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  1. Article ; Online: Su1185 IMMUNE CHECKPOINT INHIBITOR-RELATED COLITIS ASSESSMENT AND PROGNOSIS: CAN UCEIS, MAYO AND NANCY INDEX SCORING POINT THE WAY?

    Cheung, Vincent T. / Gupta, Tarun / Olsson-Brown, Anna C. / Subramanian, Sreedhar / Sasson, Sarah C. / Heseltine, Jonathan / Fryer, Eve / Collantes-Bellido, Elena / Sacco, Joseph J. / Pirmohamed, Munir / Simmons, Alison / Klenerman, Paul / Fairfax, Benjamin P. / Payne, Miranda J. / Middleton, Mark R. / Brain, Oliver

    Gastroenterology

    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.1016/s0016-5085(20)32033-3
    Database COVID19

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  2. Article ; Online: Correction to: Adverse Childhood Experiences and Complex Post‑traumatic Stress in Pregnant Teens: A Pilot Study.

    Anastas, Jeane W / Payne, Nancy A / Ghuman, Sharon J

    Maternal and child health journal

    2021  Volume 25, Issue 11, Page(s) 1806

    Language English
    Publishing date 2021-06-11
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1339905-6
    ISSN 1573-6628 ; 1092-7875
    ISSN (online) 1573-6628
    ISSN 1092-7875
    DOI 10.1007/s10995-021-03178-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Adverse Childhood Experiences and Complex Post-traumatic Stress in Pregnant Teens: A Pilot Study.

    Anastas, Jeane W / Payne, Nancy A / Ghuman, Sharon A

    Maternal and child health journal

    2021  Volume 25, Issue 5, Page(s) 741–750

    Abstract: Introduction: Pregnant teens are seen as a group at risk, yet one area that remains understudied is the impact of trauma on their mental health, maternal fetal attachment and pregnancy-related health behavior.: Methods: A pilot study of urban ... ...

    Abstract Introduction: Pregnant teens are seen as a group at risk, yet one area that remains understudied is the impact of trauma on their mental health, maternal fetal attachment and pregnancy-related health behavior.
    Methods: A pilot study of urban pregnant teens receiving home visiting services examined trauma exposure, complex traumatic stress, maternal fetal attachment, and health behaviors of pregnancy. The sample (n = 36) was recruited over a period of 20 months from Nurse-Family Partnership of New York City (NFP-NYC) service sites. The teens interviewed completed scales measuring adverse childhood experiences (ACEs), symptoms of complex posttraumatic stress (TSCC), prenatal attachment (MAAS), and pregnancy health behaviors (HPQ-II).
    Findings: Over one third of participants reported 4 or more ACEs (36%), and scores on the Trauma Symptom Checklist subscales ranged from a low of 11% for anger to 25% for depression, anxiety and post-traumatic stress. Maternal-fetal attachment was strong and pregnancy health behaviors were positive. The number of ACEs was related to traumatic stress symptoms but not to maternal fetal attachment or health behaviors in pregnancy.
    Conclusions: Pregnant teens with trauma histories could benefit from access to trauma-informed mental health services integrated into the obstetrical or home-visiting services they receive.
    MeSH term(s) Adolescent ; Adverse Childhood Experiences ; Female ; Humans ; Mental Health ; Pilot Projects ; Pregnancy ; Pregnant Women ; Stress Disorders, Post-Traumatic/epidemiology
    Language English
    Publishing date 2021-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1339905-6
    ISSN 1573-6628 ; 1092-7875
    ISSN (online) 1573-6628
    ISSN 1092-7875
    DOI 10.1007/s10995-020-03041-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Revised European Association for Palliative Care (EAPC) recommended framework on palliative sedation: An international Delphi study.

    Surges, Séverine M / Brunsch, Holger / Jaspers, Birgit / Apostolidis, Kathi / Cardone, Antonella / Centeno, Carlos / Cherny, Nathan / Csikós, Àgnes / Fainsinger, Robin / Garralda, Eduardo / Ling, Julie / Menten, Johan / Mercadante, Sebastiano / Mosoiu, Daniela / Payne, Sheila / Preston, Nancy / Van den Block, Lieve / Hasselaar, Jeroen / Radbruch, Lukas

    Palliative medicine

    2024  Volume 38, Issue 2, Page(s) 213–228

    Abstract: Background: The European Association for Palliative Care (EAPC) acknowledges palliative sedation as an important, broadly accepted intervention for patients with life-limiting disease experiencing refractory symptoms. The EAPC therefore developed 2009 a ...

    Abstract Background: The European Association for Palliative Care (EAPC) acknowledges palliative sedation as an important, broadly accepted intervention for patients with life-limiting disease experiencing refractory symptoms. The EAPC therefore developed 2009 a framework on palliative sedation. A revision was needed due to new evidence from literature, ongoing debate and criticism of methodology, terminology and applicability.
    Aim: To provide evidence- and consensus-based guidance on palliative sedation for healthcare professionals involved in end-of-life care, for medical associations and health policy decision-makers.
    Design: Revision between June 2020 and September 2022 of the 2009 framework using a literature update and a Delphi procedure.
    Setting: European.
    Participants: International experts on palliative sedation (identified through literature search and nomination by national palliative care associations) and a European patient organisation.
    Results: A framework with 42 statements for which high or very high level of consensus was reached. Terminology is defined more precisely with the terms
    Conclusions: This is the first framework on palliative sedation using a strict consensus methodology. It should serve as comprehensive and soundly developed information for healthcare professionals.
    MeSH term(s) Humans ; Palliative Care/methods ; Delphi Technique ; Terminal Care/methods ; Consensus ; Anesthesia ; Deep Sedation/methods
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 639247-7
    ISSN 1477-030X ; 0269-2163
    ISSN (online) 1477-030X
    ISSN 0269-2163
    DOI 10.1177/02692163231220225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Understanding the Outcomes of Supplementary Support Services in Palliative Care for Older People. A Scoping Review and Mapping Exercise.

    Dodd, Steven R / Payne, Sheila A / Preston, Nancy J / Walshe, Catherine E

    Journal of pain and symptom management

    2020  Volume 60, Issue 2, Page(s) 449–459.e21

    Abstract: Context: Supplementary support services in palliative care for older people are increasingly common, but with neither recommended tools to measure outcomes nor reviews synthesizing anticipated outcomes. Common clinically focused tools may be less ... ...

    Abstract Context: Supplementary support services in palliative care for older people are increasingly common, but with neither recommended tools to measure outcomes nor reviews synthesizing anticipated outcomes. Common clinically focused tools may be less appropriate.
    Objectives: To identify stakeholder perceptions of key outcomes from supplementary palliative care support services, then map these onto outcome measurement tools to assess relevance and item redundancy.
    Methods: A scoping review using the design by Arksey and O'Malley. EMBASE, CINAHL, MEDLINE, and PSYCHinfo searched using terms relating to palliative care, qualitative research, and supplementary support interventions. Articles were imported into Endnote™, and Covidence™ was used by two reviewers to assess against inclusion criteria. Included articles were imported into NVivo™ and thematically coded to identify key concepts underpinning outcomes. Each item within contender outcome measurement tools was assessed against each concept.
    Results: Sixty included articles focused on advance care planning, guided conversations, and volunteer befriending services. Four concepts were identified: enriching relationships; greater autonomy and perceived control; knowing more; and improved mental health. Mapping concepts to contender tool items revealed issues of relevance and redundancy. Some tools had no redundant items but mapped only to two of four outcome themes; others mapped to all concepts, but with many redundant questions. Tools such as ICECAP-Supportive Care Measure and McGill Quality of Life had high relevance and low redundancy.
    Conclusion: Pertinent outcome concepts for these services and population are not well represented in commonly used outcome measurement tools, and this may have implications in appropriately measuring outcomes. This review and mapping method may have utility in fields where selecting appropriate outcome tools can be challenging.
    MeSH term(s) Advance Care Planning ; Aged ; Hospice and Palliative Care Nursing ; Humans ; Mental Health ; Palliative Care ; Quality of Life
    Keywords covid19
    Language English
    Publishing date 2020-03-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639142-4
    ISSN 1873-6513 ; 0885-3924
    ISSN (online) 1873-6513
    ISSN 0885-3924
    DOI 10.1016/j.jpainsymman.2020.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Breaching the stalemate on assisted dying: it's time to move beyond a medicalised approach.

    Preston, Nancy / Payne, Sheila / Ost, Suzanne

    BMJ (Clinical research ed.)

    2023  Volume 382, Page(s) 1968

    MeSH term(s) Humans ; Suicide, Assisted
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.p1968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The heterogeneous mechanical properties of adolescent growth plate cartilage: A study in rabbit.

    Eckstein, Kevin N / Thomas, Stacey M / Scott, Adrienne K / Neu, Corey P / Hadley-Miller, Nancy A / Payne, Karin A / Ferguson, Virginia L

    Journal of the mechanical behavior of biomedical materials

    2022  Volume 128, Page(s) 105102

    Abstract: The growth plate is a cartilaginous tissue that functions to lengthen bones in children. When fractured, however, the growth plate can lose this critical function. Our understanding of growth plate fracture and mechanobiology is currently hindered by ... ...

    Abstract The growth plate is a cartilaginous tissue that functions to lengthen bones in children. When fractured, however, the growth plate can lose this critical function. Our understanding of growth plate fracture and mechanobiology is currently hindered by sparse information on the growth plate's microscale spatial gradients in mechanical properties. In this study, we performed microindentation across the proximal tibia growth plate of 9-week-old New Zealand White rabbits (n = 15) to characterize spatial variations in mechanical properties using linear elastic and nonlinear poroelastic material models. Mean indentation results for Hertz reduced modulus ranged from 380 to 690 kPa, with a peak in the upper hypertrophic zone and significant differences (p < 0.05) between neighboring zones. Using a subset of these animals (n = 7), we characterized zonal structure and extracellular matrix content of the growth plate through confocal fluorescent microscopy and Raman spectroscopy mapping. Comparison between mechanical properties and matrix content across the growth plate showed that proteoglycan content correlated with compressive modulus. This study is the first to measure poroelastic mechanical properties from microindentation across growth plate cartilage and to discern differing mechanical properties between the upper and lower hypertrophic zones. This latter finding may explain the location of typical growth plate fractures. The spatial variation in our reported mechanical properties emphasize the heterogeneous structure of the growth plate which is important to inform future regenerative implant design and mechanobiological models.
    MeSH term(s) Animals ; Cartilage ; Extracellular Matrix ; Growth Plate ; Rabbits ; Tibia
    Language English
    Publishing date 2022-02-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2378381-3
    ISSN 1878-0180 ; 1751-6161
    ISSN (online) 1878-0180
    ISSN 1751-6161
    DOI 10.1016/j.jmbbm.2022.105102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Analysis of Physeal Fractures from the United States National Trauma Data Bank.

    Fuchs, Joseph R / Gibly, Romie F / Erickson, Christopher B / Thomas, Stacey M / Hadley Miller, Nancy / Payne, Karin A

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 6

    Abstract: Background: Pediatric long-bone physeal fractures can lead to growth deformities. Previous studies have reported that physeal fractures make up 18-30% of total fractures. This study aimed to characterize physeal fractures with respect to sex, age, ... ...

    Abstract Background: Pediatric long-bone physeal fractures can lead to growth deformities. Previous studies have reported that physeal fractures make up 18-30% of total fractures. This study aimed to characterize physeal fractures with respect to sex, age, anatomic location, and Salter-Harris (SH) classification from a current multicenter national database.
    Methods: A retrospective cohort study was performed using the 2016 United States National Trauma Data Bank (NTDB). Patients ≤ 18 years of age with a fracture of the humerus, radius, ulna, femur, tibia, or fibula were included.
    Results: The NTDB captured 132,018 patients and 58,015 total fractures. Physeal fractures made up 5.7% (3291) of all long-bone fractures, with males accounting for 71.0% (2338). Lower extremity physeal injuries comprised 58.6% (1929) of all physeal fractures. The most common site of physeal injury was the tibia comprising 31.8% (1047), 73.9% (774) of which were distal tibia fractures. Physeal fractures were greatest at 11 years of age for females and 14 years of age for males. Most fractures were SH Type II fractures.
    Discussion and conclusions: Our analysis indicates that 5.7% of pediatric long-bone fractures involved the physis, with the distal tibia being the most common. These findings suggest a lower incidence of physeal fractures than previous studies and warrant further investigation.
    Language English
    Publishing date 2022-06-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9060914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The end of Roe v. Wade: implications for Women's mental health and care.

    Londoño Tobón, Amalia / McNicholas, Eileen / Clare, Camille A / Ireland, Luu D / Payne, Jennifer L / Moore Simas, Tiffany A / Scott, Rachel K / Becker, Madeleine / Byatt, Nancy

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1087045

    Abstract: The Supreme Court decision in Dobbs v. Jackson in June 2022 reversed precedent which had previously protected abortion prior to fetal viability as a universal right within the United States. This decision almost immediately led to abortion restrictions ... ...

    Abstract The Supreme Court decision in Dobbs v. Jackson in June 2022 reversed precedent which had previously protected abortion prior to fetal viability as a universal right within the United States. This decision almost immediately led to abortion restrictions across 25 states. The resulting lack of access to abortion care for millions of pregnant people will have profound physical and mental health consequences, the full effects of which will not be realized for years to come. Approximately 1 in 5 women access abortions in the U.S. each year. These women are diverse and represent all American groups. The Supreme court decision, however, will affect populations that have and continue to be marginalized the most. Forcing pregnant individuals to carry unwanted pregnancies worsens health outcomes and mortality risk for both the perinatal individual and the offspring. The US has one of the highest maternal mortality rates and this rate is projected to increase with abortion bans. Abortion policies also interfere with appropriate medical care of pregnant people leading to less safe pregnancies for all. Beyond the physical morbidity, the psychological sequelae of carrying a forced pregnancy to term will lead to an even greater burden of maternal mental illness, exacerbating the already existing maternal mental health crisis. This perspective piece reviews the current evidence of abortion denial on women's mental health and care. Based on the current evidence, we discuss the clinical, educational, societal, research, and policy implications of the Dobbs v. Jackson Supreme Court decision.
    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1087045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Epidemiology of Physeal Fractures and Clinically Significant Growth Disturbances Affecting the Distal Tibia, Proximal Tibia, and Distal Femur: A Retrospective Cohort Study.

    Yamamura, Minami K / Carry, Patrick M / Gibly, Romie F / Holmes, Kaley / Ogilvie, Brandon / Phillips, Alicia / Georgopoulos, Gaia / Miller, Nancy Hadley / Payne, Karin A

    The Journal of the American Academy of Orthopaedic Surgeons

    2023  Volume 31, Issue 11, Page(s) e507–e515

    Abstract: Introduction: Childhood fractures involving the physis potentially result in premature physeal closure that can lead to growth disturbances. Growth disturbances are challenging to treat with associated complications. Current literature focusing on ... ...

    Abstract Introduction: Childhood fractures involving the physis potentially result in premature physeal closure that can lead to growth disturbances. Growth disturbances are challenging to treat with associated complications. Current literature focusing on physeal injuries to lower extremity long bones and risk factors for growth disturbance development is limited. The purpose of this study was to provide a review of growth disturbances among proximal tibial, distal tibial, and distal femoral physeal fractures.
    Methods: Data were retrospectively collected from patients undergoing fracture treatment at a level I pediatric trauma center between 2008 and 2018. The study was limited to patients 0.5 to 18.9 years with a tibial or distal femoral physeal fracture, injury radiograph, and appropriate follow-up for determination of fracture healing. The cumulative incidence of clinically significant growth disturbance (CSGD) (a growth disturbance requiring subsequent physeal bar resection, osteotomy, and/or epiphysiodesis) was estimated, and descriptive statistics were used to summarize demographics and clinical characteristics among patients with and without CSGD.
    Results: A total of 1,585 patients met the inclusion criteria. The incidence of CSGD was 5.0% (95% confidence interval, 3.8% to 6.6%). All cases of growth disturbance occurred within 2 years of initial injury. The risk of CSGD peaked at 10.2 years for males and 9.1 years for females. Complex fractures that required surgical treatment, distal femoral and proximal tibial fractures, age, and initial treatment at an outside hospital were significantly associated with an increased risk of a CSGD.
    Discussion: All CSGDs occurred within 2 years of injury, indicating that these injuries should be followed for a period of at least 2 years. Patients with distal femoral or proximal tibial physeal fractures that undergo surgical treatment are at highest risk for developing a CSGD.
    Level of evidence: Level III Retrospective Cohort Study.
    MeSH term(s) Male ; Female ; Humans ; Child ; Tibia/surgery ; Retrospective Studies ; Femur/surgery ; Growth Plate/surgery ; Tibial Fractures/epidemiology ; Tibial Fractures/surgery ; Lower Extremity
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1200524-1
    ISSN 1940-5480 ; 1067-151X
    ISSN (online) 1940-5480
    ISSN 1067-151X
    DOI 10.5435/JAAOS-D-22-00303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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