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  1. Article: Egypt's groundwork blessing during the COVID-19 pandemic curse: Rheumatologic experience.

    Gheita, Tamer A / Kenawy, Sanaa A

    European journal of rheumatology

    2020  Volume 7, Issue Suppl 2, Page(s) S134–S136

    Keywords covid19
    Language English
    Publishing date 2020-04-15
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2873727-1
    ISSN 2148-4279 ; 2147-9720
    ISSN (online) 2148-4279
    ISSN 2147-9720
    DOI 10.5152/eurjrheum.2020.2058
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  2. Article ; Online: The potential role of B5: A stitch in time and switch in cytokine.

    Gheita, Alaa A / Gheita, Tamer A / Kenawy, Sanaa A

    Phytotherapy research : PTR

    2019  Volume 34, Issue 2, Page(s) 306–314

    Abstract: The wound healing process is a multifaceted sequence of activities associated with tissue restoration. Novel approaches for the perfection of wound healing have been determined as a stitch in time saves nine. Dysregulation of the immune response is a key ...

    Abstract The wound healing process is a multifaceted sequence of activities associated with tissue restoration. Novel approaches for the perfection of wound healing have been determined as a stitch in time saves nine. Dysregulation of the immune response is a key element in the pathogenesis of rheumatic diseases and serves as a potential target for novel therapeutic strategies. Vitamin B5 (VB5), also known as pantothenate or "anti-stress vitamin," is the precursor of coenzyme A, which is essential in every micro-organism. Many pantothenic acid amides acquire persuasive antimicrobial activity. Pantothenic acid improves surgical wounds healing with moisturizing and skin barrier enhancing potential. Its deficiency leads to reduced cortisol production, increased arthritic pain, myalgia, fatigue, headache, depression, insomnia, and widespread "proinflammatory" effects on the immune-system. VB5 triggers immune cells to produce cytokines and is multifunctional. The paradoxical effect of VB5 on the switch of anti-inflammatory and proinflammatory cytokines has been revealed. This review aims to present the long research journey of B5 as it is becoming a forerunner in the healing of wounds and in enhancing the immune function, thus providing potentially important therapeutic implications. As its role in healing a wound stitch is promising, amending the immune system damage too is a hopeful target.
    MeSH term(s) Animals ; Cytokines/immunology ; Humans ; Immune System/drug effects ; Pantothenic Acid/pharmacology ; Rheumatic Diseases/drug therapy ; Wound Healing/drug effects
    Chemical Substances Cytokines ; Pantothenic Acid (19F5HK2737)
    Language English
    Publishing date 2019-11-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.6537
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  4. Article ; Online: Rheumatology in Egypt: back to the future.

    Gheita, Tamer A / Eesa, Nahla N

    Rheumatology international

    2018  Volume 39, Issue 1, Page(s) 1–12

    Abstract: Medical knowledge in ancient Egypt had a remarkable reputation since rulers of other empires used to request the pharaoh to send them their best physician to treat their beloved ones. Many rheumatologic conditions as giant-cell arteritis, reactive ... ...

    Abstract Medical knowledge in ancient Egypt had a remarkable reputation since rulers of other empires used to request the pharaoh to send them their best physician to treat their beloved ones. Many rheumatologic conditions as giant-cell arteritis, reactive arthritis and other forms of spondyloarthritis have been identified in ancient Egyptian materials. Rheumatologists in Egypt are enormously expanding and mastering the tools that aid them in enhancing the management of rheumatic diseases. More Egyptian rheumatologists are actively participating in the annual European League Against Rheumatism (EULAR) and American College of Rheumatology conferences and those attached to well known state of the art centers are increasing. EULAR certified Egyptian MSUS trainers are effectively performing regionally. This review throws light on the rheumatology practice in Egypt, its progress from ancient times passing through Egyptian medical healthcare services, education systems for rheumatologists, rheumatology associations, an overview on the spectrum of rheumatic diseases through publications in the field till future perspectives. Rheumatology in Egypt is an actively growing and dynamic specialty of medicine with considerable contributions to the world's literature. These days, persistent efforts are mandatory to raise the standard of clinical and basic research, to optimize clinical practice with regard to new biologics, to develop tailored and targeted therapies for the rheumatic diseases, and to meet the medical demands of the exponentially increasing Egyptian population. Opportunities and challenges discussed high-lighten future perspectives needed to boost the rheumatology practice in Egypt.
    MeSH term(s) Egypt ; Egypt, Ancient ; History, 21st Century ; History, Ancient ; Humans ; Research ; Rheumatic Diseases/therapy ; Rheumatologists ; Rheumatology/history
    Language English
    Publishing date 2018-11-07
    Publishing country Germany
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-018-4192-0
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  5. Article ; Online: Atherogenic Index of Plasma in Women with Rheumatoid Arthritis and Systemic Lupus Erythematosus: A 10-Year Potential Predictor of Cardiovascular Disease.

    Hammam, Nevin / Abdel-Wahab, Noha / Gheita, Tamer A

    Current rheumatology reviews

    2020  Volume 17, Issue 1, Page(s) 122–130

    Abstract: Background: Women with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are at high risk of cardiovascular diseases (CVD). The atherogenic index of plasma (AIP) is a new marker for the assessment of CVD.: Objective: This study aimed ... ...

    Abstract Background: Women with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are at high risk of cardiovascular diseases (CVD). The atherogenic index of plasma (AIP) is a new marker for the assessment of CVD.
    Objective: This study aimed to determine the predictive value of AIP with long-term CVD risk among women with RA and SLE.
    Methods: This is a cross-sectional study of 99 RA and 59 SLE women. Demographic, clinical, and biochemical data were obtained, and disease activities were calculated. For each patient, the longterm risk of CVD was calculated using the Framingham risk score (FRS); AIP was derived according to the logarithmic (triglycerides/high-density lipoproteins cholesterol).
    Results: The mean age of the RA and SLE patients was 47.97 ± 8.78 and 36.75 ± 9.09 years, respectively. The median (interquartile range) of AIP values in RA and SLE patients were 0.34 (-0.15, 1.02) and 0.33 (-0.53, 0.96), respectively, while FRS values of RA patients and SLE patients were 6.38 ± 5.58 and 4.86 ± 4.5, respectively (p >0.05). There was a moderate correlation between AIP and FRS in RA and SLE patients (r=0.42, p=0.002 and r=0.33, p=0.007, respectively). According to the multivariate regression analyses, we found that AIP value is an independent factor for FRS in RA (β: 4.13, 95% confidence interval; 1.71, 6.18; p=0.008) and in SLE patients (β: 6.19, 95% confidence interval; 2.58, 9.81; p<0.001).
    Conclusions: We reported that AIP can be used as an independent indicator for long-term CVD risk in RA and SLE patients.
    MeSH term(s) Adult ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/complications ; Atherosclerosis/etiology ; Cardiovascular Diseases/etiology ; Cross-Sectional Studies ; Female ; Humans ; Lupus Erythematosus, Systemic/blood ; Lupus Erythematosus, Systemic/complications ; Middle Aged
    Language English
    Publishing date 2020-10-08
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1875-6360
    ISSN (online) 1875-6360
    DOI 10.2174/1573397116666201007123403
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  6. Article ; Online: Egypt’s groundwork blessing during the COVID-19 pandemic curse

    Tamer A. Gheita / Sanaa A. Kenawy

    European Journal of Rheumatology, Vol 7, Iss -2, Pp S134-S

    Rheumatologic experience

    2020  Volume 136

    Keywords Immunologic diseases. Allergy ; RC581-607 ; covid19
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher AVES Yayincilik
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Therapeutic potential of mesenchymal stem cells for scleroderma induced in mouse model.

    Elessawi, Dina Fathy / Gabr, Hala / Badawy, Monda Mohamed Maher / Gheita, Tamer A

    Tissue & cell

    2021  Volume 73, Page(s) 101671

    Abstract: Objective: To examine the potential therapeutic effect of mesenchymal stem cells (MSCs) for experimental scleroderma.: Materials and methods: Fifty-four mice six-week-old (30-35 g) were studied. Hypochlorous acid (HOCl) induced scleroderma was ... ...

    Abstract Objective: To examine the potential therapeutic effect of mesenchymal stem cells (MSCs) for experimental scleroderma.
    Materials and methods: Fifty-four mice six-week-old (30-35 g) were studied. Hypochlorous acid (HOCl) induced scleroderma was considered. Mice were divided into 3 groups: (I) Control: Six mice did not receive any treatment and were sacrificed at the end of the experiment; (II) HOCl mice (induced scleroderma as a positive control): (III) MSCs-treated HOCl mice: Thirty six HOCl-induced mice were injected with MSCs (7.5 × 105) intravenous every week for 3 weeks. Skin pieces were taken from the backs of mice and lung tissue pieces. a smooth muscle actin (α-SMA) and transforming growth factor-β (TGF-β1) were analysed or fixed in 10 % formalin for skin and lung tissue histopathological analysis. Plasma nitric oxide (NO) was also assayed.
    Results: There was a significant rise in the NO level and of the cutaneous and lung tissue α-SMA and TGF-β1 in untreated scleroderma-induced mice. The values significantly normalized after MSC therapy over the 7 weeks duration of the study. The altered histopathology of the skin and lung tissues in the scleroderma-induced mice showed a remarkable tendency to normalization of the skin and lung parenchyma and vasculature.
    Conclusion: There was a significant rise in the level of NO and skin and lung tissue α-SMA and TGF-β1 in untreated scleroderma-induced mice and values were significantly normalized after MSC therapy over the 7 weeks duration of the study. Altered histopathology of the skin and lung appeared nearly normal after MSC therapy.
    MeSH term(s) Animals ; Disease Models, Animal ; Humans ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/cytology ; Mice ; Nitric Oxide/blood ; Scleroderma, Systemic/blood ; Scleroderma, Systemic/therapy ; Skin/pathology ; Transforming Growth Factor beta/metabolism
    Chemical Substances Transforming Growth Factor beta ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2021-10-22
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 204424-9
    ISSN 1532-3072 ; 0040-8166
    ISSN (online) 1532-3072
    ISSN 0040-8166
    DOI 10.1016/j.tice.2021.101671
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    Zs.A 1016: Show issues Location:
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  8. Article ; Online: Impact of secondhand smoking on disease activity in women with rheumatoid arthritis.

    Hammam, Nevin / Gheita, Tamer A

    Clinical rheumatology

    2017  Volume 36, Issue 11, Page(s) 2415–2420

    Abstract: Smoking is an established risk factor for the development and severity of rheumatoid arthritis (RA) with prominent production of cytokines. The aim of the work was to study the possible effect of secondhand exposure on disease activity in non-smoking ... ...

    Abstract Smoking is an established risk factor for the development and severity of rheumatoid arthritis (RA) with prominent production of cytokines. The aim of the work was to study the possible effect of secondhand exposure on disease activity in non-smoking female RA patients. This cross-sectional study include 100 women with RA attending the rheumatology outpatient clinic and were grouped according to the non-smoking status into those not exposed to smoking and those considered secondhand smokers (SHS). Disease activity score in 28 joints (DAS28) was calculated and the patients' global assessment (PGA) score were assessed. The mean age of the patients was 45.2 ± 12.1 years and disease duration was 8.3 ± 6 years. Their DAS28 score was 4.3 ± 0.93 with a PGA score of 1.47 ± 1.36. Forty-seven of the patients were SHS and 53 were non-exposed. The secondhand smokers were significantly younger (41.6 ± 11.7 years) than the non-smokers (48.3 ± 11.6 years) (p = 0.005), and the DAS28 was significantly higher (4.6 ± 0.84 versus 4.1 ± 0.97; p = 0.02) compared to non-smokers. The disease duration and medications received were comparable. There is evidence pointing to the important role of secondhand smoking on disease activity in RA female patients. Studying the effect of secondhand smoking in view of the cytokine milieu could help confirm the relation to the disease pathogenesis. Taking into consideration the risk of cardiovascular disease and interplay with other potential factors should be well thought of. It is essential to draw patients' attention to the expected hazardous effect of passive smoking.
    Language English
    Publishing date 2017-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-017-3795-2
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  9. Article: The potential role of B5: A stitch in time and switch in cytokine

    Gheita, Alaa A / Gheita, Tamer A / Kenawy, Sanaa A

    Phytotherapy research. 2020 Feb., v. 34, no. 2

    2020  

    Abstract: The wound healing process is a multifaceted sequence of activities associated with tissue restoration. Novel approaches for the perfection of wound healing have been determined as a stitch in time saves nine. Dysregulation of the immune response is a key ...

    Abstract The wound healing process is a multifaceted sequence of activities associated with tissue restoration. Novel approaches for the perfection of wound healing have been determined as a stitch in time saves nine. Dysregulation of the immune response is a key element in the pathogenesis of rheumatic diseases and serves as a potential target for novel therapeutic strategies. Vitamin B5 (VB5), also known as pantothenate or “anti‐stress vitamin,” is the precursor of coenzyme A, which is essential in every micro‐organism. Many pantothenic acid amides acquire persuasive antimicrobial activity. Pantothenic acid improves surgical wounds healing with moisturizing and skin barrier enhancing potential. Its deficiency leads to reduced cortisol production, increased arthritic pain, myalgia, fatigue, headache, depression, insomnia, and widespread “proinflammatory” effects on the immune‐system. VB5 triggers immune cells to produce cytokines and is multifunctional. The paradoxical effect of VB5 on the switch of anti‐inflammatory and proinflammatory cytokines has been revealed. This review aims to present the long research journey of B5 as it is becoming a forerunner in the healing of wounds and in enhancing the immune function, thus providing potentially important therapeutic implications. As its role in healing a wound stitch is promising, amending the immune system damage too is a hopeful target.
    Keywords amides ; antimicrobial properties ; coenzyme A ; cortisol ; cytokines ; headache ; immune response ; immune system ; microorganisms ; pantothenic acid ; pathogenesis ; sleep disorders ; therapeutics ; tissue repair
    Language English
    Dates of publication 2020-02
    Size p. 306-314.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note REVIEW
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.6537
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: The potential of genetically guided treatment in Behçet's disease.

    Gheita, Tamer A / Gheita, Heba A / Kenawy, Sanaa A

    Pharmacogenomics

    2016  Volume 17, Issue 10, Page(s) 1165–1174

    Abstract: Continuous identification of specific targets and candidate genes together with novel approaches offers new promises for the future of gene therapy design in Behçet's disease (BD). Personalized medicine based on pharmacogenomics is being developed at the ...

    Abstract Continuous identification of specific targets and candidate genes together with novel approaches offers new promises for the future of gene therapy design in Behçet's disease (BD). Personalized medicine based on pharmacogenomics is being developed at the clinical stage to improve treatment response. Screening the whole gene and regulatory regions is important when searching for novel variants associated with such complex diseases. Different host genetic factors play significant roles in susceptibility to BD. Thus, identifying these genes responsible for susceptibility and resistance to BD may offer a notable contribution toward understanding its pathogenesis, and may lead to the development of novel prophylactic and treatment strategies. Evidenced-based treatment strategy is recommended for the management in BD patients. This review sheds light on the immunopathogenesis and pharmacogenetics of BD with special attention to the treatment targeting gene polymorphisms. In conclusion, the potential of genetically guided treatment in BD takes us back to the future for an accurate management strategy of this serious rheumatic disease. The ongoing discovery of pivotal genes related to the susceptibility, manifestations, disease activity and treatment options provide substantial hope to the reduced frequency of BD, effective control and improvement in the prognosis. Targeted gene therapy could be a leading option in the treatment armamentarium of BD.
    MeSH term(s) Antirheumatic Agents/administration & dosage ; Behcet Syndrome/genetics ; Behcet Syndrome/metabolism ; Behcet Syndrome/therapy ; Genetic Predisposition to Disease/genetics ; Humans ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/metabolism ; Pharmacogenetics/methods ; Treatment Outcome
    Chemical Substances Antirheumatic Agents ; Inflammation Mediators
    Language English
    Publishing date 2016-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2015-0004
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