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  1. Article ; Online: In memoriam William Clifford Roberts, MD (September 11, 1932 June 15, 2023).

    Maximilian Buja, Louis

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

    2023  Volume 67, Page(s) 107571

    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Letter
    ZDB-ID 1134600-0
    ISSN 1879-1336 ; 1054-8807
    ISSN (online) 1879-1336
    ISSN 1054-8807
    DOI 10.1016/j.carpath.2023.107571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The history, science, and art of wine and the case for health benefits: perspectives of an oenophilic cardiovascular pathologist.

    Buja, Louis Maximilian

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

    2022  Volume 60, Page(s) 107446

    Abstract: This article stems from the intersection of the author's long-standing interests in science, medicine, pathology and oenology. A discussion is provided of selected aspects of the science of viticulture and wine production as well as qualities of the ... ...

    Abstract This article stems from the intersection of the author's long-standing interests in science, medicine, pathology and oenology. A discussion is provided of selected aspects of the science of viticulture and wine production as well as qualities of the finished product crafted by the art of the wine maker. The case for health benefits of moderate consumption of wine and other alcoholic beverages also is discussed. Based on the "French paradox," an analysis is presented of the evidence for the special effects of red wine consumption, particularly as part of the Mediterranean diet and lifestyle. A concluding perspective is given in support of wine as a promoter of civility and social engagement.
    MeSH term(s) Alcohol Drinking ; Cardiovascular System ; Humans ; Pathologists ; Wine
    Language English
    Publishing date 2022-05-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1134600-0
    ISSN 1879-1336 ; 1054-8807
    ISSN (online) 1879-1336
    ISSN 1054-8807
    DOI 10.1016/j.carpath.2022.107446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Electron microscopic identification of SARS-CoV-2.

    Buja, Louis Maximilian

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

    2021  Volume 52, Page(s) 107337

    MeSH term(s) COVID-19 ; Electrons ; Humans ; Microscopy, Electron ; SARS-CoV-2
    Language English
    Publishing date 2021-04-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1134600-0
    ISSN 1879-1336 ; 1054-8807
    ISSN (online) 1879-1336
    ISSN 1054-8807
    DOI 10.1016/j.carpath.2021.107337
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  4. Article ; Online: A novel coronavirus meets the cardiovascular system: Society for Cardiovascular Pathology Symposium 2021.

    Buja, Louis Maximilian / Stone, James R

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

    2021  Volume 53, Page(s) 107336

    MeSH term(s) Autopsy ; Biomedical Research ; COVID-19/complications ; COVID-19/mortality ; COVID-19/pathology ; COVID-19/virology ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/pathology ; Cardiovascular Diseases/virology ; Cardiovascular System/pathology ; Cardiovascular System/virology ; Host-Pathogen Interactions ; Humans ; SARS-CoV-2/pathogenicity
    Language English
    Publishing date 2021-04-23
    Publishing country United States
    Document type Congress ; Editorial
    ZDB-ID 1134600-0
    ISSN 1879-1336 ; 1054-8807
    ISSN (online) 1879-1336
    ISSN 1054-8807
    DOI 10.1016/j.carpath.2021.107336
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  5. Article ; Online: Commentary on the spectrum of cardiopulmonary pathology in COVID-19.

    Buja, Louis Maximilian / Zhao, Bihong / McDonald, Michelle / Ottaviani, Giulia / Wolf, Dwayne A

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

    2021  Volume 53, Page(s) 107339

    MeSH term(s) COVID-19 ; Heart ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-05-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1134600-0
    ISSN 1879-1336 ; 1054-8807
    ISSN (online) 1879-1336
    ISSN 1054-8807
    DOI 10.1016/j.carpath.2021.107339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Complexities and complications of extreme obesity.

    Ali, Haval / Naik, Udit / McDonald, Michelle / Almosa, Mohammad / Horn, Karen / Staines, Alexis / Buja, Louis Maximilian

    Autopsy & case reports

    2022  Volume 12, Page(s) e2021402

    Abstract: Obesity is a common chronic disorder and has detrimental long-term consequences if left untreated. Herein, we report a case of a young lady who suffered from morbid obesity and many of its consequences, and we present a literature review of these ... ...

    Abstract Obesity is a common chronic disorder and has detrimental long-term consequences if left untreated. Herein, we report a case of a young lady who suffered from morbid obesity and many of its consequences, and we present a literature review of these complications. While the cause of obesity is multifactorial, the genetic component is particularly important in the pathophysiology of marked obesity. Resistance to Leptin is considered one of the main causes of obesity. There is a unique relationship between polycystic ovary syndrome and obesity, as observed in our case. Obesity is associated with cardiovascular and lung diseases such as heart failure, thromboembolic disease, sleep apnea, and pulmonary hypertension. Our patient had cardiomegaly (730 gm) with eccentric hypertrophy of left and right ventricles. The coronary arteries and aorta were free of atherosclerosis, which is a surprising finding that relates to the mysterious phenomenon of obesity paradox. The terminal event in our young woman was multiple segmental and subsegmental pulmonary arterial thrombi/thromboemboli superimposed on chronic cardiopulmonary stress due to massive obesity.
    Language English
    Publishing date 2022-10-05
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 2815488-5
    ISSN 2236-1960
    ISSN 2236-1960
    DOI 10.4322/acr.2021.402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Machine Learning Algorithm Improves the Diagnostic Accuracy of the Histologic Component of Antibody Mediated Rejection (AMR-H) in Cardiac Transplant Endomyocardial Biopsies.

    Glass, Matthew / Ji, Zhicheng / Davis, Richard / Pavlisko, Elizabeth / DiBernardo, Louis / Carney, John / Fishbein, Gregory / Luthringer, Daniel / Miller, Dylan / Mitchell, Richard / Larsen, Brandon / Butt, Yasmeen / Bois, Melanie / Maleszewski, Joseph / Halushka, Marc / Seidman, Michael / Lin, Chieh-Yu / Buja, Maximilian / Stone, James /
    Dov, David / Carin, Lawrence / Glass, Carolyn

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

    2024  , Page(s) 107646

    Abstract: Background: Pathologic antibody mediated rejection (pAMR) remains a major driver of graft failure in cardiac transplant patients. The endomyocardial biopsy remains the primary diagnostic tool but presents with challenges, particularly in distinguishing ... ...

    Abstract Background: Pathologic antibody mediated rejection (pAMR) remains a major driver of graft failure in cardiac transplant patients. The endomyocardial biopsy remains the primary diagnostic tool but presents with challenges, particularly in distinguishing the histologic component (pAMR-H) defined by 1) intravascular macrophage accumulation in capillaries and 2) activated endothelial cells that expand the cytoplasm to narrow or occlude the vascular lumen. Frequently, pAMR-H is difficult to distinguish from acute cellular rejection (ACR) and healing injury. With the advent of digital slide scanning and advances in machine deep learning, artificial intelligence technology is widely under investigation in the areas of oncologic pathology, but in its infancy in transplant pathology. For the first time, we determined if a machine learning algorithm could distinguish pAMR-H from normal myocardium, healing injury and ACR.
    Materials and methods: A total of 4,212 annotations (1,053 regions of normal, 1,053 pAMR-H, 1,053 healing injury and 1,053 ACR) were completed from 300 hematoxylin and eosin slides scanned using a Leica Aperio GT450 digital whole slide scanner at 40X magnification. All regions of pAMR-H were annotated from patients confirmed with a previous diagnosis of pAMR2 (>50% positive C4d immunofluorescence and/or >10% CD68 positive intravascular macrophages). Annotations were imported into a Python 3.7 development environment using the OpenSlide™ package and a convolutional neural network approach utilizing transfer learning was performed.
    Results: The machine learning algorithm showed 98% overall validation accuracy and pAMR-H was correctly distinguished from specific categories with the following accuracies: normal myocardium (99.2%), healing injury (99.5%) and ACR (99.5%).
    Conclusion: Our novel deep learning algorithm can reach acceptable, and possibly surpass, performance of current diagnostic standards of identifying pAMR-H. Such a tool may serve as an adjunct diagnostic aid for improving the pathologist's accuracy and reproducibility, especially in difficult cases with high inter-observer variability. This is one of the first studies that provides evidence that an artificial intelligence machine learning algorithm can be trained and validated to diagnose pAMR-H in cardiac transplant patients. Ongoing studies include multi-institutional verification testing to ensure generalizability.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1134600-0
    ISSN 1879-1336 ; 1054-8807
    ISSN (online) 1879-1336
    ISSN 1054-8807
    DOI 10.1016/j.carpath.2024.107646
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  8. Article ; Online: Environmental oxygen affects ex vivo growth and proliferation of mesenchymal progenitors by modulating mitogen-activated protein kinase and mammalian target of rapamycin signaling.

    da Graça Cabreira, Maria / Wang, Xiaohong / Critsinelis, Andre / Setegne, Mekedlawit / Lotfi, Parisa / Wan, Ying-Wooi / Barrios, Gabriela / Mei, Zhuyong / Gee, Adrian P / Buja, Louis Maximilian / Perin, Emerson

    Cytotherapy

    2022  Volume 24, Issue 12, Page(s) 1201–1210

    Abstract: Background aims: Stem and progenitor cells of hematopoietic and mesenchymal lineages reside in the bone marrow under low oxygen (O: Methods: Using cell-based assays and transcriptome and proteome data, the authors compared MSC cultures simultaneously ...

    Abstract Background aims: Stem and progenitor cells of hematopoietic and mesenchymal lineages reside in the bone marrow under low oxygen (O
    Methods: Using cell-based assays and transcriptome and proteome data, the authors compared MSC cultures simultaneously grown under a conventional 19.95% O
    Results: In 5% O
    Conclusions: Based on the potential benefits for the growth and metabolism of MSCs, the authors propose the use of 5% O
    MeSH term(s) Oxygen/metabolism ; Cells, Cultured ; Mitogen-Activated Protein Kinases ; Sirolimus ; Cell Proliferation ; Cell Differentiation/physiology ; TOR Serine-Threonine Kinases
    Chemical Substances Oxygen (S88TT14065) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Sirolimus (W36ZG6FT64) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2022-09-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2039821-9
    ISSN 1477-2566 ; 1465-3249
    ISSN (online) 1477-2566
    ISSN 1465-3249
    DOI 10.1016/j.jcyt.2022.06.005
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  9. Article: The Importance of the Autopsy in Medicine: Perspectives of Pathology Colleagues.

    Buja, Louis Maximilian / Barth, Rolf F / Krueger, Gerhard R / Brodsky, Sergey V / Hunter, Robert L

    Academic pathology

    2019  Volume 6, Page(s) 2374289519834041

    Abstract: This article presents a perspective on the importance of the autopsy in medical practice and science based on experiences of the authors as physician-scientists involved in autopsy practice. Our perspectives are presented on the seminal contributions of ... ...

    Abstract This article presents a perspective on the importance of the autopsy in medical practice and science based on experiences of the authors as physician-scientists involved in autopsy practice. Our perspectives are presented on the seminal contributions of the autopsy in the areas of cardiovascular disease, including congenital heart disease, atherosclerosis, coronary artery disease, and myocardial infarction, and infectious disease, including tuberculosis and viral infections. On the positive side of the future of the autopsy, we discuss the tremendous opportunities for important research to be done by application of advanced molecular biological techniques to formalin-fixed, paraffin-embedded tissue blocks obtained at autopsy. We also note with concern the countervailing forces impacting the influence of pathology in education and clinical practice at our academic medical centers, which also present impediments to increasing autopsy rates. Our challenge as academic pathologists, whose careers have been molded by involvement in the autopsy, is to counter these trends. The challenges are great but the benefits for medicine and society are enormous.
    Language English
    Publishing date 2019-03-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2819382-9
    ISSN 2374-2895
    ISSN 2374-2895
    DOI 10.1177/2374289519834041
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  10. Article ; Online: Consensus statement on the processing, interpretation and reporting of temporal artery biopsy for arteritis.

    Nair, Vidhya / Fishbein, Gregory A / Padera, Robert / Seidman, Michael A / Castonguay, Mathieu / Leduc, Charles / Tan, Carmela D / Rodriguez, E Rene / Maleszewski, Joseph J / Miller, Dylan / Romero, Maria / Lomasney, Jon / d'Amati, Giulia / De Gaspari, Monica / Rizzo, Stefania / Angelini, Annalisa / Basso, Cristina / Litovsky, Silvio / Buja, Louis Maximilian /
    Stone, James R / Veinot, John P

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

    2023  Volume 67, Page(s) 107574

    Abstract: Giant cell arteritis (GCA) is the most common systemic vasculitis in adults in Europe and North America, typically involving the extra-cranial branches of the carotid arteries and the thoracic aorta. Despite advances in noninvasive imaging, temporal ... ...

    Abstract Giant cell arteritis (GCA) is the most common systemic vasculitis in adults in Europe and North America, typically involving the extra-cranial branches of the carotid arteries and the thoracic aorta. Despite advances in noninvasive imaging, temporal artery biopsy (TAB) remains the gold standard for establishing a GCA diagnosis. The processing of TAB depends largely on individual institutional protocol, and the interpretation and reporting practices vary among pathologists. To address this lack of uniformity, the Society for Cardiovascular Pathology formed a committee tasked with establishing consensus guidelines for the processing, interpretation, and reporting of TAB specimens, based on the existing literature. This consensus statement includes a discussion of the differential diagnoses including other forms of arteritis and noninflammatory changes of the temporal artery.
    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1134600-0
    ISSN 1879-1336 ; 1054-8807
    ISSN (online) 1879-1336
    ISSN 1054-8807
    DOI 10.1016/j.carpath.2023.107574
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