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Article ; Online: Effect of Flavanol-Rich Cacao Extract on the Profile of Mood State in Healthy Middle-Aged Japanese Women: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.

Murakami, Rika / Natsume, Midori / Ito, Kentaro / Ebihara, Shukuko / Terauchi, Masakazu

2023 Volume 15, Issue 17

Abstract: To investigate the effects of flavanol-rich cacao extract on healthy middle-aged women's fatigue and mood conditions, we conducted a randomized, double-blind, placebo-controlled study in women aged 40-60 years who had reported fatigue and had shown high ... ...

Abstract	To investigate the effects of flavanol-rich cacao extract on healthy middle-aged women's fatigue and mood conditions, we conducted a randomized, double-blind, placebo-controlled study in women aged 40-60 years who had reported fatigue and had shown high levels of a serum oxidative stress marker. We randomized the participants (
MeSH term(s)	Female ; Humans ; Middle Aged ; Cacao ; East Asian People ; Fatigue ; Pilot Projects ; Plant Extracts/pharmacology
Chemical Substances	Plant Extracts
Language	English
Publishing date	2023-09-03
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15173843
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Diacylglycerol kinase ζ interacts with sphingomyelin synthase 1 and sphingomyelin synthase-related protein via different regions.

Furuta, Masataka / Murakami, Chiaki / Numagami, Yuki / Suzuki, Rika / Sakane, Fumio

FEBS open bio

2023 Volume 13, Issue 7, Page(s) 1333–1345

Abstract: We previously reported that diacylglycerol (DG) kinase (DGK) δ interacts with DG-generating sphingomyelin synthase (SMS)-related protein (SMSr), but not SMS1 or SMS2, via their sterile α motif domains (SAMDs). However, it remains unclear whether other ... ...

Abstract	We previously reported that diacylglycerol (DG) kinase (DGK) δ interacts with DG-generating sphingomyelin synthase (SMS)-related protein (SMSr), but not SMS1 or SMS2, via their sterile α motif domains (SAMDs). However, it remains unclear whether other DGK isozymes interact with SMSs. Here, we found that DGKζ, which does not contain SAMD, interacts with SMSr and SMS1, but not SMS2. Deletion mutant analyses demonstrated that SAMD in the N-terminal cytosolic region of SMSr binds to the N-terminal half catalytic domain of DGKζ. However, the C-terminal cytosolic region of SMS1 interacts with the catalytic domain of DGKζ. Taken together, these results indicate that DGKζ associates with SMSr and SMS1 in different manners and suggest that they compose new DG signaling pathways.
MeSH term(s)	Diacylglycerol Kinase/genetics ; Diacylglycerol Kinase/metabolism ; Isoenzymes/genetics
Chemical Substances	phosphatidylcholine-ceramide phosphocholine transferase (EC 2.7.8.-) ; Diacylglycerol Kinase (EC 2.7.1.107) ; Isoenzymes
Language	English
Publishing date	2023-05-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2651702-4
ISSN	2211-5463 ; 2211-5463
ISSN (online)	2211-5463
ISSN	2211-5463
DOI	10.1002/2211-5463.13628
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Article ; Online: Diacylglycerol kinase ζ interacts with sphingomyelin synthase 1 and sphingomyelin synthase‐related protein via different regions

Masataka Furuta / Chiaki Murakami / Yuki Numagami / Rika Suzuki / Fumio Sakane

FEBS Open Bio, Vol 13, Iss 7, Pp 1333-

2023 Volume 1345

Abstract: We previously reported that diacylglycerol (DG) kinase (DGK) δ interacts with DG‐generating sphingomyelin synthase (SMS)‐related protein (SMSr), but not SMS1 or SMS2, via their sterile α motif domains (SAMDs). However, it remains unclear whether other ... ...

Abstract	We previously reported that diacylglycerol (DG) kinase (DGK) δ interacts with DG‐generating sphingomyelin synthase (SMS)‐related protein (SMSr), but not SMS1 or SMS2, via their sterile α motif domains (SAMDs). However, it remains unclear whether other DGK isozymes interact with SMSs. Here, we found that DGKζ, which does not contain SAMD, interacts with SMSr and SMS1, but not SMS2. Deletion mutant analyses demonstrated that SAMD in the N‐terminal cytosolic region of SMSr binds to the N‐terminal half catalytic domain of DGKζ. However, the C‐terminal cytosolic region of SMS1 interacts with the catalytic domain of DGKζ. Taken together, these results indicate that DGKζ associates with SMSr and SMS1 in different manners and suggest that they compose new DG signaling pathways.
Keywords	diacylglycerol kinase ; sphingomyelin synthase ; sphingomyelin synthase‐related protein ; sterile α motif domain ; Biology (General) ; QH301-705.5
Subject code	572
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Diacylglycerol kinase η regulates cell proliferation and its levels are elevated by glucocorticoids in undifferentiated neuroblastoma cells.

Masuda, Yuka / Murakami, Chiaki / Suzuki, Rika / Sakane, Fumio

Biochemical and biophysical research communications

2022 Volume 602, Page(s) 41–48

Abstract: Knockout mice of diacylglycerol kinase (DGK) η, which has been repeatedly suggested to be associated with bipolar disorder (BPD) by genome-wide association studies, exhibited abnormal behaviors similar to the manic phase of BPD. Chronic stress is also ... ...

Abstract	Knockout mice of diacylglycerol kinase (DGK) η, which has been repeatedly suggested to be associated with bipolar disorder (BPD) by genome-wide association studies, exhibited abnormal behaviors similar to the manic phase of BPD. Chronic stress is also linked to changes in mood symptoms, including BPD. In the present study, we analyzed the effects of the glucocorticoid stress hormones, triamcinolone acetonide (TAA) and dexamethasone (DEX), on DGKη protein levels in neuroblastoma cell lines, Neuro-2a and SH-SY5Y. The protein levels of DGKη were significantly increased in the undifferentiated Neuro-2a and SH-SY5Y cells by TAA and DEX, but not in the differentiated neuroblastoma cells. To assess the functions of DGKη in undifferentiated neuroblastoma cells, we established DGKη-deficient SH-SY5Y cells using the clustered regularly interspaced palindromic repeat/caspase 9 system. Notably, proliferation of DGKη-deficient SH-SY5Y cells was markedly attenuated, concomitant with the decrease in levels of phosphorylated extracellular signal-regulated kinase. Taken together, these results suggest that DGKη levels are increased in undifferentiated neuroblastoma cells by glucocorticoid stress hormones and regulate cell proliferation.
MeSH term(s)	Animals ; Cell Line, Tumor ; Cell Proliferation ; Diacylglycerol Kinase/metabolism ; Genome-Wide Association Study ; Glucocorticoids/pharmacology ; Mice ; Mice, Knockout ; Neuroblastoma
Chemical Substances	Glucocorticoids ; Diacylglycerol Kinase (EC 2.7.1.107)
Language	English
Publishing date	2022-02-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.02.100
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Article: A Trimming Technique: A Case Report of a Novel Surgical Approach for Cesarean Scar Dehiscence During Cesarean Section.

Katsura, Daisuke / Tsuji, Shunichiro / Hoshiyama, Takako / Zen, Rika / Inatomi, Ayako / Murakami, Takashi

Yonago acta medica

2023 Volume 66, Issue 2, Page(s) 287–291

Abstract: Cesarean section can lead to residual myometrial thickness thinning and cesarean scar syndrome. We report a novel trimming technique for residual myometrial thickness recovery in women with cesarean scar syndrome. Case 1: A 33-year-old woman who ... ...

Abstract	Cesarean section can lead to residual myometrial thickness thinning and cesarean scar syndrome. We report a novel trimming technique for residual myometrial thickness recovery in women with cesarean scar syndrome. Case 1: A 33-year-old woman who developed cesarean scar syndrome (CSS) and abnormal uterine bleeding post-cesarean scar became pregnant following hysteroscopic treatment. The myometrium at previous scar was dehiscent; therefore, a transverse incision was made above the scar. Post-operative uterine recovery failed owing to lochia retention, and developed cesarean scar syndrome again. Case 2: A 29-year-old woman who developed cesarean scar syndrome post-cesarean section became pregnant spontaneously. The myometrium at the previous scar was dehiscent like case 1. Scar repair was performed using a trimming technique during cesarean section; there were no subsequent complications and she conceived again spontaneously. Performing this novel surgical procedure during cesarean section may contribute to residual myometrial thickness recovery in women with cesarean scar syndrome.
Language	English
Publishing date	2023-04-10
Publishing country	Japan
Document type	Case Reports
ZDB-ID	840719-8
ISSN	1346-8049 ; 0513-5710
ISSN (online)	1346-8049
ISSN	0513-5710
DOI	10.33160/yam.2023.05.004
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Article: Management of Cartilage Conduction Hearing Aids in Pediatric Patients.

Yakawa, Satomi / Sugiuchi, Tomoko / Myojin, Rika / Sato, Kiyoko / Murakami, Takako / Miyoshi, Yuki / Sugio, Yuichiro

Audiology research

2023 Volume 13, Issue 6, Page(s) 871–888

Abstract: Forty-nine children who started wearing cartilage conduction hearing aids (CC-HAs) before completing elementary school (17 with bilateral hearing loss and 32 with unilateral hearing loss) were followed-up and examined. The wearing and utilization status ... ...

Abstract	Forty-nine children who started wearing cartilage conduction hearing aids (CC-HAs) before completing elementary school (17 with bilateral hearing loss and 32 with unilateral hearing loss) were followed-up and examined. The wearing and utilization status of the CC-HA and its progress to date were evaluated. In addition, 33 participants who purchased the CC-HAs were interviewed to assess the wearing effect. Eleven of seventeen children with bilateral hearing loss and 25 of 32 children with unilateral hearing loss continued to use the CC-HAs. In terms of wearing effect, a good wearing effect was reported, even by those with unilateral hearing loss. In cases where it was difficult to wear CC-HAs stably with pasting or ear tips, it was possible to fix them stably using commercially available hair bands and eyeglass vines. In two cases, the CC-HAs were worn from infancy. With ingenuity and appropriate educational and medical support, it is possible to wear CC-HAs from infancy.
Language	English
Publishing date	2023-11-06
Publishing country	Switzerland
Document type	Journal Article
ISSN	2039-4330
ISSN	2039-4330
DOI	10.3390/audiolres13060076
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Article ; Online: Human sphingomyelin synthase 1 generates diacylglycerol in the presence and absence of ceramide via multiple enzymatic activities.

Suzuki, Rika / Murakami, Chiaki / Dilimulati, Kamila / Atsuta-Tsunoda, Kyoko / Kawai, Takuma / Sakane, Fumio

FEBS letters

2023 Volume 597, Issue 21, Page(s) 2672–2686

Abstract: Sphingomyelin (SM) synthase 1 (SMS1), which is involved in lipodystrophy, deafness, and thrombasthenia, generates diacylglycerol (DG) and SM using phosphatidylcholine (PC) and ceramide as substrates. Here, we found that SMS1 possesses DG-generating ... ...

Abstract	Sphingomyelin (SM) synthase 1 (SMS1), which is involved in lipodystrophy, deafness, and thrombasthenia, generates diacylglycerol (DG) and SM using phosphatidylcholine (PC) and ceramide as substrates. Here, we found that SMS1 possesses DG-generating activities via hydrolysis of PC and phosphatidylethanolamine (PE) in the absence of ceramide and ceramide phosphoethanolamine synthase (CPES) activity. In the presence of the same concentration (4.7 mol%) of PC and ceramide, the amounts of DG produced by SMS and PC-phospholipase C (PLC) activities of SMS1 were approximately 65% and 35% of total DG production, respectively. PC-PLC activity showed substrate selectivity for saturated and/or monounsaturated fatty acid-containing PC species. A PC-PLC/SMS inhibitor, D609, inhibited only SMS activity. Mn
MeSH term(s)	Humans ; Ceramides ; Diglycerides ; Phosphatidylcholines ; Sphingomyelins ; Transferases (Other Substituted Phosphate Groups)/genetics
Chemical Substances	Ceramides ; Diglycerides ; phosphatidylcholine-ceramide phosphocholine transferase (EC 2.7.8.-) ; Phosphatidylcholines ; Sphingomyelins ; Transferases (Other Substituted Phosphate Groups) (EC 2.7.8.-) ; SGMS1 protein, human (EC 2.7.8.-)
Language	English
Publishing date	2023-09-24
Publishing country	England
Document type	Journal Article
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1002/1873-3468.14735
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Article: Diacylglycerol kinase η regulates cell proliferation and its levels are elevated by glucocorticoids in undifferentiated neuroblastoma cells

Masuda, Yuka / Murakami, Chiaki / Suzuki, Rika / Sakane, Fumio

Biochemical and biophysical research communications. 2022 Apr. 30, v. 602

2022

Abstract	Knockout mice of diacylglycerol kinase (DGK) η, which has been repeatedly suggested to be associated with bipolar disorder (BPD) by genome-wide association studies, exhibited abnormal behaviors similar to the manic phase of BPD. Chronic stress is also linked to changes in mood symptoms, including BPD. In the present study, we analyzed the effects of the glucocorticoid stress hormones, triamcinolone acetonide (TAA) and dexamethasone (DEX), on DGKη protein levels in neuroblastoma cell lines, Neuro-2a and SH-SY5Y. The protein levels of DGKη were significantly increased in the undifferentiated Neuro-2a and SH-SY5Y cells by TAA and DEX, but not in the differentiated neuroblastoma cells. To assess the functions of DGKη in undifferentiated neuroblastoma cells, we established DGKη-deficient SH-SY5Y cells using the clustered regularly interspaced palindromic repeat/caspase 9 system. Notably, proliferation of DGKη-deficient SH-SY5Y cells was markedly attenuated, concomitant with the decrease in levels of phosphorylated extracellular signal-regulated kinase. Taken together, these results suggest that DGKη levels are increased in undifferentiated neuroblastoma cells by glucocorticoid stress hormones and regulate cell proliferation.
Keywords	bipolar disorder ; caspase-9 ; cell proliferation ; dexamethasone ; diacylglycerol kinase ; emotions ; glucocorticoids ; mitogen-activated protein kinase ; research ; triamcinolone
Language	English
Dates of publication	2022-0430
Size	p. 41-48.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.02.100
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Diacylglycerol kinase ζ interacts with sphingomyelin synthase 1 and sphingomyelin synthase‐related protein via different regions

Furuta, Masataka / Murakami, Chiaki / Numagami, Yuki / Suzuki, Rika / Sakane, Fumio

FEBS Open Bio. 2023 July, v. 13, no. 7 p.1333-1345

2023

Abstract	We previously reported that diacylglycerol (DG) kinase (DGK) δ interacts with DG‐generating sphingomyelin synthase (SMS)‐related protein (SMSr), but not SMS1 or SMS2, via their sterile α motif domains (SAMDs). However, it remains unclear whether other DGK isozymes interact with SMSs. Here, we found that DGKζ, which does not contain SAMD, interacts with SMSr and SMS1, but not SMS2. Deletion mutant analyses demonstrated that SAMD in the N‐terminal cytosolic region of SMSr binds to the N‐terminal half catalytic domain of DGKζ. However, the C‐terminal cytosolic region of SMS1 interacts with the catalytic domain of DGKζ. Taken together, these results indicate that DGKζ associates with SMSr and SMS1 in different manners and suggest that they compose new DG signaling pathways.
Keywords	active sites ; diacylglycerol kinase ; diacylglycerols ; isozymes ; mutants ; sphingomyelins
Language	English
Dates of publication	2023-07
Size	p. 1333-1345.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2651702-4
ISSN	2211-5463
ISSN	2211-5463
DOI	10.1002/2211-5463.13628
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Human sphingomyelin synthase 1 generates diacylglycerol in the presence and absence of ceramide via multiple enzymatic activities

Suzuki, Rika / Murakami, Chiaki / Dilimulati, Kamila / Atsuta‐Tsunoda, Kyoko / Kawai, Takuma / Sakane, Fumio

FEBS Letters. 2023 Nov., v. 597, no. 21 p.2672-2686

2023

Abstract	Sphingomyelin (SM) synthase 1 (SMS1), which is involved in lipodystrophy, deafness, and thrombasthenia, generates diacylglycerol (DG) and SM using phosphatidylcholine (PC) and ceramide as substrates. Here, we found that SMS1 possesses DG‐generating activities via hydrolysis of PC and phosphatidylethanolamine (PE) in the absence of ceramide and ceramide phosphoethanolamine synthase (CPES) activity. In the presence of the same concentration (4.7 mol%) of PC and ceramide, the amounts of DG produced by SMS and PC‐phospholipase C (PLC) activities of SMS1 were approximately 65% and 35% of total DG production, respectively. PC‐PLC activity showed substrate selectivity for saturated and/or monounsaturated fatty acid‐containing PC species. A PC‐PLC/SMS inhibitor, D609, inhibited only SMS activity. Mn²⁺ inhibited only PC‐PLC activity. Intriguingly, DG attenuated SMS/CPES activities. Our study indicates that SMS1 is a unique enzyme with PC‐PLC/PE‐PLC/SMS/CPES activities.
Keywords	ceramides ; deafness ; diacylglycerols ; enzymes ; humans ; hydrolysis ; phosphatidylcholines ; phosphatidylethanolamines ; sphingomyelins
Language	English
Dates of publication	2023-11
Size	p. 2672-2686.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1002/1873-3468.14735
Database	NAL-Catalogue (AGRICOLA)

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