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  1. Article ; Online: Reply to: Higher PEEP in intubated COVID-19-associated ARDS patients? We are not sure.

    Somhorst, Peter / van der Zee, Philip / Endeman, Henrik / Gommers, Diederik

    Critical care (London, England)

    2022  Volume 26, Issue 1, Page(s) 388

    MeSH term(s) Humans ; COVID-19 ; Respiration, Artificial ; Positive-Pressure Respiration ; Respiratory Distress Syndrome/therapy
    Language English
    Publishing date 2022-12-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-022-04262-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: PEEP-FiO

    Somhorst, Peter / van der Zee, Philip / Endeman, Henrik / Gommers, Diederik

    Critical care (London, England)

    2022  Volume 26, Issue 1, Page(s) 272

    Abstract: Rationale: It is unknown how to titrate positive end-expiratory pressure (PEEP) in patients with COVID-19-related acute respiratory distress syndrome (ARDS). Guidelines recommend the one-size-fits-all PEEP-FiO: Objectives: To compare baseline PEEP ... ...

    Abstract Rationale: It is unknown how to titrate positive end-expiratory pressure (PEEP) in patients with COVID-19-related acute respiratory distress syndrome (ARDS). Guidelines recommend the one-size-fits-all PEEP-FiO
    Objectives: To compare baseline PEEP according to the high PEEP-FiO
    Methods: We performed an EIT-guided decremental PEEP trial in patients with moderate-to-severe COVID-19-related ARDS upon intensive care unit admission. PEEP was set at the lowest PEEP above the intersection of curves representing relative alveolar overdistention and collapse. Baseline PEEP was compared with PEEP set according to EIT. We identified patients in whom the EIT-guided PEEP trial resulted in a decrease or increase in PEEP of ≥ 2 cmH
    Measurements and main results: We performed a PEEP trial in 75 patients. In 23 (31%) patients, PEEP was decreased ≥ 2 cmH
    Conclusions: An EIT-guided PEEP trial resulted in a relevant change in PEEP in 63% of patients. These results support the hypothesis that PEEP should be personalized in patients with ARDS.
    MeSH term(s) COVID-19/complications ; COVID-19/therapy ; Electric Impedance ; Humans ; Respiration, Artificial ; Respiratory Distress Syndrome/therapy ; Retrospective Studies
    Language English
    Publishing date 2022-09-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-022-04135-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Flow-controlled ventilation decreases mechanical power in postoperative ICU patients.

    Van Oosten, Julien P / Francovich, Juliette E / Somhorst, Peter / van der Zee, Philip / Endeman, Henrik / Gommers, Diederik A M P J / Jonkman, Annemijn H

    Intensive care medicine experimental

    2024  Volume 12, Issue 1, Page(s) 30

    Abstract: Background: Mechanical power (MP) is the energy delivered by the ventilator to the respiratory system and combines factors related to the development of ventilator-induced lung injury (VILI). Flow-controlled ventilation (FCV) is a new ventilation mode ... ...

    Abstract Background: Mechanical power (MP) is the energy delivered by the ventilator to the respiratory system and combines factors related to the development of ventilator-induced lung injury (VILI). Flow-controlled ventilation (FCV) is a new ventilation mode using a constant low flow during both inspiration and expiration, which is hypothesized to lower the MP and to improve ventilation homogeneity. Data demonstrating these effects are scarce, since previous studies comparing FCV with conventional controlled ventilation modes in ICU patients suffer from important methodological concerns.
    Objectives: This study aims to assess the difference in MP between FCV and pressure-controlled ventilation (PCV). Secondary aims were to explore the effect of FCV in terms of minute volume, ventilation distribution and homogeneity, and gas exchange.
    Methods: This is a physiological study in post-cardiothoracic surgery patients requiring mechanical ventilation in the ICU. During PCV at baseline and 90 min of FCV, intratracheal pressure, airway flow and electrical impedance tomography (EIT) were measured continuously, and hemodynamics and venous and arterial blood gases were obtained repeatedly. Pressure-volume loops were constructed for the calculation of the MP.
    Results: In 10 patients, optimized FCV versus PCV resulted in a lower MP (7.7 vs. 11.0 J/min; p = 0.004). Although FCV did not increase overall ventilation homogeneity, it did lead to an improved ventilation of the dependent lung regions. A stable gas exchange at lower minute volumes was obtained.
    Conclusions: FCV resulted in a lower MP and improved ventilation of the dependent lung regions in post-cardiothoracic surgery patients on the ICU. Trial registration Clinicaltrials.gov identifier: NCT05644418. Registered 1 December 2022, retrospectively registered.
    Language English
    Publishing date 2024-03-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2740385-3
    ISSN 2197-425X
    ISSN 2197-425X
    DOI 10.1186/s40635-024-00616-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reply to van den Berg and van der Hoeven: In Patients with ARDS, Optimal PEEP Should Not Be Determined Using the Intersection of Relative Collapse and Relative Overdistention.

    van der Zee, Philip / Somhorst, Peter / Endeman, Henrik / Gommers, Diederik

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 8, Page(s) 1189–1190

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Electric Impedance ; Humans ; Pandemics ; Pneumonia, Viral ; Positive-Pressure Respiration ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202006-2460LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Latent class analysis-based subgroups and response to corticosteroids in hospitalised community-acquired pneumonia patients: a validation study.

    Wittermans, Esther / van der Zee, Philip A / Qi, Hongchao / Grutters, Jan C / Voorn, G Paul / Bos, Willem Jan W / van de Garde, Ewoudt M W / Endeman, Henrik

    ERJ open research

    2023  Volume 9, Issue 2

    Abstract: In patients with community-acquired pneumonia, LCA can identify robust prognostic subgroups based on clinical and inflammatory parameters. Yet, these subgroups have not proven robust in predicting response to adjunctive dexamethasone treatment. ...

    Abstract In patients with community-acquired pneumonia, LCA can identify robust prognostic subgroups based on clinical and inflammatory parameters. Yet, these subgroups have not proven robust in predicting response to adjunctive dexamethasone treatment.
    Language English
    Publishing date 2023-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00577-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Recruitment Maneuvers and Higher PEEP, the So-Called Open Lung Concept, in Patients with ARDS.

    van der Zee, Philip / Gommers, Diederik

    Critical care (London, England)

    2019  Volume 23, Issue 1, Page(s) 73

    Abstract: This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2019 . Further information about the ... ...

    Abstract This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2019 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901 .
    MeSH term(s) Humans ; Lung/physiopathology ; Positive-Pressure Respiration/methods ; Respiration, Artificial/methods ; Respiration, Artificial/trends ; Respiratory Distress Syndrome, Adult/physiopathology ; Respiratory Distress Syndrome, Adult/therapy ; Ventilator-Induced Lung Injury/physiopathology ; Ventilator-Induced Lung Injury/prevention & control
    Language English
    Publishing date 2019-03-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-019-2365-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Electrical Impedance Tomography for Positive End-Expiratory Pressure Titration in COVID-19-related Acute Respiratory Distress Syndrome.

    van der Zee, Philip / Somhorst, Peter / Endeman, Henrik / Gommers, Diederik

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 2, Page(s) 280–284

    MeSH term(s) Adolescent ; Aged ; Betacoronavirus ; COVID-19 ; Cardiography, Impedance ; Cohort Studies ; Coronavirus Infections/complications ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/therapy ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/therapy ; Positive-Pressure Respiration ; Respiratory Distress Syndrome/diagnostic imaging ; Respiratory Distress Syndrome/therapy ; Respiratory Distress Syndrome/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202003-0816LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.80: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Article ; Online: Frontotemporal Lobar Degeneration Case with an N-Terminal

    Van Schoor, Evelien / Vandenbulcke, Mathieu / Bercier, Valérie / Vandenberghe, Rik / van der Zee, Julie / Van Broeckhoven, Christine / Otto, Markus / Hanseeuw, Bernard / Van Damme, Philip / Van Den Bosch, Ludo / Thal, Dietmar Rudolf

    Biomolecules

    2022  Volume 12, Issue 3

    Abstract: Recently, disease-associated variants of ... ...

    Abstract Recently, disease-associated variants of the
    MeSH term(s) Brain/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Frontotemporal Dementia ; Frontotemporal Lobar Degeneration/genetics ; Frontotemporal Lobar Degeneration/metabolism ; Frontotemporal Lobar Degeneration/pathology ; Humans ; Mutation ; RNA, Messenger/genetics
    Chemical Substances DNA-Binding Proteins ; RNA, Messenger
    Language English
    Publishing date 2022-03-12
    Publishing country Switzerland
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12030440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.

    Tromp, Katja / van der Zee, Philip / Rokx, Casper / van Kampen, Jeroen / Gommers, Diederik / Endeman, Henrik

    Biomarker insights

    2021  Volume 16, Page(s) 11772719211021647

    Abstract: Corticosteroids reduced mortality rate in patients with coronavirus disease 2019 (COVID-19). Previously, we hypothesized that corticosteroids mitigate the inflammation response resulting in reduced coagulation and thrombosis. In this retrospective study, ...

    Abstract Corticosteroids reduced mortality rate in patients with coronavirus disease 2019 (COVID-19). Previously, we hypothesized that corticosteroids mitigate the inflammation response resulting in reduced coagulation and thrombosis. In this retrospective study, we included 27 patients with COVID-19 that received high-dose corticosteroids (methylprednisolone 1000 mg i.v. daily for 3 days) for persistent respiratory failure or an excessive inflammation response. We found that inflammation, coagulation, and ventilation parameters improved significantly after methylprednisolone. The viral loads of SARS-CoV-2 remained stable or decreased. These results provides insight into the reduced mortality rate observed in patients with COVID-19 treated with corticosteroids.
    Language English
    Publishing date 2021-06-04
    Publishing country United States
    Document type Journal Article
    ISSN 1177-2719
    ISSN 1177-2719
    DOI 10.1177/11772719211021647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Latent class analysis-based subgroups and response to corticosteroids in hospitalised community-acquired pneumonia patients

    Esther Wittermans / Philip A. van der Zee / Hongchao Qi / Jan C. Grutters / G. Paul Voorn / Willem Jan W. Bos / Ewoudt M.W. van de Garde / Henrik Endeman

    ERJ Open Research, Vol 9, Iss

    a validation study

    2023  Volume 2

    Keywords Medicine ; R
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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