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  1. Article ; Online: Online interprofessional education during and post the COVID-19 pandemic: a commentary.

    Khalili, Hossein

    Journal of interprofessional care

    2020  Volume 34, Issue 5, Page(s) 687–690

    Abstract: The full impact of the COVID-19 pandemic on higher education and interprofessional education programs in particular is yet to be determined, however, it is clear that this pandemic is changing the way we live, learn, and work. Online education is ... ...

    Abstract The full impact of the COVID-19 pandemic on higher education and interprofessional education programs in particular is yet to be determined, however, it is clear that this pandemic is changing the way we live, learn, and work. Online education is becoming the new normal in academia, but it is a development that may be posing a conundrum to some. Teachers of interprofessional education are expected to employ online education, but some may lack the knowledge and expertise to create and facilitate an engaging, positive, and supportive online environment for their students. This report discusses the application of Meaningful Discourse and the Community of Inquiry principles on developing online learning communities in interprofessional education.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Education, Distance ; Health Personnel/education ; Humans ; Interprofessional Relations ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1099758-1
    ISSN 1469-9567 ; 0884-3988 ; 1356-1820
    ISSN (online) 1469-9567
    ISSN 0884-3988 ; 1356-1820
    DOI 10.1080/13561820.2020.1792424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Online interprofessional education during and post the COVID-19 pandemic

    Khalili, Hossein

    Journal of Interprofessional Care

    a commentary

    2020  Volume 34, Issue 5, Page(s) 687–690

    Keywords General Medicine ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1099758-1
    ISSN 1469-9567 ; 1356-1820
    ISSN (online) 1469-9567
    ISSN 1356-1820
    DOI 10.1080/13561820.2020.1792424
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Linezolid pharmacokinetics: a systematic review for the best clinical practice.

    Heidari, Shima / Khalili, Hossein

    European journal of clinical pharmacology

    2022  Volume 79, Issue 2, Page(s) 195–206

    Abstract: Objectives: To summarize the pharmacokinetics of linezolid to optimize the dosing regimen in special populations.: Methods: A literature search was performed in three largest medical databases, including Embase, Scopus, and PubMed. The main applied ... ...

    Abstract Objectives: To summarize the pharmacokinetics of linezolid to optimize the dosing regimen in special populations.
    Methods: A literature search was performed in three largest medical databases, including Embase, Scopus, and PubMed. The main applied keywords were linezolid and pharmacokinetics. Of 3663 retrieved publications in the English language, 35 original research articles, clinical studies, and case reports about linezolid pharmacokinetics in different populations such as pregnant women, pediatrics, elderly subjects, obese people, individuals with organ dysfunction, and critically ill patients were included. RESULTS AND CONCLUSION: Dose adjustment is not currently recommended for linezolid in patients with mild to moderate renal or hepatic impairment, older adults, and pregnant women. Although dose adjustment is not recommended in patients with severe renal or hepatic impairment, it should be considered that these patients are more vulnerable to linezolid adverse effects and drug interactions. In pediatrics, reducing the linezolid dosing interval to 8 h is suggested. Despite the lack of sufficient information in obese individuals, dosing based on body weight or use of higher dose seems to be justifiable to prevent sub-therapeutic concentrations. Although dose adjustment of linezolid is not recommended in critically ill patients, administration of linezolid as continuous intravenous infusion is suggested in this population. Blood level monitoring should be considered in populations that are vulnerable to linezolid underexposure (such as critically ill patients with augmented renal clearance, pediatrics, overweight, and obese patients) or overexposure (such as elderly, patients with hepatic and renal impairment). To assess the efficacy and safety of linezolid, the area under the concentration-time curve over 24 h to minimum inhibitory concentration (AUC0-24 h/MIC) equal to 80-120, percentage of time above the MIC ≥ 85%, and serum trough concentration between 2 and 7 mg/L are suggested.
    MeSH term(s) Pregnancy ; Humans ; Female ; Child ; Aged ; Linezolid ; Anti-Bacterial Agents ; Critical Illness ; Kidney ; Renal Insufficiency/drug therapy ; Obesity/drug therapy ; Microbial Sensitivity Tests
    Chemical Substances Linezolid (ISQ9I6J12J) ; Anti-Bacterial Agents
    Language English
    Publishing date 2022-12-24
    Publishing country Germany
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 121960-1
    ISSN 1432-1041 ; 0031-6970
    ISSN (online) 1432-1041
    ISSN 0031-6970
    DOI 10.1007/s00228-022-03446-4
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  4. Article: Online interprofessional education during and post the COVID-19 pandemic: a commentary

    Khalili, Hossein

    J Interprof Care

    Abstract: The full impact of the COVID-19 pandemic on higher education and interprofessional education programs in particular is yet to be determined, however, it is clear that this pandemic is changing the way we live, learn, and work. Online education is ... ...

    Abstract The full impact of the COVID-19 pandemic on higher education and interprofessional education programs in particular is yet to be determined, however, it is clear that this pandemic is changing the way we live, learn, and work. Online education is becoming the new normal in academia, but it is a development that may be posing a conundrum to some. Teachers of interprofessional education are expected to employ online education, but some may lack the knowledge and expertise to create and facilitate an engaging, positive, and supportive online environment for their students. This report discusses the application of Meaningful Discourse and the Community of Inquiry principles on developing online learning communities in interprofessional education.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #648393
    Database COVID19

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  5. Article ; Online: Treatment options for infections caused by multidrug-resistant Gram-negative bacteria: a guide to good clinical practice.

    Delroba, Khadijeh / Alaei, Maryam / Khalili, Hossein

    Future microbiology

    2023  Volume 18, Page(s) 287–294

    Abstract: The rapid emergence of multidrug-resistant Gram-negative bacterial infections necessitates the development of new treatments or the repurposing of available antibiotics. Here, treatment options for treatment of these infections, recent guidelines and ... ...

    Abstract The rapid emergence of multidrug-resistant Gram-negative bacterial infections necessitates the development of new treatments or the repurposing of available antibiotics. Here, treatment options for treatment of these infections, recent guidelines and evidence are reviewed. Studies that included treatment options for infections caused by multidrug-resistant Gram-negative bacteria (Enterobacterales and nonfermenters), as well as extended-spectrum β-lactamase-producing and carbapenem-resistant bacteria, were considered. Potential agents for the treatment of these infections, considering type of microorganism, mechanism of resistant, source and severity of infection as well as pharmacotherapy considerations, are summarized.
    MeSH term(s) Humans ; Gram-Negative Bacteria ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/microbiology ; Drug Resistance, Multiple, Bacterial ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2254620-0
    ISSN 1746-0921 ; 1746-0913
    ISSN (online) 1746-0921
    ISSN 1746-0913
    DOI 10.2217/fmb-2022-0160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Reply to Dorgham et al., "Considering Personalized Interferon Beta Therapy for COVID-19".

    Davoudi-Monfared, Effat / Khalili, Hossein

    Antimicrobial agents and chemotherapy

    2021  Volume 65, Issue 4

    MeSH term(s) COVID-19 ; Humans ; Immunotherapy ; Interferon beta-1a ; SARS-CoV-2
    Chemical Substances Interferon beta-1a (XRO4566Q4R)
    Language English
    Publishing date 2021-03-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.00083-21
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  7. Article ; Online: Do interferons play a role in COVID-19?

    Arasteh, Omid / Khalili, Hossein

    International journal of clinical practice

    2021  Volume 75, Issue 11, Page(s) e14721

    MeSH term(s) Antiviral Agents/therapeutic use ; COVID-19 ; Humans ; Interferons ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Interferons (9008-11-1)
    Language English
    Publishing date 2021-10-21
    Publishing country India
    Document type Letter
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1111/ijcp.14721
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  8. Article ; Online: Botulinum Toxin Injection for the Treatment of Third, Fourth, and Sixth Nerve Palsy: A Meta-Analysis.

    Khalili, Mohammad Reza / Roshanshad, Amirhossein / Vardanjani, Hossein Molavi

    Journal of pediatric ophthalmology and strabismus

    2023  , Page(s) 1–12

    Abstract: The efficacy of botulinum toxin injection for the treatment of third, fourth, and sixth nerve palsy was evaluated. PubMed, Scopus, EMBASE, Web of Science, and Google Scholar databases were searched. Data about the duration of palsy (acute vs chronic), ... ...

    Abstract The efficacy of botulinum toxin injection for the treatment of third, fourth, and sixth nerve palsy was evaluated. PubMed, Scopus, EMBASE, Web of Science, and Google Scholar databases were searched. Data about the duration of palsy (acute vs chronic), cause of the palsy, type of toxin used, mean dose, and other background characteristics were collected. Outcome variables were success rate (defined by alleviation of diplopia or reduction in eye deviation) and standardized mean difference of prism diopter and abduction deficit before and after injection. The Joanna Briggs Institute checklist was implemented for the risk of bias assessment. The analysis included 38 articles, comprising 643 patients. The overall treatment success rate in acute and chronic nerve palsy was 79% and 33%, respectively. The success rate was not significantly different between different subgroups of age, type of botulinum toxin, pre-injection prism diopter, etiology of the palsy, duration of follow-up, and mean dose of botulinum toxin injection. However, in both acute and chronic palsy, diabetes etiology was accompanied by the highest success rate. Overall symptomatic response to botulinum injection was 84% (95% CI: 67% to 96%), whereas functional response was observed in 64% (95% CI: 47% to 79%) of the patients. The odds ratio for the success rate of treatment of palsies with botulinum toxin versus expectant management was 2.67 (95% CI: 1.12 to 6.36) for acute palsy and 0.87 (95% CI: 0.17 to 4.42) for chronic palsy. Botulinum toxin can be used for the treatment of acute third, fourth, and sixth nerve palsy, especially in patients with acute palsy and more severe tropia.
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 800921-1
    ISSN 1938-2405 ; 0191-3913
    ISSN (online) 1938-2405
    ISSN 0191-3913
    DOI 10.3928/01913913-20231120-02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Adherence to recommendations for the evaluation and management of fungal infections in a referral teaching hospital in Iran: A retrospective cross-sectional study.

    Atashgar, Haura / Khalili, Hossein / Salehi, Mohammadreza / Mohammadi, Mostafa

    Journal of infection in developing countries

    2023  Volume 17, Issue 3, Page(s) 411–417

    Abstract: Introduction: Early diagnosis and appropriate management of fungal infections are critical for reducing complications and mortality in hospitalized patients. Due to the lack of appropriate local management protocols as well as the unavailability and ... ...

    Abstract Introduction: Early diagnosis and appropriate management of fungal infections are critical for reducing complications and mortality in hospitalized patients. Due to the lack of appropriate local management protocols as well as the unavailability and cost of advanced tests for diagnosis of fungal infections, the irrational use of antifungals is a concern in developing countries.
    Objectives: This study was designed to evaluate diagnosis and management of fungal infections in hospitalized patients.
    Methods: In a retrospective cross-sectional study, the use of parenteral antifungal medications among hospitalized patients was evaluated according to the prepared protocols adapted from the international guidelines.
    Results: Among 151 patients, diagnostic approaches were appropriate and inappropriate in 90 and 61 patients respectively. Indications for antifungal drug administration were empiric therapy (80.1%) followed by targeted therapy (19.2%) and prophylaxis (0.7%). The indications were appropriate and inappropriate in 123 and 28 patients respectively. Selection of antifungals was appropriate in 117 patients, inappropriate in 16 patients, and was not assessable in other cases. The doses of antifungal medications were appropriate and inappropriate in 111 and 14 patients respectively. Among 151 patients, the duration of treatment was appropriate just in 33 cases. The techniques for antifungal administration were appropriate in 133 patients and inappropriate in 18 cases.
    Conclusions: Due to limited access to diagnostic tests, most parenteral antifungal medications were administered as empiric therapy. The diagnostic workups, treatment monitoring, and follow-up were inadequate in most patients. Development of local diagnostic and management protocols for invasive fungal infections and considering a stewardship program for antifungal medications are essential for each medical center.
    MeSH term(s) Humans ; Antifungal Agents/therapeutic use ; Cross-Sectional Studies ; Retrospective Studies ; Iran ; Mycoses/diagnosis ; Mycoses/drug therapy ; Hospitals, Teaching ; Referral and Consultation
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2023-03-31
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2394024-4
    ISSN 1972-2680 ; 2036-6590
    ISSN (online) 1972-2680
    ISSN 2036-6590
    DOI 10.3855/jidc.16828
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Ascorbic acid in septic shock.

    Khalili, Hossein

    Journal of research in pharmacy practice

    2016  Volume 5, Issue 4, Page(s) 301–302

    Language English
    Publishing date 2016-11-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2734861-1
    ISSN 2279-042X ; 2319-9644
    ISSN (online) 2279-042X
    ISSN 2319-9644
    DOI 10.4103/2279-042X.192452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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