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Article ; Online: Cobalamin Deficiency and Acute-Onset Auditory and Visual Hallucinations in an Elderly Man.

Nichols, Nona A / Naqvi, Neha F / Munjal, Sahil / Kimball, James N

Journal of the Academy of Consultation-Liaison Psychiatry

2020 Volume 62, Issue 1, Page(s) 131–139

MeSH term(s)	Aged ; Hallucinations ; Humans ; Male ; Vitamin B 12 ; Vitamin B 12 Deficiency/complications
Chemical Substances	Vitamin B 12 (P6YC3EG204)
Keywords	covid19
Language	English
Publishing date	2020-08-31
Publishing country	Netherlands
Document type	Case Reports
ISSN	2667-2960
ISSN (online)	2667-2960
DOI	10.1016/j.psym.2020.08.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Antiepileptics in Electroconvulsive Therapy: A Mechanism-Based Review of Recent Literature.

Cinderella, Margaret A / Nichols, Nona A / Munjal, Sahil / Yan, Jason / Kimball, James N / Gligorovic, Predrag

The journal of ECT

2021 Volume 38, Issue 2, Page(s) 133–137

Abstract: Abstract: Although prior conventional wisdom strongly recommended complete discontinuation of medications increasing the seizure threshold before electroconvulsive therapy (ECT), more recent literature suggests that anticonvulsants should be considered ... ...

Abstract	Abstract: Although prior conventional wisdom strongly recommended complete discontinuation of medications increasing the seizure threshold before electroconvulsive therapy (ECT), more recent literature suggests that anticonvulsants should be considered a relative rather than an absolute contraindication to proceeding with therapy. Most literature regarding the use of use antiepileptic drugs in ECT focuses on antiepileptic mood stabilizers with which most psychiatrists are familiar. However, there is considerably less information available about the use of newer antiepileptics in conjunction with ECT, which may be prescribed to a patient with epilepsy or off-label for psychiatric reasons.In this article, we provide a mechanism-based review of recent available literature concerning the use of antiepileptics during ECT and discuss which medications have the most robust evidence supporting their continued use in select patients. Finally, we highlight important considerations for psychiatrists when deciding how to proceed with patients on antiepileptics who require ECT.
MeSH term(s)	Anticonvulsants/therapeutic use ; Antimanic Agents ; Electroconvulsive Therapy/adverse effects ; Humans
Chemical Substances	Anticonvulsants ; Antimanic Agents
Language	English
Publishing date	2021-11-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1426385-3
ISSN	1533-4112 ; 1095-0680
ISSN (online)	1533-4112
ISSN	1095-0680
DOI	10.1097/YCT.0000000000000805
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Article: Cobalamin Deficiency and Acute-Onset Auditory and Visual Hallucinations in an Elderly Man

Nichols, Nona A / Naqvi, Neha F / Munjal, Sahil / Kimball, James N

Psychosomatics

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #33004220
Database	COVID19

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Article: Electroconvulsive therapy--an outdated treatment, or one whose time has come?

Kimball, James N

Southern medical journal

2007 Volume 100, Issue 5, Page(s) 462–463

MeSH term(s)	Electroconvulsive Therapy ; Humans ; Mental Disorders/therapy ; Treatment Outcome
Language	English
Publishing date	2007-05
Publishing country	United States
Document type	Editorial
ZDB-ID	185329-6
ISSN	1541-8243 ; 0038-4348
ISSN (online)	1541-8243
ISSN	0038-4348
DOI	10.1097/SMJ.0b013e318046f8c1
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Article ; Online: Medical Comorbidities and Medication Use Among Homeless Adults Seeking Mental Health Treatment.

Arnold, Elizabeth Mayfield / Strenth, Chance R / Hedrick, Luke P / Paterson, Robert C / Curiel, Julian / Joseph, Amira E / Brown, Thomas W / Kimball, James N

Community mental health journal

2020 Volume 56, Issue 5, Page(s) 885–893

Abstract: ... have mental health problems. This study used secondary data (N = 933) from a mental health clinic ...

Abstract	Little is known about the medical conditions and medication use of individuals who are homeless and have mental health problems. This study used secondary data (N = 933) from a mental health clinic serving homeless adults. Primary outcomes were the number and types of self-reported medical conditions and medications. About half (52.60%) of participants were taking one or more medications (mean = 1.67; SD = 2.30), most commonly antidepressants, antipsychotics, and anticonvulsants. Most frequently reported medical conditions were headaches/migraines, hypertension, and arthritis with a mean of 3.09 (SD = 2.74) conditions. Age and sex were significant predictors of the number of medical conditions. Age and the length of time homeless were significant predictors of the number of medications taken. Results suggest that those who are older and have been homeless longer appear to be increased risk for health problems and may need more medications to manage these conditions.
MeSH term(s)	Adult ; Comorbidity ; Cross-Sectional Studies ; Homeless Persons ; Humans ; Mental Health ; Self Report
Language	English
Publishing date	2020-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	215855-3
ISSN	1573-2789 ; 0010-3853
ISSN (online)	1573-2789
ISSN	0010-3853
DOI	10.1007/s10597-020-00552-4
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Article ; Online: Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression.

Sirpilla, Olivia / Sakemura, R Leo / Hefazi, Mehrdad / Huynh, Truc N / Can, Ismail / Girsch, James H / Tapper, Erin E / Cox, Michelle J / Schick, Kendall J / Manriquez-Roman, Claudia / Yun, Kun / Stewart, Carli M / Ogbodo, Ekene J / Kimball, Brooke L / Mai, Long K / Gutierrez-Ruiz, Omar L / Rodriguez, Makena L / Gluscevic, Martina / Larson, Daniel P /

Abel, Alex M / Wierson, Wesley A / Olivier, Gloria / Siegler, Elizabeth L / Kenderian, Saad S

Nature biomedical engineering

2024

Abstract: Allogeneic mesenchymal stromal cells (MSCs) are a safe treatment option for many disorders of the immune system. However, clinical trials using MSCs have shown inconsistent therapeutic efficacy, mostly owing to MSCs providing insufficient ... ...

Abstract	Allogeneic mesenchymal stromal cells (MSCs) are a safe treatment option for many disorders of the immune system. However, clinical trials using MSCs have shown inconsistent therapeutic efficacy, mostly owing to MSCs providing insufficient immunosuppression in target tissues. Here we show that antigen-specific immunosuppression can be enhanced by genetically modifying MSCs with chimaeric antigen receptors (CARs), as we show for E-cadherin-targeted CAR-MSCs for the treatment of graft-versus-host disease in mice. CAR-MSCs led to superior T-cell suppression and localization to E-cadherin
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Journal Article
ISSN	2157-846X
ISSN (online)	2157-846X
DOI	10.1038/s41551-024-01195-6
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Article ; Online: CD19 occupancy with tafasitamab increases therapeutic index of CART19 cell therapy and diminishes severity of CRS.

Sakemura, R Leo / Manriquez Roman, Claudia / Horvei, Paulina / Siegler, Elizabeth L / Girsch, James H / Sirpilla, Olivia L / Stewart, Carli M / Yun, Kun / Can, Ismail / Ogbodo, Ekene J / Adada, Mohamad M / Bezerra, Evandro D / Kankeu Fonkoua, Lionel Aurelien / Hefazi, Mehrdad / Ruff, Michael W / Kimball, Brooke L / Mai, Long K / Huynh, Truc N / Nevala, Wendy K /

Ilieva, Kristina / Augsberger, Christian / Patra-Kneuer, Maria / Schanzer, Jürgen / Endell, Jan / Heitmüller, Christina / Steidl, Stefan / Parikh, Sameer A / Ding, Wei / Kay, Neil E / Nowakowski, Grzegorz S / Kenderian, Saad S

Blood

2024 Volume 143, Issue 3, Page(s) 258–271

Abstract: Abstract: In the development of various strategies of anti-CD19 immunotherapy for the treatment of B-cell malignancies, it remains unclear whether CD19 monoclonal antibody therapy impairs subsequent CD19-targeted chimeric antigen receptor T-cell (CART19) ...

Abstract	Abstract: In the development of various strategies of anti-CD19 immunotherapy for the treatment of B-cell malignancies, it remains unclear whether CD19 monoclonal antibody therapy impairs subsequent CD19-targeted chimeric antigen receptor T-cell (CART19) therapy. We evaluated the potential interference between the CD19-targeting monoclonal antibody tafasitamab and CART19 treatment in preclinical models. Concomitant treatment with tafasitamab and CART19 showed major CD19 binding competition, which led to CART19 functional impairment. However, when CD19+ cell lines were pretreated with tafasitamab overnight and the unbound antibody was subsequently removed from the culture, CART19 function was not affected. In preclinical in vivo models, tafasitamab pretreatment demonstrated reduced incidence and severity of cytokine release syndrome and exhibited superior antitumor effects and overall survival compared with CART19 alone. This was associated with transient CD19 occupancy with tafasitamab, which in turn resulted in the inhibition of CART19 overactivation, leading to diminished CAR T apoptosis and pyroptosis of tumor cells.
MeSH term(s)	Immunotherapy ; Antibodies, Monoclonal, Humanized ; Therapeutic Index ; Antigens, CD19 ; Immunotherapy, Adoptive/methods
Chemical Substances	tafasitamab (QQA9MLH692) ; Antibodies, Monoclonal, Humanized ; Antigens, CD19
Language	English
Publishing date	2024-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2022018905
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Article ; Online: Proof-of-concept study exploring the effect of spesolimab in patients with moderate-to-severe hidradenitis suppurativa: A randomized, double-blind, placebo-controlled clinical trial.

Alavi, Afsaneh / Prens, Errol / Kimball, Alexa B / Frew, John W / Krueger, James G / Mukhopadhyay, Sutirtha / Gao, Heli / Ranganathan, Usha / Ivanoff, Nathalie B / Hernandez Daly, Ana C / Zouboulis, Christos C

The British journal of dermatology

2024

Abstract: ... reported outcomes (PROs).: Results: In this completed trial, randomized patients (N=52) received ... spesolimab (n=35) or placebo (n=17). The difference (95% confidence interval) versus placebo in least squares ...

Abstract	Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease with a considerable disease burden. Existing treatment options are limited and often suboptimal; a high unmet need exists for effective targeted therapies. Objective: To explore the effects of spesolimab treatment in patients with HS. Methods: This randomized, double-blind, placebo-controlled, proof-of-clinical-concept study was conducted at 25 centers across 12 countries from May 3, 2021, to April 21, 2022. Patients had moderate-to-severe HS for ≥1 year before enrollment. Patients were randomized (2:1) to receive a loading dose of 3600 mg intravenous spesolimab (1200 mg at Weeks 0, 1, and 2) or matching placebo, followed by maintenance with either 1200 mg subcutaneous spesolimab every 2 weeks from Week 4-10 or matching placebo. The primary endpoint was the percentage change from baseline in total abscess and inflammatory nodule (AN) count at Week 12. Secondary endpoints were the absolute change from baseline in International Hidradenitis Suppurativa Severity Score System (IHS4), percentage change from baseline in draining tunnel (dT) count, the proportion of patients achieving a dT count of zero, absolute change from baseline in revised Hidradenitis Suppurativa Area and Severity Index (HASI-R), the proportion of patients achieving Hidradenitis Suppurativa Clinical Response (HiSCR50), the proportion of patients with ≥1 flare (all at Week 12), and patient-reported outcomes (PROs). Results: In this completed trial, randomized patients (N=52) received spesolimab (n=35) or placebo (n=17). The difference (95% confidence interval) versus placebo in least squares mean are reported. At Week 12, the percentage change in total AN count was similar between treatment arms: -4.1% (-31.7, 23.4). There was greater numerical improvement in the spesolimab arm, as measured by IHS4: -13.9 (-25.6, -2.3); percentage change from baseline in dT count: -96.6% (-154.5, -38.8); and the proportion of patients achieving a dT count of zero: 18.3% (-7.9, 37.5). Spesolimab treatment also improved HASI-R and HiSCR50 versus placebo. Spesolimab demonstrated a favorable safety profile, similar to that observed in trials in other diseases. Conclusions: This exploratory proof-of-clinical-concept study supports the development of spesolimab as a new therapeutic option in HS. ClinicalTrials.gov identifier: NCT04762277.
Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1093/bjd/ljae144
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Article ; Online: Electroconvulsive therapy- and succinylcholine-related asystole.

Arias, Lorraine / O'Brien, James J / Kimball, James N

The journal of ECT

2009 Volume 25, Issue 2, Page(s) 144

MeSH term(s)	Acetylcholine/chemistry ; Acetylcholine/pharmacology ; Atropine/therapeutic use ; Depressive Disorder, Major/complications ; Depressive Disorder, Major/physiopathology ; Depressive Disorder, Major/therapy ; Electroconvulsive Therapy/adverse effects ; Female ; Heart Arrest/etiology ; Heart Arrest/physiopathology ; Heart Arrest/prevention & control ; Humans ; Middle Aged ; Muscarinic Antagonists/pharmacology ; Neuromuscular Depolarizing Agents/adverse effects ; Neuromuscular Depolarizing Agents/chemistry ; Succinylcholine/adverse effects ; Succinylcholine/chemistry
Chemical Substances	Muscarinic Antagonists ; Neuromuscular Depolarizing Agents ; Atropine (7C0697DR9I) ; Succinylcholine (J2R869A8YF) ; Acetylcholine (N9YNS0M02X)
Language	English
Publishing date	2009-06
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	1426385-3
ISSN	1533-4112 ; 1095-0680
ISSN (online)	1533-4112
ISSN	1095-0680
DOI	10.1097/YCT.0b013e31818a8493
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Article ; Online: Noninvasive vagus nerve stimulation alters neural response and physiological autonomic tone to noxious thermal challenge.

Lerman, Imanuel / Davis, Bryan / Huang, Mingxiong / Huang, Charles / Sorkin, Linda / Proudfoot, James / Zhong, Edward / Kimball, Donald / Rao, Ramesh / Simon, Bruce / Spadoni, Andrea / Strigo, Irina / Baker, Dewleen G / Simmons, Alan N

PloS one

2019 Volume 14, Issue 2, Page(s) e0201212

Abstract: ... stimuli (applied to left lower extremity), were measured in 30 healthy subjects (n = 15 sham and n = 15 ...

Abstract	The mechanisms by which noninvasive vagal nerve stimulation (nVNS) affect central and peripheral neural circuits that subserve pain and autonomic physiology are not clear, and thus remain an area of intense investigation. Effects of nVNS vs sham stimulation on subject responses to five noxious thermal stimuli (applied to left lower extremity), were measured in 30 healthy subjects (n = 15 sham and n = 15 nVNS), with fMRI and physiological galvanic skin response (GSR). With repeated noxious thermal stimuli a group × time analysis showed a significantly (p < .001) decreased response with nVNS in bilateral primary and secondary somatosensory cortices (SI and SII), left dorsoposterior insular cortex, bilateral paracentral lobule, bilateral medial dorsal thalamus, right anterior cingulate cortex, and right orbitofrontal cortex. A group × time × GSR analysis showed a significantly decreased response in the nVNS group (p < .0005) bilaterally in SI, lower and mid medullary brainstem, and inferior occipital cortex. Finally, nVNS treatment showed decreased activity in pronociceptive brainstem nuclei (e.g. the reticular nucleus and rostral ventromedial medulla) and key autonomic integration nuclei (e.g. the rostroventrolateral medulla, nucleus ambiguous, and dorsal motor nucleus of the vagus nerve). In aggregate, noninvasive vagal nerve stimulation reduced the physiological response to noxious thermal stimuli and impacted neural circuits important for pain processing and autonomic output.
MeSH term(s)	Adolescent ; Adult ; Brain/diagnostic imaging ; Brain/physiopathology ; Brain Mapping ; Female ; Galvanic Skin Response/physiology ; Hot Temperature/adverse effects ; Humans ; Lower Extremity ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neural Pathways/diagnostic imaging ; Neural Pathways/physiopathology ; Pain/diagnostic imaging ; Pain/physiopathology ; Pain Management/methods ; Pain Perception/physiology ; Pilot Projects ; Vagus Nerve Stimulation ; Young Adult
Language	English
Publishing date	2019-02-13
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0201212
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