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Article ; Online: Stereodivergent Total Syntheses of (+)-Mycaperoxides C, D, G Methyl Ester and (-)-Mycaperoxide B.

Kerim, Mansour D / Evanno, Laurent / Ferrié, Laurent

Chemistry (Weinheim an der Bergstrasse, Germany)

2022 Volume 29, Issue 6, Page(s) e202203004

Abstract: ... the total syntheses of (+)-mycaperoxides D, C, G methyl ester, and (-)-mycaperoxide B in 11 to 15 steps ... toward (+)-mycaperoxide D methyl ester (2), the isolation of the eight possible diastereomers under their ethyl thioester ...

Abstract	Mycaperoxides are natural endoperoxides isolated from different Mycale genus sponges, showing significant antiviral or antibacterial activities. We report herein the first total syntheses of representative congeners of this family from sclareol using a stereodivergent approach. Thus, an innovative oxidative ring expansion of cyclobutanol was used to bring the 1,2-dioxane subunit, and a Mukaiyama aldol reaction on peroxycarbenium species was utilized to install the propionic acid subunit. During the study toward (+)-mycaperoxide D methyl ester (2), the isolation of the eight possible diastereomers under their ethyl thioester form allowed to build a pertinent database for further NMR assignment studies. Thus, we completed the total syntheses of (+)-mycaperoxides D, C, G methyl ester, and (-)-mycaperoxide B in 11 to 15 steps, confirming their original assignment.
MeSH term(s)	Esters ; Magnetic Resonance Spectroscopy ; Stereoisomerism
Chemical Substances	Esters
Language	English
Publishing date	2022-12-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202203004
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Article ; Online: Visitor engagement with zoo staff and interpretive demonstrations increases visitor stay time in two free-flight aviaries.

Lyon, Cassandra E M / Alba, Andrew C / Burgess, Amy / Weibel, Chelsea J / Miller, Dave / Alligood, Christina / Ferrie, Gina M

Zoo biology

2023 Volume 43, Issue 2, Page(s) 136–148

Abstract: Understanding how visitors spend time in zoo exhibits is important as zoological facilities work to enhance visitor experience and conservation education outcomes. We explored a variety of factors we hypothesized would influence visitor stay times in two ...

Abstract	Understanding how visitors spend time in zoo exhibits is important as zoological facilities work to enhance visitor experience and conservation education outcomes. We explored a variety of factors we hypothesized would influence visitor stay times in two aviaries at Disney's Animal Kingdom®. Within these aviaries, visitors could utilize educational materials, listen to staff-led demonstrations, or talks, view animal training sessions, or speak directly with animal care or education staff. We observed visitors and recorded the opportunities they utilized in the exhibit. Visitors to either aviary who conversed with exhibit-specific staff stayed between 67% and 89% longer than visitors who did not. In addition, visitors who used a bird guide while in either aviary stayed between 59% and 82% longer than those who did not. Those who listened to an animal care talk or engaged with a staff-led demonstration stayed between 50% and 68% longer than those who did not have the option to participate in such activities. This study provides insight into how exhibit offerings can influence visitor behavior. Implementing strategies used in this study to increase visitors' time in an exhibit may enhance visitor experience and improve learning outcomes.
MeSH term(s)	Humans ; Animals ; Animals, Zoo ; Animal Welfare ; Animal Husbandry
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1499116-0
ISSN	1098-2361 ; 0733-3188
ISSN (online)	1098-2361
ISSN	0733-3188
DOI	10.1002/zoo.21812
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Article ; Online: Subspecific identity and a comparison of genetic diversity between wild and ex situ wildebeest.

Caspers, Lauren M / Ferrie, Gina M / Wolfe, Kristen / Hoffman, Eric A

Zoo biology

2020 Volume 39, Issue 2, Page(s) 129–140

Abstract: ... geographically separated from the brindled wildebeest (C. t. taurinus). However, after an import of wildebeest ... at multiple institutions. We sequenced the mitochondrial control region (d-loop) from a portion of the managed ... to confidently identify C. t. albojubatus as the subspecies identity of the sampled portion of our population ...

Abstract	The original North American ex situ wildebeest population was believed to originate from the white-bearded wildebeest (Connochaetes taurinus albojubatus), which is both morphologically distinct and geographically separated from the brindled wildebeest (C. t. taurinus). However, after an import of wildebeest into North America in 2001, managers have suspected that white-bearded and brindled wildebeest were mixed in herds at multiple institutions. We sequenced the mitochondrial control region (d-loop) from a portion of the managed North American population and compared our sequences with previously published sequences from wild individuals to determine the subspecific identity and genetic diversity of our ex situ population. We were able to confidently identify C. t. albojubatus as the subspecies identity of the sampled portion of our population. Within our population, haplotype and nucleotide diversity were low (0.169 and 0.001, respectively) with a single common haplotype (H1) containing 41 of the 45 individuals sequenced, while two rare haplotypes (H2 and H3) were derived from three individuals and a single individual, respectively. Nucleotide and haplotype diversity were greater overall in the wild populations compared with our managed population. However, C. t. albojubatus was found to exhibit lower nucleotide diversity in both wild and ex situ populations when compared to other wild subspecies. Though the overall goal of the North American wildebeest population is for public education and not reintroduction, maintaining genetic diversity is vital for the long-term viability of this managed population, which may benefit from periodic supplementation of wild animals.
MeSH term(s)	Animals ; Animals, Zoo ; Antelopes/classification ; Antelopes/genetics ; DNA, Mitochondrial ; Female ; Genetic Variation ; Haplotypes ; Male ; North America ; Sequence Analysis, DNA
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2020-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1499116-0
ISSN	1098-2361 ; 0733-3188
ISSN (online)	1098-2361
ISSN	0733-3188
DOI	10.1002/zoo.21530
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Book ; Online: Quantum Geometric Machine Learning for Quantum Circuits and Control

Perrier, Elija / Ferrie, Christopher / Tao, Dacheng

2020

Abstract: The application of machine learning techniques to solve problems in quantum control together with established geometric methods for solving optimisation problems leads naturally to an exploration of how machine learning approaches can be used to enhance ... ...

Abstract	The application of machine learning techniques to solve problems in quantum control together with established geometric methods for solving optimisation problems leads naturally to an exploration of how machine learning approaches can be used to enhance geometric approaches to solving problems in quantum information processing. In this work, we review and extend the application of deep learning to quantum geometric control problems. Specifically, we demonstrate enhancements in time-optimal control in the context of quantum circuit synthesis problems by applying novel deep learning algorithms in order to approximate geodesics (and thus minimal circuits) along Lie group manifolds relevant to low-dimensional multi-qubit systems, such as SU(2), SU(4) and SU(8). We demonstrate the superior performance of greybox models, which combine traditional blackbox algorithms with prior domain knowledge of quantum mechanics, as means of learning underlying quantum circuit distributions of interest. Our results demonstrate how geometric control techniques can be used to both (a) verify the extent to which geometrically synthesised quantum circuits lie along geodesic, and thus time-optimal, routes and (b) synthesise those circuits. Our results are of interest to researchers in quantum control and quantum information theory seeking to combine machine learning and geometric techniques for time-optimal control problems. Comment: 28 pages, 14 figures. Code and select datasets available at https://github.com/eperrier/quant-geom-machine-learning
Keywords	Quantum Physics ; Computer Science - Machine Learning ; Mathematics - Differential Geometry
Subject code	006
Publishing date	2020-06-19
Publishing country	us
Document type	Book ; Online
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Article ; Online: Preventing misdiagnosis of epilepsy.

Ferrie, C D

Archives of disease in childhood

2006 Volume 91, Issue 3, Page(s) 206–209

MeSH term(s)	Child ; Clinical Competence ; Diagnosis, Differential ; Diagnostic Errors/prevention & control ; Electroencephalography ; Epilepsy/diagnosis ; Humans
Language	English
Publishing date	2006-03
Publishing country	England
Document type	Comment ; Journal Article ; Review
ZDB-ID	524-1
ISSN	1468-2044 ; 0003-9888 ; 1359-2998
ISSN (online)	1468-2044
ISSN	0003-9888 ; 1359-2998
DOI	10.1136/adc.2005.088906
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Article ; Online: Repurposing the Ordering of Routine Laboratory Tests in Hospitalised Medical Patients (RePORT): results of a cluster randomised stepped-wedge quality improvement study.

Ambasta, Anshula / Omodon, Onyebuchi / Herring, Alyssa / Ferrie, Leah / Pokharel, Surakshya / Mehta, Ashi / Liu, Liberty / Hews-Girard, Julia / Tam, Cheuk / Taylor, Simon / Lonergan, Kevin / Faris, Peter / Duncan, Diane / Woodhouse, Douglas

BMJ quality & safety

2023 Volume 32, Issue 9, Page(s) 517–525

Abstract: Background: Low-value use of laboratory tests is a global challenge. Our objective was to evaluate an intervention bundle to reduce repetitive use of routine laboratory testing in hospitalised patients.: Methods: We used a stepped-wedge design to ... ...

Abstract	Background: Low-value use of laboratory tests is a global challenge. Our objective was to evaluate an intervention bundle to reduce repetitive use of routine laboratory testing in hospitalised patients. Methods: We used a stepped-wedge design to implement an intervention bundle across eight medical units. Our intervention included educational tools and social comparison reports followed by peer-facilitated report discussion sessions. The study spanned October 2020-June 2021, divided into control, feasibility testing, intervention and a follow-up period. The primary outcomes were the number and costs of routine laboratory tests ordered per patient-day. We used generalised linear mixed models, and analyses were by intention to treat. Results: We included a total of 125 854 patient-days. Patient groups were similar in age, sex, Charlson Comorbidity Index and length of stay during the control, intervention and follow-up periods. From the control to the follow-up period, there was a 14% (incidence rate ratio (IRR)=0.86, 95% CI 0.79 to 0.92) overall reduction in ordering of routine tests with the intervention, along with a 14% (β coefficient=-0.14, 95% CI -0.07 to -0.21) reduction in costs of routine testing. This amounted to a total cost savings of $C1.15 per patient-day. There was also a 15% (IRR=0.85, 95% CI 0.79, 0.92) reduction in ordering of all common tests with the intervention and a 20% (IRR=1.20, 95% CI 1.10 to 1.30) increase in routine test-free patient-days. No worsening was noted in patient safety endpoints with the intervention. Conclusions: A multifaceted intervention bundle using education and facilitated multilevel social comparison was associated with a safe and effective reduction in use of routine daily laboratory testing in hospitals. Further research is needed to understand how system-level interventions may increase this effect and which intervention elements are necessary to sustain results.
MeSH term(s)	Humans ; Quality Improvement ; Diagnostic Tests, Routine ; Hospitalization
Language	English
Publishing date	2023-05-10
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2592909-4
ISSN	2044-5423 ; 2044-5415
ISSN (online)	2044-5423
ISSN	2044-5415
DOI	10.1136/bmjqs-2022-015611
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Article: Systematic Characterization of Multi-Rust Resistance Genes from a 'Parula × Thatcher' Population with a High-Density Genetic Map.

Zhang, Wentao / Boyle, Kerry / Gao, Peng / Polley, Brittany / Brost, Jennifer M / Francis, Tammy / Sidebottom, Christine / McCallum, Brent D / Kutcher, Hadley R / Randhawa, Harpinder / Fetch, Tom G / Ferrie, Alison M R / Fobert, Pierre R

Phytopathology

2023 Volume 113, Issue 5, Page(s) 847–857

Abstract: Pyramiding multiple resistant genes has been proposed as the most effective way to control wheat rust diseases globally. Identifying the most effective pyramids is challenged by the large pool of rust resistance genes and limited information about their ... ...

Abstract	Pyramiding multiple resistant genes has been proposed as the most effective way to control wheat rust diseases globally. Identifying the most effective pyramids is challenged by the large pool of rust resistance genes and limited information about their mechanisms of resistance and interactions. Here, using a high-density genetic map, a double haploid population, and multi-rust field testing, we aimed to systematically characterize the most effective gene pyramids for rust resistance from the durable multi-rust resistant CIMMYT cultivar Parula. We revealed that the Parula resistance gene pyramid contains
MeSH term(s)	Chromosome Mapping ; Plant Diseases/genetics ; Canada ; Quantitative Trait Loci/genetics ; Basidiomycota/genetics ; Disease Resistance/genetics
Language	English
Publishing date	2023-06-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	208889-7
ISSN	1943-7684 ; 0031-949X
ISSN (online)	1943-7684
ISSN	0031-949X
DOI	10.1094/PHYTO-06-22-0238-FI
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Article ; Online: An Arginine-Rich Motif in the ORF2 capsid protein regulates the hepatitis E virus lifecycle and interactions with the host cell.

PLoS pathogens

2022 Volume 18, Issue 8, Page(s) e1010798

Abstract: Hepatitis E virus (HEV) infection is the most common cause of acute viral hepatitis worldwide. Hepatitis E is usually asymptomatic and self-limiting but it can become chronic in immunocompromised patients and is associated with increased fulminant ... ...

Abstract	Hepatitis E virus (HEV) infection is the most common cause of acute viral hepatitis worldwide. Hepatitis E is usually asymptomatic and self-limiting but it can become chronic in immunocompromised patients and is associated with increased fulminant hepatic failure and mortality rates in pregnant women. HEV genome encodes three proteins including the ORF2 protein that is the viral capsid protein. Interestingly, HEV produces 3 isoforms of the ORF2 capsid protein which are partitioned in different subcellular compartments and perform distinct functions in the HEV lifecycle. Notably, the infectious ORF2 (ORF2i) protein is the structural component of virions, whereas the genome-free secreted and glycosylated ORF2 proteins likely act as a humoral immune decoy. Here, by using a series of ORF2 capsid protein mutants expressed in the infectious genotype 3 p6 HEV strain as well as chimeras between ORF2 and the CD4 glycoprotein, we demonstrated how an Arginine-Rich Motif (ARM) located in the ORF2 N-terminal region controls the fate and functions of ORF2 isoforms. We showed that the ARM controls ORF2 nuclear translocation likely to promote regulation of host antiviral responses. This motif also regulates the dual topology and functionality of ORF2 signal peptide, leading to the production of either cytosolic infectious ORF2i or reticular non-infectious glycosylated ORF2 forms. It serves as maturation site of glycosylated ORF2 by furin, and promotes ORF2-host cell membrane interactions. The identification of ORF2 ARM as a unique central regulator of the HEV lifecycle uncovers how viruses settle strategies to condense their genetic information and hijack cellular processes.
MeSH term(s)	Amino Acid Motifs ; Capsid Proteins/chemistry ; Capsid Proteins/metabolism ; Female ; Glycosylation ; Hepatitis E/genetics ; Hepatitis E/metabolism ; Hepatitis E virus/growth & development ; Humans ; Pregnancy
Chemical Substances	Capsid Proteins
Language	English
Publishing date	2022-08-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1010798
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Article ; Online: Neuroprotective Effects of a Novel Demeclocycline Derivative Lacking Antibiotic Activity: From a Hit to a Promising Lead Compound.

Tomas-Grau, Rodrigo / González-Lizárraga, Florencia / Ploper, Diego / Avila, César L / Socías, Sergio B / Besnault, Pierre / Tourville, Aurore / Mella, Rosa M / Villacé, Patricia / Salado, Clarisa / Rose, Clémence / Seon-Méniel, Blandine / Brunel, Jean-Michel / Ferrié, Laurent / Raisman-Vozari, Rita / Michel, Patrick P / Figadère, Bruno / Chehín, Rosana

Cells

2022 Volume 11, Issue 17

Abstract: The antibiotic tetracycline demeclocycline (DMC) was recently reported to rescue α-synuclein (α-Syn) fibril-induced pathology. However, the antimicrobial activity of DMC precludes its potential use in long-term neuroprotective treatments. Here, we ... ...

Abstract	The antibiotic tetracycline demeclocycline (DMC) was recently reported to rescue α-synuclein (α-Syn) fibril-induced pathology. However, the antimicrobial activity of DMC precludes its potential use in long-term neuroprotective treatments. Here, we synthesized a doubly reduced DMC (DDMC) derivative with residual antibiotic activity and improved neuroprotective effects. The molecule was obtained by removal the dimethylamino substituent at position 4 and the reduction of the hydroxyl group at position 12a on ring A of DMC. The modifications strongly diminished its antibiotic activity against Gram-positive and Gram-negative bacteria. Moreover, this compound preserved the low toxicity of DMC in dopaminergic cell lines while improving its ability to interfere with α-Syn amyloid-like aggregation, showing the highest effectiveness of all tetracyclines tested. Likewise, DDMC demonstrated the ability to reduce seeding induced by the exogenous addition of α-Syn preformed fibrils (α-Syn
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Demeclocycline ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Humans ; Lead ; Neuroblastoma ; Neuroprotective Agents/pharmacology ; Synucleinopathies
Chemical Substances	Anti-Bacterial Agents ; Neuroprotective Agents ; Lead (2P299V784P) ; Demeclocycline (5R5W9ICI6O)
Language	English
Publishing date	2022-09-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11172759
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Article ; Online: Precision tomography of a three-qubit donor quantum processor in silicon.

Nature

2022 Volume 601, Issue 7893, Page(s) 348–353

Abstract: Nuclear spins were among the first physical platforms to be considered for quantum information ... ...

Abstract	Nuclear spins were among the first physical platforms to be considered for quantum information processing
Language	English
Publishing date	2022-01-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-021-04292-7
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