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Article ; Online: The oxymoron of image-guided resection in 3 T MRI-negative extratemporal epilepsy: Technique and postoperative results.

Kogias, Evangelos / Evangelou, Petros / Schmeiser, Barbara / Reinacher, Peter C / Altenmüller, Dirk-Matthias

2018 Volume 166, Page(s) 16–22

Abstract: ... achieved resection.: Patients and methods: Seven patients with 3 T MRI-negative extratemporal epilepsy ...

Abstract	Objective: We share our experience with extratemporal MRI-negative epilepsies that received "image-guided" resection with the use of neuronavigation after invasive presurgical video-EEG monitoring. We describe and discuss our technique of image generation, navigation system registration, and surgical resection. In addition, we evaluate seizure outcome with respect to the preoperatively planned versus achieved resection. Patients and methods: Seven patients with 3 T MRI-negative extratemporal epilepsy received navigation-guided resective surgery. The resection plan was based on electrophysiological data from intracranial EEG recordings. For each case a resection segment was created in the neuronavigation device in a systematic manner. We compared the preoperatively planned segment to the achieved resection and looked for correlation with postoperative seizure outcome according to Engel classification, at last follow-up (mean 2.4 years, range 1-4 years). Results: Mean volume of planned resections was 23.8 ± 15.3 cm Conclusion: The use of neuronavigation for planning and executing a tailored resection in MRI-negative extratemporal epilepsy is elaborate but can be an effective procedure.
MeSH term(s)	Adolescent ; Adult ; Epilepsy/diagnostic imaging ; Epilepsy/surgery ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Neuronavigation/methods ; Retrospective Studies ; Surgery, Computer-Assisted/methods ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2018-01-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	193107-6
ISSN	1872-6968 ; 0303-8467
ISSN (online)	1872-6968
ISSN	0303-8467
DOI	10.1016/j.clineuro.2018.01.017
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Article ; Online: Upper urinary tract urothelial cancers: where it is A:T.

Olivier, Magali / Hollstein, Monica / Schmeiser, Heinz Hans / Straif, Kurt / Wild, Christopher P

Nature reviews. Cancer

2012 Volume 12, Issue 8, Page(s) 503–504

Abstract: Despite a ban on the use of plants of the Aristolochia genus in herbal medicine, as they contain known carcinogens, urothelial carcinoma attributable to the use of this plant seems to be more common than previously thought. ...

Abstract	Despite a ban on the use of plants of the Aristolochia genus in herbal medicine, as they contain known carcinogens, urothelial carcinoma attributable to the use of this plant seems to be more common than previously thought.
MeSH term(s)	Aristolochia/poisoning ; Humans ; Plant Extracts/poisoning ; Plants, Medicinal/poisoning ; Ureteral Neoplasms/etiology ; Urologic Neoplasms/etiology
Chemical Substances	Plant Extracts
Language	English
Publishing date	2012-09-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2062767-1
ISSN	1474-1768 ; 1474-175X
ISSN (online)	1474-1768
ISSN	1474-175X
DOI	10.1038/nrc3311
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Article ; Online: Der Effekt intensivierter Trainingstherapie bei axialer Spondyloarthritis im teilstationären Setting.

Schneidereit, T / Delia, D / Schmeiser, T / Buehring, B

Zeitschrift fur Rheumatologie

2023 Volume 83, Issue 3, Page(s) 210–216

Abstract: Background: Day care units are an essential part of psychiatric treatment in Germany. In rheumatology they are also regularly used. Axial spondylarthritis (axSpA) is an inflammatory rheumatic disease that causes pain, diminished quality of life, ... ...

Title translation	The effect of intensified training therapy on axial spondylarthritis in day care units.
Abstract	Background: Day care units are an essential part of psychiatric treatment in Germany. In rheumatology they are also regularly used. Axial spondylarthritis (axSpA) is an inflammatory rheumatic disease that causes pain, diminished quality of life, limitations in activities of daily living and ability to work, especially if insufficiently treated. The multimodal rheumatologic complex treatment with at least 14 days of inpatient care is an established tool to control exacerbated disease activity. The feasibility and effect of an equivalent treatment in a day care setting has not yet been evaluated. Methods: The effect of a therapy in a day care unit comparable to the inpatient multimodal rheumatologic complex treatment was investigated using clinically established patient reported outcomes (NAS pain, FFbH, BASDAI, BASFI). Results: Selected subgroups of axSpA patients can routinely and effectively be treated in day care units. Intensified multimodal as well as nonintensified treatment forms lead to reduced disease activity. Additionally, compared to nonintensified treatment, the intensified multimodal treatment approach leads to significantly reduced pain, and disease-related and functional limitations in daily life. Conclusion: If available, treatment in a day care unit can complement the established inpatient treatment modalities in selected axSpA patients. In cases with high disease activity and suffering, intensified multimodal treatment should be preferred due to better outcomes.
MeSH term(s)	Humans ; Spondylarthritis/therapy ; Quality of Life ; Day Care, Medical ; Activities of Daily Living ; Spondylitis, Ankylosing ; Axial Spondyloarthritis ; Pain ; Arthritis, Rheumatoid
Language	German
Publishing date	2023-03-09
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	124985-x
ISSN	1435-1250 ; 0340-1855 ; 0301-6382
ISSN (online)	1435-1250
ISSN	0340-1855 ; 0301-6382
DOI	10.1007/s00393-023-01333-6
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Article ; Online: Endothelial/lymphocyte activation leads to prominent CD4+ T cell infiltration in the gastric mucosa of patients with systemic sclerosis.

Manetti, Mirko / Neumann, Elena / Müller, Adelheid / Schmeiser, Tim / Saar, Petra / Milia, Anna Franca / Endlicher, Esther / Roeb, Elke / Messerini, Luca / Matucci-Cerinic, Marco / Ibba-Manneschi, Lidia / Müller-Ladner, Ulf

Arthritis and rheumatism

2008 Volume 58, Issue 9, Page(s) 2866–2873

Abstract: ... leukocyte common antigen, CD3/T cells, CD4/T helper cells, CD8/cytotoxic T cells, CD20/B cells, CD14/monocytes, CD68 ... vascular endothelial growth factor (VEGF).: Results: T cell infiltration was a prominent finding in gastric specimens ... from patients with SSc. The CD4+/CD8+ T cell ratio was significantly increased in SSc specimens compared ...

Abstract	Objective: Although gastrointestinal tract dysfunction is a common feature in patients with systemic sclerosis (SSc; scleroderma), few studies have addressed the pathogenetic mechanisms of gastrointestinal tract involvement in SSc. We previously showed that severe fibrosis and increased expression of profibrotic cytokines are important hallmarks in the gastric wall of patients with SSc. The aim of the present study was to investigate whether immune and/or microvascular abnormalities may account for tissue damage in gastric wall specimens obtained from patients with SSc. Methods: Gastric biopsy samples from 27 patients with SSc and 15 healthy control subjects were analyzed by immunohistochemistry for CD45/leukocyte common antigen, CD3/T cells, CD4/T helper cells, CD8/cytotoxic T cells, CD20/B cells, CD14/monocytes, CD68/macrophages, cell adhesion molecules CD11a/lymphocyte function-associated antigen 1 (LFA-1), CD49d/very late activation antigen 4 (VLA-4), CD54/intercellular adhesion molecule 1 (ICAM-1), CD106/vascular cell adhesion molecule 1 (VCAM-1), CD31/platelet endothelial cell adhesion molecule 1, and vascular endothelial growth factor (VEGF). Results: T cell infiltration was a prominent finding in gastric specimens from patients with SSc. The CD4+/CD8+ T cell ratio was significantly increased in SSc specimens compared with controls. T cells were found in both lymphocyte aggregates and diffuse infiltrates and strongly expressed the activation markers VLA-4, LFA-1, and ICAM-1. Endothelial cells showed corresponding surface activation with strong expression of VCAM-1 and ICAM-1. Mature B cells were frequently observed arranged in aggregates and rarely were seen in a diffuse pattern. Most lymphocyte aggregates lacked monocyte/macrophages. No difference in microvascular density was observed between SSc specimens and controls. Both SSc and control specimens showed weak or no expression of VEGF. Conclusion: Our findings provide the first evidence that endothelial/lymphocyte activation leading to prominent CD4+ T cell infiltration may play a key pathogenetic role within the gastric wall of patients with SSc and may represent an important therapeutic target.
MeSH term(s)	Adult ; Aged ; CD4-Positive T-Lymphocytes/immunology ; Case-Control Studies ; Female ; Fibrosis/immunology ; Fibrosis/pathology ; Gastric Mucosa/immunology ; Gastric Mucosa/pathology ; Humans ; Immunohistochemistry ; Lymphocyte Activation/immunology ; Male ; Microscopy, Confocal ; Middle Aged ; Scleroderma, Systemic/immunology ; Scleroderma, Systemic/pathology ; Statistics, Nonparametric
Language	English
Publishing date	2008-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	127294-9
ISSN	1529-0131 ; 0004-3591 ; 2326-5191
ISSN (online)	1529-0131
ISSN	0004-3591 ; 2326-5191
DOI	10.1002/art.23806
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Zs.A 24: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 523: Show issues

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Article: Rheumatoide Arthritis

Schmeiser, Tim

Arzneimitteltherapie

2020 Volume 38, Issue 9, Page(s) 341

Language	German
Document type	Article
ZDB-ID	380334-X
ISSN	0723-6913
Database	Current Contents Medicine

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Article ; Online: Seltene Ursache eines entzündlichen Rückenschmerzes.

Schneidereit, T / Schmeiser, T / Mucke, J

Zeitschrift fur Rheumatologie

2022 Volume 82, Issue 4, Page(s) 328–330

Title translation	Rare cause of inflammatory back pain.
MeSH term(s)	Humans ; Low Back Pain/etiology
Language	German
Publishing date	2022-09-29
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	124985-x
ISSN	1435-1250 ; 0340-1855 ; 0301-6382
ISSN (online)	1435-1250
ISSN	0340-1855 ; 0301-6382
DOI	10.1007/s00393-022-01273-7
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Article: Evidence for the involvement of host-derived OKT8-positive T cells in the rejection of T-depleted, HLA-identical bone marrow grafts.

Bunjes, D / Heit, W / Arnold, R / Schmeiser, T / Wiesneth, M / Carbonell, F / Porzsolt, F / Raghavachar, A / Heimpel, H

Transplantation

1987 Volume 43, Issue 4, Page(s) 501–505

Abstract: The recent introduction of a variety of techniques for removing T cells from bone marrow grafts has ... patients with HLA-identical sibling grafts purged of T cells by a single incubation ... with the monoclonal antibody Campath-1 and donor complement. This approach was successful in reducing T cell contamination ...

Abstract	The recent introduction of a variety of techniques for removing T cells from bone marrow grafts has reduced the incidence of graft-versus-host disease (GVHD)-associated morbidity and mortality. Whether this advance will be translated into improved patient survival is unclear at present, mainly because these procedures increase the risk of graft failure. Since 1983 we have transplanted 25 consecutive leukemia patients with HLA-identical sibling grafts purged of T cells by a single incubation with the monoclonal antibody Campath-1 and donor complement. This approach was successful in reducing T cell contamination of the graft and preventing acute and chronic GVHD. In this group of patients two suffered irreversible graft failure and one developed reversible graft failure. In a similarly sized group of patients previously transplanted with unpurged marrow according to the Seattle protocol, no episodes of graft failure occurred. Since other causes of graft failure, such as drug toxicity or viral infections, could be largely excluded, this suggested that the graft failures were specifically related to the purging process. In haploidentical bone marrow transplantation (BMT) O'Reilly has identified residual host-versus-graft activity (HVG) as a cause of graft failure. The causes and mechanisms of graft failure in T-depleted HLA-identical sibling transplants have not been extensively investigated to date. In the three graft failures observed by us, the loss of the graft was preceded by the appearance of a population of activated lymphocytes. We have determined the phenotype and origin of this population and investigated its interactions with donor hemopoietic tissue in vitro.
MeSH term(s)	Antigens, Differentiation, T-Lymphocyte ; Antigens, Surface/analysis ; Bone Marrow Transplantation ; Graft Rejection ; HLA Antigens/immunology ; Humans ; Leukemia/therapy ; Lymphocyte Activation ; T-Lymphocytes/immunology ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Regulatory/immunology
Chemical Substances	Antigens, Differentiation, T-Lymphocyte ; Antigens, Surface ; HLA Antigens
Language	English
Publishing date	1987-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/00007890-198704000-00009
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 509: Show issues

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Conference proceedings: Lyme-Arthritis – Ist ein protrahierter Verlauf eher die Regel als die Ausnahme?

Dormann, Andreas / Schmeiser, Tim

2020 , Page(s) VS.17

Event/congress	Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); sine loco [digital]; ; Deutsche Gesellschaft für Orthopädische Rheumatologie; 2020
Keywords	Medizin, Gesundheit
Publishing date	2020-09-09
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/20dgrh201
Database	German Medical Science

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Article ; Conference proceedings: Prävalenz der Osteoporose bei Systemischer Sklerose

Schneidereit, T / Schmeiser, T / Khder, R / Thiele, A

Osteologie

2020 Volume 29, Issue 01

Event/congress	Osteologie 2020, Salzburg, 2020-03-12
Language	German
Publishing date	2020-02-01
Publisher	© Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2113634-8
ISSN	2567-5818 ; 1019-1291
ISSN (online)	2567-5818
ISSN	1019-1291
DOI	10.1055/s-0039-3402878
Database	Thieme publisher's database

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Article ; Online: Granule cell dispersion in two mouse models of temporal lobe epilepsy and reeler mice is associated with changes in dendritic orientation and spine distribution.

Puhahn-Schmeiser, Barbara / Kleemann, Tobias / Jabbarli, Ramazan / Bock, Hans H / Beck, Jürgen / Freiman, Thomas M

Hippocampus

2022 Volume 32, Issue 7, Page(s) 517–528

Abstract: Temporal lobe epilepsy is characterized by hippocampal neuronal death in CA1 and hilus. Dentate gyrus granule cells survive but show dispersion of the compact granule cell layer. This is associated with decrease of the glycoprotein Reelin, which ... ...

Abstract	Temporal lobe epilepsy is characterized by hippocampal neuronal death in CA1 and hilus. Dentate gyrus granule cells survive but show dispersion of the compact granule cell layer. This is associated with decrease of the glycoprotein Reelin, which regulates neuron migration and dendrite outgrow. Reelin-deficient (reeler) mice show no layering, their granule cells are dispersed throughout the dentate gyrus. We studied granule cell dendritic orientation and distribution of postsynaptic spines in reeler mice and two mouse models of temporal lobe epilepsy, namely the p35 knockout mice, which show Reelin-independent neuronal migration defects, and mice with unilateral intrahippocampal kainate injection. Granule cells were Golgi-stained and analyzed, using a computerized camera lucida system. Granule cells in naive controls exhibited a vertically oriented dendritic arbor with a small bifurcation angle if positioned proximal to the hilus and a wider dendritic bifurcation angle, if positioned distally. P35 knockout- and kainate-injected mice showed a dispersed granule cell layer, granule cells showed basal dendrites with wider bifurcation angles, which lost position-specific differences. Reeler mice lacked dendritic orientation. P35 knockout- and kainate-injected mice showed increased dendritic spine density in the granule cell layer. Molecular layer dendrites showed a reduced spine density in kainate-injected mice only, whereas in p35 knockouts no reduced spine density was seen. Reeler mice showed a homogenous high spine density. We hypothesize that granule cells migrate in temporal lobe epilepsy, develop new dendrites which show a spread of the dendritic tree, create new spines in areas proximal to mossy fiber sprouting, which is present in p35 knockout- and kainate-injected mice and loose spines on distal dendrites if mossy cell death is present, as it was in kainate-injected mice only. These results are in accordance with findings in epilepsy patients.
MeSH term(s)	Animals ; Dendrites/metabolism ; Dentate Gyrus ; Disease Models, Animal ; Epilepsy, Temporal Lobe/chemically induced ; Epilepsy, Temporal Lobe/metabolism ; Humans ; Kainic Acid/toxicity ; Mice ; Mice, Neurologic Mutants ; Neurons/metabolism
Chemical Substances	Kainic Acid (SIV03811UC)
Language	English
Publishing date	2022-05-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1074352-2
ISSN	1098-1063 ; 1050-9631
ISSN (online)	1098-1063
ISSN	1050-9631
DOI	10.1002/hipo.23447
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