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Article ; Online: L-

Kim, So Hee / Kim, Bokyung / Kim, Jung Hak / Kim, Dong-Hoon / Lee, Seung Hoon / Lee, Dong-Seok / Lee, Hong J

2021 Volume 10, Issue 8

Abstract: ... Therefore, to overcome these deficiencies, we investigated whether tetracycline-inducible L- ...

Abstract	Canines are useful in mammalian preclinical studies because they are larger than rodents and share many diseases with humans. Canine fetal fibroblast cells (CFFs) are an easily accessible source of somatic cells. However, they are easily driven to senescence and become unusable with continuous in vitro culture. Therefore, to overcome these deficiencies, we investigated whether tetracycline-inducible L-
MeSH term(s)	Animals ; Cell Proliferation ; Cell Self Renewal/physiology ; Cellular Reprogramming ; Dogs ; Female ; Fetus/cytology ; Fetus/metabolism ; Fibroblasts/cytology ; Fibroblasts/metabolism ; G1 Phase ; Polycomb-Group Proteins/metabolism ; Promoter Regions, Genetic ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism
Chemical Substances	Polycomb-Group Proteins ; Proto-Oncogene Proteins c-myc
Language	English
Publishing date	2021-08-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10081980
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Article ; Online: L. reuteri

Bai, Jin / Wang, Shuyang / Xu, Fuqiang / Dong, Miaoyin / Wang, Junkai / Sun, Xisi / Xiao, Guoqing

International journal of radiation biology

2023 Volume 99, Issue 5, Page(s) 779–790

Abstract: Background: Probiotics such as : Methods: We investigated the therapeutic efficacy of : Results: Anti-proliferation effect of live probiotic combined with inactivated probiotic JMR-01 (LP + IP) on CT-26 reached a maximum of 39.55% among other ... ...

Abstract	Background: Probiotics such as Methods: We investigated the therapeutic efficacy of Results: Anti-proliferation effect of live probiotic combined with inactivated probiotic JMR-01 (LP + IP) on CT-26 reached a maximum of 39.55% among other experiment groups at 24 h when the ratio of cell to CFU was 1:1 in vitro. These activities have been fully validated in vivo, tumor-bearing mice treated by Conclusions: JMR-01 LP + IP adjuvant
MeSH term(s)	Animals ; Mice ; Limosilactobacillus reuteri ; Gastrointestinal Microbiome ; Lactobacillus ; Colonic Neoplasms/radiotherapy ; Carcinoma
Language	English
Publishing date	2023-02-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3065-x
ISSN	1362-3095 ; 0020-7616 ; 0955-3002
ISSN (online)	1362-3095
ISSN	0020-7616 ; 0955-3002
DOI	10.1080/09553002.2023.2142979
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Article ; Online: Isolation and characterization of dihydrohomoisoflavonoids from Portulaca oleracea L.

Liu, Jianbo / Wang, Hongqing / Shao, Hongjie / Sun, Junhua / Dong, Chaoxuan / Chen, Ruoyun / Kang, Jie

Phytochemistry

2024 Volume 222, Page(s) 114071

Abstract: ... portulacasides A-D and epiportulacasides A-D (5-8)], were obtained from Portulaca oleracea L. Among them, (R,S ...

Abstract	Eight pairs of dihydrohomoisoflavonoids (1-8), including four pairs of enantiomeric aglycones [(R,S)-portulacanones B (1) and C (2) and (R,S)-oleracones C (3) and Q (4)] and four pairs of epimeric glycosides [portulacasides A-D and epiportulacasides A-D (5-8)], were obtained from Portulaca oleracea L. Among them, (R,S)-oleracone Q (4) and four pairs of epimeric glycosides (5-8) were reported for the first time. The 50% EtOH fraction from the 70% EtOH extract prevented HepG2 human liver cancer cell damage induced by N-acetyl-p-aminophenol (APAP), and the cell survival rate was 62.3%. Portulacaside B (6a), which was isolated from the 50% EtOH fraction, exhibited hepatoprotective and anti-inflammatory effects. The compound increased the survival rate of APAP-damaged HepG2 human liver cancer cells from 40.0% to 51.2% and reduced nitric oxide production in RAW 264.7 macrophages, resulting in an inhibitory rate of 46.8%.
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2024.114071
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Article ; Online: Effects of l-Serine on Macrolide Resistance in Streptococcus suis.

Wu, Tong / Wang, Xiaozhen / Dong, Yue / Xing, Chen / Chen, Xueying / Li, Lu / Dong, Chunliu / Li, Yanhua

Microbiology spectrum

2022 Volume 10, Issue 4, Page(s) e0068922

Abstract: ... in drug-resistant S. suis. The addition of l-serine restored the fungicidal effect of macrolides on S ...

Abstract	Streptococcus suis is an important zoonotic pathogen. Due to the indiscriminate use of macrolides, S. suis has developed a high level of drug resistance, which has led to a serious threat to human and animal health. However, it takes a long time to develop new antibacterial drugs. Therefore, we consider the perspective of bacterial physiological metabolism to ensure that the development of bacterial resistance to existing drugs is alleviated and bacterial susceptibility to drugs is restored. In the present study, an untargeted metabolomics analysis showed that the serine catabolic pathway was inhibited in drug-resistant S. suis. The addition of l-serine restored the fungicidal effect of macrolides on S. suis
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial ; Humans ; Macrolides/pharmacology ; Macrolides/therapeutic use ; Microbial Sensitivity Tests ; Reactive Oxygen Species/metabolism ; Reactive Oxygen Species/pharmacology ; Reactive Oxygen Species/therapeutic use ; Serine/metabolism ; Serine/pharmacology ; Serine/therapeutic use ; Streptococcal Infections/drug therapy ; Streptococcal Infections/microbiology ; Streptococcus suis/genetics ; Streptococcus suis/metabolism
Chemical Substances	Anti-Bacterial Agents ; Macrolides ; Reactive Oxygen Species ; Serine (452VLY9402)
Language	English
Publishing date	2022-07-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00689-22
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Article ; Online: L-lysine moderates thermal aggregation of coconut proteins induced by thermal treatment.

Wang, Liqiang / Zhang, Youbang / Li, Run / Xiang, Dong

Scientific reports

2023 Volume 13, Issue 1, Page(s) 13310

Abstract: This work attempts to investigate the inhibitory effect of L-lysine (Lys) on the thermal ...

Abstract	This work attempts to investigate the inhibitory effect of L-lysine (Lys) on the thermal aggregation of coconut protein (CP). The results showed that under neutral conditions (pH = 7), temperature reduced the solubility and enhanced the thermally induced gel formation of CP. In addition, Lys reduced the fluorescence properties, particle size and increased the turbidity of CP, which had an inhibitory effect on heat induced gels. The results indicate that Lys plays an important role in inhibiting protein thermal aggregation by interacting with CP to create steric hindrance and increase protein electrostatic repulsion.
MeSH term(s)	Animals ; Lysine ; Cocos ; Disgust ; Estrus ; Fluorescence ; Protein Aggregates
Chemical Substances	Lysine (K3Z4F929H6) ; Protein Aggregates
Language	English
Publishing date	2023-08-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-38758-7
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Article ; Online: Biomimetic synthesis of L-DOPA inspired by tyrosine hydroxylase.

Du, Dong / Su, Yingli / Shang, Qi / Chen, Chan / Tang, Weikang / Zhang, Ling / Ren, Haisheng / Liu, Wenbin

Journal of inorganic biochemistry

2022 Volume 234, Page(s) 111878

Abstract: L-3,4-dihydroxyphenylalanine (L-DOPA) is in high demand as the cornerstone for treatment ... of Parkinson's disease. The current production of L-DOPA is associated with poor productivity and long production period ... Biomimetic system inspired from tyrosine hydroxylase was developed to achieve the production of L-DOPA ...

Abstract	L-3,4-dihydroxyphenylalanine (L-DOPA) is in high demand as the cornerstone for treatment of Parkinson's disease. The current production of L-DOPA is associated with poor productivity and long production period. Biomimetic system inspired from tyrosine hydroxylase was developed to achieve the production of L-DOPA from tyrosine with high reactivity, efficiency, and specificity. The biomimetic system owned close resemblance of component and structure in comparison with tyrosine hydroxylase, consisting of tyrosine as substrate, a redox complex of Fe
MeSH term(s)	Ascorbic Acid ; Biomimetics ; Dihydroxyphenylalanine ; Edetic Acid ; Hydrogen Peroxide ; Tandem Mass Spectrometry ; Tyrosine/chemistry ; Tyrosine 3-Monooxygenase/chemistry
Chemical Substances	Tyrosine (42HK56048U) ; Dihydroxyphenylalanine (63-84-3) ; Edetic Acid (9G34HU7RV0) ; Hydrogen Peroxide (BBX060AN9V) ; Tyrosine 3-Monooxygenase (EC 1.14.16.2) ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2022-05-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2022.111878
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Article ; Online: L-carnitine promotes liver regeneration after hepatectomy by enhancing lipid metabolism.

Zhou, Xi / Huang, Guobin / Wang, Lu / Zhao, Yuanyuan / Li, Junbo / Chen, Dong / Wei, Lai / Chen, Zhishui / Yang, Bo

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 487

Abstract: ... metabolites in the process of liver regeneration. We screened L-carnitine as our research object through metabolite detection ... liver regeneration. We divided the mouse into four groups: control group (70% hepatectomy group); L-carnitine group ... before operation) (L-carnitine were given before operation); L-carnitine group (after operation)(L-carnitine were ...

Abstract	Background: Lipid metabolism plays an important role in liver regeneration, but its regulation still requires further research. In this study, lipid metabolites involved in mouse liver regeneration at different time points were sequenced and analyzed to study their influence on liver regeneration and its mechanism. Methods: Our experiment was divided into two parts. The first part examined lipid metabolites during liver regeneration in mice. In this part, lipid metabolites were sequentially analyzed in the livers of 70% mouse hepatectomy models at 0, 1, 3and 7 days after operation to find the changes of lipid metabolites in the process of liver regeneration. We screened L-carnitine as our research object through metabolite detection. Therefore, in the second part, we analyzed the effects of carnitine on mouse liver regeneration and lipid metabolism during liver regeneration. We divided the mouse into four groups: control group (70% hepatectomy group); L-carnitine group (before operation) (L-carnitine were given before operation); L-carnitine group (after operation)(L-carnitine were given after operation) and L-carnitine + perhexiline maleate (before operation) group. Weighing was performed at 24 h, 36 and 48 h in each group, and oil red staining, HE staining and MPO staining were performed. Tunnel fluorescence staining, Ki67 staining and serological examination. Results: Sequencing analysis of lipid metabolites in 70% of mouse livers at different time points after hepatectomy showed significant changes in carnitine metabolites. The results showed that, compared with the control group the mouse in L-carnitine group (before operation) at 3 time points, the number of fat drops in oil red staining was decreased, the number of Ki67 positive cells was increased, the number of MPO positive cells was decreased, the number of Tunnel fluorescence positive cells was decreased, and the liver weight was increased. Serum enzymes were decreased. Compared with control group, L-carnitine group (after operation) showed similar trends in all indexes at 36 and 48 h as L-carnitine group (before operation). L-carnitine + perhexiline maleate (before operation) group compared with control group, the number of fat drops increased, the number of Ki67 positive cells decreased, and the number of MPO positive cells increased at 3 time points. The number of Tunnel fluorescent positive cells increased and serum enzyme increased. However, both liver weights increased. Conclusion: L-carnitine can promote liver cell regeneration by promoting lipid metabolism and reduce aseptic inflammation caused by excessive lipid accumulation.
MeSH term(s)	Mice ; Animals ; Hepatectomy ; Liver Regeneration/physiology ; Lipid Metabolism ; Carnitine/pharmacology ; Carnitine/metabolism ; Ki-67 Antigen/metabolism ; Liver/metabolism ; Lipids
Chemical Substances	Carnitine (S7UI8SM58A) ; Ki-67 Antigen ; Lipids
Language	English
Publishing date	2023-07-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-04317-x
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Article ; Online: Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L.

Xu, Xia / Yu, Tao / Dong, Lingling / Glauben, Rainer / Wu, Siyuan / Huang, Ronghua / Qumu, Shiwei / Chang, Chenli / Guo, Jing / Pan, Lin / Yang, Ting / Lin, Xin / Huang, Ke / Chen, Zhihua / Wang, Chen

Signal transduction and targeted therapy

2023 Volume 8, Issue 1, Page(s) 390

Abstract: ... discovery is that eosinophil-derived cathepsin L contributed to the degradation of the extracellular matrix ... thereby leading to emphysema in pulmonary tissue. Inhibition of cathepsin L resulted in a reduction ... with serum cathepsin L levels, which were higher in emphysema patients than those without emphysema ...

Abstract	Patients with chronic obstructive pulmonary disease (COPD) who exhibit elevated blood eosinophil levels often experience worsened lung function and more severe emphysema. This implies the potential involvement of eosinophils in the development of emphysema. However, the precise mechanisms underlying the development of eosinophil-mediated emphysema remain unclear. In this study, we employed single-cell RNA sequencing to identify eosinophil subgroups in mouse models of asthma and emphysema, followed by functional analyses of these subgroups. Assessment of accumulated eosinophils unveiled distinct transcriptomes in the lungs of mice with elastase-induced emphysema and ovalbumin-induced asthma. Depletion of eosinophils through the use of anti-interleukin-5 antibodies ameliorated elastase-induced emphysema. A particularly noteworthy discovery is that eosinophil-derived cathepsin L contributed to the degradation of the extracellular matrix, thereby leading to emphysema in pulmonary tissue. Inhibition of cathepsin L resulted in a reduction of elastase-induced emphysema in a mouse model. Importantly, eosinophil levels correlated positively with serum cathepsin L levels, which were higher in emphysema patients than those without emphysema. Expression of cathepsin L in eosinophils demonstrated a direct association with lung emphysema in COPD patients. Collectively, these findings underscore the significant role of eosinophil-derived cathepsin L in extracellular matrix degradation and remodeling, and its relevance to emphysema in COPD patients. Consequently, targeting eosinophil-derived cathepsin L could potentially offer a therapeutic avenue for emphysema patients. Further investigations are warranted to explore therapeutic strategies targeting cathepsin L in emphysema patients.
MeSH term(s)	Animals ; Humans ; Mice ; Asthma/genetics ; Cathepsin L/genetics ; Emphysema ; Eosinophils/metabolism ; Lung/metabolism ; Pancreatic Elastase ; Pulmonary Disease, Chronic Obstructive/genetics ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Emphysema/genetics ; Pulmonary Emphysema/metabolism
Chemical Substances	Cathepsin L (EC 3.4.22.15) ; Pancreatic Elastase (EC 3.4.21.36)
Language	English
Publishing date	2023-10-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2886872-9
ISSN	2059-3635 ; 2095-9907
ISSN (online)	2059-3635
ISSN	2095-9907
DOI	10.1038/s41392-023-01634-x
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Article ; Online: Genetic linkage map construction and QTL analysis for plant height in proso millet (Panicum miliaceum L.).

Jiang, Yanmiao / Dong, Li / Li, Haiquan / Liu, Yanan / Wang, Xindong / Liu, Guoqing

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

2024 Volume 137, Issue 4, Page(s) 78

Abstract: ... Proso millet (Panicum miliaceum L.) has the lowest water requirements of all cultivated cereal crops ...

Abstract	Key message: A genetic linkage map representing proso millet genome was constructed with SSR markers, and a major QTL corresponding to plant height was mapped on chromosome 14 of this map. Proso millet (Panicum miliaceum L.) has the lowest water requirements of all cultivated cereal crops. However, the lack of a genetic map and the paucity of genomic resources for this species have limited the utility of proso millet for detailed genetic studies and hampered genetic improvement programs. In this study, 97,317 simple sequence repeat (SSR) markers were developed based on the genome sequence of the proso millet landrace Longmi 4. Using some of these markers in conjunction with previously identified SSRs, an SSR-based linkage map for proso millet was successfully constructed using a large mapping population (316 F
MeSH term(s)	Panicum/genetics ; Chromosome Mapping ; Phenotype ; Microsatellite Repeats ; Genetic Linkage ; Genome, Plant
Language	English
Publishing date	2024-03-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2170-2
ISSN	1432-2242 ; 0040-5752
ISSN (online)	1432-2242
ISSN	0040-5752
DOI	10.1007/s00122-024-04576-2
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Article: Unraveling the 2,3-diketo-L-gulonic acid-dependent and -independent impacts of L-ascorbic acid on somatic cell reprogramming.

Liang, Lining / He, Meiai / Zhang, Yixin / Wang, Chenchen / Qin, Zhaohui / Li, Qian / Yang, Tingting / Meng, Fei / Zhou, Yusheng / Ge, Haofei / Song, Weining / Chen, Shiyu / Dong, Linna / Ren, Qiwen / Li, Changpeng / Guo, Lin / Sun, Hao / Zhang, Wei / Pei, Duanqing /

Zheng, Hui

Cell & bioscience

2023 Volume 13, Issue 1, Page(s) 218

Abstract: Background: L-ascorbic acid (Asc) plays a pivotal role in regulating various biological processes ... capabilities in promoting reprogramming through both 2,3-diketo-L-gulonic acid (DKG), a key metabolite during ...

Abstract	Background: L-ascorbic acid (Asc) plays a pivotal role in regulating various biological processes, including somatic cell reprogramming, through multiple pathways. However, it remains unclear whether Asc regulates reprogramming directly or functions through its metabolites. Results: Asc exhibited dual capabilities in promoting reprogramming through both 2,3-diketo-L-gulonic acid (DKG), a key metabolite during Asc degradation, dependent and independent routes. On the one hand, Asc facilitated reprogramming by promoting cell proliferation and inducing the conversion from pre-induced pluripotent stem cells (pre-iPSCs) to iPSCs through DKG-independent pathways. Additionally, Asc triggered mesenchymal-epithelial transition (MET) and activated glycolysis via DKG-dependent mechanisms. Notably, DKG alone activated a non-canonical tricarboxylic acid cycle characterized by increased succinate, fumarate, and malate. Consequently, this shift redirected oxidative phosphorylation toward glycolysis and induced MET. Moreover, owing to its antioxidant capabilities, Asc directly inhibited glycolysis, thereby preventing positive feedback between glycolysis and epithelial-mesenchymal transition, ultimately resulting in a higher level of MET. Conclusion: These findings unveil the intricate functions of Asc in the context of reprogramming. This study sheds light on the DKG-dependent and -independent activities of Asc during reprogramming, offering novel insights that may extend the application of Asc to other biological processes.
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2593367-X
ISSN	2045-3701
ISSN	2045-3701
DOI	10.1186/s13578-023-01160-x
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