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  1. Article ; Online: Oral Fungal Infections: Past, Present, and Future.

    Cannon, Richard D

    Frontiers in oral health

    2022  Volume 3, Page(s) 838639

    Abstract: Oral fungal infections have afflicted humans for millennia. Hippocrates ( ...

    Abstract Oral fungal infections have afflicted humans for millennia. Hippocrates (
    Language English
    Publishing date 2022-02-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-4842
    ISSN (online) 2673-4842
    DOI 10.3389/froh.2022.838639
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  2. Article ; Online: Effects of simulated long-term exposure to bottled, neutral pH electrolyzed oxidizing water on the properties of denture base resins.

    Krishnan, Chitra Shankar / Li, Kai Chun / Tompkins, Geoffrey R / Lyons, Karl M / Cannon, Richard D

    The Journal of prosthetic dentistry

    2024  

    Abstract: Statement of problem: Denture stomatitis can pose serious health risks, especially to older people. Chemical denture cleaning agents must be effective, yet not adversely affect the longevity of removable dentures. Ready-to-use (RTU) neutral pH ... ...

    Abstract Statement of problem: Denture stomatitis can pose serious health risks, especially to older people. Chemical denture cleaning agents must be effective, yet not adversely affect the longevity of removable dentures. Ready-to-use (RTU) neutral pH electrolyzed oxidizing water (EOW) is an effective biocide against Candida albicans biofilms on denture resins, but the effects of daily disinfection with EOW on the physical and mechanical properties of resins have not been established.
    Purpose: The purpose of this in vitro study was to investigate the effects of simulated long-term exposure to RTU EOW on the color, surface characteristics, and flexural strength of denture base resins.
    Material and methods: Heat-polymerized (HP), 3D printed (3D) and computer-aided design and computer-aided manufacture (CAD-CAM)-milled (CC) denture resin specimens (square: 20×20×3.3 mm; beam: 64×10×3.3 mm) were immersed in tap water (TW), RTU EOW (Neutral Anolyte ANK; Envirolyte; EOW), or a commercial denture cleaning tablet solution (Polident 3-Minute; Glaxo SmithKline; PD), mimicking a 5-minute once daily disinfection routine performed up to 3.0 years. Color and surface roughness were recorded (n=3, squares), and changes in color (∆E
    Results: No significant changes were found in either color or surface roughness for HP, 3D, and CC resins after 1.5-year and 3.0-year immersion in any of the agents (P>.05). The surface hardness of 3D resins reduced by 14% with TW and by 23% with EOW and PD at 3.0 years. The flexural strengths of all 3 resins were unaffected by 3.0-year immersion (P>.05).
    Conclusions: Simulated long-term immersion disinfection with RTU neutral pH EOW did not adversely affect the physical and mechanical properties of HP or CC denture resins.
    Language English
    Publishing date 2024-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218157-5
    ISSN 1097-6841 ; 0022-3913
    ISSN (online) 1097-6841
    ISSN 0022-3913
    DOI 10.1016/j.prosdent.2024.03.034
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  3. Article ; Online: Effect of the Rho-Kinase/ROCK Signaling Pathway on Cytoskeleton Components.

    Guan, Guangzhao / Cannon, Richard D / Coates, Dawn E / Mei, Li

    Genes

    2023  Volume 14, Issue 2

    Abstract: The mechanical properties of cells are important in tissue homeostasis and enable cell growth, division, migration and the epithelial-mesenchymal transition. Mechanical properties are determined to a large extent by the cytoskeleton. The cytoskeleton is ... ...

    Abstract The mechanical properties of cells are important in tissue homeostasis and enable cell growth, division, migration and the epithelial-mesenchymal transition. Mechanical properties are determined to a large extent by the cytoskeleton. The cytoskeleton is a complex and dynamic network composed of microfilaments, intermediate filaments and microtubules. These cellular structures confer both cell shape and mechanical properties. The architecture of the networks formed by the cytoskeleton is regulated by several pathways, a key one being the Rho-kinase/ROCK signaling pathway. This review describes the role of ROCK (Rho-associated coiled-coil forming kinase) and how it mediates effects on the key components of the cytoskeleton that are critical for cell behaviour.
    MeSH term(s) rho-Associated Kinases/chemistry ; rho-Associated Kinases/metabolism ; rho-Associated Kinases/pharmacology ; Cytoskeleton/metabolism ; Microtubules/metabolism ; Signal Transduction ; Actin Cytoskeleton/metabolism
    Chemical Substances rho-Associated Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14020272
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  4. Article ; Online: The effect of surface roughening of orthodontic elastomers on hydrophobicity and in vitro adherence of Streptococcus gordonii.

    Skilbeck, Michael G / Cannon, Richard D / Farella, Mauro / Mei, Li

    Journal of the mechanical behavior of biomedical materials

    2023  Volume 143, Page(s) 105881

    Abstract: Objectives: Biofilm formation around orthodontic appliances causes gingivitis, enamel decalcification and caries. Bacteria adhere less readily to superhydrophobic surfaces. The aim of this study was to determine whether a superhydrophobic surface could ... ...

    Abstract Objectives: Biofilm formation around orthodontic appliances causes gingivitis, enamel decalcification and caries. Bacteria adhere less readily to superhydrophobic surfaces. The aim of this study was to determine whether a superhydrophobic surface could be generated on orthodontic elastomers by surface modification in order to reduce bacterial adhesion.
    Materials and methods: Orthodontic elastomers were modified with sandpapers of various grit sizes (80-600 grit). Surface roughness of the modified and unmodified surfaces was assessed qualitatively with scanning electron microscopy and quantitatively with confocal microscopy. Water contact angles were measured with a goniometer to quantify hydrophobicity. Measurements were performed on unextended elastomers (100% original length) and elastomers extended to 150%, and 200% of the original length. Adhesion of Streptococcus gordonii to saliva coated elastomers was measured by counting colony forming units on agar plates.
    Results: Abrasion with different sandpapers produced elastomers with surface roughness (R
    Conclusion: The surface roughness of orthodontic elastomers influences both their hydrophobicity and bacterial adhesion. Superhydrophobicity of elastomers could not be achieved with sandpaper abrasion.
    MeSH term(s) Elastomers ; Streptococcus gordonii ; Surface Properties ; Bacterial Adhesion ; Hydrophobic and Hydrophilic Interactions
    Chemical Substances Elastomers
    Language English
    Publishing date 2023-05-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2378381-3
    ISSN 1878-0180 ; 1751-6161
    ISSN (online) 1878-0180
    ISSN 1751-6161
    DOI 10.1016/j.jmbbm.2023.105881
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  5. Article ; Online: Electrolysed oxidising water as a multi-purpose biocide in dental healthcare-A scoping review.

    Krishnan, Chitra S / Tompkins, Geoffrey R / Lyons, Karl M / Cannon, Richard D

    Gerodontology

    2023  Volume 40, Issue 4, Page(s) 422–462

    Abstract: Objectives: The objective of this scoping review was to map evidence of electrolysed oxidising water (EOW) as a biocide for dental applications of relevance to older people and identify research gaps.: Background: EOW is an emerging, "green," and ... ...

    Abstract Objectives: The objective of this scoping review was to map evidence of electrolysed oxidising water (EOW) as a biocide for dental applications of relevance to older people and identify research gaps.
    Background: EOW is an emerging, "green," and cost-effective biocide. There are no reviews on the landscape of EOW research as either an antiseptic or disinfectant in dental healthcare or its suitability for the oral healthcare of older people.
    Materials and methods: The review follows the PRISMA Extension for Scoping Reviews (PRISMA-ScR) guidelines. Database searches (Google Scholar, PubMed, Web of Science, Ovid, Scopus and Science Direct) were undertaken using MESH terms and Boolean operators with no date restrictions, to identify full-text, original reports published in English-language peer-reviewed journals.
    Results: The search yielded 114 papers that met the inclusion/exclusion criteria. Dental applications of EOW include its use as an endodontic irrigant (39%); mouth rinse/surgical irrigant (21%); disinfectant for dental unit water lines (19%) and dental biomaterials (17%); and for antimicrobial efficacy, effects on oral tissues and on dental material properties. Most studies (83%) evaluated a single EOW formulation (acidic, moderately acidic or neutral) that was either generated at 'point-of-use' (POU; 72%), bottled ('ready-to-use', RTU; 24%) or from unspecified (3%) sources. Six reports evaluated storage-related parameters and 25 evaluated clinical applications; 89 were in vitro studies and one investigated the cost-effectiveness of POU EOW.
    Conclusions: Neutral-pH, EOW is effective as an antimicrobial agent without deleterious effects on oral tissues. However, research on the impact of storage conditions, anti-Candida biofilm efficacy and mechanism of action against yeasts, long-term effects on denture materials and cost-effectiveness is required to establish the suitability of EOW as a multipurpose biocide for dental healthcare, including infection-control requirements relating to older people.
    MeSH term(s) Humans ; Aged ; Disinfectants/therapeutic use ; Water ; Anti-Infective Agents ; Anti-Infective Agents, Local ; Delivery of Health Care
    Chemical Substances Disinfectants ; Water (059QF0KO0R) ; Anti-Infective Agents ; Anti-Infective Agents, Local
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 604810-9
    ISSN 1741-2358 ; 0734-0664
    ISSN (online) 1741-2358
    ISSN 0734-0664
    DOI 10.1111/ger.12712
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    Zs.B 2593: Show issues Location:
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  6. Article ; Online: Voriconazole Treatment Induces a Conserved Sterol/Pleiotropic Drug Resistance Regulatory Network, including an Alternative Ergosterol Biosynthesis Pathway, in the Clinically Important FSSC Species,

    James, Jasper E / Santhanam, Jacinta / Cannon, Richard D / Lamping, Erwin

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 10

    Abstract: ... Fusarium ... ...

    Abstract Fusarium keratoplasticum
    Language English
    Publishing date 2022-10-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8101070
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  7. Article ; Online: Lipid nanodiscs as a template for high-resolution cryo-EM structures of peripheral membrane proteins.

    S Cannon, Kevin / Sarsam, Reta D / Tedamrongwanish, Tanita / Zhang, Kevin / Baker, Richard W

    Journal of structural biology

    2023  Volume 215, Issue 3, Page(s) 107989

    Abstract: Peripheral membrane proteins are ubiquitous throughout cell biology and are required for a variety of cellular processes such as signal transduction, membrane trafficking, and autophagy. Transient binding to the membrane has a profound impact on protein ... ...

    Abstract Peripheral membrane proteins are ubiquitous throughout cell biology and are required for a variety of cellular processes such as signal transduction, membrane trafficking, and autophagy. Transient binding to the membrane has a profound impact on protein function, serving to induce conformational changes and alter biochemical and biophysical parameters by increasing the local concentration of factors and restricting diffusion to two dimensions. Despite the centrality of the membrane in serving as a template for cell biology, there are few reported high-resolution structures of peripheral membrane proteins bound to the membrane. We analyzed the utility of lipid nanodiscs to serve as a template for cryo-EM analysis of peripheral membrane proteins. We tested a variety of nanodiscs and we report a 3.3 Å structure of the AP2 clathrin adaptor complex bound to a 17-nm nanodisc, with sufficient resolution to visualize a bound lipid head group. Our data demonstrate that lipid nanodiscs are amenable to high-resolution structure determination of peripheral membrane proteins and provide a framework for extending this analysis to other systems.
    MeSH term(s) Lipid Bilayers/chemistry ; Nanostructures/chemistry ; Models, Molecular ; Membrane Proteins/chemistry ; Cryoelectron Microscopy/methods
    Chemical Substances Lipid Bilayers ; Membrane Proteins
    Language English
    Publishing date 2023-06-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1032718-6
    ISSN 1095-8657 ; 1047-8477
    ISSN (online) 1095-8657
    ISSN 1047-8477
    DOI 10.1016/j.jsb.2023.107989
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1428: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1.

    Madani, Golnoush / Lamping, Erwin / Cannon, Richard D

    mSphere

    2021  Volume 6, Issue 1

    Abstract: Pleiotropic drug resistance (PDR) ATP-binding cassette (ABC) transporters of the ABCG family are eukaryotic membrane proteins that pump an array of compounds across organelle and cell membranes. Overexpression of the archetype fungal PDR transporter Cdr1 ...

    Abstract Pleiotropic drug resistance (PDR) ATP-binding cassette (ABC) transporters of the ABCG family are eukaryotic membrane proteins that pump an array of compounds across organelle and cell membranes. Overexpression of the archetype fungal PDR transporter Cdr1 is a major cause of azole antifungal drug resistance in
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily G/genetics ; ATP Binding Cassette Transporter, Subfamily G/metabolism ; Candida albicans/genetics ; Candida albicans/metabolism ; Cysteine/genetics ; Cysteine/metabolism ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Mutation ; Protein Folding ; Protein Transport ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism
    Chemical Substances ATP Binding Cassette Transporter, Subfamily G ; CDR1 protein, Candida albicans ; Fungal Proteins ; Membrane Transport Proteins ; Cysteine (K848JZ4886)
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/mSphere.01318-20
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  9. Article: Probiotic

    Shi, Jun / Ma, DongXue / Gao, ShanHu / Long, Fei / Wang, Xin / Pu, XingYu / Cannon, Richard D / Han, Ting-Li

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1219763

    Abstract: Introduction: Obesity and diabetes are common chronic metabolic disorders which can cause an imbalance of the intestinal flora and gut-liver metabolism. Several studies have shown that probiotics, including : Methods: In this study, we evaluated the ... ...

    Abstract Introduction: Obesity and diabetes are common chronic metabolic disorders which can cause an imbalance of the intestinal flora and gut-liver metabolism. Several studies have shown that probiotics, including
    Methods: In this study, we evaluated the effects of EcN-OMVs on high-fat diet (HFD)-induced obesity and HFD + streptozotocin (STZ)-induced diabetes.
    Results: EcN-OMVs could reduce body weight, decrease blood glucose, and increase plasma insulin in obese mice. Similarly, EcN-OMVs treatment could modify the ratio of
    Discussion: Overall, this study showed that EcN-OMVs might act as post-biotic agents that could modulate gut-liver metabolism and ameliorate the pathophysiology of obesity and diabetes.
    Language English
    Publishing date 2023-08-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1219763
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  10. Article ; Online: Effect of the Rho-Kinase/ROCK Signaling Pathway on Cytoskeleton Components

    Guan, Guangzhao / Cannon, Richard D. / Coates, Dawn E. / Mei, Li

    Genes (Basel). 2023 Jan. 20, v. 14, no. 2

    2023  

    Abstract: The mechanical properties of cells are important in tissue homeostasis and enable cell growth, division, migration and the epithelial-mesenchymal transition. Mechanical properties are determined to a large extent by the cytoskeleton. The cytoskeleton is ... ...

    Abstract The mechanical properties of cells are important in tissue homeostasis and enable cell growth, division, migration and the epithelial-mesenchymal transition. Mechanical properties are determined to a large extent by the cytoskeleton. The cytoskeleton is a complex and dynamic network composed of microfilaments, intermediate filaments and microtubules. These cellular structures confer both cell shape and mechanical properties. The architecture of the networks formed by the cytoskeleton is regulated by several pathways, a key one being the Rho-kinase/ROCK signaling pathway. This review describes the role of ROCK (Rho-associated coiled-coil forming kinase) and how it mediates effects on the key components of the cytoskeleton that are critical for cell behaviour.
    Keywords cell growth ; homeostasis ; microtubules
    Language English
    Dates of publication 2023-0120
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14020272
    Database NAL-Catalogue (AGRICOLA)

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