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  1. Article: Electrochemical investigations for COVID-19 detection-A comparison with other viral detection methods.

    Bukkitgar, Shikandar D / Shetti, Nagaraj P / Aminabhavi, Tejraj M

    Chemical engineering journal (Lausanne, Switzerland : 1996)

    2020  Volume 420, Page(s) 127575

    Abstract: Virus-induced infection such as SARS-CoV-2 is a serious threat to human health and the economic setback of the world. Continued advances in the development of technologies are required before the viruses undergo mutation. The low concentration of viruses ...

    Abstract Virus-induced infection such as SARS-CoV-2 is a serious threat to human health and the economic setback of the world. Continued advances in the development of technologies are required before the viruses undergo mutation. The low concentration of viruses in environmental samples makes the detection extremely challenging; simple, accurate and rapid detection methods are in urgent need. Of all the analytical techniques, electrochemical methods have the established capabilities to address the issues. Particularly, the integration of nanotechnology would allow miniature devices to be made available at the point-of-care. This review outlines the capabilities of electrochemical methods in conjunction with nanotechnology for the detection of SARS-CoV-2. Future directions and challenges of the electrochemical biosensors for pathogen detection are covered including wearable and conformal biosensors, detection of plant pathogens, multiplexed detection, and reusable biosensors for on-site monitoring, thereby providing low-cost and disposable biosensors.
    Keywords covid19
    Language English
    Publishing date 2020-11-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2012137-4
    ISSN 1873-3212 ; 1385-8947
    ISSN (online) 1873-3212
    ISSN 1385-8947
    DOI 10.1016/j.cej.2020.127575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Electrochemical investigations for COVID-19 detection-A comparison with other viral detection methods

    Bukkitgar, Shikandar D. / Shetti, Nagaraj P. / Aminabhavi, Tejraj M.

    Chemical Engineering Journal

    2020  , Page(s) 127575

    Keywords Industrial and Manufacturing Engineering ; General Chemistry ; General Chemical Engineering ; Environmental Chemistry ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2012137-4
    ISSN 1873-3212 ; 1385-8947
    ISSN (online) 1873-3212
    ISSN 1385-8947
    DOI 10.1016/j.cej.2020.127575
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Electrochemical behavior of an anticancer drug 5-fluorouracil at methylene blue modified carbon paste electrode.

    Bukkitgar, Shikandar D / Shetti, Nagaraj P

    Materials science & engineering. C, Materials for biological applications

    2016  Volume 65, Page(s) 262–268

    Abstract: A novel sensor for the determination of 5-fluorouracil was constructed by electrochemical deposition of methylene blue on surface of carbon paste electrode. The electrode surface morphology was studied using Atomic force microscopy and XRD. The ... ...

    Abstract A novel sensor for the determination of 5-fluorouracil was constructed by electrochemical deposition of methylene blue on surface of carbon paste electrode. The electrode surface morphology was studied using Atomic force microscopy and XRD. The electrochemical activity of modified electrode was characterized using cyclic voltammetry and differential pulse method. The developed sensor shows impressive enlargement in sensitivity of 5-fluorouracil determination. The peak currents obtained from differential pulse voltammetry was linear with concentration of 5-fluorouracil in the range 4×10(-5)-1×10(-7)M and detection limit and quantification limit were calculated to be 2.04nM and 6.18nM respectively. Further, the sensor was successfully applied in pharmaceutical and biological fluid sample analysis.
    MeSH term(s) Antineoplastic Agents/analysis ; Antineoplastic Agents/urine ; Carbon/chemistry ; Electrochemical Techniques ; Electrodes ; Fluorouracil/analysis ; Fluorouracil/urine ; Humans ; Hydrogen-Ion Concentration ; Limit of Detection ; Methylene Blue/chemistry ; Microscopy, Atomic Force ; Reproducibility of Results
    Chemical Substances Antineoplastic Agents ; Carbon (7440-44-0) ; Methylene Blue (T42P99266K) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2016-08-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2012160-X
    ISSN 1873-0191 ; 0928-4931
    ISSN (online) 1873-0191
    ISSN 0928-4931
    DOI 10.1016/j.msec.2016.04.045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Electrochemical investigations for COVID-19 detection-A comparison with other viral detection methods

    Bukkitgar, Shikandar D / Shetti, Nagaraj P / Aminabhavi, Tejraj M

    Chem Eng J

    Abstract: Virus-induced infection such as SARS-CoV-2 is a serious threat to human health and the economic setback of the world. Continued advances in the development of technologies are required before the viruses undergo mutation. The low concentration of viruses ...

    Abstract Virus-induced infection such as SARS-CoV-2 is a serious threat to human health and the economic setback of the world. Continued advances in the development of technologies are required before the viruses undergo mutation. The low concentration of viruses in environmental samples makes the detection extremely challenging; simple, accurate and rapid detection methods are in urgent need. Of all the analytical techniques, electrochemical methods have the established capabilities to address the issues. Particularly, the integration of nanotechnology would allow miniature devices to be made available at the point-of-care. This review outlines the capabilities of electrochemical methods in conjunction with nanotechnology for the detection of SARS-CoV-2. Future directions and challenges of the electrochemical biosensors for pathogen detection are covered including wearable and conformal biosensors, detection of plant pathogens, multiplexed detection, and reusable biosensors for on-site monitoring, thereby providing low-cost and disposable biosensors.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #898556
    Database COVID19

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  5. Article ; Online: Conventional and Nanotechnology-Based Sensing Methods for SARS Coronavirus (2019-nCoV).

    Shetti, Nagaraj P / Mishra, Amit / Bukkitgar, Shikandar D / Basu, Soumen / Narang, Jagriti / Raghava Reddy, Kakarla / Aminabhavi, Tejraj M

    ACS applied bio materials

    2021  Volume 4, Issue 2, Page(s) 1178–1190

    Abstract: Ongoing pandemic coronavirus (COVID-19) has affected over 218 countries and infected 88,512,243 and 1,906,853 deaths reported by Jan. 8, 2021. At present, vaccines are being developed in Europe, Russia, USA, and China, although some of these are in phase ...

    Abstract Ongoing pandemic coronavirus (COVID-19) has affected over 218 countries and infected 88,512,243 and 1,906,853 deaths reported by Jan. 8, 2021. At present, vaccines are being developed in Europe, Russia, USA, and China, although some of these are in phase III of trials, which are waiting to be available for the general public. The only option available now is by vigorous testing, isolation of the infected cases, and maintaining physical and social distances. Numerous methods are now available or being developed for testing the suspected cases, which may act as carriers of the virus. In this review, efforts have been made to discuss the conventional as well as fast, rapid, and efficient testing methods developed for the diagnosis of 2019-nCoV.Testing methods can be based on the sensing of targets, which include RNA, spike proteins and antibodies such as IgG and IgM. Apart from the development of RNA targeted PCR, antibody and VSV pseudovirus neutralization assay along with several other diagnostic techniques have been developed. Additionally, nanotechnology-based sensors are being developed for the diagnosis of the virus, and these are also discussed.
    MeSH term(s) Animals ; Antibodies, Immobilized/immunology ; Antibodies, Neutralizing/analysis ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Biosensing Techniques/methods ; COVID-19/diagnosis ; Graphite/chemistry ; Humans ; Metal Nanoparticles/chemistry ; Nanotechnology/methods ; SARS-CoV-2/chemistry ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/analysis ; Spike Glycoprotein, Coronavirus/immunology
    Chemical Substances Antibodies, Immobilized ; Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Graphite (7782-42-5)
    Language English
    Publishing date 2021-02-04
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.0c01545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nanostructured titanium oxide hybrids-based electrochemical biosensors for healthcare applications.

    Shetti, Nagaraj P / Bukkitgar, Shikandar D / Reddy, Kakarla Raghava / Reddy, Ch Venkata / Aminabhavi, Tejraj M

    Colloids and surfaces. B, Biointerfaces

    2019  Volume 178, Page(s) 385–394

    Abstract: Biosensors are promising biotechnology products that can be widely used for environmental monitoring, food analysis, and healthcare diagnostics. To detect analytes of interest, the use of nanotechnology in bio-analytical devices is advantageous for ... ...

    Abstract Biosensors are promising biotechnology products that can be widely used for environmental monitoring, food analysis, and healthcare diagnostics. To detect analytes of interest, the use of nanotechnology in bio-analytical devices is advantageous for increased sensitivity, device simplification, and rapid sensing with multiple capabilities. Depending on the application, biosensors can be fabricated from different materials. TiO
    MeSH term(s) Biosensing Techniques/methods ; Electrochemistry/methods ; Nanostructures/chemistry ; Nanotechnology/methods ; Titanium/chemistry
    Chemical Substances titanium dioxide (15FIX9V2JP) ; Titanium (D1JT611TNE)
    Language English
    Publishing date 2019-03-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2019.03.013
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  7. Article ; Online: ZnO-based nanostructured electrodes for electrochemical sensors and biosensors in biomedical applications.

    Shetti, Nagaraj P / Bukkitgar, Shikandar D / Reddy, Kakarla Raghava / Reddy, Ch Venkata / Aminabhavi, Tejraj M

    Biosensors & bioelectronics

    2019  Volume 141, Page(s) 111417

    Abstract: Fascinating properties of ZnO nanostructures have created much interest due to their importance in health care and environmental monitoring. Current worldwide production and their wide range of applications signify ZnO to be a representative of multi- ... ...

    Abstract Fascinating properties of ZnO nanostructures have created much interest due to their importance in health care and environmental monitoring. Current worldwide production and their wide range of applications signify ZnO to be a representative of multi-functional oxide material. Recent nanotechnological developments have stimulated the production of various forms of ZnO nanostructures such as nano-layers, nanoparticles, nanowires, etc. Due to their enhanced sensing properties, improved binding ability with biomolecules as well as biological activities have enabled them as suitable candidates for the fabrication of biosensor devices in the biomedical arena. In this review, the synthesis of ZnO nanostructures, mechanism of their interaction with biomolecules and their applications as sensors in health care area are discussed considering the biosensors for molecules with small molecular weight, infectious diseases, and pharmaceutical compounds.
    MeSH term(s) Animals ; Biosensing Techniques/instrumentation ; Biosensing Techniques/methods ; Electrochemical Techniques/instrumentation ; Electrochemical Techniques/methods ; Electrodes ; Equipment Design ; Humans ; Nanostructures/chemistry ; Nanostructures/ultrastructure ; Nanotechnology/instrumentation ; Nanotechnology/methods ; Zinc Oxide/chemistry
    Chemical Substances Zinc Oxide (SOI2LOH54Z)
    Language English
    Publishing date 2019-06-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2019.111417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Electrochemical oxidation of loop diuretic furosemide in aqueous acid medium and its analytical application

    Shikandar D. Bukkitgar / Nagaraj P. Shetti

    Cogent Chemistry, Vol 2, Iss

    2016  Volume 1

    Abstract: An investigation of oxidative–reductive mechanisms of pharmaceutically important molecules gives us information about the metabolic fact of targeted drug. As compared to recent ongoing, time-consuming and costly techniques, there is an urgent needing for ...

    Abstract An investigation of oxidative–reductive mechanisms of pharmaceutically important molecules gives us information about the metabolic fact of targeted drug. As compared to recent ongoing, time-consuming and costly techniques, there is an urgent needing for development of a sensitive technique, which can help easy understanding of these pathways. Therefore, in the present work, an effective, low-cost and time-saving technique to investigate the reaction mechanism of furosemide in aqueous acid medium is attempted. Furosemide undergoes two-proton and two-electron transfer reaction. The product obtained was analysed by UV spectra. It was found that the chemical oxidation and electrochemical oxidation of furosemide follows two different pathways. In addition, an effective technique has been developed to determine furosemide in its trace level. Good recoveries and low detection limit accomplished the magnitude of the proposed method. The proposed method was adopted for furosemide determination in human urine and pharmaceutical samples.
    Keywords furosemide ; cyclic voltammetry ; reaction mechanism ; hetrogeneous rate constant ; Science ; Q ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2016-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Point of care detection of COVID-19: Advancement in biosensing and diagnostic methods.

    Suleman, Shariq / Shukla, Sudheesh K / Malhotra, Nitesh / Bukkitgar, Shikandar D / Shetti, Nagaraj P / Pilloton, Roberto / Narang, Jagriti / Nee Tan, Yen / Aminabhavi, Tejraj M

    Chemical engineering journal (Lausanne, Switzerland : 1996)

    2021  Volume 414, Page(s) 128759

    Abstract: The recent outbreak of COVID-19 has created much inconvenience and fear that the virus can seriously affect humans, causing health hazards and death. This pandemic has created much worry and as per the report by World Health Organization (WHO), more than ...

    Abstract The recent outbreak of COVID-19 has created much inconvenience and fear that the virus can seriously affect humans, causing health hazards and death. This pandemic has created much worry and as per the report by World Health Organization (WHO), more than 43 million individuals in 215 countries and territories were affected. People around the world are still struggling to overcome the problems associated with this pandemic. Of all the available methods, reverse-transcriptase polymerase chain reaction (RT-PCR) has been widely practiced for the pandemic detection even though several diagnostic tools are available having varying accuracy and sensitivity. The method offers many advantages making it a life-saving tool, but the method has the limitation of transporting to the nearest pathology lab, thus limiting its application in resource limited settings. This has a risen a crucial need for point-of-care devices for on-site detection. In this venture, biosensors have been used, since they can be applied immediately at the point-of-care. This review will discuss about the available diagnostic methods and biosensors for COVID-19 detection.
    Language English
    Publishing date 2021-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2012137-4
    ISSN 1873-3212 ; 1385-8947
    ISSN (online) 1873-3212
    ISSN 1385-8947
    DOI 10.1016/j.cej.2021.128759
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  10. Article ; Online: Electrooxidation of antihistamine drug methdilazine and its analysis in human urine and blood samples

    Nagaraj P. Shetti / Deepti S. Nayak / Shikandar D. Bukkitgar

    Cogent Chemistry, Vol 2, Iss

    2016  Volume 1

    Abstract: The electrochemical oxidation of an antihistamine drug, methdilazine, was studied in 9.2 pH with 0.2 M phosphate buffer as supporting electrolyte at 25 ± 0.2°C. Glassy carbon electrode was used to perform the experiment at cyclic voltammetry, linear ... ...

    Abstract The electrochemical oxidation of an antihistamine drug, methdilazine, was studied in 9.2 pH with 0.2 M phosphate buffer as supporting electrolyte at 25 ± 0.2°C. Glassy carbon electrode was used to perform the experiment at cyclic voltammetry, linear sweep voltammetry and differential pulse voltammetric techniques. The dependence of the current on pH, concentration and scan rate were investigated. Differential pulse voltammetric technique was adopted to know the linear relation between peak current and methdilazine concentration. The linear response was obtained in the range of 3.0 μM–1.0 mM with a detection limit of 0.1 μM. The proposed method was also applied for the quantitative determination of methdilazine in pharmaceuticals and biological samples.
    Keywords methdilazine ; electrochemical studies ; oxidation mechanism ; biological sample analysis ; Science ; Q ; Chemistry ; QD1-999
    Language English
    Publishing date 2016-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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