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  1. Article ; Online: Lack of Effect of Antioxidants on Biopharmaceutics Classification System (BCS) Class III Drug Permeability.

    Chiang Yu, Yuly / Lu, Dongmei / Rege, Bhagwant / Polli, James E

    Journal of pharmaceutical sciences

    2024  

    Abstract: The addition of antioxidants to pharmaceutical products is a potential approach to inhibit nitrosamine formation, particularly in solid oral dosage forms like tablets and capsules. The objective was to assess the effect of ten antioxidants on the ... ...

    Abstract The addition of antioxidants to pharmaceutical products is a potential approach to inhibit nitrosamine formation, particularly in solid oral dosage forms like tablets and capsules. The objective was to assess the effect of ten antioxidants on the permeability of four Biopharmaceutics Classification System (BCS) Class III drugs. Bi-directional drug permeability studies in the absence and presence of antioxidants were performed in vitro across MDCK-II monolayers. No antioxidant increased drug permeability, while the positive control sodium lauryl sulfate always increased drug permeability. Results support that any of the ten antioxidants, up to at least 10 mg, can be added to a solid oral dosage form without modulating passive drug intestinal permeability. Additional considerations are also discussed.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1016/j.xphs.2024.03.005
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: The impact of dry eye disease on corneal nerve parameters: A systematic review and meta-analysis.

    Chiang, Jeremy Chung Bo / Tran, Vincent / Wolffsohn, James S

    Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

    2023  Volume 43, Issue 5, Page(s) 1079–1091

    Abstract: Purpose: Dry eye disease (DED) is a growing global health problem with a significant impact on the quality of life of patients. While neurosensory abnormalities have been recognised as a contributor to DED pathophysiology, the potential role of in vivo ... ...

    Abstract Purpose: Dry eye disease (DED) is a growing global health problem with a significant impact on the quality of life of patients. While neurosensory abnormalities have been recognised as a contributor to DED pathophysiology, the potential role of in vivo corneal confocal microscopy in detecting nerve loss or damage remains unclear. This systematic review with meta-analysis (PROSPERO registered CRD42022381861) investigated whether DED has an impact on sub-basal corneal nerve parameters.
    Methods: PubMed, Embase and Web of Science Core Collection databases were searched from inception to 9 December 2022. Studies using laser scanning confocal microscopy to compare corneal nerve parameters of DED with healthy eyes were included. Study selection process and data extraction were performed by two independent members of the review team.
    Results: Twenty-two studies with 916 participants with DED and 491 healthy controls were included, with 21 of these studies included in subsequent meta-analyses. There was a decrease in total corneal nerve length (-3.85 mm/mm
    Conclusions: Standardisation is required in terms of terminology and analysis, with more research needed to potentially improve the clinical applicability and practicality of corneal nerve imaging. Further investigation is also required to confirm the diagnostic accuracy of this imaging modality and its potential for monitoring DED treatment efficacy.
    MeSH term(s) Humans ; Quality of Life ; Cornea/innervation ; Dry Eye Syndromes/diagnosis ; Image Processing, Computer-Assisted ; Microscopy, Confocal/methods
    Language English
    Publishing date 2023-06-25
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 604564-9
    ISSN 1475-1313 ; 0275-5408
    ISSN (online) 1475-1313
    ISSN 0275-5408
    DOI 10.1111/opo.13186
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    In stock of ZB MED Cologne/Königswinter

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  3. Book ; Online: Bitcoin Trace-Net

    Chiang, James

    Formal Contract Verification at Signing Time

    2020  

    Abstract: Smart contracting protocols promise to regulate the transfer of cryptocurrency amongst participants in a trustless manner. A safe smart contract implementation should ensure that each participant can always append a contract transaction to the blockchain ...

    Abstract Smart contracting protocols promise to regulate the transfer of cryptocurrency amongst participants in a trustless manner. A safe smart contract implementation should ensure that each participant can always append a contract transaction to the blockchain in order move the contract towards secure completion. To this goal, we propose Bitcoin Trace-Net, a contract verification framework which generates an executable symbolic model from the underlying contract implementation. A Trace-Net model consists of a Petri Net formalism enriched with a Dolev-Yao-like actor knowledge model. The explicit symbolic actor knowledge model supports the verification of contracts featuring cryptographic sub-protocols, which may not be observable on the blockchain. Trace-Net is sufficiently expressive to accurately model blockchain semantics such as the delay between a transaction broadcast and its subsequent confirmation, as well as adversarial blockchain reorganizations of finite depths, both of which can break smart contract safety. As an implementation level framework, Trace-Net can be instantiated at run-time to monitor and verify smart contract protocol executions.

    Comment: Currently under submission. Earlier version presented at MIT Cryptoeconomic Systems Conference 2020
    Keywords Computer Science - Cryptography and Security ; F.3.1
    Subject code 005
    Publishing date 2020-07-15
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Topical ivermectin 1.0% cream in the treatment of ocular demodicosis.

    Smith, Martin / Wolffsohn, James S / Chiang, Jeremy Chung Bo

    Contact lens & anterior eye : the journal of the British Contact Lens Association

    2023  Volume 47, Issue 1, Page(s) 102099

    Abstract: Purpose: Ocular demodicosis can cause debilitating ocular surface disease. As ivermectin is effective at reducing Demodex proliferation in rosacea, this study investigated the efficacy of topical ivermectin 1.0% cream in treating ocular demodicosis.: ... ...

    Abstract Purpose: Ocular demodicosis can cause debilitating ocular surface disease. As ivermectin is effective at reducing Demodex proliferation in rosacea, this study investigated the efficacy of topical ivermectin 1.0% cream in treating ocular demodicosis.
    Methods: This retrospective single-centre clinical practice chart analysis involved the off-label treatment of patients who had ocular demodicosis with topical ivermectin 1.0 % cream (Soolantra, Galderma Ltd, UK) applied nightly to the lid margins of both eyes for 3 months. Ocular surface health was assessed at baseline when the treatment was prescribed and followed up at 3 and 12 months after baseline. Slit lamp biomicroscopy was used to take digital images of the upper eyelid lashes. Manual image analysis with ImageJ was conducted by a masked assessor to quantify signs of ocular demodicosis including the number of lashes with collarettes, with visible Demodex tails and with follicle pouting.
    Results: Data from a total of 75 patients with ocular demodicosis were analysed for this study (mean age 66.6 ± 13.9 years, 44 female). The numbers of lashes with collarettes (Median [Interquartile range]: 8 [4-13] at baseline to 0 [0-2] at the final visit, p < 0.001) and lashes with follicle pouting (3 [1-5] at baseline to 0 [0-1.8] at the final visit, p < 0.001) decreased with treatment. Any sign of lashes with visible tails was eliminated by the final visit (p < 0.007). Fluorescein staining severity score also improved, particularly from baseline (1 [0-2]) to the second visit (0 [0-1], p < 0.001).
    Conclusions: The findings of this study show evidence for the efficacy of a 3-month course of topical ivermectin 1.0% cream in treating ocular demodicosis as indicated by reduction in collarettes, follicle pouting and visible Demodex tails. More research is warranted to improve the diagnosis, management and monitoring of this condition which is often overlooked or misdiagnosed.
    MeSH term(s) Humans ; Female ; Middle Aged ; Aged ; Aged, 80 and over ; Ivermectin/therapeutic use ; Mite Infestations/diagnosis ; Mite Infestations/drug therapy ; Retrospective Studies ; Rosacea/diagnosis ; Rosacea/drug therapy ; Rosacea/complications ; Eyelids ; Blepharitis/drug therapy
    Chemical Substances Ivermectin (70288-86-7)
    Language English
    Publishing date 2023-12-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2004847-6
    ISSN 1476-5411 ; 1367-0484
    ISSN (online) 1476-5411
    ISSN 1367-0484
    DOI 10.1016/j.clae.2023.102099
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  5. Article ; Online: Comments on Surgeon-Patient Sex Concordance and Postoperative Outcomes.

    Chiang, Ping-Hao / Chen, Chih-Wei / Wei, James Cheng-Chung

    JAMA surgery

    2022  Volume 157, Issue 7, Page(s) 636–637

    MeSH term(s) Humans ; Postoperative Complications/epidemiology ; Postoperative Period ; Retrospective Studies ; Surgeons
    Language English
    Publishing date 2022-03-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2022.0292
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  6. Article ; Online: Association between tonsillectomy and COVID-19 in chronic tonsillitis patients.

    Chiang, Ping-Hao / Liu, Hung-Kai / Chen, Yi-Ling / Wang, Yu-Hsun / Wei, James Cheng-Chung

    The British journal of surgery

    2023  Volume 110, Issue 11, Page(s) 1553–1554

    Language English
    Publishing date 2023-09-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znad291
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  7. Article ; Online: Joule heating and electroosmotic flow in cellular micro/nano electroporation.

    Pan, Junjie / Wang, Xinyu / Chiang, Chi-Ling / Ma, Yifan / Cheng, Junao / Bertani, Paul / Lu, Wu / Lee, L James

    Lab on a chip

    2024  Volume 24, Issue 4, Page(s) 819–831

    Abstract: Localized micro/nano-electroporation (MEP/NEP) shows tremendous potential in cell transfection with high cell viability, precise dose control, and good transfection efficacy. In MEP/NEP, micro or nanochannels are used to tailor the electric field ... ...

    Abstract Localized micro/nano-electroporation (MEP/NEP) shows tremendous potential in cell transfection with high cell viability, precise dose control, and good transfection efficacy. In MEP/NEP, micro or nanochannels are used to tailor the electric field distribution. Cells are positioned tightly by a micron or nanochannel, and the cargoes are delivered into the cell
    MeSH term(s) Electroosmosis ; Heating ; Electroporation/methods ; Transfection ; Microfluidics
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2056646-3
    ISSN 1473-0189 ; 1473-0197
    ISSN (online) 1473-0189
    ISSN 1473-0197
    DOI 10.1039/d3lc00568b
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  8. Article ; Online: Challenges and Lessons Learned in Autologous Chimeric Antigen Receptor T-Cell Therapy Development from a Statistical Perspective.

    Li, Daniel / Xu, Zhenzhen / Wen, Shihua / Ananthakrishnan, Revathi / Kim, Yeonhee / Rantell, Khadija Rerhou / Anderson, Patricia / Whitmore, James / Chiang, Alan

    Therapeutic innovation & regulatory science

    2024  

    Abstract: Chimeric antigen receptor (CAR) T-cell therapy is a human gene therapy product where T cells from a patient are genetically modified to enable them to recognize desired target antigen(s) more effectively. In recent years, promising antitumor activity has ...

    Abstract Chimeric antigen receptor (CAR) T-cell therapy is a human gene therapy product where T cells from a patient are genetically modified to enable them to recognize desired target antigen(s) more effectively. In recent years, promising antitumor activity has been seen with autologous CAR T cells. Since 2017, six CAR T-cell therapies for the treatment of hematological malignancies have been approved by the Food and Drug Administration (FDA). Despite the rapid progress of CAR T-cell therapies, considerable statistical challenges still exist for this category of products across all phases of clinical development that need to be addressed. These include (but not limited to) dose finding strategy, implementation of the estimand framework, use of real-world data in contextualizing single-arm CAR T trials, analysis of safety data and long-term follow-up studies. This paper is the first step in summarizing and addressing these statistical hurdles based on the development of the six approved CAR T-cell products.
    Language English
    Publishing date 2024-05-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2708397-4
    ISSN 2168-4804 ; 2168-4790
    ISSN (online) 2168-4804
    ISSN 2168-4790
    DOI 10.1007/s43441-024-00652-3
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  9. Article ; Online: Methodological considerations when discussing the fracture risk of atrial fibrillation patients taking different drug.

    Chiang, Ping-Hao / Hsu, Yung-Chih / Wei, James Cheng-Chung

    European heart journal

    2021  Volume 42, Issue 35, Page(s) 3575

    MeSH term(s) Anticoagulants ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Humans ; Pharmaceutical Preparations ; Warfarin
    Chemical Substances Anticoagulants ; Pharmaceutical Preparations ; Warfarin (5Q7ZVV76EI)
    Language English
    Publishing date 2021-08-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab459
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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Preliminary dosimetric comparison between fixed and rotating source stereotactic radiosurgery systems.

    Draeger, Emily / Chen, Zhe Jay / Hansen, James E / Chiang, Veronica / Tien, Christopher J

    Journal of applied clinical medical physics

    2023  Volume 24, Issue 5, Page(s) e13907

    Abstract: Purpose: The Akesis Galaxy RTi (AK) is a novel rotational : Methods: Thirteen patients, previously treated on a GK Icon, were re-planned on the AK treatment planning system using the same prescription doses and isodoses as the original GK plans. The ... ...

    Abstract Purpose: The Akesis Galaxy RTi (AK) is a novel rotational
    Methods: Thirteen patients, previously treated on a GK Icon, were re-planned on the AK treatment planning system using the same prescription doses and isodoses as the original GK plans. The cohort includes patients treated for brain metastases, schwannomas, pituitary adenomas, trigeminal neuralgias, and arteriovenous malformations. Plans are evaluated with target coverage metrics (D
    Results: AK plans use fewer shots and larger collimation compared to GK plans, resulting in statistically significant reductions in treatment time (p = 0.047) by as much as 88.4 minutes while maintaining comparable target V
    Conclusion: This cohort demonstrates that the AK system is able to achieve largely comparable dosimetric results to GK, typically with shorter treatment times. Further investigation with a larger cohort is underway.
    MeSH term(s) Humans ; Radiosurgery/methods ; Retrospective Studies ; Brain Neoplasms/secondary ; Radiometry ; Pituitary Neoplasms/radiotherapy ; Pituitary Neoplasms/surgery ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy Dosage
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010347-5
    ISSN 1526-9914 ; 1526-9914
    ISSN (online) 1526-9914
    ISSN 1526-9914
    DOI 10.1002/acm2.13907
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