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  1. Article ; Online: Efficacy of face masks depends on spatial relation between host and recipient and who is being protected.

    Grover, Cliff

    BMJ (Clinical research ed.)

    2020  Volume 369, Page(s) m2016

    MeSH term(s) COVID-19 ; Communicable Disease Control/instrumentation ; Coronavirus Infections/prevention & control ; Equipment Design ; Host-Pathogen Interactions ; Humans ; Masks ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Respiratory Protective Devices ; Spatio-Temporal Analysis
    Keywords covid19
    Language English
    Publishing date 2020-05-22
    Publishing country England
    Document type Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m2016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Radiation Treatment Time and Overall Survival in Locally Advanced Non-small Cell Lung Cancer.

    McMillan, Matthew T / Ojerholm, Eric / Verma, Vivek / Higgins, Kristin A / Singhal, Sunil / Predina, Jarrod D / Berman, Abigail T / Grover, Surbhi / Robinson, Cliff G / Simone, Charles B

    International journal of radiation oncology, biology, physics

    2017  Volume 98, Issue 5, Page(s) 1142–1152

    Abstract: Purpose: Prolonged radiation treatment (RT) time (RTT) has been associated with worse survival in several malignancies. The present study investigated whether delays during RT are associated with overall survival (OS) in non-small cell lung cancer ( ... ...

    Abstract Purpose: Prolonged radiation treatment (RT) time (RTT) has been associated with worse survival in several malignancies. The present study investigated whether delays during RT are associated with overall survival (OS) in non-small cell lung cancer (NSCLC).
    Methods and materials: The National Cancer Database was queried for patients with stage III NSCLC who had received definitive concurrent chemotherapy and fractionated RT to standard doses (59.4-70.0 Gy) and fractionation from 2004 to 2013. The RTT was classified as standard or prolonged for each treatment regimen according to the radiation dose and number of fractions. Cox proportional hazards models were used to evaluate the association between the following factors and OS: RTT, RT fractionation, demographic and pathologic factors, and chemotherapeutic agents.
    Results: Of 14,154 patients, the RTT was prolonged in 6262 (44.2%). Factors associated with prolonged RTT included female sex (odds ratio [OR] 1.21, P<.0001), black race (OR 1.20, P=.001), nonprivate health insurance (OR 1.30, P<.0001), and lower income (<$63,000 annually, OR 1.20, P<.0001). The median OS was significantly worse for patients with prolonged RTT than that for those with standard RTT (18.6 vs 22.7 months, P<.0001). Furthermore, the OS worsened with each cumulative interval of delay (standard RTT vs prolonged 1-2 days, 20.5 months, P=.009; prolonged 3-5 days, 17.9 months, P<.0001; prolonged 6-9 days, 17.7 months, P<.0001; prolonged >9 days, 17.1 months, P<.0001). On multivariable analysis, prolonged RTT was independently associated with inferior OS (hazard ratio 1.21, P<.0001). Prolonged RTT as a continuous variable was also significantly associated with worse OS (hazard ratio 1.001, P=.0007).
    Conclusions: Delays during RT appear to negatively affect survival for patients with locally advanced NSCLC. We have detailed the demographic and socioeconomic barriers influencing prolonged RTT as a method to address the health disparities in this regard. Cumulative interruptions of RT should be minimized.
    MeSH term(s) Aged ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Continental Population Groups ; Databases, Factual/statistics & numerical data ; Dose Fractionation ; Female ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Lung Neoplasms/radiotherapy ; Male ; Middle Aged ; Proportional Hazards Models ; Radiotherapy/mortality ; Sex Factors ; Social Class ; Socioeconomic Factors ; Survival Analysis ; Time Factors
    Language English
    Publishing date 2017-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2017.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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