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  1. Book ; Online ; E-Book: Lifecycles of pathogenic protists in humans

    de Souza, Wanderley

    (Microbiology monographs ; 35)

    2022  

    Author's details Wanderley de Souza editor
    Series title Microbiology monographs ; 35
    Collection
    Keywords Parasitology ; Veterinary microbiology ; Microbiology ; Medical microbiology
    Language English
    Size 1 Online-Ressource(viii, 617 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021226737
    ISBN 978-3-030-80682-8 ; 9783030806811 ; 3-030-80682-0 ; 3030806812
    DOI 10.1007/978-3-030-80682-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Biology of <em>Trypanosoma cruzi</em>

    De Souza, Wanderley

    2019  

    Keywords Pathology ; Medical parasitology
    Size 1 electronic resource (234 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021046154
    ISBN 9781839682056 ; 1839682051
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Contribution of microscopy to a better understanding of the anatomy of pathogenic protists.

    de Souza, Wanderley

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 17, Page(s) e2321515121

    Abstract: In this Inaugural Article the author briefly revises its scientific career and how he starts to work with parasitic protozoa. Emphasis is given to his contribution to topics such as a) the structural organization of the surface of protozoa using freeze- ... ...

    Abstract In this Inaugural Article the author briefly revises its scientific career and how he starts to work with parasitic protozoa. Emphasis is given to his contribution to topics such as a) the structural organization of the surface of protozoa using freeze-fracture and deep-etching; b) the cytoskeleton of protozoa, especially structures such as the subpellicular microtubules of trypanosomatids, the conoid of
    MeSH term(s) Male ; Humans ; Eukaryota ; Microtubules ; Cytoskeleton ; Microscopy, Electron, Scanning ; Axoneme
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2321515121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
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  4. Book ; Online: Interaction of Trypanosoma cruzi with Host Cells

    Souza, Wanderley De

    2014  

    Abstract: Trypanosoma cruzi is a pathogenic protozoan of the Trypanosomatidade Family, which is the etiological agent of Chagas' disease. Chagas' disease stands out for being endemic among countries in Latin America, affecting about 15 million people. Recently, ... ...

    Abstract Trypanosoma cruzi is a pathogenic protozoan of the Trypanosomatidade Family, which is the etiological agent of Chagas' disease. Chagas' disease stands out for being endemic among countries in Latin America, affecting about 15 million people. Recently, Chagas has become remarkable in European countries as well due to cases of transmission via infected blood transfusion. An important factor that has exacerbated the epidemiological picture in Brazil, Colombia and Venezuela is infection after the oral intake of contaminated foods such as sugar cane, açai and bacaba juices. Trypanosoma cruzi is an intracellular protozoan that exhibits a complex life cycle, involving multiple developmental stages found in both vertebrate and invertebrate hosts. In vertebrate hosts, the trypomastigote form invades a large variety of nucleated cells using multiple mechanisms.-

    The invasion process involves several steps: (a) attraction of the protozoan to interact with the host cell surface; (b) parasite-host cell recognition; (c) adhesion of the parasite to the host cell surface; (d) cell signalling events that culminate in the internalization of the parasite through endocytic processes; (e) biogenesis of a large vacuole where the parasite is initially located, and is also known as parasitophorous vacuole (PV); (f) participation of endocytic pathway components in the internalization process; (g) participation of cytoskeleton components in the internalization process; (h) transformation of the trypomastigote into the amastigote form within the PV; (i) lysis of the membrane of the PV; (j) multiplication of amastigotes within the host cell in direct contact with cell structures and organelles; (k) transformation of amastigotes into trypomastigotes, and (l) rupture of the host cell releasing trypomastigotes into the extracellular space.-

    The kinetics of the interaction process and even the fate of the parasite within the cell vary according to the nature of the host cell and its state of immunological activation
    Keywords Medicine (General) ; Immunologic diseases. Allergy ; Science (General) ; Microbiology
    Size 1 electronic resource (97 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020087980
    ISBN 9782889193370 ; 2889193373
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Development in the Chemotherapy of Infectious Diseases caused by Intracellular Pathogenic Protozoa: Trypanosoma and Leishmania.

    Souza, Wanderley de

    Current pharmaceutical design

    2021  Volume 27, Issue 14, Page(s) 1649

    MeSH term(s) Communicable Diseases ; Humans ; Leishmania ; Protozoan Proteins ; Trypanosoma ; Trypanosoma cruzi
    Chemical Substances Protozoan Proteins
    Language English
    Publishing date 2021-06-10
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/138161282714210429112726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Stimulation of microvesicle secretion in Trichomonas vaginalis.

    Santana de Andrade, Júlio César / Benchimol, Marlene / de Souza, Wanderley

    Experimental parasitology

    2024  Volume 259, Page(s) 108722

    Abstract: Trichomonas vaginalis is an extracellular flagellate protozoan and the etiological agent of human trichomoniasis, a sexually transmitted infection (STI) with a high incidence. Several reports have shown that this protozoan releases microvesicles into the ...

    Abstract Trichomonas vaginalis is an extracellular flagellate protozoan and the etiological agent of human trichomoniasis, a sexually transmitted infection (STI) with a high incidence. Several reports have shown that this protozoan releases microvesicles into the culture medium, which show high potential in modulating cell-to-cell communication and the host response to infections. However, the biogenesis of these vesicles has not been analyzed in detail. In the present study, high-resolution ion scanning microscopy (SEM) and transmission electron microscopy (TEM) were used to analyze the surface of control cells and cells incubated in the presence of Ca
    MeSH term(s) Female ; Humans ; Trichomonas vaginalis ; Calcium Ionophores ; Microscopy, Electron, Transmission ; Trichomonas Vaginitis/parasitology ; Extracellular Vesicles ; Trichomonas Infections
    Chemical Substances Calcium Ionophores
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391089-1
    ISSN 1090-2449 ; 0014-4894
    ISSN (online) 1090-2449
    ISSN 0014-4894
    DOI 10.1016/j.exppara.2024.108722
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  7. Book ; Online: Toxoplasmose & Toxoplasma gondii

    Souza, Wanderley de / Jr, Rubens Belfort

    2014  

    Abstract: A infecção por Toxoplasma gondii é hoje muito disseminada ao redor do mundo, especialmente no Brasil. A coletânea parte da história da descoberta desse parasita e da doença por ele causada, a toxoplasmose, e visita os diferentes aspectos relacionados ao ... ...

    Abstract A infecção por Toxoplasma gondii é hoje muito disseminada ao redor do mundo, especialmente no Brasil. A coletânea parte da história da descoberta desse parasita e da doença por ele causada, a toxoplasmose, e visita os diferentes aspectos relacionados ao tema. São apresentados o ciclo evolutivo, a epidemiologia, o diagnóstico, o quadro clínico e o tratamento, em uma ampla revisão sobre o assunto, provavelmente a mais completa já realizada. Somente nos anos 1970 desvendou-se o ciclo de vida desse protozoário, do qual o gato é hospedeiro definitivo. Outros animais de sangue quente, entre eles o ser humano, são hospedeiros intermediários. Muitos indivíduos infectados pelo T. gondii não apresentam sintomas, mas, quando a doença se manifesta, pode ter diferentes configurações, afetando gânglios, olhos, coração, pulmões, fígado, cérebro e meninges, ou articulações. Além de uma completa revisão, a obra também traz para o leitor o que há de mais atual no conhecimento científico acerca da toxoplasmose e do T. gondii. O livro cobre praticamente todos os campos do conhecimento sobre o agente etiológico e a doença, apresentando novos aspectos, particularmente em relação à bioquímica, à interação entre o parasita e a célula hospedeira e à resposta imunológica à infecção
    Keywords Medicine (General)
    Size 1 electronic resource ( pages)
    Publisher SciELO Books - Editora FIOCRUZ
    Document type Book ; Online
    Note Portuguese ; Open Access
    HBZ-ID HT020589963
    ISBN 9788575415719 ; 8575415719
    DOI 10.7476/9788575415719
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article: Ultrastructural Alterations of the Human Pathogen

    Benchimol, Marlene / Gadelha, Ana Paula / de Souza, Wanderley

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 6

    Abstract: This review presents the main cell characteristics altered after in vitro incubation of the parasite with commercial drugs used to treat the disease caused ... ...

    Abstract This review presents the main cell characteristics altered after in vitro incubation of the parasite with commercial drugs used to treat the disease caused by
    Language English
    Publishing date 2023-06-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12060810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: COVID-19 and parasitology.

    de Souza, Wanderley

    Parasitology research

    2020  Volume 119, Issue 7, Page(s) 2369–2370

    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-30
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 284966-5
    ISSN 1432-1955 ; 0932-0113 ; 0044-3255
    ISSN (online) 1432-1955
    ISSN 0932-0113 ; 0044-3255
    DOI 10.1007/s00436-020-06719-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Giardia intestinalis and its endomembrane system.

    Benchimol, Marlene / de Souza, Wanderley

    The Journal of eukaryotic microbiology

    2022  Volume 69, Issue 6, Page(s) e12893

    Abstract: Giardia intestinalis has unique characteristics, even in the absence of certain organelles. For instance, Golgi and mitochondria are not found. On the other hand, there is a network of peripheral vacuoles (PVs) and mitosomes. The endoplasmic reticulum ( ... ...

    Abstract Giardia intestinalis has unique characteristics, even in the absence of certain organelles. For instance, Golgi and mitochondria are not found. On the other hand, there is a network of peripheral vacuoles (PVs) and mitosomes. The endoplasmic reticulum (ER), nuclear membrane, peroxisomes, and lipid bodies are present. The peripheral vacuole system seems to play several simultaneous roles. It is involved in the endocytic activity of the trophozoite but also has characteristics of early and late endosomes and even lysosomes, establishing a connection with the ER. Some of the PVs contain small vesicles, acting as multivesicular bodies, including the release of exosomes. The mitosomes are surrounded by two membranes, divide during mitosis, and are distributed throughout the cell. They do not contain DNA, enzymes involved in the citric acid cycle, respiratory chain, or ATP synthesis. However, they contain the iron-sulfur complex and transporters as TOM and TIM. Some mitosomes are linked to flagellar axonemes through a fibrillar connection. During encystation, two types of larger cytoplasmic vesicles appear. One originating from the ER contains the cyst wall proteins. Another contains carbohydrates. Both migrate to the cell periphery and fuse with plasma membrane secreting their contents to give rise to the cell wall.
    MeSH term(s) Animals ; Giardia lamblia/genetics ; Trophozoites/metabolism ; Golgi Apparatus ; Endoplasmic Reticulum/metabolism ; Mitochondria
    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1147218-2
    ISSN 1550-7408 ; 1066-5234
    ISSN (online) 1550-7408
    ISSN 1066-5234
    DOI 10.1111/jeu.12893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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