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  1. Article ; Online: Beim Schutzschild für Spaltlampen Ecken und Kanten abrunden.

    Heiduschka, Peter

    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft

    2020  Volume 117, Issue 6, Page(s) 528

    Title translation Round off corners and edges of the protective shield for slit lamps.
    MeSH term(s) Protective Devices ; Slit Lamp
    Language German
    Publishing date 2020-05-14
    Publishing country Germany
    Document type Letter
    ZDB-ID 1105167-x
    ISSN 1433-0423 ; 0941-293X
    ISSN (online) 1433-0423
    ISSN 0941-293X
    DOI 10.1007/s00347-020-01124-3
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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Position of the ISTENT Inject

    Zimmermann, Julian Alexander / Storp, Jens Julian / Merté, Ralph-Laurent / Heiduschka, Peter / Eter, Nicole / Brücher, Viktoria Constanze

    Journal of clinical medicine

    2023  Volume 12, Issue 16

    Abstract: Glaucoma is one of the leading causes of irreversible blindness globally and is characterized by the gradual loss of retinal ganglion cells. The primary risk factor for the development and progression of glaucoma is increased intraocular pressure (IOP). ... ...

    Abstract Glaucoma is one of the leading causes of irreversible blindness globally and is characterized by the gradual loss of retinal ganglion cells. The primary risk factor for the development and progression of glaucoma is increased intraocular pressure (IOP). Numerous surgical interventions exist to lower IOP should conservative therapy fail. One trend in recent years has been minimally invasive glaucoma surgery (MIGS) as an alternative to traditional methods. The ISTENT inject
    Language English
    Publishing date 2023-08-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12165171
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  3. Article ; Online: Overexpression of Neuregulin-1 Type III Has Impact on Visual Function in Mice.

    Su, Nan / Zhang, Weiqi / Eter, Nicole / Heiduschka, Peter / Zhang, Mingyue

    International journal of molecular sciences

    2022  Volume 23, Issue 9

    Abstract: Schizophrenia is associated with several brain deficits, including abnormalities in visual processes. Neuregulin-1 (Nrg1) is a family of trophic factors containing an epidermal growth factor (EGF)-like domain. It is thought to play a role in neural ... ...

    Abstract Schizophrenia is associated with several brain deficits, including abnormalities in visual processes. Neuregulin-1 (Nrg1) is a family of trophic factors containing an epidermal growth factor (EGF)-like domain. It is thought to play a role in neural development and has been linked to neuropsychiatric disorders. Abnormal Nrg1 expression has been observed in schizophrenia in clinical studies. Moreover, in schizophrenia, there is more and more evidence found about pathological changes of the retina regarding structural, neurochemical and physiological parameters. However, mechanisms of these changes are not well known. To investigate this, we analysed the function of the visual system using electroretinography (ERG) and the measurement of visual evoked potentials (VEP) in transgenic mice overexpressing Nrg1 type III of three different ages (12 weeks, 24 weeks and 55 weeks). ERG amplitudes tended to be higher in transgenic mice than in control mice in 12-week old mice, whereas the amplitudes were almost similar in older mice. VEP amplitudes were larger in transgenic mice at all ages, with significant differences at 12 and 55 weeks (
    MeSH term(s) Animals ; Brain/metabolism ; Evoked Potentials, Visual ; Mice ; Mice, Transgenic ; Neuregulin-1/genetics ; Neuregulin-1/metabolism ; Schizophrenia/metabolism
    Chemical Substances Neuregulin-1
    Language English
    Publishing date 2022-04-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23094489
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  4. Book ; Online ; Thesis: Effects of subretinal injection of human lipofuscin on murine retina as a novel animal model of age-related macular degeneration

    Su, Nan [Verfasser] / Heiduschka, Peter [Akademischer Betreuer]

    2022  

    Author's details Nan Su ; Betreuer: Peter Heiduschka
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitäts- und Landesbibliothek Münster
    Publishing place Münster
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article: Lymphocyte-to-Monocyte Ratio Might Serve as a Prognostic Marker in Young Patients with Tongue Squamous Cell Carcinoma.

    Kandathil, Sam Augustine / Peter Truta, Ina / Kadletz-Wanke, Lorenz / Heiduschka, Gregor / Stoiber, Stefan / Kenner, Lukas / Herrmann, Harald / Huskic, Harun / Brkic, Faris F

    Journal of personalized medicine

    2024  Volume 14, Issue 2

    Abstract: Background: Young patients with tongue squamous cell carcinoma (TSCC) mostly lack typical prognostic markers and face a dire prognosis. The aim of this study was to analyze the prognostic relevance of lymphocyte-to-monocyte ratio (LMR) in TSCC patients, ...

    Abstract Background: Young patients with tongue squamous cell carcinoma (TSCC) mostly lack typical prognostic markers and face a dire prognosis. The aim of this study was to analyze the prognostic relevance of lymphocyte-to-monocyte ratio (LMR) in TSCC patients, with a special emphasis on patients under 45 years.
    Methods: This retrospective study included all patients primarily treated for TSCC. The prognostic relevance of LMR was investigated in terms of predicting the overallsurvival (OS) and disease-free survival (DFS).
    Results: A total of 74 patients were included and the young cohort (<45 years) comprised 27 individuals. The mortality and recurrence rates were 39.2% (
    Conclusions: Our results reveal that pretreatment LMR might become a prognostic tool for young TSCC patients, especially due to its availability. However, further studies on larger cohorts are necessary to validate our results.
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14020159
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  6. Article ; Online: The first reported case of a deletion of the entire RPGR gene in a family with X-linked retinitis pigmentosa.

    Mihailovic, Nataša / Schimpf-Linzenbold, Simone / Sattler, Inga / Eter, Nicole / Heiduschka, Peter

    Ophthalmic genetics

    2022  Volume 43, Issue 5, Page(s) 679–684

    Abstract: Clinical phenotypes of a patient with a deletion of the ... ...

    Abstract Clinical phenotypes of a patient with a deletion of the entire
    MeSH term(s) Eye Proteins/genetics ; Genetic Diseases, X-Linked/diagnosis ; Genetic Diseases, X-Linked/genetics ; Genetic Diseases, X-Linked/therapy ; Humans ; Mutation ; Pedigree ; Phenotype ; Retina ; Retinitis Pigmentosa/diagnosis ; Retinitis Pigmentosa/genetics ; Retinitis Pigmentosa/therapy
    Chemical Substances Eye Proteins ; RPGR protein, human
    Language English
    Publishing date 2022-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199279-7
    ISSN 1744-5094 ; 0167-6784 ; 1381-6810
    ISSN (online) 1744-5094
    ISSN 0167-6784 ; 1381-6810
    DOI 10.1080/13816810.2022.2083181
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1708: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Overexpression of Neuregulin-1 Type III Has Impact on Visual Function in Mice

    Nan Su / Weiqi Zhang / Nicole Eter / Peter Heiduschka / Mingyue Zhang

    International Journal of Molecular Sciences, Vol 23, Iss 4489, p

    2022  Volume 4489

    Abstract: Schizophrenia is associated with several brain deficits, including abnormalities in visual processes. Neuregulin-1 (Nrg1) is a family of trophic factors containing an epidermal growth factor (EGF)-like domain. It is thought to play a role in neural ... ...

    Abstract Schizophrenia is associated with several brain deficits, including abnormalities in visual processes. Neuregulin-1 (Nrg1) is a family of trophic factors containing an epidermal growth factor (EGF)-like domain. It is thought to play a role in neural development and has been linked to neuropsychiatric disorders. Abnormal Nrg1 expression has been observed in schizophrenia in clinical studies. Moreover, in schizophrenia, there is more and more evidence found about pathological changes of the retina regarding structural, neurochemical and physiological parameters. However, mechanisms of these changes are not well known. To investigate this, we analysed the function of the visual system using electroretinography (ERG) and the measurement of visual evoked potentials (VEP) in transgenic mice overexpressing Nrg1 type III of three different ages (12 weeks, 24 weeks and 55 weeks). ERG amplitudes tended to be higher in transgenic mice than in control mice in 12-week old mice, whereas the amplitudes were almost similar in older mice. VEP amplitudes were larger in transgenic mice at all ages, with significant differences at 12 and 55 weeks ( p values between 0.003 and 0.036). Latencies in ERG and VEP measurements did not differ considerably between control mice and transgenic mice at any age. Our data show for the first time that overexpression of Nrg1 type III changed visual function in transgenic mice. Overall, this investigation of visual function in transgenic mice may be helpful to understand corresponding changes that occur in schizophrenia, as they may find use as biomarkers for psychiatric disorders as well as a potential tool for diagnosis in psychiatry.
    Keywords electroretinography ; visual evoked potential ; neuregulin 1 ; schizophrenia ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 150
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Durable 3D murine ex vivo retina glaucoma models for optical coherence tomography.

    Barroso, Álvaro / Ketelhut, Steffi / Nettels-Hackert, Gerburg / Heiduschka, Peter / Del Amor, Rocío / Naranjo, Valery / Kemper, Björn / Schnekenburger, Jürgen

    Biomedical optics express

    2023  Volume 14, Issue 9, Page(s) 4421–4438

    Abstract: Durable and standardized phantoms with optical properties similar to native healthy and disease-like biological tissues are essential tools for the development, performance testing, calibration and comparison of label-free high-resolution optical ... ...

    Abstract Durable and standardized phantoms with optical properties similar to native healthy and disease-like biological tissues are essential tools for the development, performance testing, calibration and comparison of label-free high-resolution optical coherence tomography (HR-OCT) systems. Available phantoms are based on artificial materials and reflect thus only partially ocular properties. To address this limitation, we have performed investigations on the establishment of durable tissue phantoms from ex vivo mouse retina for enhanced reproduction of in vivo structure and complexity. In a proof-of-concept study, we explored the establishment of durable 3D models from dissected mouse eyes that reproduce the properties of normal retina structures and tissue with glaucoma-like layer thickness alterations. We explored different sectioning and preparation procedures for embedding normal and N-methyl-D-aspartate (NMDA)-treated mouse retina in transparent gel matrices and epoxy resins, to generate durable three-dimensional tissue models. Sample quality and reproducibility were quantified by thickness determination of the generated layered structures utilizing computer-assisted segmentation of OCT B-scans that were acquired with a commercial HR-OCT system at a central wavelength of 905 nm and analyzed with custom build software. Our results show that the generated 3D models feature thin biological layers close to current OCT resolution limits and glaucoma-like tissue alterations that are suitable for reliable HR-OCT performance characterization. The comparison of data from resin-embedded tissue with native murine retina in gels demonstrates that by utilization of appropriate preparation protocols, highly stable samples with layered structures equivalent to native tissues can be fabricated. The experimental data demonstrate our concept as a promising approach toward the fabrication of durable biological 3D models suitable for high-resolution OCT system performance characterization supporting the development of optimized instruments for ophthalmology applications.
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.494271
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  9. Article ; Online: Expression of purinergic receptors on microglia in the animal model of choroidal neovascularisation.

    Li, Lu / Liu, Juejun / Xu, Amin / Heiduschka, Peter / Eter, Nicole / Chen, Changzheng

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 12389

    Abstract: To investigate the effect of P2 receptor on microglia and its inhibitor PPADS on choroidal neovascularization. Forty ... ...

    Abstract To investigate the effect of P2 receptor on microglia and its inhibitor PPADS on choroidal neovascularization. Forty CX3CR1
    MeSH term(s) Animals ; Choroidal Neovascularization/drug therapy ; Choroidal Neovascularization/etiology ; Choroidal Neovascularization/metabolism ; Lasers/adverse effects ; Mice ; Microglia/drug effects ; Microglia/metabolism ; Purinergic P2 Receptor Antagonists/pharmacology ; Purinergic P2 Receptor Antagonists/therapeutic use ; Pyridoxal Phosphate/analogs & derivatives ; Pyridoxal Phosphate/pharmacology ; Pyridoxal Phosphate/therapeutic use ; Receptors, Purinergic P2/genetics ; Receptors, Purinergic P2/metabolism
    Chemical Substances Purinergic P2 Receptor Antagonists ; Receptors, Purinergic P2 ; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid (149017-66-3) ; Pyridoxal Phosphate (5V5IOJ8338)
    Language English
    Publishing date 2021-06-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-91989-4
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  10. Article ; Online: A modified protocol for isolation of retinal microglia from the pig.

    Zhang, Yahan / Erhard, Anna Lena / Plagemann, Tanja / Eter, Nicole / Heiduschka, Peter

    Experimental eye research

    2021  Volume 207, Page(s) 108584

    Abstract: Microglia are the resident immune cells in the retina. To investigate their properties and behaviour, a reliable and yielding procedure to culture them is necessary. We here describe a way of isolation of microglial cells from the porcine retina, as pig ... ...

    Abstract Microglia are the resident immune cells in the retina. To investigate their properties and behaviour, a reliable and yielding procedure to culture them is necessary. We here describe a way of isolation of microglial cells from the porcine retina, as pig eyes are similar to human eyes in size, structure and vasculature, including similarities in proteins and pathways. Retina was isolated from fresh pig eyes, dissociated by a mixture of collagenase, hyaluronidase and DNAse, and passed through a cell strainer. After triple centrifugation with decreasing velocity and re-suspension, cells were seeded into poly-d-lysine coated culture flasks and cultured using DMEM and macrophage-colony stimulating factor (M-CSF). Number of cells increased gradually during the first 10-14 days, till they could be split and used for experiments. Identity of isolated cells as microglia was assessed by immunostaining against the microglia/macrophage markers Iba1, CD11b, CD68, CD45 and TMEM119. Phagocytic function of microglia could be demonstrated by phagocytosis of fluorescence beads and their response to lipopolysaccharide (LPS). As a conclusion, we developed a protocol for isolation and cultivation of pig retinal microglial cells that are suitable for research in the laboratory.
    MeSH term(s) Animals ; Biomarkers/metabolism ; Cell Count ; Cell Culture Techniques ; Cell Separation/methods ; Immunohistochemistry ; Microglia/cytology ; Microglia/metabolism ; Phagocytosis/physiology ; Retina/cytology ; Retina/metabolism ; Sus scrofa
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-04-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80122-7
    ISSN 1096-0007 ; 0014-4835
    ISSN (online) 1096-0007
    ISSN 0014-4835
    DOI 10.1016/j.exer.2021.108584
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 163: Show issues Location:
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