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  1. Article ; Online: Drug discovery for parasitic diseases: powered by technology, enabled by pharmacology, informed by clinical science.

    Rao, Srinivasa P S / Manjunatha, Ujjini H / Mikolajczak, Sebastian / Ashigbie, Paul G / Diagana, Thierry T

    Trends in parasitology

    2023  Volume 39, Issue 4, Page(s) 260–271

    Abstract: While prevention is a bedrock of public health, innovative therapeutics are needed to complement the armamentarium of interventions required to achieve disease control and elimination targets for neglected diseases. Extraordinary advances in drug ... ...

    Abstract While prevention is a bedrock of public health, innovative therapeutics are needed to complement the armamentarium of interventions required to achieve disease control and elimination targets for neglected diseases. Extraordinary advances in drug discovery technologies have occurred over the past decades, along with accumulation of scientific knowledge and experience in pharmacological and clinical sciences that are transforming many aspects of drug R&D across disciplines. We reflect on how these advances have propelled drug discovery for parasitic infections, focusing on malaria, kinetoplastid diseases, and cryptosporidiosis. We also discuss challenges and research priorities to accelerate discovery and development of urgently needed novel antiparasitic drugs.
    MeSH term(s) Humans ; Drug Discovery ; Parasitic Diseases/drug therapy ; Antiparasitic Agents/pharmacology ; Antiparasitic Agents/therapeutic use ; Malaria/drug therapy ; Technology
    Chemical Substances Antiparasitic Agents
    Language English
    Publishing date 2023-02-18
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2023.01.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Biomolecule conjugated inorganic nanoparticles for biomedical applications: A review.

    Krishna, R Hari / Chandraprabha, M N / Monika, Prakash / Br, Tanuja / Chaudhary, Vishal / Manjunatha, C

    Biotechnology & genetic engineering reviews

    2022  , Page(s) 1–42

    Abstract: Last decade has witnessed impressive progress in the fields of medicine and bioengineering with the aid of nanomaterials. Nanomaterials are favoured for their improved bio-chemical as well as mechanical properties with tremendous applications in ... ...

    Abstract Last decade has witnessed impressive progress in the fields of medicine and bioengineering with the aid of nanomaterials. Nanomaterials are favoured for their improved bio-chemical as well as mechanical properties with tremendous applications in biomedical domains such as disease diagnosis, targeted drug delivery, medical imaging,
    Language English
    Publishing date 2022-11-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 49457-4
    ISSN 2046-5556 ; 0264-8725
    ISSN (online) 2046-5556
    ISSN 0264-8725
    DOI 10.1080/02648725.2022.2147678
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  3. Article ; Online: Hydrothermal synthesis of novel heterostructured Ag/TiO

    Adarsha, J R / Ravishankar, T N / Ananda, A / Manjunatha, C R / Shilpa, B M / Ramakrishnappa, T

    Water environment research : a research publication of the Water Environment Federation

    2022  Volume 94, Issue 6, Page(s) e10744

    Abstract: In this work, we reported the successful synthesis of novel Ag/ ... ...

    Abstract In this work, we reported the successful synthesis of novel Ag/TiO
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Catalysis ; Methylene Blue/chemistry ; Nanocomposites/chemistry ; Titanium/chemistry ; Titanium/pharmacology
    Chemical Substances Anti-Bacterial Agents ; titanium dioxide (15FIX9V2JP) ; Titanium (D1JT611TNE) ; Methylene Blue (T42P99266K)
    Language English
    Publishing date 2022-06-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1098976-6
    ISSN 1554-7531 ; 1047-7624 ; 1061-4303
    ISSN (online) 1554-7531
    ISSN 1047-7624 ; 1061-4303
    DOI 10.1002/wer.10744
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  4. Article: Video consultations from tele aftercare clinic: An early experience from an Indian geriatric psychiatry service.

    Mukku, Shiva Shanker Reddy / Manjunatha, Narayana / Kumar, Channaveerachari Naveen / Sivakumar, Palanimuthu T / Math, Suresh Bada

    Indian journal of psychiatry

    2021  Volume 63, Issue 1, Page(s) 102–103

    Language English
    Publishing date 2021-02-15
    Publishing country India
    Document type Journal Article
    ZDB-ID 221523-8
    ISSN 0019-5545
    ISSN 0019-5545
    DOI 10.4103/psychiatry.IndianJPsychiatry_719_19
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  5. Article ; Online: Synthesis, antitubercular activity and molecular docking study of substituted [1,3]dioxino[4,5-

    Venkatesh, Talavara / Bodke, Yadav D / Manjunatha, B / Ravi Kumar, S

    Nucleosides, nucleotides & nucleic acids

    2021  Volume 40, Issue 11, Page(s) 1037–1049

    Abstract: We have developed a simple and convenient method for the synthesis of substituted-aryllidine-2,2-dimethyl-7-thioxo/oxo-4H-[1,3]dioxino[4,5-d]pyrimidine derivatives ( ...

    Abstract We have developed a simple and convenient method for the synthesis of substituted-aryllidine-2,2-dimethyl-7-thioxo/oxo-4H-[1,3]dioxino[4,5-d]pyrimidine derivatives (
    MeSH term(s) Antitubercular Agents/chemical synthesis ; Antitubercular Agents/chemistry ; Antitubercular Agents/pharmacology ; Catalysis ; Chemistry Techniques, Synthetic ; Drug Development/methods ; Humans ; Microbial Sensitivity Tests ; Molecular Conformation ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Structure ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Structure-Activity Relationship
    Chemical Substances Antitubercular Agents ; Pyrimidines
    Language English
    Publishing date 2021-09-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2008956-9
    ISSN 1532-2335 ; 1525-7770
    ISSN (online) 1532-2335
    ISSN 1525-7770
    DOI 10.1080/15257770.2021.1972310
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  6. Article ; Online: Development of fiber-enriched muffins using pomegranate peel powder and its effect on physico-chemical properties and shelf life of the muffins.

    Giri, Namrata A / Gaikwad, Prasad / Gaikwad, Nilesh N / Manjunatha, Nanjundappa / Krishnakumar, Thulasimani / Kad, Vikram / Raigond, Pinky / Suryavanshi, Swati / Marathe, Rajiv Arvind

    Journal of the science of food and agriculture

    2023  Volume 104, Issue 4, Page(s) 2346–2358

    Abstract: Background: Pomegranate peel is a by-product from the pomegranate processing industries and is a rich source of dietary fibers and bioactive compounds. It has good antioxidant and antimicrobial properties. In the present study, the effects of ... ...

    Abstract Background: Pomegranate peel is a by-product from the pomegranate processing industries and is a rich source of dietary fibers and bioactive compounds. It has good antioxidant and antimicrobial properties. In the present study, the effects of substitution of refined wheat flour with pomegranate peel powder (PPP) at a rate of 2%, 4%, 6%, 8% and 10% on the physico-chemical and sensorial properties as well as on the oxidative and microbial stability of muffins were investigated.
    Results: A significant reduction in specific volume (1.99 to 1.57 cm
    Conclusion: The present study provides the opportunity to use PPP as functional ingredients and natural preservative in the preparation of muffins. © 2023 Society of Chemical Industry.
    MeSH term(s) Pomegranate ; Powders ; Flour/analysis ; Triticum/chemistry ; Fruit ; Antioxidants
    Chemical Substances Powders ; Antioxidants
    Language English
    Publishing date 2023-12-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 184116-6
    ISSN 1097-0010 ; 0022-5142
    ISSN (online) 1097-0010
    ISSN 0022-5142
    DOI 10.1002/jsfa.13138
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  7. Article ; Online: Combining heteronuclear correlation NMR with spin-diffusion to detect relayed Cl-H-H and N-H-H proximities in molecular solids.

    Raval, Parth / Trébosc, Julien / Pawlak, Tomasz / Nishiyama, Yusuke / Brown, Steven P / Manjunatha Reddy, G N

    Solid state nuclear magnetic resonance

    2022  Volume 120, Page(s) 101808

    Abstract: Analysis of short-to-intermediate range intermolecular interactions offers a great way of characterizing the solid-state organization of small molecules and materials. This can be achieved by two-dimensional (2D) homo- and heteronuclear correlation NMR ... ...

    Abstract Analysis of short-to-intermediate range intermolecular interactions offers a great way of characterizing the solid-state organization of small molecules and materials. This can be achieved by two-dimensional (2D) homo- and heteronuclear correlation NMR spectroscopy, for example, by carrying out experiments at high magnetic fields in conjunction with fast magic-angle spinning (MAS) techniques. But, detecting 2D peaks for heteronuclear dipolar coupled spin pairs separated by greater than 3 Å is not always straightforward, particularly when low-gamma quadrupolar nuclei are involved. Here, we present a 2D correlation NMR experiment that combines the advantages of heteronuclear-multiple quantum coherence (HMQC) and proton-based spin-diffusion (SD) pulse sequences using radio-frequency-driven-recouping (RFDR) to probe inter and intramolecular
    MeSH term(s) Dopamine ; Histidine/chemistry ; Magnetic Resonance Spectroscopy/methods ; Nuclear Magnetic Resonance, Biomolecular ; Protons
    Chemical Substances Protons ; Histidine (4QD397987E) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2022-06-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1122088-0
    ISSN 1527-3326 ; 0926-2040
    ISSN (online) 1527-3326
    ISSN 0926-2040
    DOI 10.1016/j.ssnmr.2022.101808
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  8. Article: Comparative Study of Coronary Aretery Angiography Findings and High Sensitive C-Reactive Protean Levels with Coronary Artery Disease at Tertiary Care Hospital.

    T, Manjunatha / Shetty, Meenakshi

    The Journal of the Association of Physicians of India

    2020  Volume 68, Issue 1, Page(s) 56

    MeSH term(s) C-Reactive Protein ; Coronary Angiography ; Coronary Artery Disease ; Humans ; Tertiary Care Centers
    Chemical Substances C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2020-02-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
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  9. Article ; Online: Spatiotemporal Rainfall Variability and Trend Analysis of Shimsha River Basin, India.

    A, Bharath / Maddamsetty, Ramesh / M, Manjunatha / T V, Reshma

    Environmental science and pollution research international

    2023  Volume 30, Issue 49, Page(s) 107084–107103

    Abstract: Karnataka state has the second highest rainfed agricultural land in India, where agricultural output relies heavily on rainfall. The Shimsha basin, a sub-basin of Cauvery in the state, comes under a semi-arid region and predominantly consists of rainfed ... ...

    Abstract Karnataka state has the second highest rainfed agricultural land in India, where agricultural output relies heavily on rainfall. The Shimsha basin, a sub-basin of Cauvery in the state, comes under a semi-arid region and predominantly consists of rainfed agricultural land. Rainfall patterns have changed dramatically with time resulting in frequent floods and droughts. Understanding the spatiotemporal distribution of rainfall and its change patterns in the area would benefit sustainable agriculture planning and water resources management practices. The current study aims to determine the variability and trend in rainfall. The daily rainfall data of the Shimsha basin from 1989 to 2018 is collected, and the annual, seasonal, and monthly rainfall totals and the number of rainy days are derived. All the time series are subjected to statistical methods to examine rainfall variability and trend. The mean, standard deviation, coefficient of variation (CV), and Standardized Anomaly Index are used for the preliminary and variability analysis, while the coefficient of skewness and kurtosis are used to understand the rainfall distribution characteristics. The homogenous and serially independent series are identified by homogeneity and serial correlation tests. The trend in the homogenous and serially independent series is identified by Mann-Kendall and Spearman's rank correlation tests, while the magnitude of the trend is quantified using the Sen's slope technique, and the trend change point is evaluated using the sequential Mann-Kendall test. Based on the study, the average rainfall in the study area is 801.86 mm, with CV ranging from 43.3 to 22.27%. The southwest monsoon (SWM) season brings the greatest rain to the basin, followed by the post-monsoon (PM), summer, and winter seasons. In the annual time frame, except one station, all other stations have shown significant or insignificant increasing trends. The seasonal rainfall has shown insignificant rising trends during the summer and winter seasons while insignificant increasing and decreasing trends during the PM season. The SWM season has indicated significant increasing trends, insignificant increasing and decreasing trends. Overall, the study area has noticed an increased annual and seasonal rainfall except for the post-monsoon season, during which the rainfall showed a considerable decline. The findings of the study are helpful in water resource management, agricultural planning, and socioeconomic development in the study area.
    MeSH term(s) Rivers ; India ; Seasons ; Agriculture ; Rain
    Language English
    Publishing date 2023-02-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-25720-3
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  10. Article: Identification of stable resistant donors against necrosis inducing strain of bean common mosaic virus in common bean (Phaseolus vulgaris L.)

    Manjunatha, L. / Basavaraja, T. / Manjunatha, N. / Srinivasa, N. / Kumar, Vijay / Chandora, Rahul / Singh, Mohar / Singh, N. P.

    Archiv für Phytopathologie und Pflanzenschutz. 2021 Oct. 2, v. 54, no. 15-16

    2021  

    Abstract: Most of the commercially approved cultivars of Phaseolus vulgaris were susceptible to bean common mosaic virus (BCMV) which results in severe reduction in yield. In the present study, a total of 350 common bean genotypes were screened under natural ... ...

    Abstract Most of the commercially approved cultivars of Phaseolus vulgaris were susceptible to bean common mosaic virus (BCMV) which results in severe reduction in yield. In the present study, a total of 350 common bean genotypes were screened under natural epiphytotic conditions and artificial inoculation during 2016–2017, 2017–2018 and 2018–2019. Only eleven genotypes viz., EC400445, EC400414, ET4515B, EC540173, IC360831, BD9116291, EC31084, EC541703, ET8409, IC340947 and IC356024 were found stable resistant. The BCMV infection was confirmed through reverse-transcription polymerase chain reaction using coat protein gene amplification. The amplified region was sequenced and analyzed. Percent identity of BCMV-K with reported BCMV strains from different parts of world and based on nucleotide sequence ranged between 94% and 99.70% and maximum identity (99.70%) is observed with the strains of Uttar Pradesh (MT265069) and Himachal Pradesh (FJ387162, EU492546). The identified resistant sources from this study could be utilized as donors to develop BCMV resistant common bean cultivars.
    Keywords Bean common mosaic virus ; Phaseolus vulgaris ; beans ; coat proteins ; cultivars ; gene amplification ; necrosis ; nucleotide sequences ; reverse transcriptase polymerase chain reaction ; India
    Language English
    Dates of publication 2021-1002
    Size p. 1033-1046.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2068307-8
    ISSN 1477-2906 ; 0323-5408
    ISSN (online) 1477-2906
    ISSN 0323-5408
    DOI 10.1080/03235408.2021.1877432
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