applications of the analysis of their genetic cargo.
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11020404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Wildfire effects on the hydrogeochemistry of a river severely polluted by acid mine drainage.

    Romero-Matos, Jonatan / Cánovas, Carlos R / Macías, Francisco / Pérez-López, Rafael / León, Rafael / Millán-Becerro, Ricardo / Nieto, Jose Miguel

    Water research

    2023  Volume 233, Page(s) 119791

    Abstract: This study evaluates for the first time the impact of a large wildfire on the hydrogeochemistry of a deeply AMD-affected river at the beginning of the wet season. To accomplish this, a high-resolution water monitoring campaign was performed within the ... ...

    Abstract This study evaluates for the first time the impact of a large wildfire on the hydrogeochemistry of a deeply AMD-affected river at the beginning of the wet season. To accomplish this, a high-resolution water monitoring campaign was performed within the basin coinciding with the first rainfalls after summer. Unlike similar events recorded in AMD-affected areas, where dramatic increases in most dissolved element concentrations, and decreases in pH values are observed as a result of evaporitic salts flushing and the transport of sulfide oxidation products from mine sites, a slight increase in pH values (from 2.32 to 2.88) and decrease in element concentrations (e.g.; Fe: 443 to 205 mg/L; Al: 1805 to 1059 mg/L; sulfate: 22.8 to 13.3 g/L) was observed with the first rainfalls after the fire. The washout of wildfire-ash deposited in the riverbanks and the drainage area, constituted by alkaline mineral phases, seems to have counterbalanced the usual behavior and patterns of the river hydrogeochemistry during autumn. Geochemical results indicate that a preferential dissolution occurs during ash washout (K > Ca > Na), with a quick release of K followed by an intense dissolution of Ca and Na. On the other hand, in unburnt zones parameters and concentrations vary to a lesser extent than burnt areas, being the washout of evaporitic salts the dominant process. With subsequent rainfalls ash plays a minor role on the river hydrochemistry. Elemental ratios (Fe/SO
    MeSH term(s) Rivers ; Wildfires ; Water Pollutants, Chemical/analysis ; Salts ; Environmental Monitoring
    Chemical Substances Water Pollutants, Chemical ; Salts
    Language English
    Publishing date 2023-02-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 202613-2
    ISSN 1879-2448 ; 0043-1354
    ISSN (online) 1879-2448
    ISSN 0043-1354
    DOI 10.1016/j.watres.2023.119791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 78/260: Show issues
    Z 3381: Show issues

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  7. Article ; Online: Phosphogypsum weathering and implications for pollutant discharge into an estuary

    Millán-Becerro, Ricardo / Pérez López, Rafael / Cánovas, Carlos R. / Macías, Francisco / León, Rafael

    Journal of Hydrology. 2023 Feb., v. 617 p.128943-

    2023  

    Abstract: Approximately 100 million tons of phosphogypsum were stockpiled onto marsh soils of the Tinto River estuary (Huelva, SW Spain). This study focuses on the hydraulic response of the phosphogypsum stack to the different weathering agents, as well as on the ... ...

    Abstract Approximately 100 million tons of phosphogypsum were stockpiled onto marsh soils of the Tinto River estuary (Huelva, SW Spain). This study focuses on the hydraulic response of the phosphogypsum stack to the different weathering agents, as well as on the hydrochemical behavior of highly acidic and polluted effluents from its leaching during different hydrological conditions. To address these issues, a CTD-Diver was installed in a bore-hole within a phosphogypsum stack profile, which recorded the variations in the water-table of the stack, and edge outflows samples were collected around the perimeter of the stack during four sampling periods in different seasons. During dry periods, the water-table of the stack remains almost static and is controlled only by the tide oscillations. However, during rainy events this water-level rapidly increases up to 20 cm and subsequently decreases, defining peaks that coincide with the rainfalls. Having a hydraulic connection to the sea and groundwater flow in conduits, the phosphogypsum stack behaves as an anthropogenic karstic-coastal aquifer. Regarding the hydrochemical behavior of the edge outflows, the concentrations of most pollutants (e.g., PO₄, Al, As, Cd or U) showed a slight decrease from the dry-warm to the rainy period. These leachates releases high concentrations of contaminants to the estuary, e.g., PO₄, As and U (average values of 5000, 6.9 and 3.0 t/yr, respectively). The results obtained in this study could contribute to the development of effective treatment systems for leachates from phosphogypsum stack of Huelva and to minimize their impact on the surrounding estuarine environment.
    Keywords aquifers ; estuaries ; groundwater flow ; hydrochemistry ; marshes ; phosphogypsum ; pollutants ; rivers ; water table ; wet season ; Spain ; Phosphogypsum stack ; Anthropic aquifer ; Highly polluted leachates ; Ría de Huelva estuary
    Language English
    Dates of publication 2023-02
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 1473173-3
    ISSN 1879-2707 ; 0022-1694
    ISSN (online) 1879-2707
    ISSN 0022-1694
    DOI 10.1016/j.jhydrol.2022.128943
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Oxidative-Stress-Related Genes in Osteoporosis: A Systematic Review.

    León-Reyes, Guadalupe / Argoty-Pantoja, Anna D / Becerra-Cervera, Adriana / López-Montoya, Priscilla / Rivera-Paredez, Berenice / Velázquez-Cruz, Rafael

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: Osteoporosis is characterized by a decline in bone mineral density (BMD) and increased fracture risk. Free radicals and antioxidant systems play a central role in bone remodeling. This study was conducted to illustrate the role of oxidative-stress- ... ...

    Abstract Osteoporosis is characterized by a decline in bone mineral density (BMD) and increased fracture risk. Free radicals and antioxidant systems play a central role in bone remodeling. This study was conducted to illustrate the role of oxidative-stress-related genes in BMD and osteoporosis. A systematic review was performed following the PRISMA guidelines. The search was computed in PubMed, Web of Sciences, Scopus, EBSCO, and BVS from inception to November 1st, 2022. The risk of bias was evaluated using the Joanna Briggs Institute Critical Appraisal Checklist tool. A total of 427 potentially eligible articles exploring this search question were detected. After removing duplicates (n = 112) and excluding irrelevant manuscripts based on screenings of their titles and abstracts (n = 317), 19 articles were selected for full-text review. Finally, 14 original articles were included in this systematic review after we applied the exclusion and inclusion criteria. Data analyzed in this systematic review indicated that oxidative-stress-related genetic polymorphisms are associated with BMD at different skeletal sites in diverse populations, influencing the risk of osteoporosis or osteoporotic fracture. However, it is necessary to look deep into their association with bone metabolism to determine if the findings can be translated into the clinical management of osteoporosis and its progression.
    Language English
    Publishing date 2023-04-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12040915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Stability, Content of Bioactive Compounds and Antioxidant Activity of Emulsions with Propolis Extracts during Simulated In Vitro Digestion.

    González Montiel, Lucio / León-López, Arely / García-Ceja, Adelfo / Franco-Fernández, Melitón Jesús / Pérez-Soto, Elizabeth / Cenobio-Galindo, Antonio de Jesús / Campos-Montiel, Rafael G / Aguirre-Álvarez, Gabriel

    Foods (Basel, Switzerland)

    2024  Volume 13, Issue 5

    Abstract: The objective in this work was the evaluation of the stability and content of bioactive compounds (total phenols and total flavonoids) and antioxidant activity of emulsions of ethanolic extracts of propolis obtained by ultrasound, during simulated in ... ...

    Abstract The objective in this work was the evaluation of the stability and content of bioactive compounds (total phenols and total flavonoids) and antioxidant activity of emulsions of ethanolic extracts of propolis obtained by ultrasound, during simulated in vitro digestion. The emulsions prepared with propolis extracts were evaluated on certain properties: their emulsion efficiency, stability (zeta potential, particle size, electrical conductivity), content of bioactive compound (total phenolics and total flavonoids), antioxidant activity and their behavior during simulated in vitro digestion. Based on the total phenol content, an emulsification efficiency of 87.8 ± 1.9% to 97.8 ± 3.8% was obtained. The particle size of the emulsions was 322.5 ± 15.33 nm to 463.9 ± 33.65 nm, with a zeta potential of -31.5 ± 0.66 mV to -28.2 ± 1.0 mV and electrical conductivity of 22.7 ± 1.96 µS/cm to 30.6 ± 0.91 µS/cm. These results indicate good emulsion stability. During simulated in vitro digestion, the content of bioactive compounds (total phenolics, total flavonoids) and antioxidant activity were affected during 77 days of storage at 4 °C. It was concluded that the emulsion process fulfills the function of protecting the bioactive compounds and therefore their biological activity.
    Language English
    Publishing date 2024-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods13050779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: In vitro propagation from axillary buds of the endangered tree

    Hernández-García, Alejandra / Ambriz-Parra, Enrique / López-Albarrán, Pablo / Cruz-de León, José / Salgado-Garciglia, Rafael

    Plant biotechnology (Tokyo, Japan)

    2022  Volume 38, Issue 4, Page(s) 409–414

    Abstract: Dalbergia ... ...

    Abstract Dalbergia congestiflora
    Language English
    Publishing date 2022-01-13
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2210142-1
    ISSN 1347-6114 ; 1342-4580
    ISSN (online) 1347-6114
    ISSN 1342-4580
    DOI 10.5511/plantbiotechnology.21.0901a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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