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Article: Birmingham hip resurfacing: a systematic review of outcomes at minimum 10-years follow-up.

Davey, M S / Mohan, K / Gavin, E / Power, F R / Curtin, W / Kaar, K / Murphy, C G

2024 Volume 89, Issue 4, Page(s) 581–586

Abstract: Although controversy surrounding the use of metal-on-metal (MoM) arthroplasty implants continues to exist, satisfactory clinical and radiological outcomes have been reported following Birmingham Hip Resurfacing (BHR) at long-term follow-up, leading to an ...

Abstract	Although controversy surrounding the use of metal-on-metal (MoM) arthroplasty implants continues to exist, satisfactory clinical and radiological outcomes have been reported following Birmingham Hip Resurfacing (BHR) at long-term follow-up, leading to an Orthopaedic Data Evaluation Panel (ODEP) rating of 13A. The purpose of this study was to systematically review the literature to evaluate the functional outcomes, radiological outcomes and revision rates following BHR at a minimum of 10 years follow-up. Using the PRISMA guidelines, two independent reviewers performed a literature search using Pubmed, Embase and Scopus databases. Only studies reporting on outcomes of BHR with a minimum of 10 years' follow-up were considered for inclusion. A total of 12 studies including 7132 hips (64.8% males), with mean follow-up of 11.5 years (10-15.3), met our inclusion criteria. Of included patients, 94.3% of patient underwent BHR for osteoarthritis at a mean age was 52.0 years (48-52). At final follow-up, 96% of patients reported being satisfied with their BHR, with mean Harris Hip Scores of 93.6 and Oxford Hip Scores of 16.5. Rates of radiological femoral neck narrowing of greater than 10% and non-progressive radiological loosening were reported as 2.0% and 3.8% respectively. At final follow-up, the overall revision rate was 4.9% (334/7132), deep infection rate was 0.4%, metal allergy/insensitivity rate was 1.6%, metal reaction rate was 0.3%, rate of peri-prosthetic fracture was 0.9% and aseptic loosening rates were 1.6%. This systematic review demonstrates that BHR results in satisfactory clinical outcomes, acceptable implant survivorship, low complication rates and modest surgical revision rates in the long-term at minimum 10-year follow-up.
MeSH term(s)	Male ; Humans ; Middle Aged ; Female ; Arthroplasty, Replacement, Hip/adverse effects ; Follow-Up Studies ; Databases, Factual ; Fractures, Bone ; Osteoarthritis
Language	English
Publishing date	2024-01-11
Publishing country	Belgium
Document type	Systematic Review ; Journal Article
ZDB-ID	210367-9
ISSN	0001-6462 ; 1784-407X
ISSN	0001-6462 ; 1784-407X
DOI	10.52628/89.4.10045
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Unfractionated heparin reverses aspirin inhibition of platelets during coronary artery bypass graft surgery.

Turnbull, Robert E / Hafeez, Azhar / Sander, Katrin N / Barrett, David A / Murphy, Gavin J / Goodall, Alison H

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8572

Abstract: Unfractionated heparin (UFH) is an effective antithrombotic during surgery but has known adverse effects, in particular on platelets. A marked increase in platelet responsiveness has previously been observed in patients within minutes of receiving UFH, ... ...

Abstract	Unfractionated heparin (UFH) is an effective antithrombotic during surgery but has known adverse effects, in particular on platelets. A marked increase in platelet responsiveness has previously been observed in patients within minutes of receiving UFH, despite adequate inhibition by aspirin prior to heparin. We studied this phenomenon in patients undergoing cardiac artery bypass grafting (n = 17) to determine whether the effects of heparin were systemic or platelet-specific. All patients' platelets were fully inhibited by aspirin prior to surgery, but within 3 min of receiving heparin spontaneous aggregation and responses to arachidonic acid (AA) and ADP increased significantly (p ≥ 0.0002), and activated platelets were found in the circulation. While there was no rise in thromboxane in the plasma following heparin, levels of the major platelet 12-lipoxygenase product, 12-HETE, rose significantly. Mixing experiments demonstrated that the changes caused by heparin resided primarily in the platelets, while addition of AA pathway inhibitors, and analysis of oxylipins provided evidence that, following heparin, aggregating platelets regained their ability to synthesise thromboxane. These findings highlight potentially unrecognised pro-thrombotic and pro-inflammatory changes during CABG surgery, and provide further evidence of adverse effects associated with UFH.
MeSH term(s)	Humans ; Heparin/pharmacology ; Drug-Related Side Effects and Adverse Reactions ; Arachidonic Acid ; Aspirin/pharmacology ; Coronary Artery Bypass ; Thromboxanes
Chemical Substances	Heparin (9005-49-6) ; Arachidonic Acid (27YG812J1I) ; Aspirin (R16CO5Y76E) ; Thromboxanes
Language	English
Publishing date	2024-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58005-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: IL-6-GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models.

Science advances

2023 Volume 9, Issue 15, Page(s) eadf4490

Abstract: Liver steatosis is an increasing health issue with few therapeutic options, partly because of a paucity of experimental models. In humanized liver rodent models, abnormal lipid accumulation in transplanted human hepatocytes occurs spontaneously. Here, we ...

Abstract	Liver steatosis is an increasing health issue with few therapeutic options, partly because of a paucity of experimental models. In humanized liver rodent models, abnormal lipid accumulation in transplanted human hepatocytes occurs spontaneously. Here, we demonstrate that this abnormality is associated with compromised interleukin-6 (IL-6)-glycoprotein 130 (GP130) signaling in human hepatocytes because of incompatibility between host rodent IL-6 and human IL-6 receptor (IL-6R) on donor hepatocytes. Restoration of hepatic IL-6-GP130 signaling, through ectopic expression of rodent IL-6R, constitutive activation of GP130 in human hepatocytes, or humanization of an
MeSH term(s)	Humans ; Mice ; Animals ; Interleukin-6/metabolism ; Cytokine Receptor gp130/metabolism ; Lipid Droplets/metabolism ; Hepatocytes/metabolism ; Fatty Liver ; Glycoproteins ; Lipids
Chemical Substances	Interleukin-6 ; Cytokine Receptor gp130 (133483-10-0) ; Glycoproteins ; Lipids
Language	English
Publishing date	2023-04-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adf4490
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Article ; Online: Sit Less and Move More-A Multicomponent Intervention With and Without Height-Adjustable Workstations in Contact Center Call Agents: A Pilot Randomized Controlled Trial.

Morris, Abigail S / Murphy, Rebecca C / Hopkins, Nicola D / Low, David A / Healy, Genevieve N / Edwardson, Charlotte L / Collins, Brendan / Timpson, Hannah / Shepherd, Sam O / Cochrane, Madeleine / Gavin, David / Graves, Lee E F

Journal of occupational and environmental medicine

2020 Volume 63, Issue 1, Page(s) 44–56

Abstract: Objective: To pilot a multicomponent intervention to sit less and move more, with (SLAMM+) and without (SLAMM) height-adjustable workstations, in contact center call agents.: Methods: Agents were individually randomized to SLAMM or SLAMM+ in this 10- ... ...

Abstract	Objective: To pilot a multicomponent intervention to sit less and move more, with (SLAMM+) and without (SLAMM) height-adjustable workstations, in contact center call agents. Methods: Agents were individually randomized to SLAMM or SLAMM+ in this 10-month, parallel, open-label, pilot trial. Mixed-methods assessed response, recruitment, retention, attrition and completion rates, adverse effects, trial feasibility and acceptability, preliminary effectiveness on worktime sitting, and described secondary outcomes. Results: The participant recruitment rate, and randomization, data collection, and interventions were mostly acceptable. Refinements to organization recruitment were identified. High staff turnover negatively impacted retention and completion rates. The multicomponent intervention with height-adjustable workstations has potential to reduce sitting time at work. Conclusions: The demonstrated findings will help prepare for a future randomized controlled trial designed to assess the effect of the interventions.
MeSH term(s)	Humans ; Pilot Projects ; Sedentary Behavior ; Sitting Position ; Workplace
Language	English
Publishing date	2020-10-29
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1223932-x
ISSN	1536-5948 ; 1076-2752
ISSN (online)	1536-5948
ISSN	1076-2752
DOI	10.1097/JOM.0000000000002066
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Article ; Online: A single-cell map of dynamic chromatin landscapes of immune cells in renal cell carcinoma.

Nature cancer

2022 Volume 3, Issue 7, Page(s) 885–898

Abstract: A complete chart of the chromatin regulatory elements of immune cells in patients with cancer and their dynamic behavior is necessary to understand the developmental fates and guide therapeutic strategies. Here, we map the single-cell chromatin landscape ...

Abstract	A complete chart of the chromatin regulatory elements of immune cells in patients with cancer and their dynamic behavior is necessary to understand the developmental fates and guide therapeutic strategies. Here, we map the single-cell chromatin landscape of immune cells from blood, normal tumor-adjacent kidney tissue and malignant tissue from patients with early-stage clear cell renal cell carcinoma (ccRCC). We catalog the T cell states dictated by tissue-specific and developmental-stage-specific chromatin accessibility patterns, infer key chromatin regulators and observe rewiring of regulatory networks in the progression to dysfunction in CD8
MeSH term(s)	CD8-Positive T-Lymphocytes ; Carcinoma, Renal Cell/genetics ; Chromatin/genetics ; Humans ; Kidney Neoplasms/genetics ; NF-kappa B
Chemical Substances	Chromatin ; NF-kappa B
Language	English
Publishing date	2022-06-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2662-1347
ISSN (online)	2662-1347
DOI	10.1038/s43018-022-00391-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Outcome monitoring and risk stratification after cardiac procedure in neonates, infants, children and young adults born with congenital heart disease: protocol for a multicentre prospective cohort study (Children OMACp).

BMJ open

2023 Volume 13, Issue 8, Page(s) e071629

Abstract: Introduction: Congenital heart disease (CHD) represents the most common birth defect, affecting from 0.4% to 1.2% of children born in developed countries. The survival of these patients has increased significantly, but CHD remains one of the major ... ...

Abstract	Introduction: Congenital heart disease (CHD) represents the most common birth defect, affecting from 0.4% to 1.2% of children born in developed countries. The survival of these patients has increased significantly, but CHD remains one of the major causes of neonatal and childhood death. The aetiology of CHD is complex, with some evidence of both genetic and environmental causes. However, there is still lack of knowledge regarding modifiable risk factors and molecular and genetic mechanisms underlying the development of CHD. This study aims to develop a prospective cohort of patients undergoing cardiac procedures that will bring together routinely collected clinical data and biological samples from patients and their biological mothers, in order to investigate risk factors and predictors of postoperative-outcomes, as well as better understanding the effect of the surgical intervention on the early and long-term outcomes. Methods and analysis: Children OMACp (OMACp, outcome monitoring after cardiac procedure in congenital heart disease) is a multicentre, prospective cohort study recruiting children with CHD undergoing a cardiac procedure. The study aims to recruit 3000 participants over 5 years (2019-2024) across multiple UK sites. Routine clinical data will be collected, as well as participant questionnaires collecting sociodemographic, NHS resource use and quality of life data. Biological samples (blood, urine and surgical waste tissue from patients, and blood and urine samples from biological mothers) will be collected where consent has been obtained. Follow-up outcome and questionnaire data will be collected for 5 years. Ethics and dissemination: The study was approved by the London-Brent Research Ethics Committee on 30 July 2019 (19/SW/0113). Participants (or their parent/guardian if under 16 years of age) must provide informed consent prior to being recruited into the study. Mothers who wish to take part must also provide informed consent prior to being recruited. The study is sponsored by University Hospitals Bristol and Weston Foundation Trust and is managed by the University of Bristol. Children OMACp is adopted onto the National Institute for Health Research Clinical Research Network portfolio. Findings will be disseminated through peer-reviewed publications, presentation at conference, meetings and through patient organisations and newsletters. Trial registration number: ISRCTN17650644.
MeSH term(s)	Infant, Newborn ; Pregnancy ; Female ; Humans ; Infant ; Child ; Young Adult ; Prospective Studies ; Quality of Life ; Parturition ; Heart Defects, Congenital/surgery ; Risk Assessment ; Multicenter Studies as Topic
Language	English
Publishing date	2023-08-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-071629
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sampling strategies for species with high breeding-site fidelity: A case study in burrow-nesting seabirds.

Arneill, Gavin E / Perrins, Christopher M / Wood, Matt J / Murphy, David / Pisani, Luca / Jessopp, Mark J / Quinn, John L

PloS one

2019 Volume 14, Issue 8, Page(s) e0221625

Abstract: Sampling approaches used to census and monitor populations of flora and fauna are diverse, ranging from simple random sampling to complex hierarchal stratified designs. Usually the approach taken is determined by the spatial and temporal distribution of ... ...

Abstract	Sampling approaches used to census and monitor populations of flora and fauna are diverse, ranging from simple random sampling to complex hierarchal stratified designs. Usually the approach taken is determined by the spatial and temporal distribution of the study population, along with other characteristics of the focal species. Long-term monitoring programs used to assess seabird population trends are facilitated by their high site fidelity, but are often hampered by large and difficult to access colonies, with highly variable densities that require intensive survey. We aimed to determine the sampling effort required to (a) estimate population size with a high degree of confidence, and (b) detect different scenarios of population change in a regionally important species in the Atlantic, the Manx shearwater (Puffinus puffinus). Analyses were carried out using data collected from tape-playback surveys on four islands in the North Atlantic. To explore how sampling effort influenced confidence around abundance estimates, we used the heuristic approach of imagining the areas sampled represented the total population, and bootstrapped varying proportions of subsamples. This revealed that abundance estimates vary dramatically when less than half of all plots (n dependent on the size of the site) is randomly subsampled, leading to an unacceptable lack of confidence in population estimates. Confidence is substantially improved using a multi-stage stratified approach based on previous information on distribution in the colonies. In reality, this could lead to reducing the number of plots required by up to 80%. Furthermore, power analyses suggested that random selection of monitoring plots using a matched pairs approach generates little power to detect overall population changes of 10%, and density-dependent changes as large as 50%, because variation in density between plots is so high. Current monitoring programs have a high probability of failing to detect population-level changes due to inappropriate sampling efforts. Focusing sampling in areas of high density with low plot to plot variance dramatically increases the power to detect year to year population change, albeit at the risk of not detecting increases in low density areas, which may be an unavoidable strategy when resources are limited. We discuss how challenging populations with similar features to seabirds might be censused and monitored most effectively.
MeSH term(s)	Animals ; Birds/physiology ; Breeding ; Geography ; Ireland ; Nesting Behavior/physiology ; Population Dynamics ; Species Specificity ; Surveys and Questionnaires ; Wales
Language	English
Publishing date	2019-08-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0221625
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Potential value of a rapid syndromic multiplex PCR for the diagnosis of native and prosthetic joint infections: a real-world evidence study.

Pascual, Stéphanie / Noble, Brooklyn / Ahmad-Saeed, Nusreen / Aldridge, Catherine / Ambretti, Simone / Amit, Sharon / Annett, Rachel / O'Shea, Shaan Ashk / Barbui, Anna Maria / Barlow, Gavin / Barrett, Lucinda / Berth, Mario / Bondi, Alessandro / Boran, Nicola / Boyd, Sara E / Chaves, Catarina / Clauss, Martin / Davies, Peter / Dianzo-Delgado, Ileana T /

Esteban, Jaime / Fuchs, Stefan / Friis-Hansen, Lennart / Goldenberger, Daniel / Golle, Andrej / Groonroos, Juha O / Hoffmann, Ines / Hoffmann, Tomer / Hughes, Harriet / Ivanova, Marina / Jezek, Peter / Jones, Gwennan / Ceren Karahan, Zeynep / Lass-Flörl, Cornelia / Laurent, Frédéric / Leach, Laura / Horsbøll Pedersen, Matilde Lee / Loiez, Caroline / Lynch, Maureen / Maloney, Robert J / Marsh, Martin / Milburn, Olivia / Mitchell, Shanine / Moore, Luke S P / Moffat, Lynn / Murdjeva, Marianna / Murphy, Michael E / Nayar, Deepa / Nigrisoli, Giacomo / O'Sullivan, Fionnuala / Öz, Büşra / Peach, Teresa / Petridou, Christina / Prinz, Mojgan / Rak, Mitja / Reidy, Niamh / Rossolini, Gian Maria / Roux, Anne-Laure / Ruiz-Garbajosa, Patricia / Saeed, Kordo / Salar-Vidal, Llanos / Salas Venero, Carlos / Selvaratnam, Mathyruban / Senneville, Eric / Starzengruber, Peter / Talbot, Ben / Taylor, Vanessa / Trebše, Rihard / Wearmouth, Deborah / Willinger, Birgit / Wouthuyzen-Bakker, Marjan / Couturier, Brianne / Allantaz, Florence

Journal of bone and joint infection

2024 Volume 9, Issue 1, Page(s) 87–97

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2024-02-28
Publishing country	Germany
Document type	Journal Article
ISSN	2206-3552
ISSN	2206-3552
DOI	10.5194/jbji-9-87-2024
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Article ; Online: Sampling strategies for species with high breeding-site fidelity

Gavin E Arneill / Christopher M Perrins / Matt J Wood / David Murphy / Luca Pisani / Mark J Jessopp / John L Quinn

PLoS ONE, Vol 14, Iss 8, p e

A case study in burrow-nesting seabirds.

2019 Volume 0221625

Abstract	Sampling approaches used to census and monitor populations of flora and fauna are diverse, ranging from simple random sampling to complex hierarchal stratified designs. Usually the approach taken is determined by the spatial and temporal distribution of the study population, along with other characteristics of the focal species. Long-term monitoring programs used to assess seabird population trends are facilitated by their high site fidelity, but are often hampered by large and difficult to access colonies, with highly variable densities that require intensive survey. We aimed to determine the sampling effort required to (a) estimate population size with a high degree of confidence, and (b) detect different scenarios of population change in a regionally important species in the Atlantic, the Manx shearwater (Puffinus puffinus). Analyses were carried out using data collected from tape-playback surveys on four islands in the North Atlantic. To explore how sampling effort influenced confidence around abundance estimates, we used the heuristic approach of imagining the areas sampled represented the total population, and bootstrapped varying proportions of subsamples. This revealed that abundance estimates vary dramatically when less than half of all plots (n dependent on the size of the site) is randomly subsampled, leading to an unacceptable lack of confidence in population estimates. Confidence is substantially improved using a multi-stage stratified approach based on previous information on distribution in the colonies. In reality, this could lead to reducing the number of plots required by up to 80%. Furthermore, power analyses suggested that random selection of monitoring plots using a matched pairs approach generates little power to detect overall population changes of 10%, and density-dependent changes as large as 50%, because variation in density between plots is so high. Current monitoring programs have a high probability of failing to detect population-level changes due to inappropriate sampling efforts. ...
Keywords	Medicine ; R ; Science ; Q
Subject code	310
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Receipt of medications for opioid use disorder among youth engaged in primary care: data from 6 health systems.

Bagley, Sarah M / Chavez, Laura / Braciszewski, Jordan M / Akolsile, Mary / Boudreau, Denise M / Lapham, Gwen / Campbell, Cynthia I / Bart, Gavin / Yarborough, Bobbi Jo H / Samet, Jeffrey H / Saxon, Andrew J / Rossom, Rebecca C / Binswanger, Ingrid A / Murphy, Mark T / Glass, Joseph E / Bradley, Katharine A

Addiction science & clinical practice

2021 Volume 16, Issue 1, Page(s) 46

Abstract: Purpose: Little is known about prevalence and treatment of OUD among youth engaged in primary care (PC). Medications are the recommended treatment of opioid use disorder (OUD) for adolescents and young adults (youth). This study describes the prevalence ...

Abstract	Purpose: Little is known about prevalence and treatment of OUD among youth engaged in primary care (PC). Medications are the recommended treatment of opioid use disorder (OUD) for adolescents and young adults (youth). This study describes the prevalence of OUD, the prevalence of medication treatment for OUD, and patient characteristics associated with OUD treatment among youth engaged in PC. Methods: This cross-sectional study includes youth aged 16-25 years engaged in PC. Eligible patients had ≥ 1 PC visit during fiscal years (FY) 2014-2016 in one of 6 health systems across 6 states. Data from electronic health records and insurance claims were used to identify OUD diagnoses, office-based OUD medication treatment, and patient demographic and clinical characteristics in the FY of the first PC visit during the study period. Descriptive analyses were conducted in all youth, and stratified by age (16-17, 18-21, 22-25 years). Results: Among 303,262 eligible youth, 2131 (0.7%) had a documented OUD diagnosis. The prevalence of OUD increased by ascending age groups. About half of youth with OUD had documented depression or anxiety and one third had co-occurring substance use disorders. Receipt of medication for OUD was lowest among youth 16-17 years old (14%) and highest among those aged 22-25 (39%). Conclusions: In this study of youth engaged in 6 health systems across 6 states, there was low receipt of medication treatment, and high prevalence of other substance use disorders and mental health disorders. These findings indicate an urgent need to increase medication treatment for OUD and to integrate treatment for other substance use and mental health disorders.
MeSH term(s)	Adolescent ; Analgesics, Opioid/therapeutic use ; Buprenorphine/therapeutic use ; Cross-Sectional Studies ; Humans ; Opiate Substitution Treatment ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/epidemiology ; Primary Health Care ; United States/epidemiology ; Young Adult
Chemical Substances	Analgesics, Opioid ; Buprenorphine (40D3SCR4GZ)
Language	English
Publishing date	2021-07-07
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2492632-2
ISSN	1940-0640 ; 1940-0640
ISSN (online)	1940-0640
ISSN	1940-0640
DOI	10.1186/s13722-021-00249-3
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