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  1. Article ; Online: Pharmacodynamics of TRPV1 Agonists in a Bioassay Using Human PC-3 Cells

    Daniel Alvarez-Berdugo / Marcel Jiménez / Pere Clavé Laia Rofes

    The Scientific World Journal, Vol

    2014  Volume 2014

    Keywords Science ; Q ; Science (General) ; Q1-390
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Nutritional status of older patients with oropharyngeal dysphagia in a chronic versus an acute clinical situation

    Carrión, Silvia / Maria Roca / Alicia Costa / Viridiana Arreola / Omar Ortega / Elisabet Palomera / Mateu Serra-Prat / Mateu Cabré / Pere Clavé

    Clinical nutrition. 2017 Aug., v. 36

    2017  

    Abstract: Oropharyngeal dysphagia (OD) is a prevalent risk factor for malnutrition (MN) in older patients and both conditions are related to poor outcome.To explore the nutritional status in older patients with OD in a chronic and an acute clinical situation.We ... ...

    Abstract Oropharyngeal dysphagia (OD) is a prevalent risk factor for malnutrition (MN) in older patients and both conditions are related to poor outcome.To explore the nutritional status in older patients with OD in a chronic and an acute clinical situation.We examined 95 older (≥70 years) patients with OD associated to chronic neurological diseases or aging, and 23 older patients with OD and acute community-acquired pneumonia (CAP) with videofluoroscopy; and 15 older people without OD. We collected nutritional status, measured with the Mini Nutritional Assessment (MNA®), anthropometric measurements, and biochemistry and bioimpedance for body composition. Functional status was assessed with the Barthel index.1) Taking into consideration patients with OD with chronic conditions, 51.1% presented a MNA® ≤23.5; 16.7%, sarcopenia and a) reduced visceral and muscular protein compartments and fat compartment; b) muscular weakness c) intracellular water depletion, and d) reduced body weight. Patients with OD and MNA® ≤23 needed higher levels of nectar viscosity for a safe swallow and had increased oropharyngeal residue at spoon-thick viscosity. 2) Patients with OD and CAP, 69.5%, presented an MNA® ≤23.5 and 29.4% sarcopenia, the inflammatory response of the pneumonia adding to the more severe depletion in visceral protein and muscular mass.Prevalence of impaired nutritional status (malnutrition risk, and sarcopenia) among older patients with OD associated with either chronic or acute conditions is very high. In patients with OD and chronic diseases, poor nutritional status further impairs OD with an increase in oropharyngeal residue at spoon-thick viscosity. In the acute setting there is inflammation and an additional protein deficiency. These findings will help develop specific products both for OD and nutritional status in each specific clinical situation.
    Keywords anthropometric measurements ; biochemistry ; bioelectrical impedance ; body composition ; body weight ; chronic diseases ; dysphagia ; elderly ; functional status ; inflammation ; malnutrition ; nectar ; nutrition assessment ; nutritional status ; patients ; pneumonia ; protein deficiencies ; risk factors ; sarcopenia ; viscosity
    Language English
    Dates of publication 2017-08
    Size p. 1110-1116.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2016.07.009
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Diagnosis and Management of Oropharyngeal Dysphagia and Its Nutritional and Respiratory Complications in the Elderly

    Laia Rofes / Viridiana Arreola / Jordi Almirall / Mateu Cabré / Lluís Campins / Pilar García-Peris / Renée Speyer / Pere Clavé

    Gastroenterology Research and Practice, Vol

    2011  Volume 2011

    Abstract: Oropharyngeal dysphagia is a major complaint among older people. Dysphagia may cause two types of complications in these patients: (a) a decrease in the efficacy of deglutition leading to malnutrition and dehydration, (b) a decrease in deglutition safety, ...

    Abstract Oropharyngeal dysphagia is a major complaint among older people. Dysphagia may cause two types of complications in these patients: (a) a decrease in the efficacy of deglutition leading to malnutrition and dehydration, (b) a decrease in deglutition safety, leading to tracheobronchial aspiration which results in aspiration pneumonia and can lead to death. Clinical screening methods should be used to identify older people with oropharyngeal dysphagia and to identify those patients who are at risk of aspiration. Videofluoroscopy (VFS) is the gold standard to study the oral and pharyngeal mechanisms of dysphagia in older patients. Up to 30% of older patients with dysphagia present aspiration—half of them without cough, and 45%, oropharyngeal residue; and 55% older patients with dysphagia are at risk of malnutrition. Treatment with dietetic changes in bolus volume and viscosity, as well as rehabilitation procedures can improve deglutition and prevent nutritional and respiratory complications in older patients. Diagnosis and management of oropharyngeal dysphagia need a multidisciplinary approach.
    Keywords Diseases of the digestive system. Gastroenterology ; RC799-869 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Gastroenterology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 610
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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