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  1. Article ; Online: Comment l’alpinisme s’est trouvé inscrit à l’UNESCO

    Bernard Debarbieux

    Revue de Géographie Alpine (2019)

    2019  

    Keywords Geography. Anthropology. Recreation ; G ; Physical geography ; GB3-5030
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher Institut de Géographie Alpine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: La phagothérapie - Une arme crédible face à l’antibiorésistance.

    Dufour, Nicolas / Debarbieux, Laurent

    Medecine sciences : M/S

    2017  Volume 33, Issue 4, Page(s) 410–416

    Abstract: The continuous increase in antibiotic resistance among bacteria in infectious diseases associated with the lack of new antibiotics able to circumvent them are urging physicians, researchers and politicians to look for others options for treatments. Among ...

    Title translation Phage therapy: a realistic weapon against multidrug resistant bacteria.
    Abstract The continuous increase in antibiotic resistance among bacteria in infectious diseases associated with the lack of new antibiotics able to circumvent them are urging physicians, researchers and politicians to look for others options for treatments. Among those, phage therapy (use of natural viruses that infect bacteria, called bacteriophages) is one of the most promising approaches. In this review, we first focus on the problematic raised by multidrug resistant bacteria before addressing the main biological characteristics of bacteriophages, as well as the credibility and the relevance of phage therapy. We then introduce human applications, their potentials and limits.
    Language French
    Publishing date 2017-04
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/20173304011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Les spatialités dans l’œuvre d’Hannah Arendt

    Bernard Debarbieux

    Cybergeo (2014)

    2014  

    Abstract: This paper focuses on the spatial concepts that Hannah Arendt has referred to throughout her work. It also underlines how spatial her analysis of the main political and anthropological questions she has addressed in her most famous books is. It concludes ...

    Abstract This paper focuses on the spatial concepts that Hannah Arendt has referred to throughout her work. It also underlines how spatial her analysis of the main political and anthropological questions she has addressed in her most famous books is. It concludes that the diversity of the spatial proposals in Arendt’s work is organized with three spatialities or conceptions of space: The spatiality of places, the spatiality of positions, and the spatiality of action. These spatialities do not refer to three independant modes of existence of space; they are articulated in her analysis of human condition and of “common worlds” and subsumed to two others concepts, even much more central, in her work: identity and plurality.
    Keywords Arendt ; space ; spatiality ; politics ; identity ; Geography (General) ; G1-922
    Language German
    Publishing date 2014-04-01T00:00:00Z
    Publisher Unité Mixte de Recherche 8504 Géographie-cités
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: High-Throughput Bacteriophage Testing with Potency Determination: Validation of an Automated Pipetting and Phage Drop-Off Method.

    Dufour, Nicolas / Delattre, Raphaëlle / Debarbieux, Laurent

    Biomedicines

    2024  Volume 12, Issue 2

    Abstract: The development of bacteriophages (phages) as active pharmaceutical ingredients for the treatment of patients is on its way and regulatory agencies are calling for reliable methods to assess phage potency. As the number of phage banks is increasing, so ... ...

    Abstract The development of bacteriophages (phages) as active pharmaceutical ingredients for the treatment of patients is on its way and regulatory agencies are calling for reliable methods to assess phage potency. As the number of phage banks is increasing, so is the number of phages that need to be tested to identify therapeutic candidates. Currently, assessment of phage potency on a semi-solid medium to observe plaque-forming units is unavoidable and proves to be labor intensive when considering dozens of phage candidates. Here, we present a method based on automated pipetting and phage drop-off performed by a liquid-handling robot, allowing high-throughput testing and phage potency determination (based on phage titer and efficiency of plaquing). Ten phages were tested, individually and assembled into one cocktail, against 126
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12020466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Figures et Unité de l’idée de montagne chez Alexandre von Humboldt

    Bernard Debarbieux

    Cybergeo (2012)

    2012  

    Abstract: Though mountains are mentioned almost everywhere in Humboldt’s narratives, none of his writings was specifically dedicated to mountains as a type of landform, milieu, or category of knowledge. Aiming to contribute to a greater understanding of Humboldt’s ...

    Abstract Though mountains are mentioned almost everywhere in Humboldt’s narratives, none of his writings was specifically dedicated to mountains as a type of landform, milieu, or category of knowledge. Aiming to contribute to a greater understanding of Humboldt’s worldview, this essay strives to explain why mountains are valuable as objects his reflection. It points to the frequency with which Humboldt mentions mountains in his writings, the various scientific perspectives evoked in these references, and the overall coherence of his observations and perspectives.
    Keywords mountain ; worldview ; epistemology of geography ; concept ; Geography (General) ; G1-922
    Language German
    Publishing date 2012-08-01T00:00:00Z
    Publisher Unité Mixte de Recherche 8504 Géographie-cités
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The role of the animal host in the management of bacteriophage resistance during phage therapy.

    Gaborieau, Baptiste / Debarbieux, Laurent

    Current opinion in virology

    2022  Volume 58, Page(s) 101290

    Abstract: Multi-drug-resistant bacteria are associated with significantly higher morbidity and mortality. The possibilities for discovering new antibiotics are limited, but phage therapy - the use of bacteriophages (viruses infecting bacteria) to cure infections - ...

    Abstract Multi-drug-resistant bacteria are associated with significantly higher morbidity and mortality. The possibilities for discovering new antibiotics are limited, but phage therapy - the use of bacteriophages (viruses infecting bacteria) to cure infections - is now being investigated as an alternative or complementary treatment to antibiotics. However, one of the major limitations of this approach lies in the antagonistic coevolution between bacteria and bacteriophages, which determines the ultimate success or failure of phage therapy. Here, we review the possible influence of the animal host on phage resistance and its consequences for the efficacy of phage therapy. We also discuss the value of in vitro assays for anticipating the dynamics of phage resistance observed in vivo.
    MeSH term(s) Animals ; Bacteriophages ; Phage Therapy ; Bacteria ; Anti-Bacterial Agents
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-12-10
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2611378-8
    ISSN 1879-6265 ; 1879-6257
    ISSN (online) 1879-6265
    ISSN 1879-6257
    DOI 10.1016/j.coviro.2022.101290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Le confinement – cloisonnement au temps du Covid 19

    Debarbieux, Bernard

    2020  

    Abstract: ... suscite son lot de termes spatiaux, au minimum pour la caractériser, au maximum pour tenter d’en limiter l ...

    Abstract La pandémie liée au covid-19 a de quoi laisser perplexes celles et ceux qui s’intéressent au vocabulaire spatial des mesures de santé publique. Certes toute épidémie – phénomène éminemment spatial – suscite son lot de termes spatiaux, au minimum pour la caractériser, au maximum pour tenter d’en limiter l’expansion. Mais dans ce cas précis, on a vu déferler, peu après le virus lui-même, des termes participant d’un ensemble de mesures préventives, à valeur normative donc, aussi surprenants les .
    Keywords covid19
    Language French
    Publishing date 2020-05-04
    Publisher UMR 8504 Géographie-cités
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Phage therapy: awakening a sleeping giant.

    Roach, Dwayne R / Debarbieux, Laurent

    Emerging topics in life sciences

    2021  Volume 1, Issue 1, Page(s) 93–103

    Abstract: For a century, bacterial viruses called bacteriophages have been exploited as natural antibacterial agents. However, their medicinal potential has not yet been exploited due to readily available and effective antibiotics. After years of extensive use, ... ...

    Abstract For a century, bacterial viruses called bacteriophages have been exploited as natural antibacterial agents. However, their medicinal potential has not yet been exploited due to readily available and effective antibiotics. After years of extensive use, both properly and improperly, antibiotic-resistant bacteria are becoming more prominent and represent a worldwide public health threat. Most importantly, new antibiotics are not progressing at the same rate as the emergence of resistance. The therapeutic modality of bacteriophages, called phage therapy, offers a clinical option to combat bacteria associated with diseases. Here, we discuss traditional phage therapy approaches, as well as how synthetic biology has allowed for the creation of designer phages for new clinical applications. To implement these technologies, several key aspects and challenges still need to be addressed, such as narrow spectrum, safety, and bacterial resistance. We will summarize our current understanding of how phage treatment elicits mammalian host immune responses, as well bacterial phage resistance development, and the potential impact each will have on phage therapy effectiveness. We conclude by discussing the need for a paradigm shift on how phage therapy strategies are developed.
    Language English
    Publishing date 2021-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2882721-1
    ISSN 2397-8554 ; 2397-8554 ; 2397-8562
    ISSN (online) 2397-8554
    ISSN 2397-8554 ; 2397-8562
    DOI 10.1042/ETLS20170002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Metapopulation model of phage therapy of an acute

    Rodriguez-Gonzalez, Rogelio A / Balacheff, Quentin / Debarbieux, Laurent / Marchi, Jacopo / Weitz, Joshua S

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Infections caused by multi-drug resistant (MDR) pathogenic bacteria are a global health threat. Phage therapy, which uses phage to kill bacterial pathogens, is increasingly used to treat patients infected by MDR bacteria. However, the therapeutic outcome ...

    Abstract Infections caused by multi-drug resistant (MDR) pathogenic bacteria are a global health threat. Phage therapy, which uses phage to kill bacterial pathogens, is increasingly used to treat patients infected by MDR bacteria. However, the therapeutic outcome of phage therapy may be limited by the emergence of phage resistance during treatment and/or by physical constraints that impede phage-bacteria interactions
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.31.578251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Guérin-Pace F. et Filippova E. (dir.), 2008, Ces lieux qui nous habitent. Identité des territoires, territoires des identités, La Tour d’Aigues, Editions de l’Aube

    Bernard Debarbieux

    Cybergeo (2010)

    2010  

    Keywords Geography (General) ; G1-922
    Language German
    Publishing date 2010-11-01T00:00:00Z
    Publisher Unité Mixte de Recherche 8504 Géographie-cités
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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