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Article ; Online: Comparative Efficacy and Safety of Radiofrequency Ablation and Microwave Ablation in the Treatment of Benign Thyroid Nodules: A Systematic Review and Meta-Analysis.

Zufry, Hendra / Hariyanto, Timotius Ivan

2024 Volume 25, Issue 3, Page(s) 301–313

Abstract: Objective: The current body of evidence lacks clarity regarding the comparative efficacy and safety of radiofrequency ablation (RFA) and microwave ablation (MWA) as minimally invasive treatments for benign thyroid nodules. The primary objective of this ... ...

Abstract	Objective: The current body of evidence lacks clarity regarding the comparative efficacy and safety of radiofrequency ablation (RFA) and microwave ablation (MWA) as minimally invasive treatments for benign thyroid nodules. The primary objective of this study is to clarify these concerns. Materials and methods: A comprehensive search was conducted using the Cochrane Library, Scopus, Europe PMC, and Medline databases until October 10th, 2023, using a combination of relevant keywords. This study incorporated literature that compared RFA and MWA for benign thyroid nodules. The primary outcome was the volume reduction ratio (VRR) from baseline to follow-up. Secondary outcomes were symptom score, cosmetic score, ablation time, major complications rate, hemorrhage, hoarseness, skin burn, cough, and sympathetic nerve injury. We used Risk of Bias in Non-randomized Studies - of Interventions (ROBINS-I) tool to assess the risk of bias in the included studies. We employed random effects models to analyze the standardized mean difference (SMD) and odds ratio for the presentation of outcomes. Results: Nine studies with 2707 nodules were included. The results of our meta-analysis indicated similar efficacy between RFA and MWA in terms of VRR during the 1 (SMD 0.06; 95% confidence interval [CI]: -0.13 to 0.26; Conclusion: RFA showed a higher VRR than MWA at 6 and 12-month follow-ups, with a comparable safety profile.
MeSH term(s)	Humans ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/surgery ; Microwaves/therapeutic use ; Hoarseness/surgery ; Radiofrequency Ablation/methods ; Cough/surgery ; Hemorrhage ; Burns/surgery ; Treatment Outcome ; Retrospective Studies
Language	English
Publishing date	2024-02-25
Publishing country	Korea (South)
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2046981-0
ISSN	2005-8330 ; 1229-6929
ISSN (online)	2005-8330
ISSN	1229-6929
DOI	10.3348/kjr.2023.1004
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Zs.A 5591: Show issues

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Article: Risk of Dementia in Patients with Diabetes Using Sodium-Glucose Transporter 2 Inhibitors (SGLT2i): A Systematic Review, Meta-Analysis, and Meta-Regression.

Gunawan, Pricilla Yani / Gunawan, Paskalis Andrew / Hariyanto, Timotius Ivan

Diabetes therapy : research, treatment and education of diabetes and related disorders

2024 Volume 15, Issue 3, Page(s) 663–675

Abstract: Introduction: Dementia is quite prevalent and among the leading causes of death worldwide. According to earlier research, diabetes may increase the possibility of developing dementia. However, the association between antidiabetic agents and dementia is ... ...

Abstract	Introduction: Dementia is quite prevalent and among the leading causes of death worldwide. According to earlier research, diabetes may increase the possibility of developing dementia. However, the association between antidiabetic agents and dementia is not yet clear. This investigation examines the association between the use of sodium-glucose transporter 2 inhibitors (SGLT2i) and the risk of dementia in patients with diabetes. Methods: Up to April 18, 2023, four databases-Europe PMC, Medline, Scopus, and Cochrane Library-were searched for relevant literature. We included all studies that examine dementia risk in adults with diabetes who use SGLT2i. Random-effect models were used to compute the outcomes in this investigation, producing pooled odds ratios (OR) with 95% confidence intervals (CI). Results: Pooled data from seven observational studies revealed that SGLT2i use was linked to a lower risk of dementia in people with diabetes (OR 0.45, 95% CI 0.34-0.61; p < 0.00001, I Conclusions: According to this research, taking SGLT2i reduces the incidence of dementia in people with diabetes by having a beneficial neuroprotective impact. Randomized controlled trials (RCTs) are still required in order to verify the findings of our research.
Language	English
Publishing date	2024-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2566702-6
ISSN	1869-6961 ; 1869-6953
ISSN (online)	1869-6961
ISSN	1869-6953
DOI	10.1007/s13300-024-01538-1
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Article: Editorial: Dyslipidemia, obesity and coronavirus disease 2019 (COVID-19).

Hariyanto, Timotius Ivan / Kurniawan, Andree / Tahapary, Dicky Levenus

Frontiers in nutrition

2022 Volume 9, Page(s) 1019970

Language	English
Publishing date	2022-11-23
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.1019970
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Article ; Online: The role of nutrition-based index in predicting survival of breast cancer patients

Patricia Diana Prasetiyo / Bernard Agung Baskoro / Timotius Ivan Hariyanto

Heliyon, Vol 10, Iss 1, Pp e23541- (2024)

A systematic review and meta-analysis

1481

Abstract: Background: Prognostic nutritional index (PNI) and Controlling Nutritional Status (CONUT) are two model that incorporates the role of inflammation and nutrition factors to predict the progression of tumor. The primary objective of this investigation is ... ...

Abstract	Background: Prognostic nutritional index (PNI) and Controlling Nutritional Status (CONUT) are two model that incorporates the role of inflammation and nutrition factors to predict the progression of tumor. The primary objective of this investigation is to examine the ability of PNI and CONUT score for predicting the survival in breast cancer patients. Methods: A comprehensive search was conducted on the Cochrane Library, Scopus, Europe PMC, and Medline databases up until August 14th, 2023, utilizing a combination of relevant keywords. This review incorporates literature that examines the relationship between PNI, CONUT, and survival in breast cancer. We employed random-effect models to analyze the hazard ratio (HR) and present the outcomes together with their corresponding 95 % confidence intervals (CI). Results: A total of sixteen studies were incorporated. The results of our meta-analysis indicated that high PNI was associated with better overall survival (OS) (HR 0.38; 95%CI: 0.28–0.51, p < 0.00001, I2 = 32 %), but not disease-free survival (DFS) (HR 0.60; 95%CI: 0.33–1.10, p = 0.10, I2 = 78 %) than low PNI in breast cancer patients. Meta-analysis also indicated that high CONUT was associated with worse OS (HR 1.66; 95%CI: 1.21–2.28, p = 0.002, I2 = 78 %) and worse DFS (HR 2.09; 95%CI: 1.60–2.73, p < 0.00001, I2 = 41 %) in breast cancer patients. Conclusions: This study suggests the prognostic role of both PNI and CONUT score for predicting survival in breast cancer patients.
Keywords	Nutrition index ; Prognosis ; Breast cancer ; Neoplasm ; Oncology ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	616 ; 610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Authors' response: metabolic and drug-based approach of obstructive sleep apnea (OSA) patients with COVID-19.

Hariyanto, Timotius Ivan / Kurniawan, Andree

Sleep medicine

2021 Volume 85, Page(s) 321

MeSH term(s)	COVID-19 ; Humans ; Hypoxia ; Pharmaceutical Preparations ; SARS-CoV-2 ; Sleep Apnea, Obstructive
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2021-06-24
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	2012041-2
ISSN	1878-5506 ; 1389-9457
ISSN (online)	1878-5506
ISSN	1389-9457
DOI	10.1016/j.sleep.2021.06.013
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Zs.A 5315: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 635: Show issues

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Article: The role of nutrition-based index in predicting survival of breast cancer patients: A systematic review and meta-analysis.

Prasetiyo, Patricia Diana / Baskoro, Bernard Agung / Hariyanto, Timotius Ivan

Heliyon

2023 Volume 10, Issue 1, Page(s) e23541

Abstract	Background: Prognostic nutritional index (PNI) and Controlling Nutritional Status (CONUT) are two model that incorporates the role of inflammation and nutrition factors to predict the progression of tumor. The primary objective of this investigation is to examine the ability of PNI and CONUT score for predicting the survival in breast cancer patients. Methods: A comprehensive search was conducted on the Cochrane Library, Scopus, Europe PMC, and Medline databases up until August 14th, 2023, utilizing a combination of relevant keywords. This review incorporates literature that examines the relationship between PNI, CONUT, and survival in breast cancer. We employed random-effect models to analyze the hazard ratio (HR) and present the outcomes together with their corresponding 95 % confidence intervals (CI). Results: A total of sixteen studies were incorporated. The results of our meta-analysis indicated that high PNI was associated with better overall survival (OS) (HR 0.38; 95%CI: 0.28-0.51, Conclusions: This study suggests the prognostic role of both PNI and CONUT score for predicting survival in breast cancer patients.
Language	English
Publishing date	2023-12-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e23541
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Article ; Online: Relationship between Phenotype Models Based on Waist Circumference and Triglyceride Levels and the Risk of Chronic Kidney Disease: A Systematic Review and Meta-analysis.

Japar, Karunia Valeriani / Hariyanto, Timotius Ivan / Mardjopranoto, Mochammad Sja'bani

Journal of obesity & metabolic syndrome

2023 Volume 32, Issue 3, Page(s) 236–246

Abstract: Background: Chronic kidney disease (CKD) is a leading cause of death worldwide and has a high cost of treatment. Studies have indicated that a combination of waist circumference (WC) and triglyceride (TG) levels can be used to determine the risk of CKD. ...

Abstract	Background: Chronic kidney disease (CKD) is a leading cause of death worldwide and has a high cost of treatment. Studies have indicated that a combination of waist circumference (WC) and triglyceride (TG) levels can be used to determine the risk of CKD. This study analyzes the risk of CKD using four phenotype models based on WC and TG. Methods: This meta-analysis analyzes 113,019 participants from 13 studies. We conducted relevant literature searches in the Europe PMC, Medline, and Scopus databases using specific keywords. The results obtained were pooled into odds ratios (ORs) with 95% confidence intervals (CIs) using random-effects models. Results: Our pooled analysis revealed that the highest significant independent association was between CKD and the high WC-high TG phenotype (adjusted OR, 1.61; 95% CI, 1.39 to 1.88; Conclusion: Our study suggests that phenotype models based on WC and TG can be used as screening tools to predict the risk of CKD. Our results also indicate that WC plays a larger role than TG in the CKD risk. Further prospective studies are needed to confirm the results of our study.
Language	English
Publishing date	2023-09-18
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3021984-X
ISSN	2508-7576 ; 2508-6235
ISSN (online)	2508-7576
ISSN	2508-6235
DOI	10.7570/jomes23037
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Article ; Online: Efficacy and Safety of Fluvoxamine as Outpatient Treatment for Patients With Covid-19: A Systematic Review and Meta-analysis of Clinical Trials.

Vatvani, Akhil Deepak / Kurniawan, Andree / Hariyanto, Timotius Ivan

The Annals of pharmacotherapy

2023 Volume 57, Issue 12, Page(s) 1389–1397

Abstract: Background: Fluvoxamine may be beneficial for the management of coronavirus disease 2019 (Covid-19) because of its effect on the sigma-1 receptor. Available evidence from randomized clinical trials (RCTs) has shown conflicting results.: Objective: ... ...

Abstract	Background: Fluvoxamine may be beneficial for the management of coronavirus disease 2019 (Covid-19) because of its effect on the sigma-1 receptor. Available evidence from randomized clinical trials (RCTs) has shown conflicting results. Objective: This study sought to analyze the efficacy and safety of fluvoxamine as an outpatient treatment for Covid-19. Methods: Using specific keywords, we comprehensively go through the potential articles on PubMed, Scopus, Europe PMC, and ClinicalTrials.gov sources until February 1, 2023. We collected all published clinical trials on fluvoxamine and Covid-19. We were using Review Manager 5.4 to conduct statistical analysis. Results: We include a total of 6 trials. Our pooled analysis revealed that fluvoxamine did not offer any significant benefit when compared with placebo in reducing the risk of clinical deterioration (risk ratio [RR] = 0.83; 95% CI: 0.65-1.06, Conclusions and relevance: This study indicates that although safe, fluvoxamine was not effective for outpatient treatment of Covid-19. Until more evidence can be obtained from larger RCTs, our study did not encourage the use of fluvoxamine as routine management for patients with Covid-19.
MeSH term(s)	Humans ; COVID-19 ; Fluvoxamine/adverse effects ; Outpatients ; COVID-19 Drug Treatment ; Europe
Chemical Substances	Fluvoxamine (O4L1XPO44W)
Language	English
Publishing date	2023-03-31
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	1101370-9
ISSN	1542-6270 ; 1060-0280
ISSN (online)	1542-6270
ISSN	1060-0280
DOI	10.1177/10600280231162243
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Zs.A 900: Show issues

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Article ; Online: Authors' response: Meta-analysis of statin and outcomes of coronavirus disease 2019 (COVID-19).

Hariyanto, Timotius Ivan / Kurniawan, Andree

Nutrition, metabolism, and cardiovascular diseases : NMCD

2021 Volume 31, Issue 9, Page(s) 2740–2742

MeSH term(s)	COVID-19 ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; SARS-CoV-2
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2021-06-29
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	1067704-5
ISSN	1590-3729 ; 0939-4753
ISSN (online)	1590-3729
ISSN	0939-4753
DOI	10.1016/j.numecd.2021.06.008
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Article ; Online: Risk of Parkinson’s Disease (PD) in patients with diabetes using thiazolidinedione (TZD)

Kezia Christy Gunawan / Timotius Ivan Hariyanto

Romanian Journal of Neurology, Vol 22, Iss 3, Pp 214-

A systematic review, meta-analysis, and meta-regression

2023 Volume 222

Abstract: Background. T Parkinson’s Disease (PD) stands as the neurodegenerative disorder with the second highest incidence, leading to substantial disability and death rates. Research to date suggests a potential increased risk for PD development in individuals ... ...

Abstract	Background. T Parkinson’s Disease (PD) stands as the neurodegenerative disorder with the second highest incidence, leading to substantial disability and death rates. Research to date suggests a potential increased risk for PD development in individuals with diabetes, yet the correlation between PD and the use of antidiabetic drugs remains to be fully understood. This study aims to investigate the relationship between thiazolidinedione (TZD) use with the risk of PD in patients with diabetes. Methods. A search of literature was carried out using certain keywords across four databases up until December 11th, 2022: Europe PMC, Scopus, Medline, and Cochrane Library. The review included all studies assessing the risk of Parkinson’s Disease (PD) in patients with diabetes who were treated with thiazolidinediones (TZDs). The pooled risk ratios (RRs) with 95% confidence intervals (CIs) were determined using random-effects models. Results. Our meta-analysis from 12 observational studies revealed that TZD use was associated with reduced risk of PD in patients with diabetes (RR 0.75; 95%CI: 0.63 – 0.91, p=0.003, I2 = 92%). The neuroprotective impact of thiazolidinediones (TZDs) against Parkinson’s Disease (PD) did not show significant variation based on patient characteristics like age (p=0.3380), gender (p=0.9761), hypertension (p=0.1849), smokers (p=0.1476), stroke (p=0.4810), head injury (p=0.5025), and diabetes duration (p=0.2533). Conclusions. This study suggests that the use of TZD in patients with diabetes has a positive neuroprotective effect on the risk of PD. However, to validate these results, further randomized clinical trials (RCTs) are necessary.
Keywords	parkinson’s disease ; neurodegenerative ; thiazolidinedione ; antidiabetic ; diabetes ; Medicine ; R ; Neurology. Diseases of the nervous system ; RC346-429
Subject code	610
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Amaltea Medical Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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