LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 186

Search options

  1. Article: GLÜCKLICH WERDEN LEICHT GEMACHT? Die Medizinethiker Matthis Synofzik und Thomas E. Schläpfer beziehen Position gegen einen ausufernden Einsatz von Tiefhirnstimulation

    Synofzik, Matthis / Schläpfer, Thomas E.

    Gehirn & Geist

    2009  Volume -, Issue 10, Page(s) 33

    Language German
    Document type Article
    ZDB-ID 2072879-7
    ISSN 1618-8519
    Database Current Contents Medicine

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5667: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book: Neurobiology of psychiatric disorders

    Schläpfer, Thomas

    (Handbook of clinical neurology ; 106 = 3. ser., [vol. 28])

    2012  

    Author's details vol. ed. Thomas E. Schlaepfer
    Series title Handbook of clinical neurology ; 106 = 3. ser., [vol. 28]
    Collection
    Language English
    Size XIX, 760 S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Edinburgh u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017301999
    ISBN 978-0-444-52002-9 ; 0-444-52002-3
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 9532 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book: Tiefe Hirnstimulation

    Volkmann, Jens / Schläpfer, Thomas / Bewernick, Bettina / Gippert, Sabrina Maria / Galert, Thorsten

    neurologische, psychiatrische und philosophische Aspekte

    (Ethik in den Biowissenschaften - Sachstandsberichte des DRZE ; Band 18)

    2016  

    Author's details Jens Volkmann/Thomas E. Schläpfer/Bettina Bewernick/Sabrina M. Gippert/Thorsten Galert
    Series title Ethik in den Biowissenschaften - Sachstandsberichte des DRZE ; Band 18
    Collection
    Keywords Hirnstimulation ; Psychiatrie ; Neurologie ; Medizinische Ethik
    Subject Ärztliche Ethik ; Klinische Ethik ; Ärztliches Ethos ; Arzt ; Medizin ; Heilberuf ; Medizinethik ; Klinische Neurologie ; Seelenheilkunde ; Tiefe Hirnstimulation ; THS ; Tiefenhirnstimulation ; Hirnschrittmacher
    Language German
    Size 199 Seiten
    Edition Originalausgabe
    Publisher Verlag Karl Alber
    Publishing place Freiburg ; München
    Publishing country Germany
    Document type Book
    HBZ-ID HT018933624
    ISBN 978-3-495-48762-4 ; 3-495-48762-X
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 1768 available for loan (reading room) Lesesaal EG

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Corrigendum to "Impaired socio-affective, but intact socio-cognitive skills in patients with treatment-resistant, recurrent depression" [J. Psychiatr. Res. 153 (2022) 206-212 / https://doi.org/10.1016/j.jpsychires.2022.07.025].

    Kilian, Hannah M / Schiller, Bastian / Schläpfer, Thomas E / Heinrichs, Markus

    Journal of psychiatric research

    2024  Volume 172, Page(s) 198–199

    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Published Erratum
    ZDB-ID 3148-3
    ISSN 1879-1379 ; 0022-3956
    ISSN (online) 1879-1379
    ISSN 0022-3956
    DOI 10.1016/j.jpsychires.2024.02.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.243: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Deep Brain Stimulation for Major Depression-Steps on a Long and Winding Road.

    Schlaepfer, Thomas E

    Biological psychiatry

    2015  Volume 78, Issue 4, Page(s) 218–219

    MeSH term(s) Deep Brain Stimulation ; Depressive Disorder, Major/therapy ; Depressive Disorder, Treatment-Resistant/therapy ; Female ; Humans ; Internal Capsule/physiopathology ; Male ; Ventral Striatum/physiopathology
    Language English
    Publishing date 2015-08-15
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2015.06.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 720: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Impaired socio-affective, but intact socio-cognitive skills in patients with treatment-resistant, recurrent depression.

    Kilian, Hannah M / Schiller, Bastian / Schläpfer, Thomas E / Heinrichs, Markus

    Journal of psychiatric research

    2022  Volume 153, Page(s) 206–212

    Abstract: Background: Social withdrawal is a key symptom of depression. The resulting loss of social reinforcement in turn contributes to chronic, recurrent courses of the disease. However, it is not clear whether depressed patients have less motivation to ... ...

    Abstract Background: Social withdrawal is a key symptom of depression. The resulting loss of social reinforcement in turn contributes to chronic, recurrent courses of the disease. However, it is not clear whether depressed patients have less motivation to socially interact, or whether their skills in doing so are impaired. The current study investigates potential skill deficits in patients with treatment-resistant depression (TRD).
    Methods: 15 TRD patients and 19 age- and sex-matched healthy controls performed the EmpaToM, a paradigm which includes naturalistic video stimuli of either neutral or emotional valence and which differentiates between socio-affective (affective empathy, compassion) and socio-cognitive (theory of mind) skills.
    Results: Controlling for the baseline affective state in neutral situations, TRD patients displayed significantly reduced affective empathy towards emotional situations compared to healthy controls. Furthermore, TRD patients were less compassionate in both neutral and emotional situations. In contrast, socio-cognitive skill performances did not differ between patients and healthy controls.
    Limitations: Further studies might explore socio-affective and socio-cognitive skills in TRD patients using socio-affective/-cognitive tasks involving face-to-face social interactions.
    Conclusion: Our study revealed a specific socio-affective deficit in TRD patients, while showing intact socio-cognitive skills. Patients were less able to affectively resonate with others (affective empathy) and exhibited generally reduced feelings of compassion. These deficits might interfere with providing and receiving social support. Our study contributes to a better understanding of the underlying causes of social withdrawal and stresses the need to specifically address pervasive socio-affective deficits in psychotherapy of TRD patients.
    MeSH term(s) Cognition ; Depression ; Depressive Disorder, Treatment-Resistant/therapy ; Empathy ; Humans
    Language English
    Publishing date 2022-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 3148-3
    ISSN 1879-1379 ; 0022-3956
    ISSN (online) 1879-1379
    ISSN 0022-3956
    DOI 10.1016/j.jpsychires.2022.07.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.243: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Johann Bernhard Aloys von Gudden: The Unrecognized Role of the Psychiatrist and Neuroanatomist in Modern Stereotactic Neurosurgery.

    Coenen, Volker A / Hurwitz, Trevor A / Schlaepfer, Thomas E

    Stereotactic and functional neurosurgery

    2020  Volume 98, Issue 1, Page(s) 65–69

    Abstract: Bernhard von Gudden was the founder of the famous school of psychiatry and neuroanatomy in Munich, Germany. Beyond his association with the mysterious death of King Ludwig II of Bavaria, not much is known about Bernhard von Gudden's work in neuroanatomy. ...

    Abstract Bernhard von Gudden was the founder of the famous school of psychiatry and neuroanatomy in Munich, Germany. Beyond his association with the mysterious death of King Ludwig II of Bavaria, not much is known about Bernhard von Gudden's work in neuroanatomy. He pioneered fiber tract mapping by studying the effects of neurodegeneration following brain lesions. His ideas and work lay the foundation for subsequent fiber tract mapping strategies including the latest method using diffusion tensor magnetic resonance. This paper describes and acknowledges his contribution to the field, now collectively known as connectomics, and describes how it has become an essential tool in modern stereotactic neurosurgery.
    MeSH term(s) Germany ; History, 19th Century ; Humans ; Male ; Neuroanatomy/history ; Neurosurgery/history ; Psychiatry/history ; Stereotaxic Techniques/history
    Language English
    Publishing date 2020-02-11
    Publishing country Switzerland
    Document type Biography ; Historical Article ; Journal Article ; Portrait ; Review
    ZDB-ID 645069-6
    ISSN 1423-0372 ; 1011-6125
    ISSN (online) 1423-0372
    ISSN 1011-6125
    DOI 10.1159/000505704
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.130: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Normalized affective responsiveness following deep brain stimulation of the medial forebrain bundle in depression.

    Kilian, Hannah Marlene / Schiller, Bastian / Meyer-Doll, Dora Margarete / Heinrichs, Markus / Schläpfer, Thomas Eduard

    Translational psychiatry

    2024  Volume 14, Issue 1, Page(s) 6

    Abstract: ... affective responsiveness towards emotional versus neutral situations (i.e. affective empathy ...

    Abstract Deep brain stimulation (DBS) of the supero-lateral medial forebrain bundle (slMFB) is associated with rapid and sustained antidepressant effects in treatment-resistant depression (TRD). Beyond that, improvements in social functioning have been reported. However, it is unclear whether social skills, the basis of successful social functioning, are systematically altered following slMFB DBS. Therefore, the current study investigated specific social skills (affective empathy, compassion, and theory of mind) in patients with TRD undergoing slMFB DBS in comparison to healthy subjects. 12 patients with TRD and 12 age- and gender-matched healthy subjects (5 females) performed the EmpaToM, a video-based naturalistic paradigm differentiating between affective empathy, compassion, and theory of mind. Patients were assessed before and three months after DBS onset and compared to an age- and gender-matched sample of healthy controls. All data were analyzed using non-parametric Mann-Whitney U tests. DBS treatment significantly affected patients' affective responsiveness towards emotional versus neutral situations (i.e. affective empathy): While their affective responsiveness was reduced compared to healthy subjects at baseline, they showed normalized affective responsiveness three months after slMFB DBS onset. No effects occurred in other domains with persisting deficits in compassion and intact socio-cognitive skills. Active slMFB DBS resulted in a normalized affective responsiveness in patients with TRD. This specific effect might represent one factor supporting the resumption of social activities after recovery from chronic depression. Considering the small size of this unique sample as well as the explorative nature of this study, future studies are needed to investigate the robustness of these effects.
    MeSH term(s) Female ; Humans ; Deep Brain Stimulation ; Depression/therapy ; Medial Forebrain Bundle ; Emotions ; Empathy
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-023-02712-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Impaired socio-affective, but intact socio-cognitive skills in patients with treatment-resistant, recurrent depression

    Kilian, Hannah M. / Schiller, Bastian / Schläpfer, Thomas E. / Heinrichs, Markus

    Journal of Psychiatric Research

    2022  Volume 153, Page(s) 206–212

    Abstract: Abstract not released by publisher. ...

    Title translation Beeinträchtigte sozio-affektive, aber intakte sozio-kognitive Fähigkeiten bei Patienten mit behandlungsresistenter, rezidivierender Depression (DeepL)
    Abstract Abstract not released by publisher.
    Keywords Compassion ; Empathie ; Empathy ; Mitgefühl ; Periodische Depression ; Recurrent Depression ; Social Skills ; Social Withdrawal ; Soziale Fertigkeiten ; Sozialer Rückzug ; Theory of Mind ; Therapieresistente Depression ; Treatment Resistant Depression
    Language English
    Document type Article
    ZDB-ID 3148-3
    ISSN 1879-1379 ; 0022-3956
    ISSN (online) 1879-1379
    ISSN 0022-3956
    DOI 10.1016/j.jpsychires.2022.07.025
    Database PSYNDEX

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.243: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Resolving dyskinesias at sustained anti-OCD efficacy by steering of DBS away from the anteromedial STN to the mesencephalic ventral tegmentum - case report.

    Coenen, Volker A / Schlaepfer, Thomas E / Meyer, Dora / Kilian, Hannah / Spanier, Susanne / Sajonz, Bastian E A / Reinacher, Peter C / Reisert, Marco

    Acta neurochirurgica

    2022  Volume 164, Issue 9, Page(s) 2303–2307

    Abstract: Here we describe therapeutic results in a female patient who underwent bilateral slMFB DBS for OCD. During a 35-month long course of stimulation, she suffered from stimulation-induced dyskinesia of her right leg which we interpreted as co-stimulation of ... ...

    Abstract Here we describe therapeutic results in a female patient who underwent bilateral slMFB DBS for OCD. During a 35-month long course of stimulation, she suffered from stimulation-induced dyskinesia of her right leg which we interpreted as co-stimulation of the adjacent anteromedial subthalamic nucleus (amSTN). After reprogramming to steer the stimulation away from the amSTN medial into the direction of the mesencephalic ventral tegmentum (MVT which contains the ventral tegmental area, VTA), the dyskinesias disappeared. Remarkably, anti-OCD efficacy in the presented patient was preserved and achieved with a bilateral stimulation which by our imaging study fully avoided the amSTN.
    MeSH term(s) Deep Brain Stimulation/methods ; Dyskinesias/etiology ; Dyskinesias/therapy ; Female ; Humans ; Obsessive-Compulsive Disorder/therapy ; Subthalamic Nucleus
    Language English
    Publishing date 2022-05-02
    Publishing country Austria
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-022-05206-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.180: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top