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Article ; Online: Differential DNA methylation landscape of miRNAs genes in mice liver fibrosis.

Li, Deming / Yang, Wentong / Pang, Jiaojiao / Yu, Guoying

2024 Volume 51, Issue 1, Page(s) 475

Abstract: Background: Patients with chronic liver disease were found nearly all to have liver fibrosis, which is characterized by excess accumulation of extracellular matrix (ECM) proteins. While ECM accumulation can prevent liver infection and injury, it can ... ...

Abstract	Background: Patients with chronic liver disease were found nearly all to have liver fibrosis, which is characterized by excess accumulation of extracellular matrix (ECM) proteins. While ECM accumulation can prevent liver infection and injury, it can destroy normal liver function and architecture. miRNA's own regulation was involved in DNA methylation change. The purpose of this study is to detect DNA methylation landscape of miRNAs genes in mice liver fibrosis tissues. Methods: Male mice (10-12 weeks) were injected CCl Results: There are 769 differential methylation sites (DMS) in total between fibrotic liver tissue and normal mice liver tissue, which were related with 148 different miRNA genes. Chips array data were confirmed by bisulfite sequencing polymerase chain reaction (R = 0.953; P < 0.01). GO analysis of the target genes of 2 miRNA revealed that protein binding, cytoplasm and chromatin binding activity were commonly enriched; KEGG pathway enrichment analysis displayed that TGF-beta signaling pathway was commonly enriched. Conclusion: The DNA of 148 miRNA genes was found to have methylation change in liver fibrosis tissue. These discoveries in miRNA genes are beneficial to future miRNA function research in liver fibrosis.
MeSH term(s)	Humans ; Male ; Mice ; Animals ; DNA Methylation/genetics ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; DNA/metabolism ; Sulfites
Chemical Substances	hydrogen sulfite (OJ9787WBLU) ; MicroRNAs ; DNA (9007-49-2) ; Sulfites
Language	English
Publishing date	2024-03-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-024-09416-6
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Article ; Online: Metformin alleviates lung ischemia-reperfusion injury in a rat lung transplantation model.

Yu, Huizhi / Wang, Jing / Liu, Mingzhao / Hu, Chunlan / Sun, Jiaojiao / Xu, Bo / Lu, Shunmei / Huang, Dongxiao / Pang, Qingfeng / Hu, Chunxiao

Experimental lung research

2024 Volume 50, Issue 1, Page(s) 15–24

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Rats ; Animals ; Rats, Sprague-Dawley ; Rats, Inbred Lew ; Lung ; Lung Transplantation/adverse effects ; Reperfusion Injury/drug therapy ; Reperfusion Injury/prevention & control ; Lung Injury
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	603791-4
ISSN	1521-0499 ; 0190-2148
ISSN (online)	1521-0499
ISSN	0190-2148
DOI	10.1080/01902148.2023.2301615
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Zs.A 1568: Show issues

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Article ; Online: Risk of HBV reactivation in HCC patients undergoing combination therapy of PD-1 inhibitors and angiogenesis inhibitors in the antiviral era.

Wang, Rui / Tan, Guili / Lei, Dingjia / Li, Yadi / Gong, JiaoJiao / Tang, Yao / Pang, Hao / Luo, Huating / Qin, Bo

Journal of cancer research and clinical oncology

2024 Volume 150, Issue 3, Page(s) 158

Abstract: Background: Although routine antiviral therapy has been implemented in HCC patients, the risk of HBV reactivation (HBVr) remains with the use of programmed cell death-1(PD-1) blockade-based combination immunotherapy and the relevant risk factors are ... ...

Abstract	Background: Although routine antiviral therapy has been implemented in HCC patients, the risk of HBV reactivation (HBVr) remains with the use of programmed cell death-1(PD-1) blockade-based combination immunotherapy and the relevant risk factors are also unclear. Therefore, we aimed to identify the incidence and risk factors of HBVr in HCC patients undergoing combination therapy of PD-1 inhibitors and angiogenesis inhibitors and concurrent first-line antivirals. Methods: We included a total of 218 HBV-related HCC patients with first-line antivirals who received PD-1 inhibitors alone or together with angiogenesis inhibitors. According to the anti-tumor therapy modalities, patients were divided into PD-1 inhibitors monotherapy group (anti-PD-1 group) and combination therapy group (anti-PD-1 plus angiogenesis inhibitors group). The primary study endpoint was the incidence of HBVr. Results: HBVr occurred in 16 (7.3%) of the 218 patients, 2 cases were found in the anti-PD-1 group and the remaining 14 cases were in the combination group. The Cox proportional hazard model identified 2 independent risk factors for HBVr: combination therapy (hazard ratio [HR], 4.608, 95%CI 1.010-21.016, P = 0.048) and hepatitis B e antigen (HBeAg) positive (HR, 3.695, 95%CI 1.246-10.957, P = 0.018). Based on the above results, we developed a simple risk-scoring system and found that the high-risk group (score = 2) developed HBVr more frequently than the low-risk group (score = 0) (Odds ratio [OR], 17.000, 95%CI 1.946-148.526, P = 0.01). The area under the ROC curve (AUC-ROC) was 7.06 (95%CI 0.581-0.831, P = 0.006). Conclusion: HBeAg-positive patients receiving combination therapy have a 17-fold higher risk of HBVr than HBeAg-negative patients with PD-1 inhibitors monotherapy.
MeSH term(s)	Humans ; Hepatitis B virus ; Hepatitis B/drug therapy ; Immune Checkpoint Inhibitors/therapeutic use ; Carcinoma, Hepatocellular/drug therapy ; Angiogenesis Inhibitors/therapeutic use ; Hepatitis B e Antigens/pharmacology ; Hepatitis B e Antigens/therapeutic use ; Angiogenesis ; Liver Neoplasms/drug therapy ; Virus Activation ; Antiviral Agents/therapeutic use
Chemical Substances	Immune Checkpoint Inhibitors ; Angiogenesis Inhibitors ; Hepatitis B e Antigens ; Antiviral Agents
Language	English
Publishing date	2024-03-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-024-05677-7
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Article ; Online: Effects of Chest Compression on Ventilation Quality during Cardiopulmonary Resuscitation.

Ding, Bozhi / Pan, Chang / Pang, Jiaojiao / Wang, Jiali / Li, Ke / Xu, Feng / Chen, Yuguo

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2023 Volume 2023, Page(s) 1–4

Abstract: Ventilation is an important part of cardiopulmonary resuscitation (CPR). The advanced airway mode and 30:2 mode are used for intubated and non-intubated patients, respectively. It is debatable that passive produced by 30 compressions can provide adequate ...

Abstract	Ventilation is an important part of cardiopulmonary resuscitation (CPR). The advanced airway mode and 30:2 mode are used for intubated and non-intubated patients, respectively. It is debatable that passive produced by 30 compressions can provide adequate tidal volume for 30:2 mode. In addition, the fragmented ventilation caused by continuous compression may result in ineffective ventilation. In the study, one pig was anaesthetized and intubated for 2 CPRs. Continuous chest compressions with ventilation and continuous chest compressions without mechanical ventilation were performed in 2 CPRs, respectively. Three 10-minute data segments including a period of normal ventilation (V segment), a period of only compressions without ventilation (C segment), and a period of compressions with ventilation (C-V segment) were used to analyze peek flow (PF), peek pressure (PP) and tidal volume. All the data was presented as mean ± standard deviation. Chest compression resulted in 14.90% increase in mean PP (2401.40 ± 94.75 Pa vs 2822.06 ± 291.10 Pa, p<0.05), 81.46% increase in average PF (319.58 ± 56.93 ml/s vs 579.92 ± 80.27 ml/s, p<0.05). The mean tidal volumes for C segment, V segment and C-V segment were 189.13 ml, 514.72 ml, and 429.26ml, respectively. Continuous compressions reduced the accumulative tidal volume, but when five compressions were made in one inspiratory phase, there is almost no loss of tidal volume (510.86 ± 47.24 ml vs 514.72 ± 29.25 ml, p<0.05). The study suggested the ventilator without feedback regulation might reduce the peek pressure during CPR and 5 compressions in 2 s inspiratory phase provided higher tidal volume.Clinical Relevance- This study shows that 150 chest compressions per minute provided greater tidal volume than 100 and 120 compressions per minute; continuous chest compressions could also provide a certain amount of oxygen supply.
MeSH term(s)	Humans ; Animals ; Swine ; Cardiopulmonary Resuscitation ; Respiration, Artificial ; Ventilators, Mechanical ; Tidal Volume
Chemical Substances	polyetheretherketone (31694-16-3)
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC40787.2023.10340259
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Article ; Online: Fabrication and Biological Activities of All-in-One Composite Nanoemulsion Based on

Zhu, Yue / Chen, Teng / Feng, Tingting / Zhang, Jiaojiao / Meng, Zejing / Zhang, Ning / Luo, Gang / Wang, Zuhua / Pang, Yuxin / Zhou, Ying

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 15

Abstract: Nanoemulsion is a new multi-component drug delivery system; the selection of different oil phases can give it special physiological activity, and play the role of "medicine and pharmaceutical excipients all-in-one". In this paper, we used glycyrrhizic ... ...

Abstract	Nanoemulsion is a new multi-component drug delivery system; the selection of different oil phases can give it special physiological activity, and play the role of "medicine and pharmaceutical excipients all-in-one". In this paper, we used glycyrrhizic acid as the natural surfactant, and
MeSH term(s)	Rats ; Animals ; Tea Tree Oil/pharmacology ; Tea Tree Oil/chemistry ; Glycyrrhizic Acid/pharmacology ; Escherichia coli ; Drug Delivery Systems ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Emulsions/chemistry
Chemical Substances	Tea Tree Oil (68647-73-4) ; Glycyrrhizic Acid (6FO62043WK) ; Anti-Bacterial Agents ; Emulsions
Language	English
Publishing date	2023-08-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28155889
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Article ; Online: Palladium-Catalyzed Modular Assembly of P-Stereogenic and Axially Chiral Phosphinooxazoles (PHOX) Ligands by C-P Bond Cleavage/Intermolecular C(sp

Pang, Liangzhi / Wang, Chun / Ma, Congyue / Liu, Jiaojiao / Shi, Mengke / Yao, Chuanzhi / Yu, Jie / Li, Qiankun

Organic letters

2023 Volume 25, Issue 42, Page(s) 7705–7710

Abstract: Chiral P,N-ligands are of great interest and importance in the fields of metal-catalyzed enantioselective transformations and have found numerous applications spanning drug and polymer synthesis. Here, modular assembly of diverse P-stereogenic and ... ...

Abstract	Chiral P,N-ligands are of great interest and importance in the fields of metal-catalyzed enantioselective transformations and have found numerous applications spanning drug and polymer synthesis. Here, modular assembly of diverse P-stereogenic and axially chiral phosphinooxazoles ligands is achieved through palladium-catalyzed asymmetric cleavage of C-P bond/intermolecular C-H bond functionalization in high atroposelectivities and diastereoselectivities of up to >99% ee and >25:1 dr. This protocol features broad substrate scope and provides an avenue for facile construction of new P-stereogenic and axially chiral phosphinooxazoles ligands directly from the phosphonium salts and benzoxazoles/benzothiazoles. Evaluation of the synthesized P-stereogenic and axially chiral phosphinooxazoles ligands in two model catalytic asymmetric reactions illustrates the potential of our strategy to access valuable chiral molecules.
Language	English
Publishing date	2023-10-13
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.3c02998
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Article ; Online: Suppression effects of energy-absorbing materials on natural gas explosion in utility tunnels

Cao, Jiaojiao / Wu, Jiansong / Zhao, Yimeng / Cai, Jitao / Bai, Yiping / Pang, Lei

Energy. 2023 Oct., v. 281 p.128262-

2023

Abstract: The energy-absorbing material of metal foam have enormous potential in mitigating the consequences of natural gas explosion disaster in urban utility tunnels. When double-layer metal foam with different pore structures of first larger pores and then ... ...

Abstract	The energy-absorbing material of metal foam have enormous potential in mitigating the consequences of natural gas explosion disaster in urban utility tunnels. When double-layer metal foam with different pore structures of first larger pores and then smaller pores (LP-SP model), the suppression efficiency of explosion overpressure can reach more than 60% and is 2–3 times that of first smaller pores and then larger pores (SP-LP model), and the error between that and that of the same thickness all with smaller pore structure is only 0.86%. Similarly, the metal foams with the LP-SP model can block the explosion flame propagation chain entirely, while reversing the combination order weakens the suppression effect on the explosion flame. Two suppression mechanisms of double-layer metal foam, including the Sudden Shrinkage Effect (SSE) of the LP-SP model and the Amplification Effect (AE) of the SP-LP model. The metal foam barrier device based on SSE is designed for utility tunnels, which can take effect within 0.1 s under electromagnetic force and gravity. This study can provide scientific theoretical support for designing gas explosion suppression measures in utility tunnels.
Keywords	energy ; foams ; gravity ; models ; natural gas ; shrinkage ; Energy-absorbing material ; Metal foam ; Gas explosion ; Explosion suppression ; Utility tunnel
Language	English
Dates of publication	2023-10
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2023.128262
Database	NAL-Catalogue (AGRICOLA)

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Article: Colonization With Extensively Drug-Resistant

Zheng, Yue / Xu, Nana / Pang, Jiaojiao / Han, Hui / Yang, Hongna / Qin, Weidong / Zhang, Hui / Li, Wei / Wang, Hao / Chen, Yuguo

Frontiers in medicine

2021 Volume 8, Page(s) 667776

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-04-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.667776
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Article ; Online: Electrical-mechanical dynamical coupling between electrocardiographic and photoplethysmographic signals during cardiopulmonary resuscitation.

Chen, Shuxin / Jiang, Lijun / Xu, Feng / Pang, Jiaojiao / Pan, Chang / Chen, Yuguo / Wang, Jiali / Li, Ke

Computer methods and programs in biomedicine

2023 Volume 242, Page(s) 107809

Abstract: Background and objective: Cardiac arrest (CA) remains a significant cause of death and disability. High-quality cardiopulmonary resuscitation (CPR) can improve the survival rate of CA. A challenging issue is to find physiological indicators for ... ...

Abstract	Background and objective: Cardiac arrest (CA) remains a significant cause of death and disability. High-quality cardiopulmonary resuscitation (CPR) can improve the survival rate of CA. A challenging issue is to find physiological indicators for screening and evaluating the cardiovascular function associated with CPR. This study aimed to investigate the electrical-mechanical dynamic coupling between electrocardiographic (ECG) and photoplethysmographic (PPG) signals for indicating cardiovascular function in the progress of CPR. Method: The ECG and PPG signals were simultaneously collected from a porcine CA model (n = 10) induced by ventricular fibrillation, and were further divided into four periods: Baseline, CA, CPR, and recovery of spontaneous circulation (ROSC). Recurrence quantitative analysis (RQA) was applied to examine the nonlinear dynamics of the ECG and PPG signals individually, and cross recurrence quantitative analysis (CRQA) was used to examine the ECG-PPG dynamical coupling. Results: The CA influenced the dynamic patterns of electrical and mechanical activities and the electrical-mechanical coupling, which can be observed from the reduced entropy (ENTR) (p < 0.01), reduced determinism (DET) (p < 0.01) and reduced trapping time (TT) (p < 0.01) at CA compared to Baseline. The recurrence rate (RR), ENTR, DET, and TT at CPR were significantly lower than the parameters at ROSC but higher than those at CA. Conclusions: The electrical-mechanical dynamical coupling was sensitive to CPR and able to reflect the changes in cardiac function in the process of CPR.
MeSH term(s)	Animals ; Swine ; Cardiopulmonary Resuscitation ; Heart Arrest/therapy ; Heart Arrest/diagnosis ; Ventricular Fibrillation/diagnosis ; Ventricular Fibrillation/therapy ; Electrocardiography ; Survival Rate
Language	English
Publishing date	2023-09-23
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632564-6
ISSN	1872-7565 ; 0169-2607
ISSN (online)	1872-7565
ISSN	0169-2607
DOI	10.1016/j.cmpb.2023.107809
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Zs.B 521: Show issues

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Article ; Online: SUPER Score Contributes to Warning and Management in Early-Stage COVID-19.

Bian, Yuan / Han, Qi / Zheng, Yue / Yao, Yu / Fan, Xinhui / Lv, Ruijuan / Pang, Jiaojiao / Xu, Feng / Chen, Yuguo

Infectious medicine

2023 Volume 2, Issue 4, Page(s) 308–314

Abstract: Background: Some COVID-19 patients deteriorate to severe cases with relatively higher case-fatality rates, which increases the medical burden. This necessitates identification of patients at risk of severe disease. Early assessment plays a crucial role ... ...

Abstract	Background: Some COVID-19 patients deteriorate to severe cases with relatively higher case-fatality rates, which increases the medical burden. This necessitates identification of patients at risk of severe disease. Early assessment plays a crucial role in identifying patients at risk of severe disease. This study is to assess the effectiveness of SUPER score as a predictor of severe COVID-19 cases. Methods: We consecutively enrolled COVID-19 patients admitted to a comprehensive medical center in Wuhan, China, and recorded clinical characteristics and laboratory indexes. The SUPER score was calculated using parameters including oxygen saturation, urine volume, pulse, emotional state, and respiratory rate. In addition, the area under the receiver operating characteristic curve (AUC), specificity, and sensitivity of the SUPER score for the diagnosis of severe COVID-19 were calculated and compared with the National Early Warning Score 2 (NEWS2). Results: The SUPER score at admission, with a threshold of 4, exhibited good predictive performance for early identification of severe COVID-19 cases, yielding an AUC of 0.985 (95% confidence interval [CI] 0.897-1.000), sensitivity of 1.00 (95% CI 0.715-1.000), and specificity of 0.92 (95% CI 0.775-0.982), similar to NEWS2 (AUC 0.984; 95% CI 0.895-1.000, sensitivity 0.91; 95% CI 0.587-0.998, specificity 0.97; 95% CI 0.858-0.999). Compared with patients with a SUPER score<4, patients in the high-risk group exhibited lower lymphocyte counts, interleukin-2, interleukin-4 and higher fibrinogen, C-reactive protein, aspartate aminotransferase, and lactate dehydrogenase levels. Conclusions: In conclusion, the SUPER score demonstrated equivalent accuracy to the NEWS2 score in predicting severe COVID-19. Its application in prognostic assessment therefore offers an effective early warning system for critical management and facilitating efficient allocation of health resources.
Language	English
Publishing date	2023-10-19
Publishing country	China
Document type	Journal Article
ISSN	2772-431X
ISSN (online)	2772-431X
DOI	10.1016/j.imj.2023.09.003
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