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  1. Article ; Online: Recyclable gold(I)-catalyzed heterocyclization of ynamides with benzyl or indolyl azides towards 2-aminoindoles or 3-amino-β-carbolines.

    Wei, Li / Xiao, Xiaoqiang / Cai, Mingzhong

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 43, Page(s) 8757–8766

    Abstract: A highly efficient heterogeneous gold(I)-catalyzed heterocyclization of ynamides with benzyl or indolyl azides has been achieved in 1,2-dichloroethane under mild ... ...

    Abstract A highly efficient heterogeneous gold(I)-catalyzed heterocyclization of ynamides with benzyl or indolyl azides has been achieved in 1,2-dichloroethane under mild conditions
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob01555f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases.

    Xiao, Tengfei / Sun, Mingzhong / Zhao, Chuanxiang / Kang, Jingjing

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1037925

    Abstract: TRPV1 is a non-selective channel receptor widely expressed in skin tissues, including keratinocytes, peripheral sensory nerve fibers and immune cells. It is activated by a variety of exogenous or endogenous inflammatory mediators, triggering neuropeptide ...

    Abstract TRPV1 is a non-selective channel receptor widely expressed in skin tissues, including keratinocytes, peripheral sensory nerve fibers and immune cells. It is activated by a variety of exogenous or endogenous inflammatory mediators, triggering neuropeptide release and neurogenic inflammatory response. Previous studies have shown that TRPV1 is closely related to the occurrence and/or development of skin aging and various chronic inflammatory skin diseases, such as psoriasis, atopic dermatitis, rosacea, herpes zoster, allergic contact dermatitis and prurigo nodularis. This review summarizes the structure of the TRPV1 channel and discusses the expression of TRPV1 in the skin as well as its role of TRPV1 in skin aging and inflammatory skin diseases.
    Language English
    Publishing date 2023-02-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1037925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Percutaneous kyphoplasty combined with pediculoplasty for the surgical treatment of osteoporotic thoracolumbar burst fractures.

    Xiao, Changming / Wang, Haozhong / Lei, Yang / Xie, Mingzhong / Li, Sen

    Journal of orthopaedic surgery and research

    2024  Volume 19, Issue 1, Page(s) 87

    Abstract: Objective: This study introduces a minimally invasive technique for efficient three-column reconstruction, augmentation, and stabilization of osteoporotic thoracolumbar burst fractures (OTLBFs).: Methods: Sixty-eight patients with OTLBFs and no ... ...

    Abstract Objective: This study introduces a minimally invasive technique for efficient three-column reconstruction, augmentation, and stabilization of osteoporotic thoracolumbar burst fractures (OTLBFs).
    Methods: Sixty-eight patients with OTLBFs and no neurological deficits were included from July 2019 to September 2020. The patients were divided into two groups: the simple percutaneous kyphoplasty (PKP) group (n = 32) and the percutaneous kyphoplasty combined with pediculoplasty (PKCPP) group (n = 36). The clinical and radiological outcomes were assessed during a minimum 1-year follow-up period. Clinical outcomes were assessed via the visual analog scale (VAS) and modified MacNab grading criteria. The radiological outcomes included the Cobb angle (CA), anterior wall height (AWH), and posterior wall height (PWH). The surgery duration, postoperative analgesic dosage, length of hospital stay, and complications were recorded.
    Results: Surgery duration was not significantly different between the two groups (P > 0.05). The PKCPP group had a lower analgesic dosage and shorter hospital stay (P < 0.05). Postoperatively, the PKCPP group exhibited better VAS scores and modified MacNab scale scores (P < 0.05), but the differences at the last follow-up assessment were not significant (P > 0.05). Postoperative CA, AWH, and PWH correction were not significantly different on the first postoperative day (P > 0.05). However, the PKCPP group had significantly less CA and PWH loss of correction at the last follow-up visit (P < 0.05). The PKCPP group had significantly fewer complications (P < 0.05).
    Conclusions: The PKCPP technique complements simple PKP for OTLBFs. It quickly relieves pain, maintains the vertebral body height and Cobb angle, ensures cement stabilization, and offers more stable three-column support.
    MeSH term(s) Humans ; Kyphoplasty ; Spine ; Body Height ; Bone Cements/therapeutic use ; Osteoporotic Fractures/diagnostic imaging ; Osteoporotic Fractures/surgery ; Analgesics
    Chemical Substances Bone Cements ; Analgesics
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2252548-8
    ISSN 1749-799X ; 1749-799X
    ISSN (online) 1749-799X
    ISSN 1749-799X
    DOI 10.1186/s13018-024-04562-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Transient Receptor Potential Vanilloid1 (TRPV1) Channel Opens Sesame of T Cell Responses and T Cell-Mediated Inflammatory Diseases.

    Xiao, Tengfei / Sun, Mingzhong / Kang, Jingjing / Zhao, Chuanxiang

    Frontiers in immunology

    2022  Volume 13, Page(s) 870952

    Abstract: Transient receptor potential vanilloid1 (TRPV1) was primarily expressed in sensory neurons, and could be activated by various physical and chemical factors, resulting in the flow of extracellular ... ...

    Abstract Transient receptor potential vanilloid1 (TRPV1) was primarily expressed in sensory neurons, and could be activated by various physical and chemical factors, resulting in the flow of extracellular Ca
    MeSH term(s) Sensory Receptor Cells ; Sesamum ; T-Lymphocytes ; TRPV Cation Channels ; Transient Receptor Potential Channels
    Chemical Substances TRPV Cation Channels ; Transient Receptor Potential Channels
    Language English
    Publishing date 2022-05-11
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.870952
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  5. Article ; Online: Recyclable Gold Catalyst for the Stereoselective Thioallylation of Alkynes.

    Hu, Wenli / Niu, Bingbo / Xiao, Xiaoqiang / Cai, Mingzhong

    The Journal of organic chemistry

    2021  Volume 86, Issue 19, Page(s) 13598–13609

    Abstract: The heterogeneous gold(I)-catalyzed stereoselective thioallylation of electron-deficient alkynes with allyl sulfides has been achieved by using an MCM-41-immobilized sterically demanding NHC-gold(I) complex [MCM-41- ... ...

    Abstract The heterogeneous gold(I)-catalyzed stereoselective thioallylation of electron-deficient alkynes with allyl sulfides has been achieved by using an MCM-41-immobilized sterically demanding NHC-gold(I) complex [MCM-41-IPrAuNTf
    MeSH term(s) Alkynes ; Catalysis ; Gold
    Chemical Substances Alkynes ; Gold (7440-57-5)
    Language English
    Publishing date 2021-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.1c01641
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    Zs.A 4473: Show issues Location:
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  6. Article: Source of Evaporation for the Seasonal Precipitation in the Pearl River Delta, China

    Xiao, Mingzhong / Cui, Yuanzheng

    Water resources research. 2021 Aug., v. 57, no. 8

    2021  

    Abstract: The changes in the occurrence and intensity of precipitation have been widely observed around the world. However, exploring the causes of changes in precipitation remains challenging. To better explore the causes of precipitation changes, the evaporation ...

    Abstract The changes in the occurrence and intensity of precipitation have been widely observed around the world. However, exploring the causes of changes in precipitation remains challenging. To better explore the causes of precipitation changes, the evaporation sources of such precipitation were identified. The region from which evaporative sources contribute to precipitation in a sink region is called the precipitationshed. Based on the ERA5 reanalysis data, we identified the seasonal precipitationshed in the Pearl River Delta (PRD), one of the most densely urbanized regions in the world, using the Water Accounting Model‐2layer. The precipitationshed in the PRD has larger variation in summer and autumn, and differences in the responses of different types of precipitation to the change in the precipitationshed were identified. In autumn, results show that light precipitation increases when the evaporation contribution from the south is enhanced while heavy precipitation increases when the evaporation contribution from the northeast is enhanced in the PRD. The precipitationshed is influenced by natural climate variability. The identified differences in the response of different types of precipitation to the change in the precipitationshed further help us to better understand the influence of natural climate variability on precipitation. The influences of El Niño Southern Oscillation (ENSO), Indian Ocean Dipole (IOD), and North Atlantic Oscillation on different types of seasonal precipitation were investigated. For example, results show that more heavy precipitation is expected in the PRD in summer when the positive phase of IOD and the negative phase of ENSO occur simultaneously.
    Keywords El Nino ; North Atlantic Oscillation ; autumn ; climate ; evaporation ; research ; river deltas ; rivers ; summer ; urbanization ; water ; Indian Ocean
    Language English
    Dates of publication 2021-08
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 5564-5
    ISSN 1944-7973 ; 0043-1397
    ISSN (online) 1944-7973
    ISSN 0043-1397
    DOI 10.1029/2020WR028564
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    Z 4285: Show issues

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  7. Article ; Online: Interspecies interactions of non-O1/O139 Vibrio cholerae and Salmonella typhimurium: a rare coinfection case report.

    Yan, Dongmei / Sun, Mingzhong / Xiao, Lihua / Chen, Hongmei / Zhang, Qisi / Zhi, Yaru / Fu, Qingping

    Diagnostic microbiology and infectious disease

    2023  Volume 107, Issue 3, Page(s) 116049

    Abstract: Infectious diseases are commonly demonstrated to be caused by polymicrobial infections, which correlate with increased infection severity and poorer clinical outcomes. In this study, we report a rare intestinal coinfection case of non-O1/O139 Vibrio ... ...

    Abstract Infectious diseases are commonly demonstrated to be caused by polymicrobial infections, which correlate with increased infection severity and poorer clinical outcomes. In this study, we report a rare intestinal coinfection case of non-O1/O139 Vibrio cholerae and Salmonella typhimurium, along with V. cholerae septicemia. The data of quantitative real-time PCR and competition assay showed that V. cholerae may present enhanced virulence in the presence of S. typhimurium, and exerted an inhibitory growth effect over S. typhimurium in vitro.
    MeSH term(s) Humans ; Coinfection/diagnosis ; Salmonella typhimurium ; Vibrio cholerae non-O1/genetics ; Virulence ; Real-Time Polymerase Chain Reaction ; Cholera/diagnosis
    Language English
    Publishing date 2023-08-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2023.116049
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    Zs.A 1845: Show issues Location:
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  8. Article ; Online: Butyrate ameliorates colorectal cancer through regulating intestinal microecological disorders.

    Kang, Jingjing / Sun, Mingzhong / Chang, Yi / Chen, Hongmei / Zhang, Juan / Liang, Xiaodong / Xiao, Tengfei

    Anti-cancer drugs

    2023  Volume 34, Issue 2, Page(s) 227–237

    Abstract: The occurrence and progression of colorectal cancer (CRC) are closely related to intestinal microecological disorders. Butyrate, the representative of short chain fatty acids, possess anti-inflammatory and antioxidant effects, and its antitumor effect ... ...

    Abstract The occurrence and progression of colorectal cancer (CRC) are closely related to intestinal microecological disorders. Butyrate, the representative of short chain fatty acids, possess anti-inflammatory and antioxidant effects, and its antitumor effect has been gradually paid attention to. In this study, azoxymethane/dextran sodium sulfate induced mouse CRC model was used to explore the role and mechanism of butyrate in regulating colon cancer and its intestinal microecological balance. Outcomes exhibited that butyrate alleviated weight loss, disease activity index, and survival in CRC mice and inhibited tumor number and progression. Further research revealed that butyrate restrained the aggregation of harmful while promoting the colonization of beneficial flora, such as Actinobacteriota, Bifidobacteriales and Muribaculacea through 16S rDNA sequence analysis. This study confirmed that butyrate can ameliorate CRC by repairing intestinal microecology, providing ideas and evidence for chemical prophylactic agents, such as butyrate to remedy tumors and regulate tumor microbiota.
    MeSH term(s) Mice ; Animals ; Butyrates/adverse effects ; Colonic Neoplasms ; Disease Models, Animal ; Azoxymethane/adverse effects ; Dextran Sulfate/adverse effects ; Mice, Inbred C57BL ; Colorectal Neoplasms/pathology
    Chemical Substances Butyrates ; Azoxymethane (MO0N1J0SEN) ; Dextran Sulfate (9042-14-2)
    Language English
    Publishing date 2023-10-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1065301-6
    ISSN 1473-5741 ; 0959-4973
    ISSN (online) 1473-5741
    ISSN 0959-4973
    DOI 10.1097/CAD.0000000000001413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3125: Show issues Location:
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  9. Article: Recyclable Gold Catalyst for the Stereoselective Thioallylation of Alkynes

    Hu, Wenli / Niu, Bingbo / Xiao, Xiaoqiang / Cai, Mingzhong

    Journal of organic chemistry. 2021 Sept. 22, v. 86, no. 19

    2021  

    Abstract: The heterogeneous gold(I)-catalyzed stereoselective thioallylation of electron-deficient alkynes with allyl sulfides has been achieved by using an MCM-41-immobilized sterically demanding NHC-gold(I) complex [MCM-41-IPrAuNTf₂] as the catalyst under mild ... ...

    Abstract The heterogeneous gold(I)-catalyzed stereoselective thioallylation of electron-deficient alkynes with allyl sulfides has been achieved by using an MCM-41-immobilized sterically demanding NHC-gold(I) complex [MCM-41-IPrAuNTf₂] as the catalyst under mild conditions, delivering a wide variety of stereodefined tri- and tetrasubstituted functionalized vinyl sulfides in good to excellent yields. The new heterogeneous MCM-41-IPrAuNTf₂ catalyst exhibits an activity comparable to a homogeneous IPrAuNTf₂ complex and can be recovered via a simple filtration process and reused for at least seven consecutive cycles without any apparent loss of its catalytic activity and selectivity.
    Keywords alkynes ; catalysts ; catalytic activity ; filtration ; gold ; organic chemistry ; stereoselectivity
    Language English
    Dates of publication 2021-0922
    Size p. 13598-13609.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.1c01641
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  10. Article ; Online: Dynamic changes in permafrost distribution over China and their potential influencing factors under climate warming.

    Gao, Xin / Lin, Kairong / Liu, Meixian / Dong, Chunyu / Yao, Zeyu / Liu, Zhiyong / Xiao, Mingzhong / Xie, Xue / Huang, Liyan

    The Science of the total environment

    2023  Volume 874, Page(s) 162624

    Abstract: As a major component of the cryosphere, permafrost plays important roles in the climate system and land surface processes of the Earth. Owing to the rapidly warming climate, permafrost over the globe has degraded in recent decades. However, quantifying ... ...

    Abstract As a major component of the cryosphere, permafrost plays important roles in the climate system and land surface processes of the Earth. Owing to the rapidly warming climate, permafrost over the globe has degraded in recent decades. However, quantifying the distribution and temporal changes in permafrost is challenging. In this study, we modified the widely used surface frost number model by considering the spatial distribution of soil hydrothermal properties and then revisited the spatiotemporal patterns of permafrost distribution and its changes during the past decades (1961-2017) in China. We found that the modified surface frost number model performs well in simulating permafrost extent in China, with the overall accuracy and kappa coefficients being 0.92 and 0.78 in the calibration (1980s) and 0.94 and 0.77 in the validation period (2000s). Based on the modified model, we also found that permafrost extent in China demonstrated a significant decreasing trend over the past decades, especially on the Qinghai-Tibet Plateau (QTP), with a trend of -1.15 × 10
    Language English
    Publishing date 2023-03-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.162624
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