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  1. Book ; Online: Therapeutic Modulation of the Complement System: Clinical Indications and Emerging Drug Leads

    Lambris, John D. / Mastellos, Dimitrios C. / Reis, Edimara S.

    2020  

    Keywords Medicine ; Immunology ; complement system ; clinical trials ; therapeutics ; diseases ; drug candidates
    Size 1 electronic resource (185 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230739
    ISBN 9782889634705 ; 2889634701
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Recent developments in C3-targeted complement therapeutics.

    Mastellos, Dimitrios C / Lambris, John D

    Seminars in immunology

    2022  , Page(s) 101645

    Language English
    Publishing date 2022-07-29
    Publishing country England
    Document type Editorial
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2022.101645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A guide to complement biology, pathology and therapeutic opportunity.

    Mastellos, Dimitrios C / Hajishengallis, George / Lambris, John D

    Nature reviews. Immunology

    2023  Volume 24, Issue 2, Page(s) 118–141

    Abstract: Complement has long been considered a key innate immune effector system that mediates host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader involvement of complement in fundamental biological processes extending far beyond ... ...

    Abstract Complement has long been considered a key innate immune effector system that mediates host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader involvement of complement in fundamental biological processes extending far beyond its traditional realm in innate immunity. Complement engages in intricate crosstalk with multiple pattern-recognition and signalling pathways both in the extracellular and intracellular space. Besides modulating host-pathogen interactions, this crosstalk guides early developmental processes and distinct cell trajectories, shaping tissue immunometabolic and regenerative programmes in different physiological systems. This Review provides a guide to the system-wide functions of complement. It highlights illustrative paradigm shifts that have reshaped our understanding of complement pathobiology, drawing examples from evolution, development of the central nervous system, tissue regeneration and cancer immunity. Despite its tight spatiotemporal regulation, complement activation can be derailed, fuelling inflammatory tissue pathology. The pervasive contribution of complement to disease pathophysiology has inspired a resurgence of complement therapeutics with major clinical developments, some of which have challenged long-held dogmas. We thus highlight major therapeutic concepts and milestones in clinical complement intervention.
    MeSH term(s) Humans ; Complement System Proteins ; Immunity, Innate ; Complement Activation ; Biological Phenomena ; Biology
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2023-09-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-023-00926-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Response to "Comment on Mastellos and colleagues and efficacy of complement-targeting drugs in COVID-19".

    Mastellos, Dimitrios C / Lambris, John D

    Clinical immunology (Orlando, Fla.)

    2020  Volume 222, Page(s) 108617

    MeSH term(s) COVID-19 ; Complement C3 ; Humans ; Pharmaceutical Preparations ; SARS-CoV-2
    Chemical Substances Complement C3 ; Pharmaceutical Preparations
    Keywords covid19
    Language English
    Publishing date 2020-10-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2020.108617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Is complement the culprit behind COVID-19 vaccine-related adverse reactions?

    Mastellos, Dimitrios C / Skendros, Panagiotis / Lambris, John D

    The Journal of clinical investigation

    2021  Volume 131, Issue 11

    MeSH term(s) COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/therapeutic use ; Complement Activation/drug effects ; Complement Activation/immunology ; Complement System Proteins/immunology ; Humans ; SARS-CoV-2/immunology
    Chemical Substances COVID-19 Vaccines ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2021-05-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI151092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Compstatins: the dawn of clinical C3-targeted complement inhibition.

    Lamers, Christina / Mastellos, Dimitrios C / Ricklin, Daniel / Lambris, John D

    Trends in pharmacological sciences

    2022  Volume 43, Issue 8, Page(s) 629–640

    Abstract: Despite the growing recognition of the complement system as a major contributor to a variety of clinical conditions, the therapeutic arsenal has remained scarce. The introduction of an anti-C5 antibody in 2007 raised confidence in complement-targeted ... ...

    Abstract Despite the growing recognition of the complement system as a major contributor to a variety of clinical conditions, the therapeutic arsenal has remained scarce. The introduction of an anti-C5 antibody in 2007 raised confidence in complement-targeted therapy. However, it became apparent that inhibition of late-stage effector generation might not be sufficient in multifactorial complement disorders. Upstream intervention at the level of C3 activation has therefore been considered promising. The approval of pegcetacoplan, a C3 inhibitor of the compstatin family, in 2021 served as critical validation of C3-targeted treatment. This review delineates the evolution of the compstatin family from its academic origins to the clinic and highlights current and potential future applications of this promising drug class in complement diseases.
    MeSH term(s) Antibodies, Monoclonal, Humanized/pharmacology ; Complement C3/therapeutic use ; Complement System Proteins ; Hemoglobinuria, Paroxysmal/drug therapy ; Hemolysis ; Humans ; Peptides, Cyclic
    Chemical Substances Antibodies, Monoclonal, Humanized ; Complement C3 ; Peptides, Cyclic ; compstatin ; Complement System Proteins (9007-36-7) ; pegcetacoplan (TO3JYR3BOU)
    Language English
    Publishing date 2022-01-25
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2022.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Emerging opportunities for C3 inhibition in the eye.

    Kim, Benjamin J / Liu, Tianyu / Mastellos, Dimitrios C / Lambris, John D

    Seminars in immunology

    2022  , Page(s) 101633

    Abstract: The eye presents a unique opportunity for complement component 3 (C3) therapeutics. Drugs can be delivered directly to specific parts of the eye, and growing evidence has established a pivotal role for C3 in age-related macular degeneration (AMD). ... ...

    Abstract The eye presents a unique opportunity for complement component 3 (C3) therapeutics. Drugs can be delivered directly to specific parts of the eye, and growing evidence has established a pivotal role for C3 in age-related macular degeneration (AMD). Emerging data show that C3 may be important to the pathophysiology of other eye diseases as well. This article will discuss the location of C3 expression in the eye as well as the preclinical and clinical data regarding C3's functions in AMD. We will provide a comprehensive review of developing C3 inhibitors for the eye, including the Phase 2 and 3 data for the C3 inhibitor pegcetacoplan as a treatment for the geographic atrophy of AMD. Developing evidence also points toward C3 as a therapeutic target for stages of AMD preceding geographic atrophy. We will also discuss data illuminating C3's relationship to other eye diseases, such as Stargardt disease, diabetic retinopathy, and glaucoma. In addition to being a converging point and centerpiece of the complement cascade, C3 has broad effects as a multifaceted controller of opsonophagocytosis, microglia/macrophage recruitment, and downstream terminal pathway activity. C3 is a crucial player in the pathophysiology of AMD but also seems to have importance in other diseases that are major causes of blindness. Directions for further investigation will be highlighted, as culminating evidence suggests that we may be approaching an era of C3 therapeutics for the eye.
    Language English
    Publishing date 2022-07-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2022.101633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Response to “Comment on Mastellos and colleagues and efficacy of complement-targeting drugs in COVID-19”

    Mastellos, Dimitrios C. / Lambris, John D.

    Clinical Immunology

    2020  , Page(s) 108617

    Keywords Immunology ; Immunology and Allergy ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2020.108617
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Editorial: Therapeutic Modulation of the Complement System: Clinical Indications and Emerging Drug Leads.

    Mastellos, Dimitrios C / Reis, Edimara S / Lambris, John D

    Frontiers in immunology

    2020  Volume 10, Page(s) 3029

    MeSH term(s) Complement Activation/immunology ; Complement System Proteins/immunology ; Humans ; Immunity, Humoral/immunology ; Immunity, Innate/immunology ; Inflammation/immunology
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2020-01-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.03029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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