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  1. Article ; Online: Which trial do we need? Comparison of 7 versus 14 days of antibiotic therapy for ventilator-associated pneumonia due to highly resistant gram-negative bacteria.

    Tleyjeh, Imad M

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 29, Issue 9, Page(s) 1114–1116

    MeSH term(s) Humans ; Pneumonia, Ventilator-Associated/drug therapy ; Pneumonia, Ventilator-Associated/microbiology ; Anti-Bacterial Agents/therapeutic use ; Gram-Negative Bacteria ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/microbiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.04.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4541: Show issues Location:
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    Zs.MO 284: Show issues

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  2. Article ; Online: The Misleading "Pooled Effect Estimate" of Crude Data from Observational Studies at Critical Risk of Bias: The Case of Tocilizumab in Coronavirus Disease 2019 (COVID-19).

    Tleyjeh, Imad M

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 72, Issue 12, Page(s) e1154–e1155

    MeSH term(s) Antibodies, Monoclonal, Humanized ; COVID-19/drug therapy ; Humans ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
    Keywords covid19
    Language English
    Publishing date 2020-11-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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  3. Article ; Online: Letter About: Risk Factors for Mortality in Patients with COVID-19 in New York City.

    Tleyjeh, Imad M / Kashour, Tarek

    Journal of general internal medicine

    2021  Volume 36, Issue 3, Page(s) 811–812

    MeSH term(s) COVID-19 ; Hospital Mortality ; Humans ; New York City/epidemiology ; Risk Factors ; SARS-CoV-2
    Language English
    Publishing date 2021-01-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-020-06369-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2205: Show issues Location:
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  4. Article ; Online: Perceived efficacy of hydroxychloroquine in observational studies: Results of the confounding effect of "goals of care".

    Tleyjeh, Prof Imad M / Tlayjeh, Haytham

    International journal of antimicrobial agents

    2021  Volume 57, Issue 4, Page(s) 106308

    MeSH term(s) COVID-19/drug therapy ; Coronavirus Infections ; Humans ; Hydroxychloroquine/therapeutic use ; SARS-CoV-2
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2021-02-17
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2021.106308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3368: Show issues Location:
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    Zs.MO 500: Show issues

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  5. Article ; Online: Which are the best coronavirus disease 2019 vaccines?

    Omrani, Ali S / Tleyjeh, Imad M

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2021  Volume 27, Issue 12, Page(s) 1729–1732

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Humans
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-08-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2021.08.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 284: Show issues

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  6. Article ; Online: Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis - Author's reply.

    Kashour, Tarek / Tleyjeh, Imad M

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2021  Volume 27, Issue 8, Page(s) 1177–1178

    MeSH term(s) Antibodies, Monoclonal, Humanized/adverse effects ; COVID-19/drug therapy ; Humans ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
    Language English
    Publishing date 2021-03-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2021.02.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 284: Show issues

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  8. Article ; Online: It is time to drop hydroxychloroquine from our COVID-19 armamentarium.

    Kashour, Tarek / Tleyjeh, Imad M

    Medical hypotheses

    2020  Volume 144, Page(s) 110198

    Abstract: Chloroquine (CQ) and hydroxychloroquine (HCQ) were among the first drugs repurposed for the treatment of SARS-CoV-2 infection. A few in vitro studies confirmed that both drugs exhibited dose dependent anti-SARS-CoV-2 activities. These observations and ... ...

    Abstract Chloroquine (CQ) and hydroxychloroquine (HCQ) were among the first drugs repurposed for the treatment of SARS-CoV-2 infection. A few in vitro studies confirmed that both drugs exhibited dose dependent anti-SARS-CoV-2 activities. These observations and the encouraging results from early poorly conducted observational studies created a major hype about the therapeutic potential of these drugs in the treatment of COVID-19 disease. This was further catalyzed by media and political influences leading to a widespread use of these agents. Subsequent randomized trials revealed lack of efficacy of these agents in improving the outcomes of COVID-19 or in preventing infection in post-exposure prophylaxis studies. Nevertheless, many ongoing trials continue to actively recruit tens of thousands of patients to receive HCQ worldwide. In this perspective, we address the possible mechanisms behind the lack of efficacy and the increased risk of cardiac toxicity of HCQ in COVID-19 disease. For the lack of efficacy, we discuss the fundamental differences of treatment initiation between in vitro and in vivo studies, the pitfalls of the pharmacological calculations of effective blood drug concentrations and related dosing regimens, and the possible negative effect of HCQ on the antiviral type-I interferon response. Although it has been repeatedly claimed that HCQ has a longstanding safety track record for many decades in use, we present counterarguments for this contention due to disease-drug and drug-drug interactions. We discuss the molecular mechanisms and the cumulative epidemiological evidence of HCQ cardiac toxicity.
    MeSH term(s) Animals ; Antiviral Agents ; Arrhythmias, Cardiac/chemically induced ; Arrhythmias, Cardiac/mortality ; Azithromycin/pharmacology ; Bradycardia/chemically induced ; Bradycardia/mortality ; Death, Sudden, Cardiac ; Drug Interactions ; Heart/drug effects ; Heart Failure/chemically induced ; Heart Failure/mortality ; Humans ; Hydroxychloroquine/adverse effects ; Hydroxychloroquine/therapeutic use ; Interferon Type I/metabolism ; Mice ; Observational Studies as Topic ; Randomized Controlled Trials as Topic ; Risk ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; Interferon Type I ; Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5)
    Language English
    Publishing date 2020-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1132: Show issues Location:
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  9. Article ; Online: It is time to drop hydroxychloroquine from our COVID-19 armamentarium

    Kashour, Tarek / Tleyjeh, Imad M.

    Medical Hypotheses

    2020  Volume 144, Page(s) 110198

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110198
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Overlooked Shortcomings of Observational Studies of Interventions in Coronavirus Disease 2019: An Illustrated Review for the Clinician.

    Tleyjeh, Imad M / Kashour, Tarek / Mandrekar, Jay / Petitti, Diana B

    Open forum infectious diseases

    2021  Volume 8, Issue 8, Page(s) ofab317

    Abstract: The rapid spread of severe acute respiratory syndrome coronavirus 2 infection across the globe triggered an unprecedented increase in research activities that resulted in an astronomical publication output of observational studies. However, most studies ... ...

    Abstract The rapid spread of severe acute respiratory syndrome coronavirus 2 infection across the globe triggered an unprecedented increase in research activities that resulted in an astronomical publication output of observational studies. However, most studies failed to apply fully the necessary methodological techniques that systematically deal with different biases and confounding, which not only limits their scientific merit but may result in harm through misleading information. In this article, we address a few important biases that can seriously threaten the validity of observational studies of coronavirus disease 2019 (COVID-19). We focus on treatment selection bias due to patients' preference on goals of care, medical futility and disability bias, survivor bias, competing risks, and the misuse of propensity score analysis. We attempt to raise awareness and to help readers assess shortcomings of observational studies of interventions in COVID-19.
    Language English
    Publishing date 2021-07-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofab317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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