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Article: Polymorphism of histone H1.c’ in the population of Muscovy duck (Cairina moschata L.): a link between histone H1.c’ allelic variants and ADP-ribosylation of histone H1 subtypes

Kowalski, Andrzej

The European zoological journal. 2021 Jan. 01, v. 88, no. 1

2021

Abstract: ... to Hardy–Weinberg assumptions (p < 0.05). The total population differentiation (δ = 0.5) and polymorphism ...

Abstract	In this work, a polymorphic variability of Muscovy duck histone H1.c’ is presented along with a link of its allelic variants with an extent of ADP (Adenosine Diphosphate)-ribosylation of histone H1 non-allelic subtypes. With the use of a two-dimensional electrophoretic system, histone H1.c’ was identified as differentiated into the variously charged isoforms H1.c’1 and H1.c’2. In the population studied, they occur in the form of homozygous phenotype c’1 (frequency 0.384) and c’2 (frequency 0.288) as well as the heterozygous phenotype c’1c’2 (frequency 0.326). Because fewer heterozygotes were observed (0.326) than expected (0.496), the duck population is under inbreeding (F = 0.342, HI = 0.325) and does not conform to Hardy–Weinberg assumptions (p < 0.05). The total population differentiation (δ = 0.5) and polymorphism information content (PIC = 0.496) show that about half the bird individuals are genetically different in an intermediate diverse population. Because an array of Muscovy duck H1 histones is enriched by the complex LHL (Linker Histone Like), which is a conjugate of histone H1 subtypes with ADP-ribose, its juxtaposition with histone H1.c’ allelic variants was examined. This was to uncover a correlation of the phenotype c’2 and c’1c’2 with low intensity of modification (mean LHL density = 316284.9 ± 47776.7) and the relation of the phenotype c’1 to high modification (LHL density = 1380419.6 ± 116471.3). A disparity of more than 4 times in the abundance of ADP–ribose linkage indicates a histone H1.c’ phenotype-specific association with the level of ADP-ribosylation. It seems that such a difference between histone H1.c’ allelic variants might be related to their individual participation in the determination of histone H1 subtype modification status. With respect to this, allelic variants of histone H1.c’ may variously influence the ADP-ribosylation reaction, presumably by differentiated stimulation of the enzymes catalysing the histone H1-ADP-ribose linkage.
Keywords	Cairina moschata ; adenosine diphosphate ; ducks ; electrophoresis ; heterozygosity ; histones ; homozygosity ; phenotype
Language	English
Dates of publication	2021-0101
Size	p. 649-658.
Publishing place	Taylor & Francis
Document type	Article
ISSN	2475-0263
DOI	10.1080/24750263.2021.1912200
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Polymorphism of histone H1.c’ in the population of Muscovy duck (Cairina moschata L.)

Andrzej Kowalski

The European Zoological Journal, Vol 88, Iss 1, Pp 649-

a link between histone H1.c’ allelic variants and ADP-ribosylation of histone H1 subtypes

2021 Volume 658

Abstract: ... to Hardy–Weinberg assumptions (p < 0.05). The total population differentiation (δ = 0.5) and polymorphism ...

Abstract	In this work, a polymorphic variability of Muscovy duck histone H1.c’ is presented along with a link of its allelic variants with an extent of ADP (Adenosine Diphosphate)-ribosylation of histone H1 non-allelic subtypes. With the use of a two-dimensional electrophoretic system, histone H1.c’ was identified as differentiated into the variously charged isoforms H1.c’1 and H1.c’2. In the population studied, they occur in the form of homozygous phenotype c’1 (frequency 0.384) and c’2 (frequency 0.288) as well as the heterozygous phenotype c’1c’2 (frequency 0.326). Because fewer heterozygotes were observed (0.326) than expected (0.496), the duck population is under inbreeding (F = 0.342, HI = 0.325) and does not conform to Hardy–Weinberg assumptions (p < 0.05). The total population differentiation (δ = 0.5) and polymorphism information content (PIC = 0.496) show that about half the bird individuals are genetically different in an intermediate diverse population. Because an array of Muscovy duck H1 histones is enriched by the complex LHL (Linker Histone Like), which is a conjugate of histone H1 subtypes with ADP-ribose, its juxtaposition with histone H1.c’ allelic variants was examined. This was to uncover a correlation of the phenotype c’2 and c’1c’2 with low intensity of modification (mean LHL density = 316284.9 ± 47776.7) and the relation of the phenotype c’1 to high modification (LHL density = 1380419.6 ± 116471.3). A disparity of more than 4 times in the abundance of ADP–ribose linkage indicates a histone H1.c’ phenotype-specific association with the level of ADP-ribosylation. It seems that such a difference between histone H1.c’ allelic variants might be related to their individual participation in the determination of histone H1 subtype modification status. With respect to this, allelic variants of histone H1.c’ may variously influence the ADP-ribosylation reaction, presumably by differentiated stimulation of the enzymes catalysing the histone H1-ADP-ribose linkage.
Keywords	adp-ribosylation ; histone h1 ; histone h1.c’ ; inbreed ; muscovy duck ; polymorphism ; Zoology ; QL1-991
Subject code	616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
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Article: Proteins from toad's parotoid macroglands: do they play a role in gland functioning and chemical defence?

Kowalski, Krzysztof / Marciniak, Paweł / Rychlik, Leszek

Frontiers in zoology

2023 Volume 20, Issue 1, Page(s) 21

Abstract: Background: Parotoid gland secretion of bufonid toads is a rich source of toxic molecules that are used against predators, parasites and pathogens. Bufadienolides and biogenic amines are the principal compounds responsible for toxicity of parotoid ... ...

Abstract	Background: Parotoid gland secretion of bufonid toads is a rich source of toxic molecules that are used against predators, parasites and pathogens. Bufadienolides and biogenic amines are the principal compounds responsible for toxicity of parotoid secretion. Many toxicological and pharmacological analyses of parotoid secretions have been performed, but little is known about the processes related to poison production and secretion. Therefore, our aim was to investigate protein content in parotoids of the common toad, Bufo bufo, to understand the processes that regulate synthesis and excretion of toxins as well as functioning of parotoid macroglands. Results: Applying a proteomic approach we identified 162 proteins in the extract from toad's parotoids that were classified into 11 categories of biological functions. One-third (34.6%) of the identified molecules, including acyl-CoA-binding protein, actin, catalase, calmodulin, and enolases, were involved in cell metabolism. We found many proteins related to cell division and cell cycle regulation (12.0%; e.g. histone and tubulin), cell structure maintenance (8.4%; e.g. thymosin beta-4, tubulin), intra- and extracellular transport (8.4%), cell aging and apoptosis (7.3%; e.g. catalase and pyruvate kinase) as well as immune (7.0%; e.g. interleukin-24 and UV excision repair protein) and stress (6.3%; including heat shock proteins, peroxiredoxin-6 and superoxide dismutase) response. We also identified two proteins, phosphomevalonate kinase and isopentenyl-diphosphate delta-isomerase 1, that are involved in synthesis of cholesterol which is a precursor for bufadienolides biosynthesis. STRING protein-protein interaction network predicted for identified proteins showed that most proteins are related to metabolic processes, particularly glycolysis, stress response and DNA repair and replication. The results of GO enrichment and KEGG analyses are also consistent with these findings. Conclusion: This finding indicates that cholesterol may be synthesized in parotoids, and not only in the liver from which is then transferred through the bloodstream to the parotoid macroglands. Presence of proteins that regulate cell cycle, cell division, aging and apoptosis may indicate a high epithelial cell turnover in parotoids. Proteins protecting skin cells from DNA damage may help to minimize the harmful effects of UV radiation. Thus, our work extends our knowledge with new and important functions of parotoids, major glands involved in the bufonid chemical defence.
Language	English
Publishing date	2023-06-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2164409-3
ISSN	1742-9994
ISSN	1742-9994
DOI	10.1186/s12983-023-00499-8
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Article ; Online: A systematic review of performance-based assessment studies on cognitive biases in schizophrenia spectrum psychoses and clinical high-risk states: A summary of 40 years of research.

Gawęda, Łukasz / Kowalski, Joachim / Aleksandrowicz, Adrianna / Bagrowska, Paulina / Dąbkowska, Małgorzata / Pionke-Ubych, Renata

Clinical psychology review

2024 Volume 108, Page(s) 102391

Abstract: Cognitive models of psychosis have stimulated empirical studies on cognitive biases involved in schizophrenia spectrum psychoses and their symptoms. This systematic review aimed to summarize the studies on the role of cognitive biases as assessed in ... ...

Abstract	Cognitive models of psychosis have stimulated empirical studies on cognitive biases involved in schizophrenia spectrum psychoses and their symptoms. This systematic review aimed to summarize the studies on the role of cognitive biases as assessed in different performance-based tasks in schizophrenia spectrum psychoses and clinical high-risk states. We focused on five cognitive biases linked to psychosis, i.e., aberrant salience, attentional biases, source monitoring biases, jumping to conclusions, and bias against disconfirmatory evidence. We identified N = 324 studies published in N = 308 articles fulfilling inclusion criteria. Most studies have been cross-sectional and confirmed that the schizophrenia spectrum psychoses are related to exaggerated cognitive biases compared to healthy controls. On the contrary, less evidence suggests a higher tendency for cognitive biases in the UHR sample. The only exceptions were source monitoring and jumping to conclusions, which were confirmed to be exaggerated in both clinical groups. Hallucinations and delusions were the most frequent symptoms studied in the context of cognitive biases. Based on the findings, we presented a hypothetical model on the role of interactions between cognitive biases or additive effects of biases in shaping the risk of psychosis. Future research is warranted for further development of cognitive models for psychosis.
MeSH term(s)	Humans ; Schizophrenia ; Cross-Sectional Studies ; Psychotic Disorders/psychology ; Cognition ; Bias
Language	English
Publishing date	2024-01-14
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	604577-7
ISSN	1873-7811 ; 0272-7358
ISSN (online)	1873-7811
ISSN	0272-7358
DOI	10.1016/j.cpr.2024.102391
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Article ; Online: A decision analysis model for elective neck dissection in patients with cT1-2 cN0 oral squamous cell carcinoma.

Köhler, H F / Kowalski, L P

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

2019 Volume 39, Issue 6, Page(s) 374–380

MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/surgery ; Decision Support Techniques ; Elective Surgical Procedures ; Female ; Humans ; Male ; Middle Aged ; Mouth Neoplasms/pathology ; Mouth Neoplasms/surgery ; Neck Dissection ; Neoplasm Staging ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2019-03-25
Publishing country	Italy
Document type	Journal Article
ZDB-ID	604898-5
ISSN	1827-675X ; 0392-100X
ISSN (online)	1827-675X
ISSN	0392-100X
DOI	10.14639/0392-100X-2101
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Article ; Online: Post-retirement enlightenment syndrome: Worthy of investigation.

McLauchlan, Laura / Kelaita, Paul / Kowalski, Michala / Ritter, Alison

The International journal on drug policy

2023 Volume 117, Page(s) 104059

Abstract: Post-Retirement Enlightenment Syndrome is a term used by some in illicit drug policy to reflect the experience of having politicians "come out" in favour of drug policy reform only after retirement. To date, the phenomenon has not been examined in any ... ...

Abstract	Post-Retirement Enlightenment Syndrome is a term used by some in illicit drug policy to reflect the experience of having politicians "come out" in favour of drug policy reform only after retirement. To date, the phenomenon has not been examined in any systematic manner. While discussions of the phenomenon on social media tend to be playful, they nevertheless express real frustration with the reluctance of privately supportive sitting politicians and policing officials to speak out in favour of non-punitive and/or harm reduction-oriented policies. In this commentary, we give an overview of the phenomenon of Post-Retirement Enlightenment Syndrome. We argue that these instances of sitting officials speaking out publicly in favour of drug policy reform, as well as instances in which such apparent "enlightenment" is not publicly expressed until after retirement, are potentially highly fruitful areas for investigation. Public positions on drug policy are invariably contoured by conditions of political possibility. We raise the call for both an unpacking and examination of the structural and relational aspects of "political will" and "political courage". Sitting and retired politicians each have a role in the drug policy landscape, whether as lawmakers or as high-profile and often respected commentators. This commentary argues that a more nuanced understanding of the conditions that may support or hinder the expression of public support for drug policy reform by political office bearers, whether sitting or former, has implications for advocates and researchers invested in policy change.
MeSH term(s)	Humans ; Retirement ; Politics ; Public Policy ; Illicit Drugs
Chemical Substances	Illicit Drugs
Language	English
Publishing date	2023-05-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2010000-0
ISSN	1873-4758 ; 0955-3959
ISSN (online)	1873-4758
ISSN	0955-3959
DOI	10.1016/j.drugpo.2023.104059
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Article ; Online: Lidocaine Gel Interferes With the Antibacterial Activity of Povidone-Iodine.

Odden, Jamie L / Kowalski, Regis P / Friberg, Thomas R

Ophthalmic surgery, lasers & imaging retina

2021 Volume 52, Issue S1, Page(s) S13–S16

Abstract: Background and objective: Retina specialists use lidocaine gel as a topical anesthetic. We determined the antibacterial interaction between povidone-iodine (PI) and lidocaine gel using corneoscleral tissue as a solid phase medium.: Materials and ... ...

Abstract	Background and objective: Retina specialists use lidocaine gel as a topical anesthetic. We determined the antibacterial interaction between povidone-iodine (PI) and lidocaine gel using corneoscleral tissue as a solid phase medium. Materials and methods: Five pieces of corneoscleral tissue in five trials were inoculated with 1.000 colony-forming units of bacteria isolated from endophthalmitis. Inoculated corneal tissue were overlaid with nothing (control), lidocaine gel, 5% PI, lidocaine gel over 5% PI, and 5% PI over lidocaine gel for 5 minutes prior to placement in growth liquid medium at 37°C. Growth was monitored for 48 hours. Results: Application of lidocaine gel prior to 5% PI application provided for the growth of the five bacterial isolates, whereas 5% PI prior to lidocaine gel prevented growth. Conclusion: Using corneoscleral tissue, PI and lidocaine gel appear to have an antagonistic interaction when lidocaine gel is applied initially prior to 5% PI, preventing bactericidal activity of PI.
MeSH term(s)	Anesthetics, Local/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents, Local ; Humans ; Lidocaine/pharmacology ; Povidone-Iodine/pharmacology
Chemical Substances	Anesthetics, Local ; Anti-Bacterial Agents ; Anti-Infective Agents, Local ; Povidone-Iodine (85H0HZU99M) ; Lidocaine (98PI200987)
Language	English
Publishing date	2021-07-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2701167-7
ISSN	2325-8179 ; 2325-8160
ISSN (online)	2325-8179
ISSN	2325-8160
DOI	10.3928/23258160-20210518-03
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Article: A new, widespread venomous mammal species: hemolytic activity of Sorex araneus venom is similar to that of Neomys fodiens venom.

Kowalski, Krzysztof / Marciniak, Paweł / Rychlik, Leszek

Zoological letters

2022 Volume 8, Issue 1, Page(s) 7

Abstract: Background: Venom production has evolved independently many times in the animal kingdom, although it is rare among mammals. Venomous shrews produce toxins in their salivary glands and use their venoms to hunt and store prey. Thus far, the toxicity and ... ...

Abstract	Background: Venom production has evolved independently many times in the animal kingdom, although it is rare among mammals. Venomous shrews produce toxins in their salivary glands and use their venoms to hunt and store prey. Thus far, the toxicity and composition of shrew venoms have been studied only in two shrew species: the northern short-tailed shrew, Blarina brevicauda, and the Eurasian water shrew, Neomys fodiens. Venom of N. fodiens has potent paralytic activity which enables hunting and storing prey in a comatose state. Here, we assayed the hemolytic effects of extracts from salivary glands of N. fodiens and the common shrew, Sorex araneus, in erythrocytes of Pelophylax sp. frogs. We identified toxins in shrew venom by high-performance liquid chromatography coupled to tandem mass spectrometry. Results: Our results prove, confirming a suggestion made four centuries ago, that S. araneus is venomous. We also provide the first experimental evidence that shrew venoms produce potent hemolysis in frog erythrocytes. We found significant concentration-dependent effects of venoms of N. fodiens and S. araneus on hemolysis of red blood cells evaluated as hemoglobin release. Treatment of erythrocytes with N. fodiens venom at concentrations of 1.0 and 0.5 mg/ml and with S. araneus venom at concentration of 1.0 mg/ml caused an increased release of hemoglobin. Our findings confirm that hemolytic effects of N. fodiens venom are stronger than those produced by S. araneus venom. We identified four toxins in the venom of N. fodiens: proenkephalin, phospholipase A Conclusions: Our results clearly show that shrew venoms possess hemolytic action that may allow them to hunt larger prey. Since a member of the numerous genus Sorex is venomous, it is likely that venom production among shrews and other eulipotyphlans may be more widespread than it has previously been assumed.
Language	English
Publishing date	2022-06-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2809936-9
ISSN	2056-306X
ISSN	2056-306X
DOI	10.1186/s40851-022-00191-5
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Article ; Online: A heterogeneity of the pheasant (Phasianus colchicus L.) erythrocyte histone H1 subtype H5.

Kowalski, Andrzej

Comptes rendus biologies

2016 Volume 339, Issue 9-10, Page(s) 357–363

Abstract: ... migration, two histone H5 phenotypes (H5a and H5b) possessing similar quantitative proportion (P>0.05) were ...

Abstract	In a previous work (Górnicka-Michalska et al. (1998)), an occurrence of genetic variants in the chicken erythrocyte histone H5 has been presented. Here, the pheasant histone H5 heterogeneity is characterized to verify if the interspecies variability of this protein is caused by the analogous determinants. During screening histone H1 preparations isolated from the pheasant erythrocytes, histone H5 was identified as differently located in the electrophoretic gels. According to the rate of electrophoretic migration, two histone H5 phenotypes (H5a and H5b) possessing similar quantitative proportion (P>0.05) were distinguished. A rare phenotype H5a (frequency 0.26) migrating faster in the SDS-PAGE was low mobile in the AU-PAGE, in contrast to the frequent phenotype H5b (frequency 0.74) that moved slowly in the SDS-PAGE and roamed faster in the AU-PAGE. The electrophoretic properties of histone H5 phenotypes may reflect disparities in their net charge and molecular weight. Peptide maps of histone H5 phenotypes, obtained by partial chemical cleavage (NBS) and limited enzymatic digestion (α-chymotrypsin), revealed their C-peptides possessing the same electrophoretic mobility and the N-peptides having variable rate of the electrophoretic migration. Based on this, the identified phenotypic variation seems to be determined by a histone H5 phenotype-specific amino acid sequence region situated in the N-terminal portion of its molecule. According to the identified varied sequence stretches, histone H5 phenotype may induce specific effects related to the organization and/or function of the pheasant chromatin.
MeSH term(s)	Amino Acid Sequence ; Animals ; C-Peptide/blood ; C-Peptide/chemistry ; Chymotrypsin/chemistry ; Electrophoresis, Polyacrylamide Gel ; Erythrocytes/metabolism ; Galliformes/genetics ; Genetic Variation ; Histones/chemistry ; Histones/genetics ; Hydrolysis ; Molecular Weight ; Peptide Mapping
Chemical Substances	C-Peptide ; Histones ; Chymotrypsin (EC 3.4.21.1)
Language	English
Publishing date	2016-09
Publishing country	France
Document type	Journal Article
ZDB-ID	2072863-3
ISSN	1768-3238 ; 1631-0691
ISSN (online)	1768-3238
ISSN	1631-0691
DOI	10.1016/j.crvi.2016.07.001
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Article: Experimentally Induced Dieback Conditions Limit

Bickford, Wesley A / Snow, Danielle S / Smith, McKenzie K H / Kingsley, Kathryn L / White, James F / Kowalski, Kurt P

Microorganisms

2023 Volume 11, Issue 3

Abstract: Phragmites ... ...

Abstract	Phragmites australis
Language	English
Publishing date	2023-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11030639
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