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  1. Article: [Osugoroshi virus, a male-killer virus].

    Fujita, Ryosuke

    Uirusu

    2022  Volume 71, Issue 1, Page(s) 63–70

    Abstract: In insects, sex ratio bias is sometimes introduced by feminization, parthenogenesis, cytoplasmic incompatibility, or male-killing. Some intracellular bacteria such as Wolbachia or Spiroplasma has been known as male-killing agents. Here I introduce an ... ...

    Abstract In insects, sex ratio bias is sometimes introduced by feminization, parthenogenesis, cytoplasmic incompatibility, or male-killing. Some intracellular bacteria such as Wolbachia or Spiroplasma has been known as male-killing agents. Here I introduce an example of non-bacterial male-killing agent, Osugoroshi virus found in oriental tea tortrix.
    MeSH term(s) Animals ; DNA Viruses ; Male ; Moths/microbiology ; RNA Viruses ; Sex Ratio ; Spiroplasma ; Symbiosis ; Viruses, Unclassified ; Wolbachia
    Language Japanese
    Publishing date 2022-03-25
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 603272-2
    ISSN 0042-6857
    ISSN 0042-6857
    DOI 10.2222/jsv.71.63
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 266: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Use of covered stent grafts to treat an extracranial carotid artery aneurysm due to carotid stent deformation: A case report.

    Fujita, Ohju / Hayashi, Shigemasa / Oshima, Ryosuke / Matsuyama, Tomoki / Tamai, Hiroaki

    Clinical neurology and neurosurgery

    2024  Volume 241, Page(s) 108272

    Language English
    Publishing date 2024-04-02
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2024.108272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.53: Show issues Location:
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  3. Article ; Online: Synthesis of a diruthenium μ-η

    Takao, Toshiro / Shimogawa, Ryuichi / Fujita, Ryosuke / Egawa, Shu

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 45, Page(s) 16737–16753

    Abstract: The reaction of [ ... ...

    Abstract The reaction of [Cp
    Language English
    Publishing date 2023-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt03187j
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  4. Article ; Online: 5-ALA treatment increases intracellular heme levels and enhances CYP3A4 activity in genome-edited Caco-2 cells.

    Watanabe, Keita / Negoro, Ryosuke / Fujita, Takuya

    Biochemical and biophysical research communications

    2023  Volume 664, Page(s) 94–99

    Abstract: In nonclinical studies, models that can predict the metabolism of drug candidates by cytochrome P450 (CYP), including Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) are helpful. CYP3A4-overexpressing human cells have been used universally to ... ...

    Abstract In nonclinical studies, models that can predict the metabolism of drug candidates by cytochrome P450 (CYP), including Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) are helpful. CYP3A4-overexpressing human cells have been used universally to evaluate whether CYP3A4 metabolizes drug-candidate compounds. However, CYP3A4-overexpressing human cell lines are problematic because their activity levels are lower than that of in vivo human CYP3A4. Heme plays a paramount role in CYP activity. The rate-limiting step in heme biosynthesis is the generation of 5-aminolevulinic acid (5-ALA). In this study, we examined whether treatment with 5-ALA to CYP3A4-POR-UGT1A1-CES2 knockin and CES1 knockout (genome-edited) Caco-2 cells enhances CYP3A4 activity. A 7-day 5-ALA treatment increased intracellular heme levels in genome-edited Caco-2 cells without cytotoxicity. Moreover, consistent with the increase in intracellular heme content, 5-ALA treatment increased CYP3A4 activity in genome-edited Caco-2 cells. The results of this research are expected to be applied to pharmacokinetic studies using CYP-overexpressing human cells containing CYP3A4.
    MeSH term(s) Humans ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 CYP3A/metabolism ; Caco-2 Cells ; Aminolevulinic Acid/pharmacology ; Heme ; Cytochrome P-450 Enzyme System/metabolism
    Chemical Substances Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Aminolevulinic Acid (88755TAZ87) ; Heme (42VZT0U6YR) ; Cytochrome P-450 Enzyme System (9035-51-2) ; CYP3A4 protein, human (EC 1.14.14.55)
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.04.077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Generation of Caco-2 cells with predictable metabolism by CYP3A4, UGT1A1 and CES using the PITCh system.

    Yamada, Naoki / Negoro, Ryosuke / Watanabe, Keita / Fujita, Takuya

    Drug metabolism and pharmacokinetics

    2023  Volume 50, Page(s) 100497

    Abstract: Caco-2 cells are widely used as an in vitro intestinal model. However, the expression levels of the drug-metabolizing enzymes CYP3A4 and UGT1A1 are lower in these cells than in intestinal cells. Furthermore, the majority of prodrugs in use today are ... ...

    Abstract Caco-2 cells are widely used as an in vitro intestinal model. However, the expression levels of the drug-metabolizing enzymes CYP3A4 and UGT1A1 are lower in these cells than in intestinal cells. Furthermore, the majority of prodrugs in use today are ester-containing, and carboxylesterase (CES) 1 and CES2 are among the enzymes that process the prodrugs into drugs. In the human small intestine, CES1 is hardly expressed while CES2 is highly expressed, but the CES expression pattern in Caco-2 cells is the opposite. In this study, we generated CYP3A4-POR-UGT1A1-CES2 knock-in (KI) and CES1 knock-out (KO) Caco-2 (genome-edited Caco-2) cells using a PITCh system. Genome-edited Caco-2 cells were shown to express functional CYP3A4, POR, UGT1A1 and CES2 while the expression of the CES1 protein was completely knocked out. We performed transport assays using temocapril. The Papp value of temocapril in genome-edited Caco-2 cells was higher than that in WT Caco-2 cells. Interestingly, the amount of temocaprilat on the apical side in genome-edited Caco-2 cells was lower than that in WT Caco-2 cells. These results suggest that genome-edited Caco-2 cells are more suitable than WT Caco-2 cells as a model for predicting intestinal drug absorption and metabolism.
    MeSH term(s) Humans ; Caco-2 Cells ; Carboxylesterase/genetics ; Carboxylesterase/metabolism ; Cytochrome P-450 CYP3A/genetics ; Prodrugs/metabolism
    Chemical Substances Carboxylesterase (EC 3.1.1.1) ; CYP3A4 protein, human (EC 1.14.14.55) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Prodrugs ; temocapril hydrochloride (8G820I95VP) ; UGT1A1 enzyme (EC 2.4.1.-)
    Language English
    Publishing date 2023-02-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2095748-8
    ISSN 1880-0920 ; 1347-4367 ; 0916-1139
    ISSN (online) 1880-0920
    ISSN 1347-4367 ; 0916-1139
    DOI 10.1016/j.dmpk.2023.100497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3734: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Selective Confinement of Rare-Earth-Metal Hydrates by a Capped Metallo-Cage under Aqueous Conditions.

    Tabuchi, Ryosuke / Takezawa, Hiroki / Fujita, Makoto

    Angewandte Chemie (International ed. in English)

    2022  Volume 61, Issue 37, Page(s) e202208866

    Abstract: The properties of rare-earth-metal ions in aqueous media often depend on their various hydration modes, which allow them to exist as monomeric or oligomeric species with different coordination numbers. Capturing rare-earth-metal ions in a confined cavity ...

    Abstract The properties of rare-earth-metal ions in aqueous media often depend on their various hydration modes, which allow them to exist as monomeric or oligomeric species with different coordination numbers. Capturing rare-earth-metal ions in a confined cavity can fix their hydration modes and thus enable their intrinsic properties to be distinguished. However, the isolation of ionic species from bulk aqueous media is not an easy task due to competitive interaction with bulk water. Here, we report the encapsulation of hydrated rare-earth-metal ions in a hydrophobic cavity of a synthetic cage. Cap-like counter anions located at the cage's portals play an important role in capturing the rare-earth metals at a fixed position via electrostatic interactions. Preferential encapsulation of early lanthanoid (III) ions was observed even though all the rare-earth metals have the same hydration number and geometry, as visualized by the competitive inclusion of a dye molecule. Accordingly, the early lanthanoid ion was selectively extracted from a mixture of two rare-earth-metal ions.
    Language English
    Publishing date 2022-08-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202208866
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  7. Article: Adrenocortical Carcinoma with a Renal Vein Thrombus Extending to the Inferior Vena Cava Successfully Resected with the Left Kidney and Distal Pancreatectomy: A Case Report.

    Miyata, Takashi / Sannomiya, Yuta / Nagayama, Taigo / Kin, Ryosuke / Nishiki, Hisashi / Hashimoto, Akifumi / Kaida, Daisuke / Fujita, Hideto / Ueda, Nobuhiko / Takamura, Hiroyuki

    Case reports in oncology

    2024  Volume 17, Issue 1, Page(s) 377–385

    Abstract: Introduction: Adrenocortical carcinoma (ACC) is an extremely rare and aggressive tumor, and its clinical characteristics are poorly defined because of its rarity.: Case presentation: We report a 64-year-old man who presented with upper abdominal pain ...

    Abstract Introduction: Adrenocortical carcinoma (ACC) is an extremely rare and aggressive tumor, and its clinical characteristics are poorly defined because of its rarity.
    Case presentation: We report a 64-year-old man who presented with upper abdominal pain and weight loss. Computed tomography revealed a 15 cm left adrenal tumor compressing the pancreas ventrally and a tumor thrombus in the inferior vena cava (IVC) originating from the left renal vein. Positron emission tomography-computed tomography revealed
    Conclusion: This report of a rare case of ACC involving the pancreas with tumor thrombus extension to the IVC stresses that this combination of conditions does not preclude radical surgery. However, more data are needed regarding chemotherapy and radiotherapy, as well as relapse treatment, and further research on ACC is essential for a favorable prognosis.
    Language English
    Publishing date 2024-02-27
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000535367
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  8. Article ; Online: Three cases of neutralization of factor Xa inhibitors with andexanet alfa under rotational thromboelastography monitoring.

    Yagi, Takeshi / Kawano, Reina / Tomokage, Takuto / Ayata, Ryo / Koga, Yasutaka / Kaneda, Kotaro / Fujita, Motoki / Yamanaka, Nanami / Mori, Naomasa / Tsuruta, Ryosuke

    Acute medicine & surgery

    2024  Volume 11, Issue 1, Page(s) e954

    Abstract: Background: Factor Xa inhibitors are direct oral anticoagulants that are extremely useful in clinical applications, safe, and do not require dose adjustment. It is desirable to be able to monitor their effects in the event of hemorrhagic complications ... ...

    Abstract Background: Factor Xa inhibitors are direct oral anticoagulants that are extremely useful in clinical applications, safe, and do not require dose adjustment. It is desirable to be able to monitor their effects in the event of hemorrhagic complications requiring neutralization. However, it is difficult to monitor their activity and neutralization using conventional coagulation tests.
    Case presentation: We report three patients taking factor Xa inhibitors who underwent rotational thromboelastography (ROTEM) monitoring before and after neutralization with andexanet alfa. All three patients had hemorrhagic complications that required neutralization of their factor Xa inhibitors using andexanet alfa. One ROTEM parameter, the EXTEM clotting time (EXTEM-CT), was immediately shortened after andexanet alfa bolus administration, without subsequent extension of the EXTEM-CT assessed 4 h after the bolus dose.
    Conclusion: ROTEM parameters, particularly EXTEM-CT, might be useful for monitoring neutralization of factor Xa inhibitors.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2751184-4
    ISSN 2052-8817 ; 2052-8817
    ISSN (online) 2052-8817
    ISSN 2052-8817
    DOI 10.1002/ams2.954
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  9. Article ; Online: Whole-body MRI revealed generalized subcutaneous oedema in a patient with juvenile dermatomyositis.

    Fujita, Yuji / Kuwashima, Shigeko / Sakurai, Ryosuke / Suzuki, Atsushi / Imataka, George / Matsuda, Hadzki / Ishida, Kazuyuki / Matsushita, Takashi / Nishino, Ichizo / Yoshihara, Shigemi

    Rheumatology advances in practice

    2023  Volume 7, Issue 2, Page(s) rkad063

    Language English
    Publishing date 2023-07-28
    Publishing country England
    Document type Case Reports
    ISSN 2514-1775
    ISSN (online) 2514-1775
    DOI 10.1093/rap/rkad063
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  10. Article ; Online: Cell morphology engineering enhances grazing resistance of Synechococcus elongatus PCC 7942 for non-sterile large-scale cultivation.

    Toda, Narumi / Inoue-Kashino, Natsuko / Fujita, Hazaya / Yoshida, Ryosuke / Nimura-Matsune, Kaori / Watanabe, Satoru / Kuroda, Akio / Kashino, Yasuhiro / Hirota, Ryuichi

    Journal of bioscience and bioengineering

    2024  Volume 137, Issue 4, Page(s) 245–253

    Abstract: In the practical scale of cyanobacterial cultivation, the golden algae Poterioochromonas malhamensis is a well-known predator that causes devastating damage to the culture, referred to as pond crash. The establishment and maintenance of monoculture ... ...

    Abstract In the practical scale of cyanobacterial cultivation, the golden algae Poterioochromonas malhamensis is a well-known predator that causes devastating damage to the culture, referred to as pond crash. The establishment and maintenance of monoculture conditions are ideal for large-scale cultures. However, this is a difficult challenge because microbial contamination is unavoidable in practical-scale culture facilities. In the present study, we unexpectedly observed the pond crash phenomenon during the pilot-scale cultivation of Synechococcus elongatus PCC 7942 using a 100-L photobioreactor. This was due to the contamination with P. malhamensis, which probably originated from residual fouling. Interestingly, we found that S.elongatus PCC 7942 can alter its morphological structure when subjected to continuous grazing pressure from predators, resulting in cells that were more than 100 times longer than those of the wild-type strain. These hyper-elongated S.elongatus PCC 7942 cells had mutations in the genes encoding FtsZ or Ftn2 which are involved in bacterial cell division. Importantly, the elongated phenotype remained stable during cultivation, enabling S.elongatus PCC 7942 to thrive and resist grazing. The cultivation of the elongated S.elongatus PCC 7942 mutant strain in a 100-L pilot-scale photobioreactor under non-sterile conditions resulted in increased cyanobacterial biomass without encountering pond crash. This study demonstrates an efficient strategy for cyanobacterial cell culture in practical-scale bioreactors without the need for extensive decontamination or sterilization of the growth medium and culture facility, which can contribute to economically viable cultivation and bioprocessing of microalgae.
    MeSH term(s) Synechococcus/genetics ; Cell Engineering ; Mutation
    Language English
    Publishing date 2024-02-09
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1465387-4
    ISSN 1347-4421 ; 1389-1723
    ISSN (online) 1347-4421
    ISSN 1389-1723
    DOI 10.1016/j.jbiosc.2024.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4728: Show issues

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